Articles tagged with Autoimmune Disorders
New study reveals that blocking interleukin-23 is more effective than targeting both interleukin-23 and interleukin-12 in treating psoriasis. Interleukin-12, previously thought to contribute to the disease, actually protects against it by maintaining normal skin cell function.
Researchers from Aarhus University have developed a revolutionary technique to identify pathogenic particles in the blood, which determine the development of autoimmune diseases like Systemic Lupus Erythematosus. The technique allows for early diagnosis and potentially life-threatening consequences such as blood clots and organ damage.
Researchers at UToledo have developed a protein-based vaccine that promotes a strong immune response, effectively treating rheumatoid arthritis and improving bone quality. The findings suggest long-term benefits following immunization.
Researchers at the University at Buffalo have developed a new treatment that pairs essential proteins with lysophosphatidylserine to build immune tolerance and prevent antibody development, potentially treating autoimmune disorders and allergies.
Researchers found that the gene TCF-1 regulates specific Treg cells, leading to more severe and inflammatory colon cancers. Without TCF-1, these cells become activated and gain a gut-homing feature, resulting in harsher cancer outcomes.
The FDA has granted orphan drug status to Octagam 10%, the first and only IVIg treatment for adult dermatomyositis. The therapy is expected to become the first treatment option for adults with this rare disease, which affects approximately 10 out of every million U.S. residents.
Researchers at Washington University School of Medicine found that COVID-19 vaccination elicited a response in nearly nine out of ten people with weakened immune systems. However, the responses were only about one-third as strong as those mounted by healthy people. Despite this, the discovery is encouraging news for a population at hig...
A new study has found that the absence of Aire protein in mice leads to fertility problems similar to those affecting men with autoimmune polyendocrine syndrome type I (APS-1). Researchers discovered that Aire-dependent central tolerance plays a critical role in maintaining male fertility.
A new study reveals that the small protein MOTS-c prevents the destruction of insulin-producing pancreatic cells in mice with autoimmune diabetes. MOTS-c treatment supports regulatory T-cells and reduces the activation of killer T-cells, effectively preventing disease onset.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
Researchers discovered a protein called CTRP9 associated with pulmonary function in scleroderma patients with interstitial lung disease. Patients with higher CTRP9 levels developed more severe lung disease, while low levels were linked to preserved function. The study suggests CTRP9 could help predict treatment needs for these patients.
A study by Anglia Ruskin University found that younger people with diabetes are significantly more concerned about COVID-19 risks and have a higher likelihood of reporting worries. Social support from family, friends, and healthcare teams plays a crucial role in managing these concerns.
A growing body of studies suggests COVID-19 emulates systemic autoimmune disorders. Researchers analyzed serum from over 300 hospitalized patients, discovering a novel autoantibody that shields toxic NETs from destruction. Those with higher levels were more likely to develop severe symptoms.
A new USC study found that males are more susceptible to sepsis due to high degranulation activity, while females exhibit more NETosis, which can contribute to autoimmune disorders. The study highlights the importance of considering sex and age as predictors for immune response in personalized medicine.
A new study identified genetic risk factors for pernicious anemia, a type of anemia caused by vitamin B12 deficiency due to autoimmune reactions. The study analyzed data from over 660,000 individuals and found associations between pernicious anemia and other autoimmune diseases.
Researchers have made significant breakthroughs in understanding how the production of antibodies is regulated in human cells, using cutting-edge technologies to sequence genes in individual cells. This knowledge could lead to enhanced antibody production in vaccines and treatments for diseases such as autoimmunity and allergy.
A new study by University of Tsukuba researchers reveals how two receptors, DNAM-1 and TIGIT, maintain the necessary balance between immune activation and suppression to prevent autoimmune diseases. The findings suggest that an imbalance in this mechanism may contribute to autoimmunity, providing potential targets for treatment.
Researchers develop microneedles for immunotherapy, allowing for high efficiency and minimal invasiveness. The devices can improve the efficacy of immune checkpoint inhibitors and represent an alternative to conventional cancer vaccine designs.
Researchers used a mouse model to identify the role of autoreactive T cells against transcriptional intermediary factor 1γ (TIF1γ) in dermatomyositis. The study found that autoreactive CD8+ T cells contribute to the pathogenesis of the disease, while autoantibodies are non-pathogenic clinical markers.
A Zika virus candidate, Ad26.ZIKV.001, showed promising safety and immunogenicity in a phase I clinical trial. The vaccine induced persistent neutralizing antibody responses and was found to be safe with mild to moderate reactogenicity. Researchers recommend further development of the vaccine should the need reemerge.
Scientists have discovered genes involved in autoimmune Addison's disease, a life-threatening hormonal deficiency caused by immune system destruction. The discovery could lead to personalized treatment options and may determine the molecular repercussions of predisposing genetic variations.
A large-scale genetic study found that variants of nine genes increase the risk of developing Addison's disease, a rare autoimmune disorder. The study identified specific gene variants associated with the disease, including the AIRE gene, which plays a crucial role in immune system function.
Researchers discover that a gel containing GzmB inhibitor VTI-1002 reduces skin blistering by 50% and protects skin integrity, offering hope for targeted treatments for pemphigoid diseases. Current corticosteroids often cause severe side effects, making alternative therapies needed.
Researchers identified two novel genetic variants in the Siglec-10 protein that predispose individuals to polyneuropathy after gut infection. These variants impair the protein's ability to bind gangliosides, leading to autoantibody production and damage to neurons.
Researchers found individuals with atopic dermatitis are more likely to have autoimmune skin and gastrointestinal diseases. The study, published in the British Journal of Dermatology, analyzed over 104,000 cases of atopic dermatitis and identified its association with various autoimmune conditions.
Researchers have found that melatonin may be a viable treatment option for COVID-19, reducing the likelihood of testing positive by nearly 30%. The study analyzed patient data from Cleveland Clinic's registry and identified 34 potential repurposing candidates, including melatonin.
A genetic association study found that TERT and DSP gene variants, associated with idiopathic pulmonary fibrosis risk, are linked to microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis. These variants may be novel susceptibility genes for both conditions.
A study led by George Hajishengallis found that targeting the DEL-1 molecule could be an effective way to treat inflammatory and autoimmune conditions. The researchers discovered that DEL-1 promotes the generation and immunosuppressive activity of regulatory T cells, which are crucial in maintaining health.
Research highlights sex differences in gene expression, finding over a third of genes display sex-biased expression in at least one tissue. Sex-linked disparities contribute to increased cancer rates in males and autoimmune disorders in females.
A recent study published in Nature Communications reveals that an enzyme called HDAC3 plays a crucial role in regulating lung macrophage development and homeostasis. The research found that inhibiting this enzyme may provide a new therapeutic approach for treating lung cancer and inflammatory diseases in the airway.
The Chan Zuckerberg Initiative provides $1.3 million in funding to NORD and EURORDIS, supporting organizational capacity building and Rare Disease Day awareness campaigns. The grants aim to unite and improve the lives of over 350 million people living with rare diseases worldwide.
Researchers created a human model of congenital pituitary hypoplasia using patient-derived iPS cells to illuminate the underlying mechanisms. The model revealed that a deficiency in FGF10 from the neighboring hypothalamus caused CPH, highlighting the importance of interactions between the pituitary and hypothalamus.
Integral Molecular has developed a panel of fully humanized P2X7 antibodies against autoimmune disorders like atopic dermatitis and glomerulonephritis. The company's MPS Antibody Discovery platform successfully isolated high-affinity antibodies with antagonist or rare agonist activity.
A team of scientists from Tokyo University of Science has made a breakthrough in understanding the inflammation mechanism in IgG4-related disease. They found that cytotoxic T lymphocytes (CTLs) and T follicular helper cells (Tfh cells) are necessary for pancreatic inflammation, and propose Janus kinase (JAK) as a suitable therapeutic t...
Researchers at Lund University have discovered a protein, Lin28b, that allows self-reactive B-1 cells to develop in mice. These cells produce antibodies against the body's own substances, but are beneficial in cleaning up dead cells and preventing inflammation.
Researchers found that 89% of patients had elevated levels of autoantibodies against the adrenergic alpha 1 receptor, suggesting an autoimmune connection to postural orthostatic tachycardia syndrome. A simple blood test could aid in diagnosis, paving the way for easier identification and treatment.
Researchers have created an animal model for a devastating autoimmune brain disease, offering new hope for diagnosis and treatment. The model allows for the specific blocking of the immune system's attack on the NMDA receptor, paving the way for targeted therapeutic strategies.
A study of 17,018 individuals with autoimmune diseases found a twofold increased risk of developing Crohn's disease and ulcerative colitis after treatment with etanercept. This association suggests that anti-TNFα agents may provoke inflammatory bowel disease through common immune dysregulation mechanisms.
A large cohort study in northern England found significant clustering of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in specific regions. The researchers suggest that exposure to a persistent environmental agent may play a key role in the development of these autoimmune liver diseases.
Researchers evaluated the safety and effectiveness of uterine artery embolization (UAE) in patients with various autoimmune diseases. UAE was technically and clinically successful in all patients, with no significant difference in volume reduction rates between groups.
Researchers have discovered autoreactive cells in narcolepsy patients, providing new proof that the sleep disorder is an autoimmune disease. Autoreactivity was found not only in patients but also in healthy individuals, suggesting a trigger for the disease.
The study reveals that Foxp1 is essential for the proper functioning of Treg cells, which play a crucial role in regulating immune responses. The findings suggest that targeting Foxp1 could lead to the development of therapies that selectively modulate Treg cell activity, offering new hope for treating autoimmune diseases and cancer.
Research in mice reveals how fever boosts the ability of immune cells to reach infections by altering surface proteins. Fever-induced heat shock protein 90 (Hsp90) promotes lymphocyte adhesion and transmigration through α4 integrin activation.
A new study found that the mutated MLX gene impairs the immune system by promoting inflammasome activation, leading to chronic inflammation and arterial disease. The discovery provides potential treatments, such as tocilizumab, which has shown efficacy in other inflammatory diseases.
Researchers at Rutgers Robert Wood Johnson Medical School identified a crucial step in the immune system's defense against viruses, which also sheds light on autoimmune disorders. The study found that an immune receptor called RIG-I 'flutters' to detect viral RNAs, triggering an antiviral response.
Research reveals estrogen receptor alpha influences T cell activation, proliferation and survival in autoimmune diseases, including MS, RA, and SLE. Regulatory T cells play a crucial role in preventing autoimmune diseases, and the study identifies potential targets for novel treatments.
Research reveals huge variation in gluten-free food prescribing practice in England, with the most deprived areas having the lowest rates. The study found that factors such as clinical commissioning group policies and deprivation levels play a significant role in determining prescribing patterns.
Researchers at Ohio State University discovered a pathway that involves enzyme SAMHD1 in regulating the immune system. This study suggests blocking SAMHD1 activity might thwart disease progression and provides potential targets for new treatments.
A Houston Methodist research team has identified a critical switch controlling T-cell function and discovered a pathway to target it, potentially solving autoimmune diseases and organ transplant rejection. By inhibiting IRF4 expression in activated T-cells, the researchers found they could render them irreversibly dysfunctional.
Researchers at the University of Louisville discovered a new autoimmune disease that causes kidney failure, dubbed anti-brush border antibody (ABBA) disease. The disease was identified after analyzing biopsied kidney tissue from patients with acute kidney injury, and it affects the nephrons' brush borders by coating them with antibodies.
Researchers created a human stem cell-based model of Aicardi-Goutieres Syndrome to identify underlying genetic mechanisms and test existing drugs. Two FDA-approved HIV antiretroviral drugs showed promise in rescuing mutated cells, offering hope for future clinical trials.
Babraham Institute group leader Dr Rahul Roychoudhuri has been selected for the £200,000 Lister Institute Research Prize Fellowship to support his research on immune system regulation and suppression. His goal is to better understand how gene regulators affect T cells and potentially treat autoimmune diseases.
Researchers have identified a key feature of mevalonate kinase deficiency (MKD), a rare genetic condition, by finding untethered proteins in the cells of children with the disease. This discovery could help fast-track diagnosis and provide new insights into the disease process.
A University of Maryland expert has diagnosed Francisco Goya with a rare autoimmune syndrome or syphilis after suffering from severe illness and hearing loss in 1793. She notes that Goya's condition would have been treatable today.
Scientists have discovered clues into how a destructive autoimmune disease works using a unique microscope capable of illuminating living cell structures. They were able to see clusters of antibodies atop astrocytes, the brain cell target of the autoimmune response in neuromyelitis optica.
Researchers have explored the potential of this novel therapeutic approach, demonstrating promising pre-clinical data with over 40 scientific papers. Vectored-antibody delivery using rAAV offers advantages in treatment of various chronic and infectious diseases.
Researchers at the University of Basel have created a treatment approach using customized synthetic glycopolymers that act as molecular sponges to neutralize disease-causing antibodies. This innovative method has potential applications for treating other antibody-mediated autoimmune diseases.
Researchers at Osaka University have found that the breakdown of SEMA4D protein causes inflammation and disease in AAV patients. The study suggests that SEMA4D could be used as a new clinical marker to improve diagnosis accuracy.
The U.S. National Institutes of Health now requires funding applicants to consider sex as a variable in proposed research, aiming to address disparities in health outcomes. However, some scientists express concerns about the policy's potential impact on research costs and data quality.
A study by Brigham and Women's Hospital investigators found that 55 out of 270 genetic loci associated with seven autoimmune diseases could be mapped back to causal genes using eQTLs in immune cells. However, this only accounts for a small fraction of the genetic loci examined.