Articles tagged with Blood Vessels
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Researchers discovered that babies born with smaller kidneys are more likely to develop chronic kidney disease and high blood pressure as adults. The study found enhanced nerve activity and an inability to respond to nitric oxide promote kidney injury.
Researchers at Aarhus University have discovered ten new antibodies that can inhibit blood vessel formation near tumors, cutting off oxygen and nutrient supply. The antibodies appear to work effectively in laboratory tests and show promising therapeutic potential.
A novel molecular mechanism has been uncovered that tightens the bonds between cells lining blood vessels in mice, potentially preventing fluid leakage and improving survival rates. The discovery could lead to the development of new therapies targeting acute respiratory distress syndrome (ARDS), a fatal condition in approximately half ...
A new clinical study found that tetrahydrobiopterin (BH4) supplementation can dial back excessive sympathetic nervous system activation, leading to positive effects on arterial stiffness. BH4 is a cofactor for nitric oxide synthesis and has been shown to have beneficial effects on blood pressure and cardiovascular risk factors.
Researchers found a significant link between daily physical activity and vascular health. Inactivity for just five days can decrease the function of inner blood vessel linings, causing vascular dysfunction with prolonged effects.
Scientists at King's College London have identified the TRPA1 gene as a crucial player in the body's response to cold, triggering a vascular response that can help prevent frostbite and hypothermia. The study suggests that targeting this gene could lead to new treatments for conditions associated with cold exposure.
A new study reveals that traumatic brain injury can accelerate dementia by disrupting the brain's waste removal system, specifically the glymphatic system. This impaired system allows toxic proteins to accumulate in the brain, setting the stage for neurodegenerative diseases.
Researchers discovered that a key Ebola virus protein can trigger an excessive immune response, leading to massive inflammation and increased vascular permeability. This finding suggests a potential new target for reducing the severity of Ebola disease.
A recent study by the American Heart Association found that following a healthy diet can lower blood pressure measurements. The research, which included over 12,000 volunteers, suggested that eating a balanced diet rich in fruits, vegetables, and whole grains may be an effective way to maintain healthy blood pressure levels.
A pilot study found using a smartphone app for education and feedback about heart-healthy behavior decreased the risk of heart disease in young black women. The treatment group showed improved blood pressure, cholesterol levels, stress, anxiety, and healthy habits compared to the control group.
A team of researchers from Johns Hopkins Medicine has discovered a novel blood vessel receptor that causes relaxation in response to light. This finding may lead to the development of new therapeutic options for vascular diseases, such as Raynaud's phenomenon.
A study published in the Journal of Clinical Investigation reveals that stenting can induce deleterious blood vessel remodeling due to a specific gene variant. The researchers identify the receptor tyrosine kinase ROS1 as a potential therapeutic target for treating flow-limiting atherosclerosis.
Researchers have discovered that growth factor VEGF-B can regenerate damaged peripheral nerves in the cornea without inducing angiogenesis. This finding suggests that VEGF-B may be a suitable candidate to treat nerve damage in areas where blood vessel formation would be detrimental.
A gene that regulates blood vessel constriction is linked to aberrant blood vessel growth in premature babies, leading to vision loss. The finding suggests a new therapy to prevent damage and highlights endothelin's role in both blood pressure regulation and blood vessel formation.
Researchers have developed artificial platelet-like nanoparticles that combine morphological, mechanical, and surface chemical properties of natural platelets. These artificial platelets can simulate natural platelets' ability to collide with red blood cells, enabling selective clot formation at vascular injury sites.
A new lab device developed by Johns Hopkins engineers provides a clear view of how tumor cells spread through the body, causing over 90% of cancer-related deaths. By studying the movement of individual cancer cells, researchers aim to uncover new ways to keep cancer in check and develop effective treatment strategies.
Researchers have identified the normal function of the TEM5 protein, which is crucial for embryonic blood vessel development. The findings suggest that TEM5 could be a good target for anticancer drug therapy and potentially improve drug treatment for brain diseases by temporarily disabling the blood-brain barrier.
Researchers at University of Gothenburg have successfully grown a functional blood vessel in just one week using autologous peripheral whole blood. The breakthrough procedure involves extracting stem cells from a patient's blood, which accelerates growth and enables the creation of a new vein. This technology has the potential to benef...
Researchers identify a new type of melanoma cell in blood vessels that resists anti-angiogenic therapies. The cells, which express the protein PECAM1, help tumors evade treatment by forming functional blood-filled channels.
A new study reveals that preosteoclasts, a previously overlooked group of cells, play a crucial role in maintaining bone health. The discovery explains the success of an experimental osteoporosis drug and opens up new avenues for research into designing future studies.
Scientists at The University of Nottingham have made a major medical discovery that could lead to the development of an entirely new type of painkiller for chronic pain conditions like traumatic nerve injury. They found that a signal protein called VEGF promotes pain while its inhibiting form prevents it.
A study published in Nature Medicine has identified a receptor that promotes vascular growth and may prevent blindness in premature babies. The researchers found that activating this receptor can inhibit abnormal blood vessel growth, which is a major cause of retinopathy of prematurity.
Research on Korean adults finds that prolonged work hours are linked to a higher risk of developing coronary heart disease. Employees working 61-80 hours per week face a 42-94% increased likelihood of disease development within 10 years.
A new study published in PLOS ONE suggests that the current way of diagnosing type-2 diabetes using blood glucose levels needs to be revised. The researchers found changes in blood fat metabolites before glucose levels increased, indicating a potential alternative approach for diagnosis and treatment.
A team of researchers has identified a new target for treatment of common eye diseases, including wet macular degeneration and diabetic macular edema. Activating a biochemical pathway that suppresses VEGF's effects may offer a safer alternative to current treatments.
Researchers identified a tumor vessel-specific protein, L1, as a potential therapeutic target to reduce tumor growth and metastasis. Loss of L1 in mouse pancreatic cancer models reduced tumor angiogenesis and promoted vessel normalization.
Researchers found that mice lacking specific vascular system proteins developed normally but healed poorly from injuries. Increasing FGF signaling may improve wound healing, while inhibiting it in the eye could help patients with age-related macular degeneration or diabetic retinopathy.
Brain tumors grow exclusively within narrow spaces between and along the brain's thousands of small blood vessels, contrary to the theory of neoangiogenesis. This 'autovascular' growth allows tumor cells to draw energy and fuel their growth like normal brain tissue.
Chloroquine has been shown to inhibit tumor growth and metastases by normalizing abnormal blood vessels in tumors. This results in an increased barrier function blocking cancer cell dissemination and enhanced tumor perfusion increasing the response of the tumor to chemotherapy.
Researchers identified a genetic switch that stifles blood vessel development and used it to prevent peripheral vascular disease in a mouse model. The study's findings offer hope for new treatments targeting conditions like diabetes and atherosclerosis.
Researchers have discovered that invading glioblastoma cells hijack cerebral blood vessels to extract nutrients, damaging the brain's protective barrier and potentially leading to new cancer treatments. This finding could enable earlier delivery of anti-invasive agents to attack tumor cells.
Researchers discovered the protein SerRS acts as a brake on new blood vessel growth and pairs with c-Myc to promote proper vascular development. The study found that SerRS suppresses VEGFA transcription by recruiting SIRT2, a partner enzyme that had never been linked to angiogenesis.
Scientists from the University of Leeds have found a way to restore the function of damaged blood vessel repair cells. A protein called Akt was identified as the reason for reduced effectiveness in South Asian men's cells, which were able to be restored through the addition of active Akt.
Researchers at Brigham and Women's Hospital have successfully fabricated blood vessels using 3D bioprinting technology, addressing a critical challenge in tissue engineering. The approach involves printing agarose fibers that become the blood vessel channels, allowing for physical removal of template layers and improved cell viability.
Researchers discovered that CCL28 and its receptor are key players in angiogenesis, a hallmark of rheumatoid arthritis. This finding provides strong evidence for the binding of CCL28 to joint-lining cells as necessary for blood vessel formation.
Researchers developed a novel compound, Sticky-trap, to treat retinopathy by selectively closing off abnormal blood vessels without affecting healthy ones. The treatment has shown promise in mice and may lead to a new class of pharmacological entities for various conditions.
Researchers found that females susceptible to MS produce higher levels of the blood vessel receptor protein S1PR2 than males, leading to the inflammation that causes MS. The study's findings have implications for developing new treatments, including a drug that disables S1PR2.
Scientists have identified a potential new strategy to treat ovarian cancer by targeting multiple growth factors. By blocking several avenues that tumour cells use to escape eradication, researchers hope to develop new anticancer drugs that target ovarian tumour growth.
Researchers at the Beckman Institute developed a vascular network system that heals fiber-reinforced composites autonomously through polymerization of healing chemistries. This technology overcomes long-standing challenges in composite materials, enabling repeated self-healing and increasing structural reliability.
Professor Thomas Korff's work reduces experimental animals and promotes human umbilical cord cells to mimic vessel walls. His methods decrease animal distress and costs, while improving research results.
Researchers at Brigham and Women's Hospital have identified certain proteins in osteoclasts that may help destroy cardiovascular calcification by dissolving mineral deposits. The discovery suggests a potential therapeutic avenue for patients with cardiovascular calcification.
Scientists have identified perivascular stem cells as a reservoir of HCMV, suggesting a potential treatment target. The discovery could lead to the development of novel targeted therapies to prevent HCMV re-activation and its associated complications.
A recent study by UCLA scientists and colleagues reveals that UV light significantly enhances the ability of melanoma cells to creep along the outside of blood vessels, leading to increased metastasis. The research demonstrates that exposure to UV radiation triggers inflammation, attracting immune cells that promote this process.
Researchers discovered that sunburns contribute to melanoma development through inflammatory processes in surrounding tissue. Melanoma cells migrate along blood vessels in inflamed skin, with activated neutrophils playing a key role in metastasis.
Researchers at Harvard University's Wyss Institute have developed a bioprinting method to create intricately patterned 3D tissue constructs with multiple cell types and tiny blood vessels. The breakthrough enables the creation of thicker, functional tissues that can be used for drug testing and potentially replaced damaged human tissue.
Researchers at Rensselaer Polytechnic Institute have identified a gene associated with congenital diaphragmatic hernia, a life-threatening birth defect. The discovery reveals the genetic root of the physical defect and offers potential routes for intervention.
Researchers developed a gene delivery method targeting tumor blood vessels in mice, avoiding healthy tissues. The approach uses a deactivated virus carrying a gene of interest to hijack abnormal blood vessels and alter the tumor microenvironment.
A study in mice reveals that breakdown of brain blood vessels may amplify problems associated with Alzheimer's disease. Pericytes, a type of blood vessel cell, may provide novel targets for treatments and diagnoses.
New research reveals targeting blood vessel metabolism may block pathological growth by depriving it of energy and building blocks. Partially blocking PFKFB3 reduces blood vessel sprouting and amplifies VEGF blockade effects, offering a new treatment strategy for conditions like cancer, blindness, and inflammatory diseases.
Researchers have identified how golden staph bacteria target and destroy key immune cells, disrupting the body's defense against infection. By visualizing this process using advanced microscopy techniques, the team gained insights into how golden staph evades the immune system and causes tissue damage.
An international team of researchers at Karolinska Institutet in Sweden have discovered a new mechanism that regulates the way blood vessels grow and connect to each other. The discovery provides essential insights into vascular development and could lead to new opportunities for cancer therapy.
Early data from a Polish patient study suggest the investigational bioengineered vessel may be effective as a dialysis graft, with 100% of patients regaining blood flow after initial loss. The technology uses human tissue and has shown no signs of infection or immune reaction.
Researchers discovered that snakes can optimize their vision by controlling blood flow in their eyes when perceiving threats. The coachwhip snake's visual blood flow patterns change depending on its environment, allowing for improved visual clarity in times of need.
Researchers at Scripps Research Institute have developed a promising technique for treating human eye disease by targeting microRNAs, which can stop abnormal blood vessel growth. The approach shows promise in preventing blindness in diseases like neovascular macular degeneration and diabetic retinopathy.
Researchers at the University of Illinois Chicago identified a protein expressed by human bone marrow stem cells that guides blood vessel formation. The study found that mesenchymal stem cells support functional blood vessel growth, and their genetic signature may be used to individualize stem cell treatments for heart patients.
A study published in PLOS ONE found that a topical compound called PPADS can inhibit symptoms associated with both dry and wet AMD, offering promise for a breakthrough treatment. The researchers tested the compound on mice and observed significant reduction in tissue damage and blood vessel growth characteristic of AMD.
A study in Malawian children found chronic inflammation in blood vessels after recurrent malaria episodes, predisposing future infections and cardiovascular disease. The findings explain high childhood mortality rates in malaria-endemic areas.
Researchers have discovered that thyroid hormone affects blood vessel constriction, leading to sensitivity to temperature extremes. This knowledge may help future treatment of patients with thyroid disorders who experience temperature-related symptoms.
Researchers at UNC School of Medicine have found a class of drugs known as MDM2 inhibitors effective in regressing abnormal blood vessels responsible for vision loss associated with macular degeneration. The treatment has potential to reduce the burden on patients and physicians.
A newly discovered compound has been identified as a potential diagnostic marker for zinc status, which can help detect the harmful effects of zinc deficiency in blood vessel cells. This discovery may lead to faster and easier methods for detecting low zinc levels in the body.