Articles tagged with Lungs
The U-M artificial lung has improved blood flow and reduced risk of clotting, showing encouraging results in sheep tests. The device could potentially bridge lung disease patients to transplant, reducing the average wait time from two years.
Asthma airway remodeling begins in childhood and continues into adulthood, affecting lung function and increasing the risk of respiratory complications. A new study found that 7.4% of children with asthma developed structural abnormalities in their airways at age 18, a rate similar to adults with asthma.
Researchers at MIT have created a biodegradable polymer called biorubber that can stretch and snap back into shape, mimicking the elasticity of human organs. This breakthrough material has potential applications in tissue engineering, including heart tissue, blood vessels, and whole organs for transplantation.
A study by the American Thoracic Society found that non-smoking females with and without asthma experience decreased lung function due to secondhand smoke exposure. High levels of cotinine, a marker of secondhand smoke exposure, were associated with lower lung function in these women.
Duke University researchers found depression to be a significant predictor of worse quality of life and perceived shortness of breath in patients awaiting lung transplantation. The study suggests that treating depression could improve outcomes after lung transplantation, which could benefit patients with severe lung disease like COPD.
A study found that drinking white wine recently and over a lifetime was associated with better lung function. The researchers think the antioxidants in wine account for this positive effect. Wine consumption was linked to higher levels of protective antioxidants in the blood, which may help protect lung health.
Researchers at Duke University Medical Center have found that revascularization procedures can improve outcomes for lung transplant patients with severe coronary artery disease. The study analyzed 350 lung transplants and showed a 88% survival rate for patients who received combined heart bypass, lung transplant surgeries.
A new study suggests that an optimistic outlook may improve lung function in men with chronic obstructive pulmonary disease (COPD). Optimism was linked to higher lung function and slower rate of decline in lung function compared to pessimistic individuals, even after controlling for smoking.
A study of 1,555 adults found that drinking white wine may be beneficial for lung health, with greater lung function observed in those who consumed white wine compared to red wine. The antioxidant flavonoids in white wine are thought to play a key role in this protective effect.
A study by the American Thoracic Society found that workers in the food flavoring manufacturing industry may be at risk of developing non-reversible airway obstruction due to exposure to high concentrations of acetaldehyde and capsaicin.
Researchers at Imperial College London have successfully grown human lung cells in mice, paving the way for potential lung transplants. The breakthrough could address chronic organ shortages and rejection issues, offering new treatment options for life-threatening lung diseases.
Researchers found that blocking ICAM-1 reduced inflammation and fibrosis in lungs treated with radiation. Mice genetically engineered to lack ICAM-1 showed fewer infiltrating leukocytes and less respiratory distress.
Researchers found that fundoplication surgery, used to treat chronic heartburn, improves lung function and has a positive effect on bronchiolitis obliterans syndrome (BOS) in lung transplant patients. The procedure prevents gastric acids from splashing up the esophagus and into the lungs.
A study published in Nature Medicine found that mice without a functional vitamin C transporter gene died shortly after birth due to severe health problems. The research suggests that vitamin C plays a crucial role in fetal lung development, which could have implications for premature infants and pregnant women.
Chronic alcohol abuse can lead to life-threatening lung disease due to glutathione depletion. Glutathione depletion leaves the lungs vulnerable to injury when a serious illness such as sepsis or pneumonia occurs. Effective therapies for preventing and treating chronic alcohol abuse-related lung damage are still being designed.
Researchers developed an ELISA test that accurately identifies patients with sensitized immune systems, increasing the chances of preventing rejection in pediatric heart transplant patients. The test has shown promising results in lung transplant patients as well, suggesting its potential to become a routine clinical care tool.
University of Pittsburgh researchers found that short abstinence periods, depression/anxiety bouts, and a caregiver's smoking history increase the risk of relapse. They also developed a non-invasive ultrasound technology to detect heart recovery, enabling successful weaning from left ventricular assist devices.
Researchers found that lung injuries among mice lacking CD44 receptors developed inflammation that persisted until the receptors were restored. The study suggests a vital link between the CD44 receptor and the body's healing process.
A study by National Heart, Lung and Blood Institute's Asthma Clinical Research Network found that low to medium doses of inhaled steroids improve lung function in most asthma patients. However, high doses may not provide additional benefits but increase the risk of adverse effects.
Researchers found that asthma does not increase the risk of having a common cold, but individuals with asthma are more likely to develop severe respiratory symptoms when infected. Rhinovirus infection was also linked to longer-lasting and more severe lower-respiratory-tract symptoms in those with asthma.
Researchers identified a novel pathway controlling branching morphogenesis, a critical process in development and tissue formation. This finding has implications for understanding diseases involving abnormal branching patterns.
A new study found that a single session of moderately intense exercise improves cognitive function in people with chronic obstructive pulmonary disease (COPD), particularly in verbal fluency. The effects are cumulative, suggesting that regular physical activity is necessary to maintain mental benefits.
Researchers found Pseudomonas aeruginosa thrives in low-oxygen environments of the airways, adapting to remove oxygen and producing protective sugar coatings. This discovery suggests a new strategy to target specific enzymes critical for bacterial survival, offering hope for improved treatment options.
Cystic fibrosis (CF) patients are more susceptible to Pseudomonas aeruginosa infections due to hypoxic mucus. Hypoxia disrupts the natural antimicrobial properties of mucus, creating an ideal environment for bacterial growth.
Researchers have identified aquaporin-1 protein's role in regulating water movement into and out of cells, a fundamental requirement for life. In a study comparing normal lungs to those without the protein, scientists found increased airway wall thickness and fluid leakage in those with aquaporin-1.
A study on preterm birth found that premature infants' lungs develop under different conditions after birth, affecting lung function. Leukotriene antagonists improved treatment for moderate to severe asthma by increasing pulmonary function and reducing symptoms. A personalized oral appliance also showed significant improvement in child...
UCSD researchers identify fibulin-5 as essential for elastic fiber development and organization. Mice without fibulin-5 exhibit severe skin and lung problems, including emphysema and aortic stiffness.
Researchers found a significant link between sarcoidosis and family history, with affected individuals more likely to have siblings or parents with the disease. Air pollution during adolescence also affects lung function growth and performance, while improved HIV treatment reduces the risk of pulmonary complications.
Children who move away from polluted areas exhibit increased lung function growth compared to those staying in Los Angeles, while pollution levels affect growth rates differently. The study supports earlier findings that air quality impacts children's lung health.
Research found that over 34% of ventilated patients are sexually active, with better lung function and younger age being key factors. Meanwhile, a study in Ethiopia linked home kerosene use to increased allergy risk, while another study showed nearly 40% of COPD exacerbations are caused by respiratory viruses.
A study found excessive inflammation and abnormal markings in lungs of healthy, middle-class children exposed to high levels of air pollutants in Mexico City. The research suggests a significant link between pollution and lung disease in otherwise healthy children.
Researchers discovered a link between the CFTR gene and increased susceptibility to respiratory infections in cystic fibrosis. They found that altered CFTR can change the internal chemistry of lung cells, making them more attractive to certain bacteria.
A Sea Grant study found no Asian or North American lung flukes in over 800 Chinese mitten crabs collected in the San Francisco Bay. The crabs were analyzed alongside more than 400 crayfish, all of which were also free of the parasites.
Scientists at UNC Chapel Hill have discovered a highly ordered array of signaling molecules controlling the passage of chloride and other ions in healthy people. This breakthrough may lead to new treatments for cystic fibrosis by restoring CFTR function through genetic engineering or drug therapy.
The OPTIMA study shows that low-dose budesonide alone reduces the risk of severe asthma exacerbations and poorly controlled days by half in previously untreated patients. Adding formoterol improves symptom control and reduces exacerbations in both previously untreated and corticosteroid-treated patients.
Researchers report significant advancements in sutureless vascular graft surgery, reducing operating time by up to 90%. The new techniques enable quicker connections of blood vessels and minimize damage to the heart, paving the way for minimally invasive surgery on the beating heart.
The NETT trial found that advanced emphysema patients with severe lung obstruction or evenly distributed damage should not undergo Lung Volume Reduction Surgery (LVRS). Instead, high-risk patients had a 30-day mortality rate of 16% and only slightly improved functional outcomes six months after surgery.
Researchers discovered that fathers' cigarette consumption levels impact children's lung function, with higher levels associated with greater deficits. Non-asthmatic girls showed the greatest declines in pulmonary function tests, suggesting a potential link between paternal smoking and childhood respiratory health.
A virtual lung model developed at PNNL may help predict pollutant impact on respiratory systems, providing new insights into asthma and other pulmonary diseases. The model simulates how pollutants enter, travel through, and collect in the lungs, enabling scientists to design targeted treatments.
Researchers found that inhaling tobramycin twice daily for 12 months effectively eradicated Pseudomonas aeruginosa from the airways of 14 cystic fibrosis patients, with nine remaining free from infection at two-year follow-up. The treatment regimen cures chronic lung infections in patients started soon after colonisation.
Research reveals antioxidant supplements can mitigate the negative effects of ozone gas on lung function. Additionally, tiny airborne particles are associated with increased risk of hospital admissions for heart disease among diabetics.
Researchers found that ultrasound-induced lung damage is dependent on beamwidth, pulse duration, and exposure duration. The air-blood barrier near the surface of the lung may be the principal target for ultrasound-induced lung damage.
A long-term study of over 1000 Finnish men found that reduced lung function due to smoking increases the risk of death from all causes. Quitting smoking halts this decline and reduces mortality risk, suggesting preserving lung function in later life may predict a longer life.
A study of over 300 employees found that workplace passive smoking significantly adversely affected lung function, with a 5-10% reduction in lung function at the highest levels of exposure. Non-smokers exposed to passive smoke at home or in public places showed no similar decline.
Researchers have identified scientifically based selection criteria for patients seeking lung volume reduction surgery (LVRS) as a potential treatment for advanced emphysema. High-risk patients with severe lung damage and poor outcomes after surgery are no longer being enrolled in the study, but will continue to receive medical treatment.
Respiratory sounds can precisely determine the level of shortness of breath in asthma patients. A new computer program uses acoustic analysis to detect breathing problems, potentially setting off an alarm during sleep and enabling researchers to study conditions without inducing symptoms.
Jayraman et al. used fluorescent indicators to measure ASL salinity in normal human and CFTR-/- mice, finding no significant difference between the two groups. This noninvasive approach may provide new insights into lung diseases with poorly understood ASL properties.
Research found that periodontal disease may increase a person's risk for respiratory disorders like Chronic Obstructive Pulmonary Disease (COPD). Patients with poor periodontal health had nearly a one-and-a-half times greater risk of developing COPD. Improved oral health may help prevent the progression of COPD.
Researchers found a significant association between chronic respiratory disease and periodontal disease in the Third National Health and Nutrition Examination Survey. Poor oral health worsens respiratory function and may increase risk of serious lower-respiratory-tract infections.
A study found that using oral steroids to control severe asthma attacks reduced the risk of death from the disease by 90 percent. A written asthma action plan also significantly reduced the risk of death and hospitalization rates. Additionally, African-American women experienced a slower rate of lung function decline with age compared ...
A team of scientists at UNC-CH has discovered a human gene that produces a protein essential for generating forces powering cilia movement. This discovery could help understand and combat chronic lung diseases such as asthma and primary ciliary dyskinesia, which affect cilia function.
A recent NHLBI study found that inhaled corticosteroids do not significantly slow the progression of COPD, a disease affecting approximately 16 million Americans. However, patients treated with inhaled corticosteroids did experience fewer respiratory symptoms and improved lung sensitivity.
The American Thoracic Society recommends enhanced contact investigation to identify additional close contacts of active TB patients. Researchers also found that eliminating occupational exposure can prevent adult-onset asthma. Furthermore, children exposed to maternal smoking in utero show significant lung function deficits.
Researchers discover that mechanical deformation, such as stretching, can induce the expression of smooth muscle cell proteins and is crucial for normal lung development. This pathway may be disrupted in fetuses with oligohydramnion, leading to hypoplastic lungs.
Research by Imperial College scientists shows that previous infection history greatly affects the duration and severity of subsequent lung infections. This highlights the importance of considering past infections in vaccine design, particularly for individuals with varying ages and immune systems.
Children's lung development is slowed due to air pollution, according to a comprehensive study. Lung function growth rates were 10% lower in the most polluted community compared to cleaner areas, with effects also observed in asthmatic and healthy children.
Research highlights significant declines in lung function growth from air pollution and long-term effects of asthma on lung capacity. Studies found that children exposed to air pollution showed a 0.9% decline in annual lung function ability, while those with long-standing asthma experienced irreversible reductions in lung function.
Researchers developed a new technique that can target aerosol particles to smaller, harder-to-reach airways in the lungs of people with cystic fibrosis. The method uses fine particles and varying inhalation rates to direct the spray to different areas of the lungs.
UI researchers find that a simple sugar, xylitol, can enhance the natural defense system of the body, potentially preventing deadly bacterial infections in CF lungs. The study shows that xylitol lowers the salt concentration of the airway surface liquid, favoring antimicrobial agents and killing invading bacteria.
The Jackson Laboratory has received a $14 million NIH grant to create a center for mouse models of heart, lung, blood and sleep disorders. The center aims to develop new models and databases for biomedical researchers worldwide, as well as advance understanding of genetic mechanisms underlying healthy function and diseases.