Articles tagged with Blood Vessels
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Researchers shed light on how vertebrates developed closed circulation systems, essential for carrying blood to organs and tissues. A specific domain in tRNA synthetase plays a crucial role in proper embryonic development, influencing key regulator of new blood vessel growth.
Researchers developed a three-dimensional living tissue model to study brain tumors and therapeutics, confirming iron-oxide nanoparticles can deliver tumstatin to blood vessels surrounding gliomas. The model allows for testing of agent characteristics in a realistic environment.
The experimental drug clazosentan reduced the risk of blood vessel spasm in patients with a brain aneurysm. Patients on higher doses of the drug experienced a significant reduction in vasospasm-related complications, including neurological deficits and respiratory issues.
The study reveals that Raf-1 regulates cell adhesion, enabling cells to form new bonds and new blood vessels. The discovery may lead to cancer treatment approaches by targeting Raf-1 and disrupting tumor environments.
A new genre of medical imaging technology uses optical techniques to peer below the skin and through muscle and bone, revealing body structures. Devices such as blood vessel mappers and cancer detectors are already in use or in development, providing non-invasive views for diagnosis and study.
A Northwestern University study identified a gene that prevents blood vessels from forming in the cornea, which is essential for vision. The researchers hope to use this discovery as a basis for gene therapy to treat multiple eye disorders that cause blindness.
Researchers from Yale have devised a way to monitor the growth of laboratory-engineered blood vessels after implantation in patients using MRI and nanoparticle technology. This advance allows for noninvasive monitoring of engineered tissues, which is crucial for personalized medical treatments.
Researchers at UNC School of Medicine discovered that the protein Shc plays a vital role in forming new blood vessels through its ability to coordinate signals from growth factors and extracellular matrix. This finding highlights the importance of understanding molecular mechanisms in disease development and treatment.
Researchers developed genetically engineered blood vessels that can secrete erythropoietin, reversing anemia in mice. The system also has an on/off control mechanism, allowing for flexible dosing and minimizing antibiotic exposure.
Researchers discovered a crucial brain area, neuro-hypophysis, where biochemical commands are passed from the brain to the bloodstream. They found that oxytocin, known as the 'hormone of love,' plays a key role in the development of this structure, governing blood vessel formation during embryonic stages.
Researchers at Virginia Commonwealth University found that infiltration of white blood cells into expectant mothers' blood vessels may explain high blood pressure in pregnancy. This discovery could lead to novel treatments for preeclampsia, a leading cause of premature delivery and maternal mortality worldwide.
A new study found that a drug treatment called fasudil prevents the formation of lesions in cerebral cavernous malformation, a brain blood vessel abnormality. The treatment was tested in mice and showed promise as a potential replacement for complex surgery.
Researchers found that patients with ANCA-associated vasculitis have elevated levels of the protein Flt1, which hinders blood vessel repair. This impairment contributes to disease progression and increases the risk of kidney failure in these patients. Inhibiting Flt1 may help improve blood vessel repair and reduce this risk.
A recent study found that applying mechanical forces to a wound site immediately after healing began can disrupt vascular growth and prevent bone healing. However, delaying the application of mechanical stress until later in the healing process can enhance functional bone regeneration through adaptive remodeling.
Researchers have identified four new 'ZIP codes' in the human blood vessel network that could help fight cancer, obesity and other diseases. These shared addresses were found to be associated with specific receptors and ligands, opening up new avenues for targeted therapies.
A team of researchers has identified a way for the brain to protect itself when its energy supply is running low. The brain uses a protein called AMPK to reduce the firing frequency of electrical impulses, conserving energy. This discovery could lead to new treatments for patients at risk of stroke.
A protein that promotes neuron growth and blood vessel formation appears to halt brain degeneration in a genetic disease, according to Northwestern University research published in Nature Medicine. The study suggests a link between aging and the development of spinocerebellar ataxia type 1, a disease causing cerebellum degeneration.
University of North Carolina cardiologist Cam Patterson received the 2012 Judah Folkman Award in Vascular Biology. His groundbreaking work on angiogenesis and VEGF cell receptor signaling has led to basic research findings being translated into clinical trials for new cardiovascular therapies.
A study found that smokers are twice as likely to have strokes and almost a decade younger when they do. Quitting smoking reduces stroke risks significantly within 18 months.
Researchers at NYU Langone Medical Center identified a molecular mechanism that regulates blood vessel formation. The Semaphorin-PlexinD1 signaling pathway, which limits VEGF growth, shows promise as a future therapeutic target for cancer treatment.
A new study reveals that hydrogen sulfide helps protect blood vessels from the complications of diabetes by controlling an early checkpoint in related processes. The researchers found that diabetic rats have lower levels of 'swamp gas' and improved blood vessel function after treatment.
A recent study confirms that long-term azithromycin treatment is associated with increased infection with nontuberculous mycobacteria, a serious complication in cystic fibrosis patients. The team identified autophagy impairment as the underlying mechanism, highlighting a clinical danger of pharmacological blockade.
Researchers are working to improve lung function in babies with heart defects by boosting the recycling system that enables blood vessels to handle excess blood volume. They've found that a key enzyme is insufficiently energized, and PPAR agonists may provide the necessary boost.
Fetal exposure to nicotine causes permanent changes in blood vessel behavior, leading to high blood pressure and cardiovascular disease in adulthood. This study provides novel information on the fetal programming underlying these risks.
A team of researchers has identified the MYLIP protein as a potential new target for lowering LDL cholesterol levels. The study found that the N342S polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.
Researchers at Duke University Medical Center found that donated red blood cells lose their key feature to diminish lifesaving power with storage time. This loss can lead to complications in critically ill patients, prompting a search for ways to optimize transfusion benefits and extend stored blood's shelf life.
Research from the University of Pennsylvania suggests that ovarian cancer cells secrete chemical signals suppressing the immune system while promoting blood vessel growth. This discovery could lead to more effective cancer treatments by combining therapies targeting angiogenesis with those blocking immunosuppressive T-reg cells.
New research suggests that obstructive sleep apnea can cause changes in blood vessel function, reducing blood supply to the heart. Treatment with continuous positive airway pressure (CPAP) has been shown to improve blood supply and function in study participants.
Researchers discovered a natural plant compound that blocks vessel growth by interfering with cellular adhesion, found to reduce tumor growth and improve treatment outcomes in animal models. The compound, dehydro-alpha-lapachone, was identified as a potential new class of antiangiogenesis drugs targeting blood vessel formation.
Dr. Napoleone Ferrara has made significant contributions to the understanding of angiogenesis, a process that plays a key role in cancer proliferation and various diseases. His research led to the development of new treatments for age-related macular degeneration and cancer.
A study found that certain white blood cells, called neutrophils, can re-enter the bloodstream and cause damage to unconnected organs after trauma or major surgery. Researchers believe this process is controlled by a protein on the surface of blood vessels called JAM-C.
A new study suggests that regenerative abnormalities associated with diabetes are widespread, affecting not only nerves but also blood vessel growth and Schwann cell proliferation. By promoting blood vessel and Schwann cell growth, researchers may be able to speed up axon regeneration and repair damaged nerves and blood vessels.
Researchers found a correlation between FAP and abnormal blood vessel density in the oral mucosa, suggesting a potential screening test. The study used a device to measure vascular density in patients with FAP and controls, showing higher values in FAP patients, which could indicate an alternative marker for colon cancer risk.
Researchers have found that HDL cholesterol from patients with coronary artery disease has impaired anti-inflammatory effects on blood vessel-lining cells and fails to stimulate repair of the blood vessel lining. This study highlights the importance of considering not just abundance but also biological functions of HDL in preventing CAD.
Researchers at St. Michael's Hospital found that cells protecting blood vessels work better in patients undergoing nighttime home dialysis than those on standard hospital dialysis. This suggests that frequent nighttime dialysis might be beneficial for some patients with blood vessel damage, improving overall health outcomes.
Researchers at the University of Strathclyde have identified a heretofore unrecognised pathway regulating calcium activity within blood vessel smooth muscle cells. This discovery may lead to the development of new treatments for hypertension by targeting the constriction and dilation of blood vessels.
Researchers at Temple University discovered that a magnetic field can reduce blood viscosity by 20-30%, posing a potential new way to prevent heart attacks. By polarizing red blood cells and streamlining their movement, the magnetic field decreases friction against blood vessel walls.
UT Southwestern Medical Center researchers have found that blocking two specific RNA molecules can suppress abnormal blood vessel growth in degenerative eye disorders. This finding suggests a potential strategy to treat age-related macular degeneration, a leading cause of blindness among older people.
Researchers found that Bim is required for anti-cancer therapies targeting tumor blood vessels to be effective. The discovery could lead to new treatments by attacking both the tumor and its blood supply.
Researchers identified a new probiotic bacteria-derived soluble protein that can protect intestinal cells from inflammation and injury in mice models of colitis. The protein's delivery to the colon provided therapeutic protection against ulcerative intestinal inflammatory disorders.
Two teams from Queen's University Belfast are working on different approaches to cure Retinopathy of Prematurity (ROP) in premature babies. The first team aims to tackle the disease at an early stage, while the second team investigates using stem cells from umbilical cords to repair damaged eyes.
Researchers at UAB have discovered that blocking a specific receptor on glioma cells can starve them of nutrients, effectively stopping their invasion in the brain. The target is a drug already approved for use in Europe, which increases blood vessel size.
A recent study by Washington University researchers discovered that fatty acid synthase and nitric oxide synthase enzymes interact in endothelial cells to cause blood vessel damage in diabetes. By understanding this mechanism, they hope to develop new treatments for vascular complications of the disease.
Researchers found that endothelial cells lining blood vessels secrete molecules suppressing tumor growth and invasion. The discovery could lead to a new way to treat cancer by implanting these cells adjacent to the tumor.
VIB-K.U. Leuven scientists have decoded a potential new anti-cancer mechanism by normalizing abnormal tumor blood vessels through HRG, which prevents metastasis and enhances chemotherapy efficiency. This mechanism offers alternative possibilities for cancer treatment.
A research team led by Richard Waugh is investigating the reasons behind the limited attraction of white blood cells to injured tissue. They aim to develop pharmaceutical treatments that can modulate the response of white blood cells.
A significant increase in MMP-1, an enzyme produced in tissues under conditions of inflammation, was found in the blood vessels of women with preeclampsia, explaining edema and proteinuria. This finding also suggests a new mechanism for hypertension, with PAR1 activation potentially causing blood vessel contraction.
A new type of VEGFR-3 blocking antibody has been developed to inhibit angiogenesis in cancerous tumors. The antibody was shown to be effective even at high concentrations of the growth factor, and combining it with another inhibitor provided synergistic inhibition.
Researchers are developing a manufacturing platform to produce biodegradable frames that mimic nature's fine-grained details, including vasculature. The goal is to grow replacement cardiac tissues for people who have suffered a heart attack, and create better systems for growing and studying cells in the laboratory.
Researchers discovered that GPR124 controls the growth of blood vessels into the developing brains of mice embryos. The protein is essential for normal blood vessel development in the nervous system but can lead to abnormal hypervasculature when overexpressed.
A randomized trial found that mycophenolate mofetil was less effective than azathioprine in preventing relapses of antineutrophil cytoplasmic antibody-associated vasculitis. The study involved 156 patients with newly diagnosed AAV and followed them for a median of 39 months.
Researchers at Washington University School of Medicine discovered a new drug target that can improve the effectiveness of radiation therapy for hard-to-treat cancers. The enzyme cytosolic phospholipase A2 (cPLA2) promotes tumor angiogenesis, enabling tumors to overcome radiation effects.
Researchers found that secondhand smoke triggers a complex inflammatory response in the lungs of rats, leading to increased white blood cells, damaged lung tissue, and impaired immune function. The study suggests potential implications for treating damage caused by secondhand smoke in humans.
Researchers at the University of Louisville have developed a new technology that prevents scar tissue from forming around implanted devices, allowing them to function longer. The technology uses tiny blood vessel fragments suspended in collagen gel to create an environment that resists scarring.
Researchers discovered that galectin-3 promotes angiogenesis by binding to specific cell-adhesion proteins, suggesting potential therapeutic targets. Targeting the protein with inhibitors significantly reduced angiogenesis in mice, offering new approaches for treating diseases caused by excessive blood vessel growth.
A recent study found that long-term dietary consumption of capsaicin in chili peppers can reduce blood pressure in genetically hypertensive rats by activating the TRPV1 channel and increasing nitric oxide production. This could lead to potential benefits for humans with high blood pressure.
A study by LMU researchers found that neutrophils play a crucial role in blood coagulation and antimicrobial defense, trapping pathogens in small blood vessels. Excessive clotting, however, can lead to life-threatening conditions like heart attack and stroke.
Researchers at UC San Diego School of Medicine identify microRNA miR-132 as the 'gas pedal' controlling uncontrolled blood vessel growth. They develop an anti-miR therapy to restore functionality to the 'brake,' halting disease progression in mouse models of cancer and retinal disorders.
Researchers found that chronic morphine use decreases levels of tumor angiogenesis, mediated by suppression of signaling induced by low oxygen concentrations. This effect suggests morphine may inhibit tumor growth and serve as an anti-angiogenic agent in cancer pain management.
Daily cocoa flavanol consumption more than doubles the number of circulating angiogenic cells in the blood, increasing vessel repair and maintenance functions. High-flavanol cocoa also reduces systolic blood pressure and improves blood vessel function by 47%.