Articles tagged with Heart
Researchers discovered a genetic link between primary ciliary dyskinesia (PCD) and heterotaxy, an abnormal position of the heart and lungs. This connection suggests that PCD may cause respiratory complications in children with congenital heart disease, leading to improved diagnosis and treatment.
A recent study suggests that aprotinin can reduce bleeding during heart surgery without increasing the risk of complications. The study found no increase in heart attack risk among patients receiving aprotinin, while the risk of stroke was 35% lower.
A 47-year-old man with congestive heart failure underwent the historic surgery at UPMC, where a beating heart supported by the OCS was successfully transplanted. The patient is doing well after discharge on April 30.
For patients who need non-cardiac surgery a short time after an interventional heart procedure, bare metal stents provide a safer choice. Drug-eluting stents can lead to life-threatening cardiac complications in these patients, according to a study by Thomas Jefferson University Hospital.
A study by the American Heart Association found that patients who used an online education program were more aware of treatment options and asked their doctors about care. The program provided personalized information in lay language, leading to improved patient knowledge and behavior.
Scientists have found an enzyme called Pak 1 that acts on the heart's pacemaker to slow the rapid beating of the heart's 'fight-or-flight' reaction to adrenaline. This discovery opens up new avenues for diagnosis, drug design and treatment of common heart diseases.
Researchers developed the largest registry of US patients with Takotsubo cardiomyopathy, aiding physicians in diagnosis and management. Most patients who survived the first 48 hours had a steady recovery, with normal heart function found in 29 out of 30 patients.
A lab study found that prenatal nicotine exposure can lead to cardiac vascular dysfunction beyond the formative years, and into adulthood. Female offspring are more likely to be impacted than males, with decreased coronary flow and increased heart susceptibility to ischemia and reperfusion injury.
Researchers at Duke University Medical Center found that patients with specific gene variants were less likely to experience cognitive decline after heart surgery. These variants were involved in the inflammatory system and may provide a biological basis for the protective effect observed.
A study by Penn State researchers found that incorporating macadamia nuts into a heart-healthy diet can reduce total cholesterol, low-density lipoprotein cholesterol and triglyceride levels. The Healthy Heart diet with macadamia nuts was compared to a standard American diet in a controlled feeding study.
Reducing time interval for transported organs has been shown to increase survivorship and improve outcomes in heart transplant patients. The Organ Care System (OCS) uses warm blood perfusion technology to maintain organs in a living state during transport, allowing for evaluation of organ function and reducing cold ischemic time.
The International Society for Heart and Lung Transplantation (ISHLT) is evaluating a new mathematical modeling system for lung allocation in the US, focusing on its effectiveness and comparing it to systems used in Europe. The system aims to give every patient an equal chance at transplant based on various factors.
Most dental patients with heart disease no longer need antibiotics before dental procedures to prevent infective endocarditis. New guidelines recommend antibiotics only for patients at greatest risk, including those with artificial heart valves or congenital heart conditions.
A new counter-flow heart pump being developed by Queensland University of Technology has the potential to support both chambers of the heart simultaneously, reducing mortality rates. Clinical studies have shown that permanent left heart pumps can reduce mortality risk by up to 47%.
A new study found that ibuprofen significantly raises the risk of heart attacks in high-risk cardiovascular patients taking aspirin for osteoarthritis. The Mount Sinai researchers' findings underscore the importance of considering NSAID interactions with aspirin in these patients.
Researchers at Gladstone Institute of Cardiovascular Disease identified a critical genetic factor, microRNA miR-1-2, that regulates heart form and function. The study found that deletion of this microRNA causes defects in heart growth, function, and electrical conduction, potentially leading to new treatments for cardiovascular diseases.
Researchers at Boston Children's Hospital reviewed fetal cases of prenatal cardiac interventions, finding success rates of 79% and improvements in heart rate recovery after birth. Additionally, studies showed that most children with heart transplants regain sufficient heart function for exercise over time, with improved peak heart rate...
Researchers studied the outcomes of treating ST- elevation myocardial infarction with PCI alone or with distal protection, finding similar major adverse cardiac events and electrocardiographic results. However, post-procedure blood flow was improved in patients treated with distal protection.
A new study presents the first US controlled clinical trial using muscle stem cells to treat congestive heart failure. The procedure involves injecting autologous skeletal myoblasts into scarred tissue via a minimally invasive catheter, showing improved quality of life and potential cardiac function.
A community-based study found that intensive dietary therapy and early dosing with a medication blocking harmful hormonal effects in the heart can improve cardiovascular health and survival rates after a heart attack. The Mediterranean diet was equally beneficial as a low-fat, low-cholesterol diet.
A study at Temple University found that listening repeatedly to heart sounds on an iPod improved the stethoscope skills of general internists, increasing correct identification rates to 80%. This technique relies on intensive repetition and is essential for recognizing abnormal heart sounds and identifying dangerous conditions.
A study published in The Lancet found that chest-compression-only resuscitation boosts survival rates for out-of-hospital cardiac arrest. The study analyzed 4,068 cases of witnessed collapse and found a 19.4% favorable neurological survival rate when bystanders administered chest compressions without mouth-to-mouth ventilations.
Increased expression of an accessory subunit of L-type calcium channels is linked to altered channel behavior in human heart failure. Researchers have identified a causal role for this protein overexpression in the development of cardiac dysfunction.
Research from the Framingham Heart Study found that people with long-lived parents are more likely to avoid high blood pressure, cholesterol, and other cardiovascular risk factors in middle age. Long-lived parents also conferred a lower risk of cardiovascular disease over time.
A new study reveals that specialty heart hospitals are associated with a significant rise in heart procedures, such as bypass surgery and angioplasties. The study found that the opening of a new specialty cardiac hospital is linked to a regional increase in these procedures, particularly among patients without heart attacks.
A new study by Dr. Vivian Ho found that Certificate of Need regulations have minor benefits for open heart surgery but no benefits for angioplasty. The regulations may inadvertently increase the number of procedures performed to meet minimum volume quotas.
A Mayo Clinic study has identified a genetic mutation associated with an inherited predisposition to atrial fibrillation, a type of irregular heartbeat. The discovery may lead to improved identification and treatment of younger patients affected by this condition.
A new study published in PLoS Biology found that cells change size and shape to form the heart's chambers, with blood flow and cardiac contractility influencing cell shape. The researchers propose a balance of internal and external forces necessary for optimal chamber curvature, potentially underlying some types of heart disease.
Researchers at the University of Pennsylvania School of Medicine discovered that an enzyme important in fetal heart-cell development regulates cardiac hypertrophy, a key step in congestive heart failure. The study found that inhibiting this enzyme can prevent the onset of cardiac hypertrophy and heart failure.
Researchers at University College London have discovered the structure and function of a crucial gene regulating blood pressure. The study reveals that loss of activity in this gene leads to reduced nitric oxide production, a key player in cardiovascular health.
A Mayo Clinic research study found that over one-third of young people who died suddenly and inexplicably had genetic heart defects. The defects were caused by mutations that impair the heart's rhythm center, leading to conditions such as Long QT syndrome and catecholaminergic polymorphic ventricular tachycardia.
A blood test for NT-proBNP accurately predicts the risk of heart attack, heart failure, stroke, and death in patients with known cardiovascular disease. Higher levels of NT-proBNP are associated with a greater risk of cardiovascular events or death.
A new study found congenital heart disease prevalence increased by 85% in adults and 22% in children between 1985 and 2000. Most heart defects cause blood to flow through the heart in an abnormal way or obstruct blood flow, leading to a major public health problem.
Scientists found that persons with high multimarker scores had a risk of death four times as great and a risk of major cardiovascular events almost two times as great as those with low scores. The study used 3209 participants for 10 years, measuring 10 novel biomarkers in addition to established risk factors.
A study published in Catheterization and Cardiovascular Interventions found that an olive oil emulsion improved stent delivery in patients with abnormal heart arteries. The emulsion was successfully used to place lubricated stents in 85% of patients with no negative effects months after the procedure.
A nationwide study reveals that over 500 sudden unexplained cardiac deaths occur annually in England, mostly among young men. The researchers found that only a third of cases were correctly identified as Sudden Adult Death Syndrome (SADS), with most victims having no prior heart history or symptoms.
Researchers found that strong neodymium-iron-boron (NdFeB) magnets can cause interference with cardiac devices like pacemakers and ICDs, potentially leading to fatal consequences for patients. The study recommends caution and warning labels on products containing these magnets.
A UK review concludes that an implantable pump can help patients with rapidly deteriorating heart failure live and recover strength while waiting for a transplant. However, the device's use is limited due to high costs and quality-of-life restrictions.
Researchers develop a 3D model of a child's heart using MRI scans to simulate blood flow and optimize surgical procedures for complex congenital heart defects. The system aims to improve quality of life for children with single-ventricle hearts by reducing the need for multiple surgeries.
A study published in Nature demonstrated TB4's ability to regenerate coronary vessels in mice, a finding that could lead to new treatments for human heart disease. TB4 may prevent loss of heart muscle cells and restore blood flow, providing a much-needed treatment modality.
Researchers found a 36% survival rate for blacks and 46% for whites, despite similar levels of coronary disease. The disparity is attributed to various factors, including bias in treatment, mistrust of the medical system, and socio-economic barriers.
A new resuscitation approach called Cardiocerebral Resuscitation has been shown to improve survival rates for out-of-hospital cardiac arrest victims. The technique, which eliminates mouth-to-mouth breathing, enhances the willingness of lay individuals to engage in resuscitation.
A study found that heart failure is associated with more common factors than previously believed, including preserved ejection fraction and diastolic dysfunction. Patients with preserved ejection fraction were older and less likely to be smokers, while those with reduced ejection fraction had higher mortality rates.
Patients with peripheral arterial disease (PAD) undergoing interventional heart procedures are at higher risk for dying within a week and experiencing complications such as blood clots and bleeding. The study analyzed nearly 20,000 patients and found PAD to be a strong predictor of life or death in these cases.
Adult heart transplant recipients who received HCV-positive donor hearts had higher mortality rates and lower survival rates at 1, 5, and 10 years. The study suggests that transplanting hearts from donors with hepatitis C should be avoided if possible.
Researchers at UTMB discovered that blocking aldose reductase can short-circuit sepsis, protecting heart function and reducing deaths. The compound is similar to an existing diabetes drug in stage three clinical trials.
A study by researchers from the University of Turin found that hospital admissions for acute heart attacks among people under 60 fell by 11% after Italy's public smoking ban was introduced. The decline was largely attributed to reduced exposure to passive smoking, with only a small fraction due to active smoking.
The Heart Rhythm Society has published final recommendations for pacemaker and ICD performance, emphasizing greater transparency and patient safety. The guidelines include specific guidance for physicians, manufacturers, FDA officials, and Congress to prevent adverse events due to device malfunctions.
A systematic review of 13 clinical trials found that early, intensive statin therapy reduced cardiovascular death, unstable angina, and revascularization. The benefits were sustained for two years, with slightly less than a 20% reduction in adverse coronary events.
Researchers have identified calcineurin as essential for complete lung development, and its absence led to respiratory problems in mice. A new model of human placental development also sheds light on the complex process of placentation, while a study on thyroid structures reveals that mature T cells trigger their formation.
Researchers at University of Bristol have made a major breakthrough in measuring energy levels inside living heart cells, real-time. This could lead to better understanding of heart disease and improved recovery of the heart during cardiac surgery or after a heart attack.
Patients with end-stage renal disease have a significantly shorter life expectancy after ICD implantation, highlighting the need for continued research on prevention and treatment strategies. The study calls into question the survival benefit of ICDs in patients with kidney disease who meet current implant indications.
The International Society for Heart and Lung Transplantation releases comprehensive global guidelines for managing heart failure patients prior to transplantation. The guidelines aim to enhance patient care, optimize outcomes, and improve resource allocation.
A new study by the University of Rochester Medical Center found that genetic defects, particularly those related to Long QT Syndrome (LQTS), are significant risk factors for sudden cardiac death in teenagers. The study also identified changes in puberty among teens with LQTS as a predictor of life-threatening events.
Researchers at Thomas Jefferson University found that GRK2 protein levels are elevated in patients with failing hearts compared to those with normal heart function. The study suggests that GRK2 could be a biomarker for heart failure and potentially predict patient response to treatment.
A recent study published in the Journal of Nuclear Medicine reveals that diabetes mellitus significantly slows nerve recovery after a heart transplant. This finding highlights the importance of understanding nervous system abnormalities to guide therapeutic efforts aimed at reducing cardiac risk for patients with diabetes.
The US FDA has approved a new totally implanted artificial heart, providing hope for patients with severe heart failure. The device is designed for those who are not eligible for a heart transplant and have a short life expectancy without the device.
A lack of cardiac calsequestrin protein can cause irregular heartbeats during exercise, but not at rest. Researchers found that the protein's absence triggers premature calcium release, leading to life-threatening conditions like CPVT.
Studies found that trastuzumab treatment can cause impaired heart function in 28% of women with advanced breast cancer, which may be reversible. Additionally, radiation therapy to the left side of the chest increases the risk of heart disease and coronary artery disease.
As heart procedures increase, it's essential to monitor success of new treatments and technology to keep costs down and quality high. Financial incentives from insurance companies and peer review teams can help improve care while reducing expenses.