Articles tagged with Blood Vessels
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EndGenitor Technologies Inc. will market test kits for researchers to detect endothelial stem and progenitor cells, which can be used to treat chronic degenerative diseases associated with aging. The company aims to create cell therapy products using the 'ancestor' cells discovered by Drs. Mervin C. Yoder Jr. and David A. Ingram Jr.
Researchers successfully silenced SDF-1's signal in mice with simulated retinopathy, effectively halting the growth of new blood vessels. The study could lead to a treatment option using routine injections of an antibody-blocking substance into a patient's eye.
A new study published in Cancer Cell reveals that combining radiation with antiangiogenic therapy can significantly slow tumor growth when administered at the right time. The research found that a unique time period exists during which this combination is most effective, making it a potential breakthrough in cancer treatment.
A Mount Sinai School of Medicine study identifies the shared precursor cell, called the hemangioblast, in early mouse embryos. This finding provides strong proof for the existence of a common origin for vascular cells and hematopoietic cells.
A research team at Johns Hopkins Medicine has discovered a new protein pair that stops blood vessels' growth in developing mice, shedding light on tumor development and nerve regeneration. The study, published in Science, reveals a unique mechanism of action for the protein Sema3E, which works differently from other semaphorins.
Researchers found that Semaphorin 3E (Sema3E) and plexin-D1 proteins work together to control vascular patterning in the developing embryo. Sema3E was shown to exert a 'repulsive' force, guiding blood vessels along their proper course and preventing abnormal growth.
A study led by UCSD biologists found that blood vessels respond to low oxygen levels, which may be a potent anti-tumor strategy. The research identified a gene, HIF-1alpha, that turns on in endothelial cells when they lack oxygen, causing them to proliferate and migrate.
A recent study found that the Ras protooncogene induces inflammation via CXCL-8, a key factor in tumor growth and angiogenesis. Inhibition of CXCL-8 function led to decreased tumor angiogenesis, highlighting its potential as an anticancer therapeutic target.
Researchers discovered that Netrin-1 stimulates cell proliferation, migration, and adhesion in endothelial cells and vascular smooth muscle cells, promoting angiogenesis. This finding has implications for treating diseases such as cancer and ischemic heart disease by either inhibiting or inducing blood vessel growth.
Researchers used zebra fish to discover that nerves and blood vessels share similar guiding signals, crucial for therapeutic angiogenesis. This finding has significant implications for developing targeted forms of treatment for diseases like heart attacks.
Researchers found that S1P1 plays a crucial role in tumor angiogenesis, which is the formation of new blood vessels to supply nutrients to growing tumors. The study used RNA interference to block S1P1, demonstrating its importance in tumor growth and progression.
Researchers found that Alpha-4Beta-1 is activated by CD47, causing sickle red blood cells to stick to blood vessel walls. This discovery may lead to new therapies for sickle cell disease and other anemias.
Vascular tumor growth in children is linked to a protein called MCP-1 that recruits macrophages, stimulating angiogenesis and tumor growth. Anti-MCP-1 therapy may prevent tumor development and improve patient outcomes.
Researchers have found that astrocytes play a key role in regulating blood flow within the brain, and may hold promise as a target for new therapies to treat strokes. The study, funded by CIHR and Canadian Stroke Network, could lead to new treatments within 5-10 years.
Researchers from MIT and international collaborations found that different proportions of two key ingredients in ginseng promote or hinder blood vessel growth, with implications for wound healing and cancer treatment. The study highlights the need for stronger regulations on herbal drugs due to variable processing methods.
Researchers are exploring the potential of lysophosphatidic acid (LPA) and gelatin to promote blood vessel formation and heal wounds. The study aims to determine how LPA interacts with specific proteins, such as Hic-5, to enhance or inhibit migration.
A defect in blood vessel formation due to the LBP-1a gene mutation can lead to growth retardation, spontaneous abortion, and infant death. The study found that embryos lacking LPB-1a had abnormally large and thin blood vessels, preventing nutrient exchange with the mother's blood.
Researchers found that administering CD34+ cells to mice with stroke damage led to increased new blood vessel growth and improved neural regeneration through the production of growth factors. The findings provide direct evidence for the importance of angiogenesis in repairing stroke damage.
A new study reveals a previously unrecognized mechanism for blood vessel patterning, suggesting a potential therapeutic target for cardiovascular diseases. The discovery involves an endothelial receptor called PlexinD1, which may enable manipulation of blood vessel growth and development.
A recent study published in Neurosurgery found that administering clot-dissolving medication directly to the site of blockages resulted in a 50% success rate in reducing neurological disability, compared to 39% with IV treatment. The intra-arterial therapy showed better results in re-opening blood vessels and improving stroke outcomes.
Researchers have identified a protein, fibulin-5, that inhibits the sprouting of new blood vessels, which is crucial for cancer tumor growth. The findings suggest that fibulin-5 may be an effective cancer therapy and could also serve as a diagnostic tool to detect cancer status.
Researchers developed a non-invasive imaging method to track new blood vessel growth in the heart after a heart attack. The technique uses a radioactively labeled protein to detect changes in damaged areas over time, providing clear visualization of healing processes.
Researchers at UNC have identified a critical role for the flt-1 receptor in regulating sprouting angiogenesis, a key step in blood vessel formation. The study's findings may lead to new therapies for conditions like coronary heart disease and diabetes.
Researchers at Duke University Medical Center have identified a protein called Hypoxia Inducible Factor (HIF-1) as the master switch that enables blood vessels to survive and nourish remaining cancer cells after radiation therapy. By suppressing HIF-1 with experimental drugs, they successfully inhibited tumor growth in animals.
New research reveals that hypoxia-inducible factor-1 (HIF-1) plays a key role in tumor cells' ability to resist radiation therapy. By understanding how this protective response is activated, scientists hope to develop effective treatments to enhance radiation's effectiveness against tumors.
Researchers uncover the stimulatory and inhibitory functions of tissue factor in blood vessel generation, shedding light on diabetic retinopathy and potential new treatments. Transgenic mice studies reveal altered structures in pathologically altered vessels, suggesting a possible target for angiogenesis inhibition.
MDCT angiography successfully diagnosed suspected arterial injuries in 48 of 49 patients, with only one patient requiring a follow-up angiogram. The study suggests that MDCT angiography can replace traditional angiography as an initial diagnostic tool.
Researchers at UT Southwestern discovered a cooperative relationship between CD44 and VLA-4 receptors on T-cells to facilitate their migration into infected tissues. This bimolecular complex is necessary for firm adhesion, allowing T-cells to initiate immune responses in diseases like rheumatoid arthritis.
A high-fat fast-food breakfast causes a surge in inflammatory factors in the blood stream, overwhelming the body's natural anti-inflammatory mechanisms. Repeated exposure may lead to chronic inflammation and increase the risk of heart disease.
Scientists have discovered a key relationship between two inherited eye disorders, Norrie disease and FEVR, linked to blood vessel malformation and activation of the Wnt pathway. The study sheds light on potential treatments for these conditions and raises questions about specialized vascular development systems in other tissues.
A research team at MGH has successfully grown long-lasting blood vessels using a technique that combines endothelial and perivascular cells. The new vessels formed beautiful networks, survived, and functioned like normal vasculature tissue.
Researchers at Stanford University found that microenvironmental VEGF concentration determines the threshold between normal and aberrant blood vessel growth. Long-term continuous delivery of VEGF maintains below this threshold promotes normal angiogenesis, guiding therapeutic strategies.
Researchers found that cancer cells release signals to nearby blood vessels to stimulate new vessel growth, while blood vessels release signals to sustain migrating cancer cells. This two-way dialogue allows cancer cells to survive and grow before new blood vessels form.
Nitric oxide inhibits endothelial cell release of inflammatory substances by targeting a specific protein, thereby regulating exocytosis and preventing inflammation. Researchers have developed a novel drug that blocks this process, showing promise as an anti-clotting agent for various diseases.
Researchers have found that injecting adult bone marrow-derived stem cells into the back of mouse eyes curtails retinal degeneration and restores normal retinal tissue. The treated mice had improved vision and responded to light, offering a potential new approach for treating retinitis pigmentosa.
Researchers at Emory University Health Sciences Center have identified honokiol, a compound found in magnolia cones, as a potent inhibitor of tumor growth. Honokiol reduces endothelial cell growth and inhibits angiogenesis, potentially leading to new cancer treatments.
A new treatment approach blocks liver tumor angiogenesis by manipulating the Tie2 receptor. In mice with colon cancer metastasis to the liver, this approach shrinks tumors and extends survival. The mean survival time increased significantly compared to control mice and endostatin-treated mice.
Researchers discover PlGF-1 stabilizes vessel growth in premature infants, preventing retinal detachment and blindness. The study suggests a promising therapeutic agent to prevent oxygen-induced vascular degeneration in ROP.
Sandra McLachlan and her team reveal that cleavage of the TSHR A subunit can induce or amplify the immune response to the TSHR, resulting in autoantibodies that stimulate thyroid hormones. This finding increases understanding of why autoantibodies arise specifically to the TSHR, leading to Graves hyperthyroidism.
Scientists report evidence of catch bonds regulating white blood cell activity, offering potential targets for anti-inflammatory compounds and cancer metastasis control. Researchers discovered prolonged bond lifetimes with increasing force, contrary to initial theories.
Scientists at Northwestern University have discovered an enzyme that makes endothelial cells in the lungs susceptible to injury during periods of inflammation. They developed an experimental MLCK inhibitor, which protected normal mice from lung injury when exposed to bacterial toxin and ventilator-induced stress.
Researchers found that a combination of endostatin and radiation therapy reduced new blood vessel growth in mice with squamous cell cancer. After radiation, endostatin blocked the growth of new blood vessels, leading to long-term survival and tumor control in 40% of mice.
Scientists found that elevated levels of sFlt1 protein mediate the progression to preeclampsia by reducing angiogenic factors. Reducing VEGF-A in kidney cells also caused similar kidney disease, suggesting a plausible scenario for preeclampsia
Researchers identified sFlt1 as the root cause of preeclampsia, a condition characterized by high blood pressure and organ damage. The study's findings hold promise for developing diagnostic tools and therapies for this deadly condition.
A recent NHLBI study found a link between low levels of endothelial progenitor cells and increased cardiovascular disease risk. The study suggests that these cells play a crucial role in repairing damaged blood vessels, and their depletion may contribute to the progression of heart disease.
Research by Dr. Marja J. van Wijk reveals that microparticles can damage blood vessels and disrupt their function, contributing to pre-eclampsia. Oestrogen administration may improve vessel functioning in affected women.
Researchers used radiation to activate receptors in tumor blood vessels, enabling targeted delivery of anti-cancer drugs. The approach showed promising results in reducing side effects and delaying tumor growth.
Research suggests that taking dietary supplements of L-arginine and antioxidants like vitamins C and E may lower the risk of atherosclerosis and heart disease. The treatment reduced inflammation and increased production of eNOS, a molecule that prevents blood clots.
Molecular signals play a critical role in separating the lymphatic system from the circulatory system during fetal development. The study sheds light on the mechanisms behind this separation and its potential therapeutic applications, including influencing blood vessel growth and tumor treatment.
A new study reveals that Viagra encourages platelets to aggregate, potentially leading to thrombosis and life-threatening conditions like heart attacks and strokes. The researchers found that the drug's active ingredient raises levels of cGMP, which initially causes platelets to clump but later reverses to prevent excessive buildup.
Researchers developed a system to study blood vessel development without mural cells, revealing that angiopoietin-1 partially restores large vessel structure. The study suggests Ang1 is crucial for normal vessel stability and highlights the importance of pericytes in maintaining vascular networks.
Regular aerobic and weight-lifting activities can help diabetics control blood sugar and lower blood pressure, also providing cardiovascular benefits. Exercise training reduces total and abdominal fat, leading to improvements in insulin sensitivity, blood pressure, and blood vessel function.
African-American patients are 71% as likely as white patients to receive a referral for coronary angiography, but only 63% actually undergo the procedure. Private insurance and patient preference may play roles in the disparity.
A new vaccine has been shown to prevent stroke in rats by reducing inflammation in blood vessels. The study found that the vaccine reduced ischemic strokes by 16 times and prevented hemorrhagic strokes altogether.
Researchers from Penn State College of Medicine developed a new measurement technique to assess norepinephrine release in tissues adjacent to blood vessels. This improvement allows for more accurate data on the hormone's role in vasoconstriction and maintains adequate blood pressure when standing up.
Researchers at TSRI have developed a technique to selectively deliver adult stem cells into the eye, which can stimulate vessel growth and address inherited retinal degenerations. The cells can incorporate into the vasculature and make it normal, or be loaded with antiangiogenics to selectively wipe out the formation of new blood vessels.
A previously unrecognized function of myeloperoxidase has been identified, affecting vasculature through a pathway independent of chlorine bleach production. This discovery may lead to the development of new drugs to treat inflammatory vascular diseases and conditions like septic shock.
A new drug could provide a non-destructive way to treat blindness in diabetics, blocking the pathway that causes damage. The drug is currently being tested in clinical trials and has been funded by $4.7 million from the US-based JDRF and NHMRC.
The balancing act between COX-1 and COX-2 enzymes plays a crucial role in protecting the heart from cardiovascular disease. The study found that PGI2 production is stimulated as a response to platelet interactions with the vessel wall, limiting the harmful effects of thromboxane.
Biocompatible thin films have been successfully fabricated on various biomedical substrates using electrostatic self-assembly techniques. These films can inhibit restenosis, a tissue buildup that occurs in blood vessels after trauma, and have potential applications in stents and dialysis tubing.