Articles tagged with Pancreas
Researchers discovered human islet-derived precursor cells that reproduce easily and can differentiate into hormone-producing cells. The findings may eventually have implications for islet transplantation, an experimental treatment for type 1 diabetes.
The study reveals that VAMP8 is essential for the normal functioning of pancreatic acinar cells, which produce digestive enzymes. Mice lacking VAMP8 showed reduced levels of digestive enzymes and partial resistance to pancreatitis, suggesting a potential link between VAMP8 and this condition.
Researchers at Joslin Diabetes Center have developed a new imaging technology using magnetic resonance imaging to detect early signs of type 1 diabetes. The technology tracks miniscule magnetic nanoparticles leaking from the blood vessels of the pancreas, allowing for non-invasive monitoring of the disease's progression.
A new treatment approach has been developed to prevent autoimmune diabetes in mice by blocking the interaction between NKG2D on T cells and proteins found on abnormal cells. This breakthrough finding suggests a potential therapeutic strategy for preventing or controlling type 1 diabetes.
Scientists have developed a new genomics tool that enables the efficient mapping of genome binding sites for transcription factors in human organs. This technology has been used to study the role of transcription factor HNF4 in type 2 diabetes, revealing its association with about half of all genes needed to make the pancreas and liver.
Researchers have successfully treated individuals with Type 1 diabetes using a single infusion of islet cells, with recipients maintaining insulin independence for over one to three years. The new treatment approach uses optimized recipient immunosuppression and a novel anti-CD3 monoclonal antibody.
Researchers found no survival benefit from solitary pancreas transplantation for patients with diabetes, but may justify procedure for quality of life benefits. The study suggests weighing potential benefits against increased mortality risk, particularly in the early posttransplant period.
Research suggests that GLP-1 can generate new insulin and increase the growth of new islet cells in human pancreas tissue. This treatment delayed cell death by up to 45% and improved insulin secretion in response to glucose, offering a potential therapeutic approach for Type 2 diabetes.
Researchers at Johns Hopkins Medicine found that pancreatic cancer may be triggered by the reactivation of a growth signal normally turned off in adult tissues. By blocking this pathway, they hope to prevent the early cellular changes leading to cancer.
Researchers found that blood vessel formation in the pancreas is crucial for normal insulin production in fetuses. Exendin-4, a pancreatic hormone analog, can rescue insulin-producing cells and prevent diabetes by regulating PDX protein.
Researchers successfully transplanted bone marrow cells from a male donor mouse to a female recipient, where they developed into functional insulin-expressing cells. The findings suggest that bone marrow may be a viable source for ex vivo expansion and autologous transplantation of pancreatic beta-cell precursors.
Researchers at Vanderbilt University Medical Center have discovered a gene, PTF1p48, that plays a crucial role in the development of the pancreas. The study found that p48 is required for the formation of both exocrine and endocrine cells, which could lead to the production of insulin-secreting cells from embryonic or other stem cells.
The NIH/Office of the Director's panel endorses ERCP for diagnosing suspected ampullary cancers and treating conditions like symptomatic gallstone disease, but emphasizes caution due to potential complications such as pancreatitis.
Researchers discovered that blood vessels signal pancreatic cell differentiation, challenging the long-held assumption that organs develop independently. The study found that removing blood vessels from pancreatic tissue disrupts normal gene expression and insulin production.
A study by University of Pittsburgh surgeons found that organs from marginal donors can be just as effective as ideal donor organs in pancreas transplants. The researchers accepted organs from donors over 45 years old, resulting in a high graft survival rate and improved quality of life for patients with diabetes.
A novel surgical technique developed at the UPMC has improved graft survival rates in patients receiving combined pancreas and kidney transplants. The technique protects the pancreas from injury during removal and transport, resulting in higher patient survival rates.