Researchers developed a flexible electrochemical sensing platform that captures dynamic small-molecule chemical signals in the gut. The platform reveals a new mechanism underlying enhanced intestinal mechanosensation under microbe-related stimulation, enabling real-time monitoring of serotonin release.
Researchers at Rockefeller University have captured the first snapshot of a mechanical signaling complex in action, revealing that compression is the key to transmitting mechanical information. The study has implications for cancer and other diseases, and could lead to new treatments.
A Korea University study successfully mimics heart mechanics in organoids using three-dimensional magnetic torque, enhancing cardiac differentiation, maturation, and vascularization. This breakthrough could improve drug safety testing by providing more accurate human-relevant models for cardiotoxicity screening.
A new study reveals that body cells change their shape to close gaps such as wounds, using a combination of crawling movements and 'purse-string' contractions. The researchers discovered that the endoplasmic reticulum's ability to reorganize in response to edge curvature plays a crucial role in epithelial cell movement.
A new approach to cancer therapy is being developed by inhibiting mechanotransduction, a process that regulates processes such as tumour progression and wound healing. The INTROPY project aims to validate the potential of six molecules in blocking this process, offering a new strategy for cancer treatment.
A recent study led by IBEC demonstrates that laminin, a protein present in healthy breast tissues, prevents the effects of stiffening, protecting cells against tumor growth. The researchers observed that cells seeded on laminin-rich gel exhibited a significantly less pronounced mechanical response to substrate stiffness.
Researchers discovered how zebrafish use their hair cells to detect movement, a discovery that sheds light on the mechanisms of human hearing and balance. The study's findings suggest that the structure and function of zebrafish hair cells are nearly identical to those found in humans.
A team of scientists, led by Bailong Xiao, has discovered the molecular mechanisms underlying mechanotransduction in Piezo proteins. They found that these proteins form a novel class of ion channels with distinct modules responsible for ion conduction and mechanical force sensing.
Researchers at The Scripps Research Institute (TSRI) have discovered how a mutant gene called Tmie can cause deafness from birth. They found that reintroducing the gene in mice restored the process underpinning hearing, suggesting new treatment options for hearing loss.
Researchers at Scripps Research Institute discover TMHS protein, a key component of mechanotransduction channels in the ear. The finding suggests a promising new approach to gene therapy for certain types of deafness, as it restores sound perception in newborn deaf mice.
Researchers have identified two key proteins, TMC1 and TMC2, that are crucial for the inner ear's transduction channel. The study suggests that TMC1 is essential for hearing, while TMC2 is not, but can substitute for it in the vestibular system.
Researchers at Scripps Institute have identified a molecular defect involved in hearing loss, which sheds new light on the workings of mechanotransduction. This finding may lead to better understanding of similar processes and defects that cause disease.