Articles tagged with Blood Vessels
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
Researchers found that resveratrol inhibits formation of damaging blood vessels in the eye, a potential preventive therapy for blinding diseases. The compound's novel pathway could become a new target for therapies for eye disease and other problems related to abnormal angiogenesis.
A recent study of 700,000 people found that diabetes approximately doubles the risk of developing blood vessel diseases, including heart attacks and strokes. The disease is now estimated to be responsible for 325,000 cardiovascular deaths per year in industrialized countries.
Researchers identified a defective signaling pathway that leads to the development of vascular malformations in the brain. The study suggests that targeting this pathway may lead to new treatments for cerebral cavernomas, including the use of anticancer drugs.
A recent NIH-supported study has discovered a novel pathway that may lead to the development of new treatments for high blood pressure. By increasing certain proteins in mouse blood vessels, researchers were able to relax the vessels and lower blood pressure, reducing damage to the kidneys compared to normal mice.
Researchers observed that early blood flow begins all at once in zebrafish embryos, involving hundreds of cells. Red blood cells initially stick to the vessel wall before releasing themselves with a protease enzyme called ADAM8.
A DNA-vaccine targeting DLL4 inhibits the formation of new blood vessels in tumours, leading to reduced tumour growth. The vaccine was shown to be effective in mice with breast cancer, causing a tightly packed network of non-functional blood vessels and poor blood supply.
The protein tPA provides protection for nerve cells in the hippocampus by preventing death caused by reduced blood flow during stroke. Analysis of tPA's protective process reveals implications for therapeutic strategies to prevent nerve cell death.
A new study reveals increasing rates of age-related macular degeneration among Asians, comparable to Caucasians. An innovative laser surgery called 'bypass' has shown promise in improving vision outcomes for central retinal vein occlusion patients.
Researchers have identified SphK1 and SphK2 as crucial proteins involved in generating the molecule S1P, which affects blood vessels and the immune system. Mice lacking these proteins showed improved recovery from anaphylaxis, while those lacking only SphK1 recovered poorly.
Researchers at UMass Chan Medical School have identified a novel microRNA-mediated genetic pathway responsible for triggering vascular growth in zebrafish embryos. This discovery provides new insights into how vascular systems develop and may offer a potential therapeutic target for limiting blood vessel formation in solid cancers.
Researchers have discovered that infantile hemangiomas originate from stem cells. Steroids target these stem cells specifically, inhibiting their ability to stimulate blood vessel growth. This finding opens the way for more specific and safer therapies for hemangioma.
A new study identifies a protein pathway that protects blood vessels from hyper-inflammatory response to infection, reducing mortality rates in mouse models of avian flu and sepsis by up to 50%. The researchers found that activating the Robo4 pathway stabilizes blood vessels, preventing leakage and tissue damage.
Researchers at Karolinska Institutet identified the role of VEGF-B protein in regulating fatty acid transport proteins in blood vessel walls, leading to increased fat intake and potential new treatments for metabolic diseases. The study found that blocking VEGF-B signalling may reduce insulin resistance and blood glucose levels.
Researchers identified IFN-beta as a natural inhibitor of tumor blood vessel growth, limiting tumor growth and immune cell gene expression. This discovery provides insight into why IFN therapy benefits early cancer development.
A new chemical compound has been discovered that may help treat and prevent diastolic heart failure, a condition where the heart is unable to relax after contraction. The research found that adding tetrahydrobiopterin (BH4) to blood vessels can restore function to the heart and prevent the disease from developing.
Researchers at Imperial College London have made a groundbreaking discovery that could lead to new treatments for conditions like deep vein thrombosis and haemophilia A. The study found that factor VIII, a key protein in blood clotting, is produced by lung blood vessels rather than just the liver.
A study by University of Cincinnati researchers found that proapoptotic peptide treatment reduced food intake and fat loss in obese mice and rats, without affecting energy expenditure. The findings suggest a novel system informing brain activity about fat tissue size, influencing appetite and weight regulation.
Interleukin-6 is a key mediator of inflammation in diabetic retinopathy, inducing vascular inflammation and tissue destruction. An interleukin-6 antibody may prevent damage by targeting this inflammatory response.
Researchers block COUP-TFII to suppress tumor blood vessel growth and tumor formation. This discovery identifies a new pathway for fighting tumors and offers hope for developing new treatments, including antagonists that can intervene to halt tumor growth.
Scientists discovered that blocking delta-catenin expression disrupts inflammation-induced angiogenesis in tumors and wounds. The findings suggest that delta-catenin may be a key player in cancer progression.
Researchers have identified Notch signaling pathway activation in human angiomyolipomas and TSC2-deficient rat cells, suggesting that TSC proteins regulate Notch activity. This finding supports the idea that Notch dysregulation may underlie some of the distinctive clinical features of Tuberous Sclerosis Complex.
Researchers have identified a key protein channel that helps nerve sensors regulate blood pressure. The ASIC2 channel plays a crucial role in controlling electrical activity in blood vessels, and its absence leads to high blood pressure.
A study led by Dr. Frank Winkler followed the steps of tumor cell formation in real-time, revealing four stages required for metastasis development. Blocking angiogenesis with Avastin can suppress emergence of brain metastases.
Researchers at Karolinska Institutet identify polyphosphate as a key player in the formation of blood clots and inflammation. The study suggests that phosphatases can break down polyphosphate, preventing both conditions.
Researchers identified a new mechanism by which HRG protein inhibits angiogenesis and tumor growth in cancer patients. The study shows that the HRG fragment binds to endothelial cells and platelets, creating a microenvironment that functions as an angiogenesis inhibitor.
Researchers found that surfboard-shaped nanoparticles stay closest to blood vessel walls, offering a potential solution for targeted cancer therapy. The study suggests that current transfusion techniques may not be ideal, and alternative methods could establish proper blood arrangement faster.
Scientists observe aggressive T-cells breaching blood-brain barrier, crawling along vascular walls and forming connections with phagocytes. This breakthrough understanding may aid in developing new treatments for multiple sclerosis.
Researchers at Johns Hopkins School of Medicine found that cells in the retina can remain alive for many months and recover some or all normal function even without a proper blood supply. The study suggests that restoring blood supply to deprived regions of the retina may restore visual function.
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
Researchers from BUSM found that the 940nm wavelength laser is more effective in treating facial telangiectasias due to its superior penetration of the dermis and slower heating of vessels. This results in less pain and side effects compared to the 532nm wavelength.
Researchers at the University of Iowa discovered a way to deliver therapeutic molecules directly into brain cells using the blood-brain barrier. They found that unique alterations in the blood vessels surrounding brain cells can target specific diseases, allowing for non-invasive treatment of lysosomal storage diseases.
A new corticosteroid medication has been shown to improve vision and reduce vision loss in patients with central retinal vein occlusion. The treatment, which involves eye injections of the medication, has been proven effective in reducing vision loss by five times.
Blood vessels can spur their own growth and deliver oxygen to tissues and tumors through internal cues. The study found that a protein called Flt-1 plays a key role in regulating this process.
Researchers found that the endothelin receptor plays a role in vaso-occlusive pain in sickle cell disease, with males more sensitized to pain. Females have more of the ETB receptor, which may explain better pain control and reduced sensitivity.
The International Conference on Endothelin presented promising results for new endothelin receptor antagonist drugs, which may benefit conditions like kidney disease and pulmonary hypertension. However, challenges in determining the best treatment approach and addressing potential side effects must be overcome.
Researchers found that mice lacking protein S suffered massive blood clots and defective blood vessels, highlighting the protein's dual role in coagulation and inflammation. Protein S also binds to receptors that regulate immune responses, suggesting new targets for gene therapy.
GS-101 demonstrates significant inhibition and regression of corneal neovascularisation in a phase II study. The treatment is generally well-tolerated with no serious side effects, offering a new approach to managing ophthalmic angiogenesis.
A preclinical study suggests that ancient Chinese herbal formulas have profound nitric oxide bioactivity, which can signal blood vessel relaxation and eliminate clots. The findings offer new hope for cardiovascular disease prevention and treatment.
Researchers found that elevated arginase levels contribute to vascular eye damage in diabetic retinopathy by reducing nitric oxide production. Normalizing arginase levels could potentially halt disease progression by preventing inflammation and vascular constriction.
A new molecule known as soluble VEGFR-2 has been identified that selectively blocks lymphatic vessel growth but not blood vessel growth. This breakthrough could lead to targeted treatments for diseases such as lymphedema, transplant rejection, and tumor metastasis.
Concurrent deep vein thrombosis is more likely when superficial vein thrombosis affects the lower leg, according to a study published in Archives of Dermatology. The study found that 24% of patients with superficial vein thrombosis also had deep vein thrombosis.
Researchers have discovered that two microRNAs, miR-143 and miR-145, control the differentiation and growth of vascular smooth muscle cells. These findings suggest that targeting these microRNAs may be a potential treatment for diseases such as atherosclerosis and Alzheimer's disease.
Researchers at the University of Oklahoma Health Sciences Center discovered a natural compound that restores balance in the eye to stop diabetic retinopathy, a disease affecting five million Americans. The treatment prevents leakage, blocks inflammation, and stops unwanted blood vessel growth.
Researchers found 128 genes with varying expression levels in early clinical pregnancy compared to non-pregnant state. Gene expressions related to angiogenesis, vascular endothelial growth factor, and pyruvate metabolism were over-represented.
A team of researchers led by Dr. Jayakrishna Ambati at the University of Kentucky has discovered a biological marker for neovascular age-related macular degeneration (AMD). The marker, CCR3, shows strong potential as a means for both early detection and preventive treatment.
Researchers have discovered a new target for the diagnosis and treatment of age-related macular degeneration by blocking the activity of the CCR3 protein. This approach shows promise as a safer and more effective alternative to current treatments, which target vascular endothelial growth factor (VEGF).
A new model suggests mechanical forces play a crucial role in blood vessel growth, challenging previous assumptions about chemical gradients. This finding opens up new possibilities for treating diseases such as tumors, rheumatism, and eye disorders.
Researchers have identified a molecule called PHD2 that regulates blood vessel growth and is often found at lower-than-normal levels in human tumors. Blocking PHD2 expression allows human cancer cells to grow more quickly, increasing tumor blood vessel formation.
Researchers found that increased O-GlcNAc levels damage blood vessels by reducing nitric oxide production, increasing blood pressure and vessel contraction. This discovery could lead to new treatments targeting the O-GlcNAc pathway.
Researchers found that obstructive sleep apnea thickens blood vessels due to NADPH oxidase enzyme activation, increasing the risk of pulmonary hypertension and other heart diseases. In mice, inhibiting NADPH oxidase reduced hypoxia-induced pulmonary hypertension, suggesting potential treatment strategies.
The American College of Physicians has released a guidebook and DVD to assist patients in managing high blood pressure, a condition that increases the risk of heart disease, stroke, and kidney problems. The resource provides information on causes, risk factors, and lifestyle changes to control hypertension.
Researchers at USC have identified a new compound that targets both tumor cells and surrounding blood vessels, potentially leading to more effective treatment options for brain tumors. The study found that the compound reduced tumor growth and blood vessel density in animal studies.
A new study by Dr. Jayakrishna Ambati and colleagues found that the siRNA treatment is toxic to both blood and lymphatic endothelial cells, with potential applications in cornea transplantation and treatment of lymphatic diseases.
Researchers at Wake Forest University School of Medicine discovered a protein called ferritin binds to HKa, promoting blood vessel formation that assists in tumor growth. The study suggests preventing the binding could block tumor growth, with implications for wound care.
Researchers found that mice with mutated or missing clock genes developed thick and inflexible blood vessels, a hallmark of vascular disease. This suggests that clocks may work normally in the brain but malfunction in blood vessels to bring on hypertension and vascular disease.
A team of researchers, led by Mark Kahn, has discovered that CCM is caused by leaky junctions between cells in the lining of blood vessels, linked to mutated or missing proteins in a novel biochemical process called Heart-of-glass (HEG)-CCM pathway.
Researchers at Uppsala University developed a tool to study signals controlling blood vessel growth, enabling scientists to determine what attracts or repels vessels. This knowledge is crucial in tumor research, as unwanted angiogenesis can fuel tumor growth.
A Johns Hopkins engineer is working on coaxing human stem cells to form new blood vessels that could replace damaged tissue in people with heart disease and other illnesses. The researcher, Sharon Gerecht, aims to understand the molecular signals that cause stem cells to differentiate into blood vessels.
Researchers found that aldosterone levels were directly correlated with blood pressure levels and related changes in blood vessel function. Higher aldosterone levels were also associated with lower kidney blood flow and greater extremity blood vessel stiffness.