Articles tagged with Blood Vessels
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Researchers at University at Buffalo developed a method to isolate functional smooth muscle cells from bone marrow, which can be used in regenerative medicine for cardiovascular applications. The engineered blood vessels function similarly to native tissue, demonstrating potential as an alternative to venous grafts.
Experimental studies suggest that targeting angiogenesis with dopamine agonists and dendritic cell inhibitors may inhibit endometrial lesions and decrease cancer risk. Mouse models show reduced blood vessel formation and increased old blood vessels in treatment groups.
Researchers found that increasing omega-3 fatty acids and decreasing omega-6 fatty acids in the diet can reduce retinopathy severity by suppressing inflammatory proteins. The study suggests that omega-3 fatty acids may act as protective factors in diseases affecting retinal blood vessels.
Researchers have identified a set of molecular markers that can distinguish between healthy and tumor blood vessels, paving the way for more selective anticancer therapeutics. The study reveals 13 genes selectively overexpressed in tumor blood vessels, offering new targets for developing safer therapies.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
The Friedlander lab will work with six other laboratory groups to conduct pre-clinical work on adult stem cells, aiming to develop a new approach to treating retinal diseases. The therapy targets abnormal blood vessel formation, which is a leading cause of vision loss in Americans.
A study found that celecoxib can reduce the production of cells and molecules involved in building new blood vessels in premature infants, which may help prevent germinal matrix hemorrhages. Researchers believe this could lead to improved outcomes for babies born prematurely, reducing the risk of brain damage and related complications.
Researchers have discovered that the anti-fungal medication itraconazole can stop the growth of new blood vessels, which is commonly seen in cancers. In mice models, treatment with itraconazole reduced blood vessel growth by 67%, providing a promising lead for cancer treatment
FSU researcher Feng Zhao will receive a $450,000 fellowship award to develop methods for regenerating blood vessels damaged by secondhand tobacco smoke. She aims to construct small-diameter blood vessels that mimic the elasticity of living tissue, which could help thousands of patients undergoing bypass surgery.
Scientists at the University of Bristol have found that inflammation caused by trapped white blood cells can obstruct blood flow to the brain, leading to poor oxygen supply. This discovery suggests a new mechanism for high blood pressure, with potential therapeutic targets for treatment.
Researchers developed nanoparticles that can label and track stem cells used in medical treatments, offering a new way to monitor tumors and diagnose cardiovascular problems. The technology uses MRI scanning to detect the presence of labeled cells, allowing for more accurate measurements and better understanding of each cell type's role.
Preeclampsia researchers found specific proteins in placentas that damage maternal blood vessels, including plasminogen activator inhibitor-1 and soluble Flt-1. Microparticles from the placenta contain high levels of a mysterious protein with unknown function.
A team of researchers has identified more than 70 markers unique to ovarian tumor blood vessels, which could lead to new screening and treatment tools. The finding suggests that these markers may be a sign of an aggressive tumor and could help inform treatment decisions.
A new study suggests daily consumption of a Mars Inc. flavanol-rich cocoa drink can improve and sustain blood vessel function, reversing impairments similar to long-term drug therapy with statins. The flavanol-rich cocoa appears to have independent effects on blood vessels, unrelated to antioxidant actions.
Researchers discovered that cancer cells forming blood vessels exhibit a distinct distribution of cellular copper, which may help explain how copper-reducing cancer therapy works. This finding has implications for understanding the regulation of metal ion content in metal-binding proteins and could lead to new cancer therapies.
Researchers have identified a group of proteins that may play critical roles in causing blood vessel leakage in the eyes of people with diabetic retinopathy. CA-1, an enzyme normally found in red blood cells, was found to increase blood vessel leakage and swelling in both the eyes and brain.
Scientists at Karolinska Institutet identified a crucial role of Dll4 in blood vessel formation through angiogenesis. The study found that Dll4 signalling determines the number of sprouts and branches formed, which is essential for tissue health and disease prevention.
Researchers used MRI to detect macrophages in arterial walls, which indicate inflammation and cardiovascular disease. The study found a 79% increase in detection compared to baseline images, suggesting a potential noninvasive screening tool for heart attack risk.
A study by St. Jude researchers found that brain tumors arise from cancer stem cells living in microscopic protective niches formed by blood vessels, disrupting these niches may block tumor growth. The team showed that targeting blood vessel cells could eliminate CSCs and prevent tumor reappearance following treatment.
A study published in the Journal of Neuroscience has identified two proteins, SDF1 and Ang1, as key triggers for neuronal migration and regeneration after a stroke. These molecular signals, released by newly formed blood vessels, promote post-stroke neuroblast migration, holding promise for developing new therapies to repair brain cells.
A new study found that a commonly used drug to slow central vision loss can also treat diabetic retinopathy, a common complication of diabetes. The treatment showed promise in improving reading ability and reducing swelling in the retina by targeting vascular endothelial growth factor, a protein that promotes unwanted blood vessel growth.
Researchers propose a novel treatment strategy for retinopathy by repairing abnormal blood vessels instead of destroying them. The study shows that transplanted bone marrow-derived cells can convert leaky blood vessels into normal ones, suggesting a potential therapy for human diseases like ROP.
Researchers successfully generated smooth muscle cells from multipotent adult progenitor cells using TGF-beta and PDGFB, offering a potential source for tissue engineering. This study identifies a model system for studying the effects of therapeutics on SMC development.
Researchers have developed a manmade protein that can reverse obstructive blood vessel growth, reducing its effects on cancer, diabetic retinopathy, and macular degeneration. The protein, which targets vascular endothelial growth factor (VEGF), shows promise for treating these conditions.
A new study uses MRI techniques to discriminate between patients who will benefit from clot-dissolving drugs and those who may be harmed. The technique helps doctors make informed decisions about treatment timing, potentially improving patient outcomes.
A soluble form of a receptor called sflt-1 traps factors that enable growth of vision-obstructing blood vessels in the cornea. By eliminating sflt-1, researchers found that mice corneas consistently developed blood vessels.
Scientists identified SFLT-1 as the protein responsible for preventing blood vessel growth in corneas. Deactivating this protein allows angiogenesis to occur, leading to conditions such as macular degeneration and cancer. The discovery opens doors to new treatments by harnessing the natural anti-angiogenic properties of the eye.
Researchers at the University of Wisconsin-Madison have discovered a new compound that inhibits angiogenesis, a process essential for tumor growth. The compound, called NK-B, works by preventing the production of vascular endothelial growth factor and reducing receptor molecules that respond to VEGF.
Research reveals two proteins in blood foretell development of preeclampsia, a life-threatening complication of pregnancy. High levels of soluble endoglin and sFlt1 indicate severe forms of preeclampsia and offer hope for early detection and cure.
Researchers discover that rapamycin blocks abnormal tumor-like blood vessel formation by inhibiting Akt signaling, a key player in tumor growth. This finding suggests a potential clinical utility for rapamycin as an anti-angiogenic agent and opens up a new pathway for rapamycin's therapeutic action.
Researchers at Beth Israel Deaconess Medical Center identified a signaling pathway transforming healthy blood vessels into cancerous tumor vasculature. Rapamycin successfully blocked this pathway and reduced tumor growth and vascular leak in animal models.
Researchers identify VEGFR-3 as a key factor in preventing blood vessel growth in the cornea. The protein acts as a sink to neutralize growth factors, maintaining a blood-vessel-free cornea essential for clear vision. This discovery holds promise for treating eye disease and cancer.
Netrins, a family of proteins, accelerate blood vessel growth and restore nerve growth in ischemic and diabetic mice. This breakthrough has significant implications for treating diabetes and peripheral vascular disease.
A study found that offspring of type 2 diabetic parents exhibit endothelial dysfunction and increased risk of atherosclerosis, even without diabetes. The research suggests that early treatment may prevent progression of the disease, highlighting the importance of identifying high-risk groups.
Researchers found that atorvastatin increased circulating endothelial precursor production by 1.7 to 8-fold in SSc patients, improving Raynaud's phenomenon activity but symptoms generally returned to baseline after discontinuation.
Schepens scientists identify the intracellular switch that regulates angiogenesis, a process that can be both beneficial and detrimental to the body. The discovery may lead to more targeted drugs for diseases such as diabetic retinopathy and macular degeneration.
Researchers at Harvard Medical School have discovered a key mechanism that regulates blood vessel growth and regression. By targeting this process, new drugs may be designed to dismantle existing vessels or promote vessel regression in diseases such as diabetic retinopathy and macular degeneration.
A study using RESPeRATE, a device-guided paced breathing system, found significant reductions in blood pressure and peripheral resistance in hypertensive patients. The treatment group showed a greater systolic BP reduction correlated with the total time spent in slow breathing.
A recent study published in Heart Rhythm found that smokers are at a markedly increased risk of receiving an electrical discharge from their implantable cardioverter-defibrillators (ICDs). This risk is seven times higher than that of non-smokers, highlighting the importance of quitting smoking for patients with heart disease.
Researchers found that fibulins inhibit both tumor growth and blood-vessel formation in mice. The study showed that tumors producing fibulins grew up to 24-45% smaller than control tumors after three weeks.
Researchers at MIT developed a tool to selectively irradiate blood vessels to study radiation damage. This technique has the potential to reduce side effects for cancer patients treated with radiation therapy.
Researchers developed a model system for studying neuro-vascular interactions, enabling the creation of stable vascular networks that can connect with larger blood vessel structures. The approach uses a macroporous hydrogel polymer scaffold and co-seeds it with endothelial cells and nerve progenitor cells.
Research reveals a homing mechanism for bone marrow-derived progenitor cell recruitment to neovasculature. This process is crucial in cancer progression as it enables tumors to acquire new blood vessels.
A study reveals that angiopoietin-2 (Ang-2) plays a pivotal role in acute respiratory distress syndrome (ARDS), a condition affecting 40% of patients with sepsis. Elevated Ang-2 levels can cause leakiness in lung blood vessels, impairing lung function and leading to trouble breathing.
Research suggests that aldosterone, a hormone involved in blood pressure regulation, may also contribute to strokes. Aldosterone blockers have shown promise in animal models, reversing wall-thickening effects on blood vessels. However, gender differences and optimal treatment strategies remain unclear.
Researchers discovered that Australians with small blood vessel changes in their eyes were 70% more likely to experience a stroke over seven years. The study's findings suggest that eye examinations could help predict stroke risk, providing a potential window for early intervention.
Researchers have identified a molecular defect in red blood cells as an important cause of pulmonary hypertension, a potentially fatal lung condition. A new therapy that replenishes SNO levels in the blood has shown promise in reversing the disease.
Researchers have identified tadpoles as a suitable model system for studying the lymphatic vessel network, essential for regulating fluid in the body and supporting the immune system. This breakthrough could lead to new solutions for illnesses caused by faults in the lymphatic vessel network, including cancer and lymphedema.
Researchers discovered that Arf gene restricts blood vessel growth in the eye during embryonic development, preventing excessive growth and associated cancers. This finding may lead to new therapies for persistent hyperplastic primary vitreous and anticancer drugs.
Researchers discover that amyloid-β protein plaques attach to blood vessels, causing damage and leakage. This breakthrough understanding may lead to the development of treatments that promote plaque removal from the brain.
Researchers found that tumor cells can stimulate blood vessel growth by activating the MAPK pathway and inducing Notch ligand Jagged1, which promotes formation of new vessels. This interplay between tumor cells and blood vessel cells supports tumor growth and progression.
Scientists are exploring the relationship between manatee tears and blood vessel formation to better understand the animals' immune system. The study found that manatees have a thick, mucusy tear film rich in antimicrobial components, which may help protect against pathogens.
Researchers at MIT have developed a novel approach to creating vascularized muscle tissue using a tri-culture scaffold composed of myoblasts, endothelial cells, and fibroblasts. The resulting implants showed improved integration with the host tissues and functioned in living mice and rats.
Researchers at Medical College of Georgia have developed a new approach to inhibit blood vessel growth by targeting VEGF production within cells. The technique, which uses a gene that binds to and sequesters VEGF, has shown promising results in reducing destructive blood vessel proliferation by up to two-thirds.
Researchers found that coated stents were better at keeping blood vessels open in cirrhosis patients, with improved survival rates and fewer interventions needed. The study analyzed data from 93 patients who underwent a successful TIPS procedure using either coated or non-coated stents.
A University of California, San Diego team discovered a receptor-ligand pair that plays a critical role in the final step of blood vessel formation, allowing newly constructed vessels to 'lock' together. Inhibiting this integrin protein may starve tumors and combat cancer.
A gene mutation that protects against malaria has been found to increase the risk of aggressive prostate cancer in African-American men. Researchers discovered that mice with this mutation developed larger, more aggressive tumors due to increased angiogenic chemokine production.
Researchers found that cranberry juice powder improved vascular function in subjects with high blood cholesterol and atherosclerosis after six months. The study suggests that consuming whole foods rich in polyphenols, such as cranberries, may help protect against heart disease.
Researchers discover that MT1-MMP controls blood vessel response to PDGF-ß signaling, essential for normal vessel formation. MT1-MMP-null mice exhibit severely compromised vascular architecture, suggesting potential therapeutic targets for controlling tumor growth and metastasis.
A breakthrough discovery identifies molecules that trigger secondary cerebral vasospasm after hemorrhagic stroke, leading to potential new treatments and diagnostic tests. Elevated levels of bilirubin and a specific group of oxidation products called BOXes are found to be correlated with the condition.