Articles tagged with Blood Vessels
A new study suggests that regenerative abnormalities associated with diabetes are widespread, affecting not only nerves but also blood vessel growth and Schwann cell proliferation. By promoting blood vessel and Schwann cell growth, researchers may be able to speed up axon regeneration and repair damaged nerves and blood vessels.
Researchers at the University of Strathclyde have identified a heretofore unrecognised pathway regulating calcium activity within blood vessel smooth muscle cells. This discovery may lead to the development of new treatments for hypertension by targeting the constriction and dilation of blood vessels.
Researchers at St. Michael's Hospital found that cells protecting blood vessels work better in patients undergoing nighttime home dialysis than those on standard hospital dialysis. This suggests that frequent nighttime dialysis might be beneficial for some patients with blood vessel damage, improving overall health outcomes.
Researchers at Temple University discovered that a magnetic field can reduce blood viscosity by 20-30%, posing a potential new way to prevent heart attacks. By polarizing red blood cells and streamlining their movement, the magnetic field decreases friction against blood vessel walls.
UT Southwestern Medical Center researchers have found that blocking two specific RNA molecules can suppress abnormal blood vessel growth in degenerative eye disorders. This finding suggests a potential strategy to treat age-related macular degeneration, a leading cause of blindness among older people.
Researchers found that Bim is required for anti-cancer therapies targeting tumor blood vessels to be effective. The discovery could lead to new treatments by attacking both the tumor and its blood supply.
Researchers identified a new probiotic bacteria-derived soluble protein that can protect intestinal cells from inflammation and injury in mice models of colitis. The protein's delivery to the colon provided therapeutic protection against ulcerative intestinal inflammatory disorders.
Two teams from Queen's University Belfast are working on different approaches to cure Retinopathy of Prematurity (ROP) in premature babies. The first team aims to tackle the disease at an early stage, while the second team investigates using stem cells from umbilical cords to repair damaged eyes.
Researchers at UAB have discovered that blocking a specific receptor on glioma cells can starve them of nutrients, effectively stopping their invasion in the brain. The target is a drug already approved for use in Europe, which increases blood vessel size.
A recent study by Washington University researchers discovered that fatty acid synthase and nitric oxide synthase enzymes interact in endothelial cells to cause blood vessel damage in diabetes. By understanding this mechanism, they hope to develop new treatments for vascular complications of the disease.
Researchers found that endothelial cells lining blood vessels secrete molecules suppressing tumor growth and invasion. The discovery could lead to a new way to treat cancer by implanting these cells adjacent to the tumor.
VIB-K.U. Leuven scientists have decoded a potential new anti-cancer mechanism by normalizing abnormal tumor blood vessels through HRG, which prevents metastasis and enhances chemotherapy efficiency. This mechanism offers alternative possibilities for cancer treatment.
A research team led by Richard Waugh is investigating the reasons behind the limited attraction of white blood cells to injured tissue. They aim to develop pharmaceutical treatments that can modulate the response of white blood cells.
A significant increase in MMP-1, an enzyme produced in tissues under conditions of inflammation, was found in the blood vessels of women with preeclampsia, explaining edema and proteinuria. This finding also suggests a new mechanism for hypertension, with PAR1 activation potentially causing blood vessel contraction.
A new type of VEGFR-3 blocking antibody has been developed to inhibit angiogenesis in cancerous tumors. The antibody was shown to be effective even at high concentrations of the growth factor, and combining it with another inhibitor provided synergistic inhibition.
Researchers are developing a manufacturing platform to produce biodegradable frames that mimic nature's fine-grained details, including vasculature. The goal is to grow replacement cardiac tissues for people who have suffered a heart attack, and create better systems for growing and studying cells in the laboratory.
Researchers discovered that GPR124 controls the growth of blood vessels into the developing brains of mice embryos. The protein is essential for normal blood vessel development in the nervous system but can lead to abnormal hypervasculature when overexpressed.
A randomized trial found that mycophenolate mofetil was less effective than azathioprine in preventing relapses of antineutrophil cytoplasmic antibody-associated vasculitis. The study involved 156 patients with newly diagnosed AAV and followed them for a median of 39 months.
Researchers at Washington University School of Medicine discovered a new drug target that can improve the effectiveness of radiation therapy for hard-to-treat cancers. The enzyme cytosolic phospholipase A2 (cPLA2) promotes tumor angiogenesis, enabling tumors to overcome radiation effects.
Researchers found that secondhand smoke triggers a complex inflammatory response in the lungs of rats, leading to increased white blood cells, damaged lung tissue, and impaired immune function. The study suggests potential implications for treating damage caused by secondhand smoke in humans.
Researchers at the University of Louisville have developed a new technology that prevents scar tissue from forming around implanted devices, allowing them to function longer. The technology uses tiny blood vessel fragments suspended in collagen gel to create an environment that resists scarring.
Researchers discovered that galectin-3 promotes angiogenesis by binding to specific cell-adhesion proteins, suggesting potential therapeutic targets. Targeting the protein with inhibitors significantly reduced angiogenesis in mice, offering new approaches for treating diseases caused by excessive blood vessel growth.
A study by LMU researchers found that neutrophils play a crucial role in blood coagulation and antimicrobial defense, trapping pathogens in small blood vessels. Excessive clotting, however, can lead to life-threatening conditions like heart attack and stroke.
A recent study found that long-term dietary consumption of capsaicin in chili peppers can reduce blood pressure in genetically hypertensive rats by activating the TRPV1 channel and increasing nitric oxide production. This could lead to potential benefits for humans with high blood pressure.
Researchers at UC San Diego School of Medicine identify microRNA miR-132 as the 'gas pedal' controlling uncontrolled blood vessel growth. They develop an anti-miR therapy to restore functionality to the 'brake,' halting disease progression in mouse models of cancer and retinal disorders.
Researchers found that chronic morphine use decreases levels of tumor angiogenesis, mediated by suppression of signaling induced by low oxygen concentrations. This effect suggests morphine may inhibit tumor growth and serve as an anti-angiogenic agent in cancer pain management.
Daily cocoa flavanol consumption more than doubles the number of circulating angiogenic cells in the blood, increasing vessel repair and maintenance functions. High-flavanol cocoa also reduces systolic blood pressure and improves blood vessel function by 47%.
Researchers found that resveratrol inhibits formation of damaging blood vessels in the eye, a potential preventive therapy for blinding diseases. The compound's novel pathway could become a new target for therapies for eye disease and other problems related to abnormal angiogenesis.
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
A recent study of 700,000 people found that diabetes approximately doubles the risk of developing blood vessel diseases, including heart attacks and strokes. The disease is now estimated to be responsible for 325,000 cardiovascular deaths per year in industrialized countries.
Researchers identified a defective signaling pathway that leads to the development of vascular malformations in the brain. The study suggests that targeting this pathway may lead to new treatments for cerebral cavernomas, including the use of anticancer drugs.
A recent NIH-supported study has discovered a novel pathway that may lead to the development of new treatments for high blood pressure. By increasing certain proteins in mouse blood vessels, researchers were able to relax the vessels and lower blood pressure, reducing damage to the kidneys compared to normal mice.
Researchers observed that early blood flow begins all at once in zebrafish embryos, involving hundreds of cells. Red blood cells initially stick to the vessel wall before releasing themselves with a protease enzyme called ADAM8.
A DNA-vaccine targeting DLL4 inhibits the formation of new blood vessels in tumours, leading to reduced tumour growth. The vaccine was shown to be effective in mice with breast cancer, causing a tightly packed network of non-functional blood vessels and poor blood supply.
The protein tPA provides protection for nerve cells in the hippocampus by preventing death caused by reduced blood flow during stroke. Analysis of tPA's protective process reveals implications for therapeutic strategies to prevent nerve cell death.
A new study reveals increasing rates of age-related macular degeneration among Asians, comparable to Caucasians. An innovative laser surgery called 'bypass' has shown promise in improving vision outcomes for central retinal vein occlusion patients.
Researchers have identified SphK1 and SphK2 as crucial proteins involved in generating the molecule S1P, which affects blood vessels and the immune system. Mice lacking these proteins showed improved recovery from anaphylaxis, while those lacking only SphK1 recovered poorly.
Researchers at UMass Chan Medical School have identified a novel microRNA-mediated genetic pathway responsible for triggering vascular growth in zebrafish embryos. This discovery provides new insights into how vascular systems develop and may offer a potential therapeutic target for limiting blood vessel formation in solid cancers.
Researchers have discovered that infantile hemangiomas originate from stem cells. Steroids target these stem cells specifically, inhibiting their ability to stimulate blood vessel growth. This finding opens the way for more specific and safer therapies for hemangioma.
A new study identifies a protein pathway that protects blood vessels from hyper-inflammatory response to infection, reducing mortality rates in mouse models of avian flu and sepsis by up to 50%. The researchers found that activating the Robo4 pathway stabilizes blood vessels, preventing leakage and tissue damage.
Researchers at Karolinska Institutet identified the role of VEGF-B protein in regulating fatty acid transport proteins in blood vessel walls, leading to increased fat intake and potential new treatments for metabolic diseases. The study found that blocking VEGF-B signalling may reduce insulin resistance and blood glucose levels.
Researchers identified IFN-beta as a natural inhibitor of tumor blood vessel growth, limiting tumor growth and immune cell gene expression. This discovery provides insight into why IFN therapy benefits early cancer development.
A new chemical compound has been discovered that may help treat and prevent diastolic heart failure, a condition where the heart is unable to relax after contraction. The research found that adding tetrahydrobiopterin (BH4) to blood vessels can restore function to the heart and prevent the disease from developing.
Researchers at Imperial College London have made a groundbreaking discovery that could lead to new treatments for conditions like deep vein thrombosis and haemophilia A. The study found that factor VIII, a key protein in blood clotting, is produced by lung blood vessels rather than just the liver.
A study by University of Cincinnati researchers found that proapoptotic peptide treatment reduced food intake and fat loss in obese mice and rats, without affecting energy expenditure. The findings suggest a novel system informing brain activity about fat tissue size, influencing appetite and weight regulation.
Interleukin-6 is a key mediator of inflammation in diabetic retinopathy, inducing vascular inflammation and tissue destruction. An interleukin-6 antibody may prevent damage by targeting this inflammatory response.
Researchers block COUP-TFII to suppress tumor blood vessel growth and tumor formation. This discovery identifies a new pathway for fighting tumors and offers hope for developing new treatments, including antagonists that can intervene to halt tumor growth.
Scientists discovered that blocking delta-catenin expression disrupts inflammation-induced angiogenesis in tumors and wounds. The findings suggest that delta-catenin may be a key player in cancer progression.
Researchers have identified Notch signaling pathway activation in human angiomyolipomas and TSC2-deficient rat cells, suggesting that TSC proteins regulate Notch activity. This finding supports the idea that Notch dysregulation may underlie some of the distinctive clinical features of Tuberous Sclerosis Complex.
Researchers have identified a key protein channel that helps nerve sensors regulate blood pressure. The ASIC2 channel plays a crucial role in controlling electrical activity in blood vessels, and its absence leads to high blood pressure.
A study led by Dr. Frank Winkler followed the steps of tumor cell formation in real-time, revealing four stages required for metastasis development. Blocking angiogenesis with Avastin can suppress emergence of brain metastases.
Researchers at Karolinska Institutet identify polyphosphate as a key player in the formation of blood clots and inflammation. The study suggests that phosphatases can break down polyphosphate, preventing both conditions.
Researchers identified a new mechanism by which HRG protein inhibits angiogenesis and tumor growth in cancer patients. The study shows that the HRG fragment binds to endothelial cells and platelets, creating a microenvironment that functions as an angiogenesis inhibitor.
Researchers found that surfboard-shaped nanoparticles stay closest to blood vessel walls, offering a potential solution for targeted cancer therapy. The study suggests that current transfusion techniques may not be ideal, and alternative methods could establish proper blood arrangement faster.
Scientists observe aggressive T-cells breaching blood-brain barrier, crawling along vascular walls and forming connections with phagocytes. This breakthrough understanding may aid in developing new treatments for multiple sclerosis.
Researchers at Johns Hopkins School of Medicine found that cells in the retina can remain alive for many months and recover some or all normal function even without a proper blood supply. The study suggests that restoring blood supply to deprived regions of the retina may restore visual function.
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
Researchers from BUSM found that the 940nm wavelength laser is more effective in treating facial telangiectasias due to its superior penetration of the dermis and slower heating of vessels. This results in less pain and side effects compared to the 532nm wavelength.
Researchers at the University of Iowa discovered a way to deliver therapeutic molecules directly into brain cells using the blood-brain barrier. They found that unique alterations in the blood vessels surrounding brain cells can target specific diseases, allowing for non-invasive treatment of lysosomal storage diseases.
Blood vessels can spur their own growth and deliver oxygen to tissues and tumors through internal cues. The study found that a protein called Flt-1 plays a key role in regulating this process.