Articles tagged with Blood Vessels
A new study found that bosentan prevents experimentally induced vaso-occlusive crises in a mouse model of SCD, reducing blood vessel resistance and preventing organ damage. Bosentan may provide a new way to limit VOCs and thereby reduce mortality and morbidity in individuals with Sickle Cell Disease.
Researchers have discovered that stem cells isolated from hair follicles can differentiate into smooth muscle cells that grow new vasculature, making them ideal for engineering cardiovascular tissue regeneration. This breakthrough may lead to the development of new treatments for vascular grafts and cardiac tissue regeneration.
A UK physician's groundbreaking study reveals that siRNA therapies may have unintended consequences, such as blocking blood vessel growth in various organs. This discovery underscores the need for cautious approach in clinical trials using gene silencing technology.
Dr. Watts' research suggests that serotonin may play a role in lowering blood pressure, contradicting previous findings that it causes constriction. She hopes to resolve the 'serotonin puzzle' with her lecture and gather input from fellow physiologists.
Researchers found a blood vessel protein, Robo4, that reverses or prevents damage from two devastating eye diseases. The study's discovery could lead to new drugs to treat and prevent age-related macular degeneration and diabetic retinopathy.
Researchers are investigating how biomechanical forces affect blood vessel growth in the lungs of babies with congenital heart disease. The study aims to understand the mechanisms behind this phenomenon and potentially develop improved treatments for affected children.
A new study finds that smoking and high blood pressure have a synergistic effect, increasing the risk of hemorrhagic stroke. Quitting smoking and lowering blood pressure can significantly reduce this risk, as seen in a cohort of over 563,000 participants.
Researchers found that PPARÓ plays a protective role in the blood vessel wall, regulating vascular structure and function. This discovery provides a molecular explanation for some of the beneficial cardiovascular effects of TZD drugs.
Researchers at Massachusetts General Hospital have identified a new strategy for normalizing tumor blood supply by controlling nitric oxide levels. By selectively suppressing NO production in tumor cells while maintaining it in blood vessels, the study found improved appearance and function of the tumor's blood supply.
A new study shows that tumor blood vessels develop from precancerous stem cells, a type of cell that can become malignant. The findings suggest that screening anti-angiogenic drugs should include these cells to improve their effectiveness in blocking tumor growth.
A mouse study reveals that erythropoietin keeps blood vessels alive and growing in the eye, but administering it at the wrong time may worsen diseases. The hormone's effects depend on timing, with early administration potentially slowing disease progression and late administration accelerating it.
Researchers found that a drug originally used to treat iron poisoning triggered the growth of new blood vessels, leading to significant increases in bone density and regeneration. The treatment has broad implications for improving treatment of bone fractures and musculoskeletal disorders.
A University of South Florida fetal surgeon successfully treated a rare condition where placental blood vessels block the birth canal and can rupture during labor. The laser procedure sealed off the abnormal fetal blood vessels, eliminating prolonged hospitalization and allowing the pregnancy to progress with a vaginal delivery.
Bystolic is a once-daily medication that can be used as monotherapy or in combination with other treatments to reduce blood pressure. It selectively blocks the effects of adrenaline at the heart and vasodilates blood vessels, offering a low incidence of traditional beta blocker side effects.
Researchers found that Secretoneurin (SN) increases production in brain cells following ischemia, improving survival of primary brain cell cultures. In animal models, SN treatment reduced cerebral tissue death, improved motor performance, and enhanced brain function.
Researchers have discovered a protein called CIB1 that plays a major role in controlling new blood vessel growth, providing a potential target for drug therapies. The findings may help control unwanted blood vessel growth in diseases such as diabetic retinopathy and wound healing.
Researchers discovered that experimental drug endostatin may significantly reduce or eliminate abnormal blood vessel growth, a hallmark of advanced AMD. This finding gives hope to individuals at high risk for the disease, which affects central vision and can lead to total blindness.
A new study suggests that treatment can lower the risk of stroke in people with rare lung disease. The research, published in the journal Thorax, found that seemingly healthy patients with pulmonary arteriovenous malformations (pulmonary AVMs) have the same risk of stroke as those who are obviously unwell.
Researchers found an antibody against placental growth factor (PlGF) blocks tumor growth and enhances chemotherapy effects in mice. The antibody has a better safety profile than VEGF inhibitors, which cause severe side effects.
Scientists discovered that immune cells called macrophages play a role in age-related macular degeneration by failing to block abnormal blood vessel formation. In older mice, macrophages shift from M1 to M2 type, promoting disease progression.
Researchers used transparent zebrafish to study inflammatory breast cancer, discovering how two proteins interact to facilitate metastasis. The study reveals that vascular endothelial growth factor (VEGF) and RhoC work together to promote rapid intravasation of cancer cells into blood vessels.
Dendritic cells help trigger angiogenesis in a mouse model of endometriosis, promoting the growth of tumors and lesions. Targeting dendritic cells may prove to be a promising strategy for treating conditions dependent on angiogenesis.
Millions of patients receive transfusions with impaired blood, which can lead to heart attacks and death. Researchers found that adding nitric oxide back to stored blood restores its ability to deliver oxygen.
Researchers have found that mutated forms of the angiogenin gene are toxic to motor neurons and affect their ability to grow and extend. Targeting these faulty molecules may help maintain healthy neurons and prevent disease progression.
The adult mammalian lymphatic vasculature is derived from embryonic lymph sacs and has been shown to originate from venous endothelial cells using genetically modified mice. Understanding this origin is crucial for preventing, diagnosing, and curing lymphatic disorders.
Researchers in Australia identify two markers to isolate mesenchymal stem-like cells from endometrial tissue, which can differentiate into various cell types and repair prolapsed pelvic floors. The study opens up possibilities for using these stem cells for pelvic floor prolapse surgery and other gynaecological applications.
Researchers at Weill Cornell Medical College have discovered that preconditioning, a process where the brain is challenged with a small noxious stimulus, can shield blood vessels from stroke injury. This study found a 68% reduction in stroke intensity and a 114% boost in blood flow in areas unaffected by the stroke.
Researchers at University at Buffalo developed a method to isolate functional smooth muscle cells from bone marrow, which can be used in regenerative medicine for cardiovascular applications. The engineered blood vessels function similarly to native tissue, demonstrating potential as an alternative to venous grafts.
Experimental studies suggest that targeting angiogenesis with dopamine agonists and dendritic cell inhibitors may inhibit endometrial lesions and decrease cancer risk. Mouse models show reduced blood vessel formation and increased old blood vessels in treatment groups.
Researchers found that increasing omega-3 fatty acids and decreasing omega-6 fatty acids in the diet can reduce retinopathy severity by suppressing inflammatory proteins. The study suggests that omega-3 fatty acids may act as protective factors in diseases affecting retinal blood vessels.
Researchers have identified a set of molecular markers that can distinguish between healthy and tumor blood vessels, paving the way for more selective anticancer therapeutics. The study reveals 13 genes selectively overexpressed in tumor blood vessels, offering new targets for developing safer therapies.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
The Friedlander lab will work with six other laboratory groups to conduct pre-clinical work on adult stem cells, aiming to develop a new approach to treating retinal diseases. The therapy targets abnormal blood vessel formation, which is a leading cause of vision loss in Americans.
A study found that celecoxib can reduce the production of cells and molecules involved in building new blood vessels in premature infants, which may help prevent germinal matrix hemorrhages. Researchers believe this could lead to improved outcomes for babies born prematurely, reducing the risk of brain damage and related complications.
Researchers have discovered that the anti-fungal medication itraconazole can stop the growth of new blood vessels, which is commonly seen in cancers. In mice models, treatment with itraconazole reduced blood vessel growth by 67%, providing a promising lead for cancer treatment
FSU researcher Feng Zhao will receive a $450,000 fellowship award to develop methods for regenerating blood vessels damaged by secondhand tobacco smoke. She aims to construct small-diameter blood vessels that mimic the elasticity of living tissue, which could help thousands of patients undergoing bypass surgery.
Scientists at the University of Bristol have found that inflammation caused by trapped white blood cells can obstruct blood flow to the brain, leading to poor oxygen supply. This discovery suggests a new mechanism for high blood pressure, with potential therapeutic targets for treatment.
Researchers developed nanoparticles that can label and track stem cells used in medical treatments, offering a new way to monitor tumors and diagnose cardiovascular problems. The technology uses MRI scanning to detect the presence of labeled cells, allowing for more accurate measurements and better understanding of each cell type's role.
Preeclampsia researchers found specific proteins in placentas that damage maternal blood vessels, including plasminogen activator inhibitor-1 and soluble Flt-1. Microparticles from the placenta contain high levels of a mysterious protein with unknown function.
A team of researchers has identified more than 70 markers unique to ovarian tumor blood vessels, which could lead to new screening and treatment tools. The finding suggests that these markers may be a sign of an aggressive tumor and could help inform treatment decisions.
A new study suggests daily consumption of a Mars Inc. flavanol-rich cocoa drink can improve and sustain blood vessel function, reversing impairments similar to long-term drug therapy with statins. The flavanol-rich cocoa appears to have independent effects on blood vessels, unrelated to antioxidant actions.
Researchers discovered that cancer cells forming blood vessels exhibit a distinct distribution of cellular copper, which may help explain how copper-reducing cancer therapy works. This finding has implications for understanding the regulation of metal ion content in metal-binding proteins and could lead to new cancer therapies.
Researchers have identified a group of proteins that may play critical roles in causing blood vessel leakage in the eyes of people with diabetic retinopathy. CA-1, an enzyme normally found in red blood cells, was found to increase blood vessel leakage and swelling in both the eyes and brain.
Scientists at Karolinska Institutet identified a crucial role of Dll4 in blood vessel formation through angiogenesis. The study found that Dll4 signalling determines the number of sprouts and branches formed, which is essential for tissue health and disease prevention.
Researchers used MRI to detect macrophages in arterial walls, which indicate inflammation and cardiovascular disease. The study found a 79% increase in detection compared to baseline images, suggesting a potential noninvasive screening tool for heart attack risk.
A study by St. Jude researchers found that brain tumors arise from cancer stem cells living in microscopic protective niches formed by blood vessels, disrupting these niches may block tumor growth. The team showed that targeting blood vessel cells could eliminate CSCs and prevent tumor reappearance following treatment.
A study published in the Journal of Neuroscience has identified two proteins, SDF1 and Ang1, as key triggers for neuronal migration and regeneration after a stroke. These molecular signals, released by newly formed blood vessels, promote post-stroke neuroblast migration, holding promise for developing new therapies to repair brain cells.
A new study found that a commonly used drug to slow central vision loss can also treat diabetic retinopathy, a common complication of diabetes. The treatment showed promise in improving reading ability and reducing swelling in the retina by targeting vascular endothelial growth factor, a protein that promotes unwanted blood vessel growth.
Researchers propose a novel treatment strategy for retinopathy by repairing abnormal blood vessels instead of destroying them. The study shows that transplanted bone marrow-derived cells can convert leaky blood vessels into normal ones, suggesting a potential therapy for human diseases like ROP.
Researchers successfully generated smooth muscle cells from multipotent adult progenitor cells using TGF-beta and PDGFB, offering a potential source for tissue engineering. This study identifies a model system for studying the effects of therapeutics on SMC development.
Researchers have developed a manmade protein that can reverse obstructive blood vessel growth, reducing its effects on cancer, diabetic retinopathy, and macular degeneration. The protein, which targets vascular endothelial growth factor (VEGF), shows promise for treating these conditions.
A new study uses MRI techniques to discriminate between patients who will benefit from clot-dissolving drugs and those who may be harmed. The technique helps doctors make informed decisions about treatment timing, potentially improving patient outcomes.
Scientists identified SFLT-1 as the protein responsible for preventing blood vessel growth in corneas. Deactivating this protein allows angiogenesis to occur, leading to conditions such as macular degeneration and cancer. The discovery opens doors to new treatments by harnessing the natural anti-angiogenic properties of the eye.
A soluble form of a receptor called sflt-1 traps factors that enable growth of vision-obstructing blood vessels in the cornea. By eliminating sflt-1, researchers found that mice corneas consistently developed blood vessels.
Researchers at the University of Wisconsin-Madison have discovered a new compound that inhibits angiogenesis, a process essential for tumor growth. The compound, called NK-B, works by preventing the production of vascular endothelial growth factor and reducing receptor molecules that respond to VEGF.
Research reveals two proteins in blood foretell development of preeclampsia, a life-threatening complication of pregnancy. High levels of soluble endoglin and sFlt1 indicate severe forms of preeclampsia and offer hope for early detection and cure.
Researchers discover that rapamycin blocks abnormal tumor-like blood vessel formation by inhibiting Akt signaling, a key player in tumor growth. This finding suggests a potential clinical utility for rapamycin as an anti-angiogenic agent and opens up a new pathway for rapamycin's therapeutic action.
Researchers at Beth Israel Deaconess Medical Center identified a signaling pathway transforming healthy blood vessels into cancerous tumor vasculature. Rapamycin successfully blocked this pathway and reduced tumor growth and vascular leak in animal models.
Researchers identify VEGFR-3 as a key factor in preventing blood vessel growth in the cornea. The protein acts as a sink to neutralize growth factors, maintaining a blood-vessel-free cornea essential for clear vision. This discovery holds promise for treating eye disease and cancer.
Netrins, a family of proteins, accelerate blood vessel growth and restore nerve growth in ischemic and diabetic mice. This breakthrough has significant implications for treating diabetes and peripheral vascular disease.