Articles tagged with Blood Vessels
Researchers at Johns Hopkins University and the University of Maryland have discovered a new way to treat diabetic retinopathy by blocking two growth proteins, VEGF and angiopoietin-like 4. This could prevent many cases of proliferative diabetic retinopathy, which is the most common cause of vision loss in working-age adults in the US.
A new class of treatments may be effective in preserving vision for people with diabetic macular edema (DME). Researchers found that high levels of plasma kallikrein and associated molecules contribute to DME, and targeting this pathway may lead to new therapies.
Researchers have developed a new equation that predicts the behavior of blood cells during flow, shedding light on mechanisms behind blood disorders such as sickle cell anemia. This theory could lead to innovative solutions for blood transfusions and disease treatment.
A rare genetic syndrome is associated with increased blood vessel resistance, which may contribute to hypertension. The study identifies mutations in the PDE3A enzyme that alter its activity and increase blood pressure. The findings suggest new avenues for investigating hypertension causes and developing targeted therapies.
Sudden cardiac death accounts for 42% of deaths in on-duty firefighters over the past 5 years, exceeding traditional risks like burns and trauma. Researchers examine heat stress impact on firefighter hearts and blood vessels.
Researchers discovered that controlling the innate immune system's reaction to tissue-engineered vascular grafts can reduce abnormal narrowing and increase graft performance. The study sets the stage for developing safe and effective vascular grafts for congenital heart disease treatment.
Researchers at TU Wien and MedUni Vienna have developed artificial blood vessels that are biocompatible and can be broken down by the body. The new material has excellent mechanical properties and allows for the growth of natural tissue, making it a promising solution for bypass operations.
Researchers discover that blocking Slit2 protein prevents pathological blood vessel development in the retina, leading to a potential new treatment for vasoproliferative ocular diseases. The study suggests that therapies targeting Slit2 and its receptors may be beneficial for patients resistant to conventional anti-VEGF therapies.
Researchers have described the process of blood vessel pruning on a cellular level, revealing that cells can fuse with themselves to close vessels and prevent blood leakage. This discovery sheds light on the vascular system's ability to regulate itself through plasticity.
Researchers have identified significant vascular changes in Huntington's disease brains, finding mutant huntingtin in blood vessels and increased permeability of the blood-brain-barrier. These findings suggest that healthy cells can be infected by the mutant protein, offering new potential therapeutic targets.
A Northwestern University team has re-engineered a common drug to deliver nitric oxide, preventing cellular overgrowth and scarring in blood vessels during and after surgery. This modified protamine sulfate can slowly release nitric oxide, minimizing its negative effects while maintaining its function as an antidote for heparin.
Researchers found that folic acid supplementation increased nitric oxide production in older blood vessels, improving skin blood flow and reducing cardiovascular risk. This inexpensive alternative to pharmaceutical treatments shows promise for helping older adults cope with environmental heat waves.
Researchers at Imperial College London and Houston Methodist Research Institute have successfully delivered nucleic acids to specific areas of the body using nanoneedles, prompting the formation of new blood vessels in mice. This breakthrough technique shows promise for treating damaged organs and nerves by repairing themselves.
A study published in The Journal of Cell Biology provides new insights into the relationship between two proteins associated with cerebral cavernous malformations. Researchers found that CCM3 has an independent role in cell proliferation or survival pathways, contributing to the severity of symptoms.
Higher levels of HMGB1, a 'danger' molecule fueling inflammation and blood pressure, may contribute to male hypertension. A new study suggests targeting HMGB1 could help prevent T cell activation and lower blood pressure.
Researchers found that treating the uninjured side of the brain can boost growth factors and create new blood vessels, aiding stroke recovery. This approach also benefits the uninjured side with a boost of growth factors.
Researchers at Shanghai University developed a tri-layered artificial blood vessel composed of separate materials for mechanical strength and new cell growth. The composite allowed rapid proliferation and integration of rat fibroblast cells, overcoming limitations of existing vascular grafts.
Researchers at the University of Helsinki identified an alternative cell pathway promoting blood vessel growth that may explain why certain cancer therapies are failing to improve patient survival. This discovery could help clarify confusing trial results and potentially lead to new treatments for ovarian cancer and other cancers.
AP39 replenishes hydrogen sulfide levels, lowering heart rate and blood pressure, with potential for new cardiovascular therapies.
Researchers discovered that babies born with smaller kidneys are more likely to develop chronic kidney disease and high blood pressure as adults. The study found enhanced nerve activity and an inability to respond to nitric oxide promote kidney injury.
Researchers at Aarhus University have discovered ten new antibodies that can inhibit blood vessel formation near tumors, cutting off oxygen and nutrient supply. The antibodies appear to work effectively in laboratory tests and show promising therapeutic potential.
A novel molecular mechanism has been uncovered that tightens the bonds between cells lining blood vessels in mice, potentially preventing fluid leakage and improving survival rates. The discovery could lead to the development of new therapies targeting acute respiratory distress syndrome (ARDS), a fatal condition in approximately half ...
A new clinical study found that tetrahydrobiopterin (BH4) supplementation can dial back excessive sympathetic nervous system activation, leading to positive effects on arterial stiffness. BH4 is a cofactor for nitric oxide synthesis and has been shown to have beneficial effects on blood pressure and cardiovascular risk factors.
Researchers found a significant link between daily physical activity and vascular health. Inactivity for just five days can decrease the function of inner blood vessel linings, causing vascular dysfunction with prolonged effects.
Scientists at King's College London have identified the TRPA1 gene as a crucial player in the body's response to cold, triggering a vascular response that can help prevent frostbite and hypothermia. The study suggests that targeting this gene could lead to new treatments for conditions associated with cold exposure.
A new study reveals that traumatic brain injury can accelerate dementia by disrupting the brain's waste removal system, specifically the glymphatic system. This impaired system allows toxic proteins to accumulate in the brain, setting the stage for neurodegenerative diseases.
Researchers discovered that a key Ebola virus protein can trigger an excessive immune response, leading to massive inflammation and increased vascular permeability. This finding suggests a potential new target for reducing the severity of Ebola disease.
A pilot study found using a smartphone app for education and feedback about heart-healthy behavior decreased the risk of heart disease in young black women. The treatment group showed improved blood pressure, cholesterol levels, stress, anxiety, and healthy habits compared to the control group.
A recent study by the American Heart Association found that following a healthy diet can lower blood pressure measurements. The research, which included over 12,000 volunteers, suggested that eating a balanced diet rich in fruits, vegetables, and whole grains may be an effective way to maintain healthy blood pressure levels.
Researchers have discovered that growth factor VEGF-B can regenerate damaged peripheral nerves in the cornea without inducing angiogenesis. This finding suggests that VEGF-B may be a suitable candidate to treat nerve damage in areas where blood vessel formation would be detrimental.
A team of researchers from Johns Hopkins Medicine has discovered a novel blood vessel receptor that causes relaxation in response to light. This finding may lead to the development of new therapeutic options for vascular diseases, such as Raynaud's phenomenon.
A study published in the Journal of Clinical Investigation reveals that stenting can induce deleterious blood vessel remodeling due to a specific gene variant. The researchers identify the receptor tyrosine kinase ROS1 as a potential therapeutic target for treating flow-limiting atherosclerosis.
A gene that regulates blood vessel constriction is linked to aberrant blood vessel growth in premature babies, leading to vision loss. The finding suggests a new therapy to prevent damage and highlights endothelin's role in both blood pressure regulation and blood vessel formation.
Researchers have developed artificial platelet-like nanoparticles that combine morphological, mechanical, and surface chemical properties of natural platelets. These artificial platelets can simulate natural platelets' ability to collide with red blood cells, enabling selective clot formation at vascular injury sites.
A new lab device developed by Johns Hopkins engineers provides a clear view of how tumor cells spread through the body, causing over 90% of cancer-related deaths. By studying the movement of individual cancer cells, researchers aim to uncover new ways to keep cancer in check and develop effective treatment strategies.
Researchers have identified the normal function of the TEM5 protein, which is crucial for embryonic blood vessel development. The findings suggest that TEM5 could be a good target for anticancer drug therapy and potentially improve drug treatment for brain diseases by temporarily disabling the blood-brain barrier.
Researchers at University of Gothenburg have successfully grown a functional blood vessel in just one week using autologous peripheral whole blood. The breakthrough procedure involves extracting stem cells from a patient's blood, which accelerates growth and enables the creation of a new vein. This technology has the potential to benef...
Researchers identify a new type of melanoma cell in blood vessels that resists anti-angiogenic therapies. The cells, which express the protein PECAM1, help tumors evade treatment by forming functional blood-filled channels.
A new study reveals that preosteoclasts, a previously overlooked group of cells, play a crucial role in maintaining bone health. The discovery explains the success of an experimental osteoporosis drug and opens up new avenues for research into designing future studies.
Scientists at The University of Nottingham have made a major medical discovery that could lead to the development of an entirely new type of painkiller for chronic pain conditions like traumatic nerve injury. They found that a signal protein called VEGF promotes pain while its inhibiting form prevents it.
A study published in Nature Medicine has identified a receptor that promotes vascular growth and may prevent blindness in premature babies. The researchers found that activating this receptor can inhibit abnormal blood vessel growth, which is a major cause of retinopathy of prematurity.
Research on Korean adults finds that prolonged work hours are linked to a higher risk of developing coronary heart disease. Employees working 61-80 hours per week face a 42-94% increased likelihood of disease development within 10 years.
A team of researchers has identified a new target for treatment of common eye diseases, including wet macular degeneration and diabetic macular edema. Activating a biochemical pathway that suppresses VEGF's effects may offer a safer alternative to current treatments.
A new study published in PLOS ONE suggests that the current way of diagnosing type-2 diabetes using blood glucose levels needs to be revised. The researchers found changes in blood fat metabolites before glucose levels increased, indicating a potential alternative approach for diagnosis and treatment.
Researchers identified a tumor vessel-specific protein, L1, as a potential therapeutic target to reduce tumor growth and metastasis. Loss of L1 in mouse pancreatic cancer models reduced tumor angiogenesis and promoted vessel normalization.
Researchers found that mice lacking specific vascular system proteins developed normally but healed poorly from injuries. Increasing FGF signaling may improve wound healing, while inhibiting it in the eye could help patients with age-related macular degeneration or diabetic retinopathy.
Brain tumors grow exclusively within narrow spaces between and along the brain's thousands of small blood vessels, contrary to the theory of neoangiogenesis. This 'autovascular' growth allows tumor cells to draw energy and fuel their growth like normal brain tissue.
Chloroquine has been shown to inhibit tumor growth and metastases by normalizing abnormal blood vessels in tumors. This results in an increased barrier function blocking cancer cell dissemination and enhanced tumor perfusion increasing the response of the tumor to chemotherapy.
Researchers identified a genetic switch that stifles blood vessel development and used it to prevent peripheral vascular disease in a mouse model. The study's findings offer hope for new treatments targeting conditions like diabetes and atherosclerosis.
Researchers have discovered that invading glioblastoma cells hijack cerebral blood vessels to extract nutrients, damaging the brain's protective barrier and potentially leading to new cancer treatments. This finding could enable earlier delivery of anti-invasive agents to attack tumor cells.
Researchers discovered the protein SerRS acts as a brake on new blood vessel growth and pairs with c-Myc to promote proper vascular development. The study found that SerRS suppresses VEGFA transcription by recruiting SIRT2, a partner enzyme that had never been linked to angiogenesis.
Scientists from the University of Leeds have found a way to restore the function of damaged blood vessel repair cells. A protein called Akt was identified as the reason for reduced effectiveness in South Asian men's cells, which were able to be restored through the addition of active Akt.
Researchers at Brigham and Women's Hospital have successfully fabricated blood vessels using 3D bioprinting technology, addressing a critical challenge in tissue engineering. The approach involves printing agarose fibers that become the blood vessel channels, allowing for physical removal of template layers and improved cell viability.
Researchers discovered that CCL28 and its receptor are key players in angiogenesis, a hallmark of rheumatoid arthritis. This finding provides strong evidence for the binding of CCL28 to joint-lining cells as necessary for blood vessel formation.
Researchers developed a novel compound, Sticky-trap, to treat retinopathy by selectively closing off abnormal blood vessels without affecting healthy ones. The treatment has shown promise in mice and may lead to a new class of pharmacological entities for various conditions.
Researchers found that females susceptible to MS produce higher levels of the blood vessel receptor protein S1PR2 than males, leading to the inflammation that causes MS. The study's findings have implications for developing new treatments, including a drug that disables S1PR2.
Scientists have identified a potential new strategy to treat ovarian cancer by targeting multiple growth factors. By blocking several avenues that tumour cells use to escape eradication, researchers hope to develop new anticancer drugs that target ovarian tumour growth.
Researchers at the Beckman Institute developed a vascular network system that heals fiber-reinforced composites autonomously through polymerization of healing chemistries. This technology overcomes long-standing challenges in composite materials, enabling repeated self-healing and increasing structural reliability.
Professor Thomas Korff's work reduces experimental animals and promotes human umbilical cord cells to mimic vessel walls. His methods decrease animal distress and costs, while improving research results.
Researchers at Brigham and Women's Hospital have identified certain proteins in osteoclasts that may help destroy cardiovascular calcification by dissolving mineral deposits. The discovery suggests a potential therapeutic avenue for patients with cardiovascular calcification.