Articles tagged with Lungs
Researchers at the University at Buffalo found that impaired pulmonary function was associated with increased risk of mortality over a nearly 30-year period. The study showed that individuals with poorer lung function were more than twice as likely to die, highlighting the importance of regular lung function testing
The European Respiratory Society warns that hundreds of medicines can cause lung diseases, with 310 therapeutic substances identified as having iatrogenic effects. Early withdrawal of these medicines can reduce the risk of damaging sequelae in 70% of cases.
A large multi-center study is testing the life-saving potential and cost effectiveness of public access defibrillation (PAD). PAD involves placing defibrillators in community locations, where trained volunteers can access them, to improve emergency treatment for sudden cardiac arrest victims.
Research published in Thorax found that COPD rates in women have almost doubled over the past decade. The study analyzed data from over 4 million patients and found significant increases in COPD cases among older women. Despite this, women with severe COPD tend to survive longer than men with similar severity.
Hospital survival rates for Pneumocystis carinii pneumonia (PCP) patients have increased by 40% over the years 1992 to 1995, with a two-fold improvement in mechanical ventilation outcomes. New lung function data shows that Chinese children's lung capacity is lower than white youngsters', but also improved in certain tests.
Two separate groups of scientists identified a genetic mutation associated with primary pulmonary hypertension (PPH), a rare but devastating lung disease. Defects in the BMPR2 gene lead to abnormal proliferation of cells in the lungs characteristic of PPH.
Researchers from Massachusetts General Hospital found that inhaling nitric oxide gas can prevent the development of pulmonary vascular disease (PVD) in infant rats by reducing cell proliferation in lung arteries. The study suggests that this therapy may significantly improve the quality of life and save lives of infants at risk for PVD.
A new national study found that unusual infections and fat emboli contribute significantly to acute chest syndrome in sickle cell disease patients. The syndrome is the leading cause of death among sickle cell patients, and earlier diagnosis and treatment may save many lives.
Two studies found a decrease in respiratory illnesses among school-age children after improved air quality. Lung function continued to grow in adolescents despite cessation of growth in height, with males showing greater gains. A new diagnostic test for asthma in young children was also developed.
A Phase I study of aerosolized administration of tgAAV-CF showed efficient gene transfer throughout the upper airways of patients with mild CF lung disease. No neutralizing antibodies were detected, suggesting a good safety profile for further development.
Researchers discovered that low nitric oxide levels in mouse newborns with hypoplastic lungs hinder the proper development of blood vessels, leading to persistent pulmonary hypertension and respiratory distress. The study aims to identify genes affecting lung development and function.
Hot tubs can cause lung disease by dispersing bacteria through aerosolization, leading to symptoms like fever and weight loss. Removing the hot tub from the home is often the primary treatment for mild cases, while more severe cases require corticosteroids and antibiotics.
The American Thoracic Society announces new research findings highlighting significant differences in lung function test results between Asian Americans and European Americans. Additionally, experts discuss the potential of gene therapy for treating lung cancer, while studying lung changes caused by smoking and aging.
A recent study published in the Annals of Internal Medicine found that HIV-positive smokers are up to seven times more likely to develop emphysema. Early emphysema was detected in people with an average age of 35, highlighting the importance of quitting smoking for those living with HIV.
A new meta-analysis of 24 studies found that allergy shots can effectively treat allergic asthma in both adults and children, reducing symptoms and improving lung function. The research suggests that up to half of all adult asthmatics and an even greater proportion of children may benefit from immunotherapy.
The National Emphysema Treatment Trial (NETT) is enrolling patients with severe emphysema to compare the outcomes of those receiving maximum medical therapy versus those undergoing lung volume reduction surgery. The study aims to assess factors such as exercise ability, longevity, and related issues in both groups.
A study of over 3300 schoolchildren found that babies exposed to their mothers' cigarette smoke while in the womb had poorer lung function. The effects were particularly noticeable on small airways and were more pronounced than those caused by environmental tobacco smoke exposure after birth.
A recent study found that smoking cannabis regularly may increase the risk of developing emphysema, a disease that damages lung tissue and reduces surface area. The study examined four young men who smoked heavily and found large areas of their lungs had disappeared and been replaced with cysts.
A study of over 3300 schoolchildren reveals that exposure to maternal cigarette smoke during pregnancy significantly reduces lung function. The effects are particularly noticeable on small airways and airflow, with environmental tobacco smoke having a lesser impact.
Researchers found that using smaller mechanical breaths reduces deaths from acute lung injury and acute respiratory distress syndrome. The study showed a 22% decrease in mortality rates, giving acutely inflamed lungs a better chance of healing.
A nationwide clinical trial found that reducing tidal volumes in mechanical ventilation can cut mortality from Acute Respiratory Distress Syndrome (ARDS) by up to 22%. The study, involving 861 patients and coordinated at Massachusetts General Hospital, used a new technique with smaller oxygen puffs to provide breathing assistance.
Respiratory problems caused by workplace exposure affect various jobs, including farming, seafood industry, food processing, and manufacturing. Employers can take simple technological fixes to reduce worker risks.
A special diet formula with antioxidants and plant and fish oils reduced the need for ventilator support by an average of five days and ICU stay by five days in patients with acute respiratory distress syndrome (ARDS). The diet also significantly reduced organ failures, a common complication of ARDS.
Researchers from the Howard Hughes Medical Institute identified a crucial lipid molecule produced by M. tuberculosis to infect lung tissue. The discovery could lead to improved vaccines and treatments for tuberculosis, which kills more people than AIDS or malaria.
A Phase I/II trial of NUVANCE, an investigational once-a-week inhaled asthma treatment, suggests the drug helped stabilize lung function for up to 12 weeks following discontinuation of inhaled corticosteroids. The treatment was generally well tolerated, with minimal decline in forced expiratory volume.
A recent study published in Nature Medicine has found that gamma/delta T cells are essential for regulating airway hyperresponsiveness, which is characterized by an exaggerated response to stimuli. The research suggests that these cells have a suppressive effect on airway constriction and may be a key target for future treatments.
Researchers at University of Florida report a 92% survival rate for newborns with diaphragmatic hernia using a new treatment strategy that reduces overventilation and delays corrective surgery, significantly improving lung function and development.
Researchers have found that tiny air pollutant particles can penetrate deeper into the lungs of healthy adults, potentially threatening their health. The study suggests that these particles can move up to two times faster through the airways than previously assumed, with implications for public health and environmental regulations.
Researchers have discovered that movement of salt and liquid in and out of lung surface cells plays a central role in regulating the lungs' internal liquid coating. This finding confirms a theory of how lungs protect themselves and may suggest better ways of treating cystic fibrosis.
A study found that African dust is a major factor affecting southeast U.S. air quality, with up to half of breathable particles in the air originating from Africa. The dust can push total airborne particles above the EPA's Clean Air Act limit on certain days.
Researchers developed a new therapy using an enhanced artificial surfactant that improves oxygen levels and protects natural surfactant in lung-affected patients. The treatment has potential for treating infants and adults with difficult-to-treat lung disease cases.
A new study presented at the American Lung Association/American Thoracic Society International Conference reveals that men are more likely to smoke when angry or anxious than women. The findings also suggest that male donors' lungs may be more prone to rejection in female recipients, increasing the risk of graft failure and death.
A new ventilator treatment has been shown to significantly reduce mortality among victims of Acute Respiratory Distress Syndrome (ARDS) by 25%. The treatment involves providing smaller breaths of oxygen-rich air, which may protect the lung from injury. This life-saving breakthrough could save thousands of lives annually.
Researchers at the University of Pittsburgh Medical Center found that simultaneous bone marrow infusions at lung transplantation significantly reduced obliterative bronchiolitis, a marker for chronic rejection. The study showed a 25% reduction in chronic rejection incidence among recipients who received bone marrow infusions.
Researchers at University of Pittsburgh Medical Center found that lung transplant patients who received lungs preserved for more than six hours had similar survival rates compared to those stored for less than four hours. The study, which examined over 350 cases, suggests that the current organ allocation policy may need to be revised.
Cystic fibrosis damages young lungs due to chronic bacterial infections and a lack of liquid layer, which hinders the body's natural cleansing process. Researchers have discovered that the film of liquid coating airways is depleted in CF patients, preventing cilia from functioning properly.
A study found that spraying water with airborne bacteria in indoor swimming pools can lead to a lung disease called granulomatous pneumonitis. Lifeguards who worked long hours at pools with water features were most affected, and symptoms included cough, wheezing, and difficulty breathing.
A new study by researchers at UCSF found that bartenders who worked in smoke-free conditions after the ban reported significant drops in coughing and other respiratory problems. Lung function also improved after the implementation of the smoke-free workplace law.
A recent study found that bartenders' respiratory health and lung function improved significantly after a smoke-free environment was established in California bars. The study, supported by the National Heart, Lung, and Blood Institute, suggests that banning smoking in bars can have a positive impact on the health of bartending staff.
Researchers found that malnourished rats producing more glutathione had enhanced free-radical fighting capacities, lungs, and liver protection. Glutathione supplementation nearly doubled lung GSH levels, increasing protection against damage.
A new study found that children retain more simulated air pollution per unit of lung surface area than adults, suggesting they are more susceptible to illnesses caused by polluted air. Researchers will extend their studies to exercising volunteers to further understand the effects of particulate air pollution on children.
Scientists at the University of Pennsylvania Medical Center have developed a novel mass spectrometry technique, Micropore Membrane Inlet Mass Spectrometry (MMIMS), to quickly and accurately assess lung function. This device can directly measure trace gas tensions in small blood and breath samples.
A study by Columbia University Irving Medical Center found that exposure to household smoking during childhood and adolescence can lead to diminished lung function in young adulthood. The researchers measured lung function in over 1,400 students and found that a mother's smoking in the home was associated with reduced air flow rates.
A study by Columbia University Irving Medical Center reveals that inner-city asthma patients often rely on emergency rooms due to insufficient disease management. The research highlights the urgent need for comprehensive asthma intervention in Harlem, targeting community health workers to educate and support patients.
A new study found that consuming high levels of antioxidants like beta carotene, selenium, and vitamins C and E can significantly improve lung function, comparable to the difference between a nonsmoker and a long-term smoker. The research suggests that these antioxidants may help prevent asthma, emphysema, and chronic bronchitis.
Researchers at Johns Hopkins found that deep breaths can relax lung muscles and reduce wheezing in non-asthmatics by up to 80%. However, asthmatic patients showed minimal improvement from taking deep breaths before exposure to a contracting drug. This new finding could lead to the development of new asthma treatments.
Duke researchers have identified a lung condition in breast cancer patients that can limit therapy choices if not treated promptly. The disorder, DPTS, is successfully treated with inexpensive corticosteroids, improving pulmonary function by 17%.
A two-year study found that moderate air pollution can decrease lung function in adult hikers, even at relatively low ozone concentrations. Hikers with a history of asthma or wheezing experienced more pronounced declines.
A national trial is underway to determine the effectiveness of removing portions of lungs in patients with severe emphysema. The study aims to find out if the procedure improves long-term outcomes and reduces complications for patients with this debilitating disease.
Researchers at University at Buffalo found a miniscule increase in free radicals in the blood reflects lung damage equivalent to 3-5 years of aging. Oxidative stress was also associated with narrowing of pulmonary airways, while bilirubin showed a positive relationship to lung function.
A recent study suggests that a human gene variation affecting lung enzyme production may be associated with reduced susceptibility to lung cancer. The study found that approximately 8% of the population has the 'protective' gene form, which reduces by about 54% the risk of developing lung cancer among smokers.
Scientists found that mice lacking the macrophage elastase enzyme showed no signs of emphysema after heavy smoking. This discovery challenges previous theories and offers new hope for emphysema treatment. Researchers are now exploring metalloproteinase inhibitors to prevent the disease.
Researchers at the University of Pittsburgh Cancer Institute have found a biological switch that drives the growth of lung cells in ex-smokers, leading to an increased risk of lung cancer. The 'switch' is triggered by gastrin-releasing peptide (GRP) receptors, which capture circulating hormones and spur lung cell division.
Researchers at National Jewish Health will investigate the basic mechanisms of fibrosis and develop clinical trials to limit fibrotic response. Four interstitial lung disease research projects are underway, focusing on inflammation, growth factors, and cellular interactions.
Scientists at Johns Hopkins Medicine have found a natural antimicrobial compound called hTAP that appears to be disabled in CF patients, increasing their vulnerability to lung infections. The researchers believe mass-producing similar compounds could help fight lung infections in both CF patients and the general population.
A major seven-year national study will evaluate the safety and effectiveness of lung volume reduction surgery for people with severe emphysema. Patients selected for the surgery will undergo evaluation and medical therapy at either University of Maryland Medical Center or Johns Hopkins Hospital.
The NHLBI and HCFA have announced a clinical trial to evaluate the safety and effectiveness of lung volume reduction surgery (LVRS) for patients with emphysema. The study aims to determine whether LVRS is a viable treatment option for this population, which currently has limited treatment options.
A temporary metal filter successfully caught a life-threatening blood clot in a bedridden patient, preventing catastrophic lung damage. The procedure, performed by Johns Hopkins physicians, marks the first use of the filter in the US and holds potential for thousands of accident victims.
Researchers at Northwestern University have developed an implantable artificial lung that preserves lung function for 24 hours in animal models. The device is intended as a 'bridge to transplant' for patients awaiting lung transplants and as treatment for acute lung failure.
A five-center trial shows partial liquid ventilation is safe and effective, improving lung function and increasing survival chances for critically ill premature infants. The procedure involves introducing oxygen-rich liquid into the lungs, reducing pressure damage and improving oxygen exchange.