Articles tagged with Antioxidants
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Exercise and antioxidants such as astaxanthin have been shown to enhance brain function, particularly in the hippocampus region. The study found that mild exercise and astaxanthin are additive and mediated by the hormone leptin, leading to improved memory and neurogenesis.
Researchers found that birds have significantly lower cellular rates of energy use and antioxidant capacity compared to mammals. This may contribute to their longer lifespans, as oxidative stress is a major factor in aging. The study's authors plan to investigate the link between oxidative stress and immune defenses further.
Regular exercise increases antioxidant protein expression in skeletal muscle, driven by the cooperative action of p62 and Nrf2. Enhanced muscle contractility activates p62, leading to increased Nrf2 nuclear translocation and DNA binding activity.
Researchers developed a smart polymer that senses high oxidant levels and administers just the right amount of antioxidant to restore balance. The polymers successfully recovered water fleas' heart rates when exposed to sublethal concentrations of hydrogen peroxide.
New research reveals that melatonin's antiarrhythmic benefits are distinct from its antioxidant properties. In a rat model of heart attacks, melatonin treatment reduced incidence of ventricular tachycardia and fibrillation, but this effect was not associated with oxidative stress.
A combination of over-the-counter antioxidants shows promise for mitigating damaging effects of heart failure with preserved ejection fraction. Treatment improved markers of vascular function and inflammation in some patients, suggesting a simple and readily available option to improve vascular health.
Researchers found that antioxidants like vitamin C can block toxicity caused by hexavalent chromium in human cells, which could lead to a new treatment method for water contamination. The study suggests an oxidative mechanism is responsible for the contaminant's toxicity, and treating water with antioxidants may prevent it.
Researchers found that Aronia berries resistant to heat during production of cornmeal porridge, retaining antioxidant content. The study highlights the potential of super berries like Aronia for functional foods like porridge.
Researchers suggest that combining glucocorticoids with antioxidants could further improve clinical treatment for premature babies while minimizing potential risks. The proposed therapy aims to overcome adverse effects associated with existing glucocorticoid treatment and accelerate lung maturation in infants.
Researchers used electron accelerators to generate free radicals in water molecules, allowing them to study the damaging effects on biomolecules. This method provides a valuable tool for understanding naturally occurring antioxidants and proteins like vitamin C, with implications for developing new medications to prevent cell damage.
Researchers found that specific antioxidants are associated with particular colors of tomato fruit, suggesting a balance between these compounds. The study's results support the use of genotypes with different-colored fruit in breeding programs to increase antioxidant levels in commercial cultivars.
Researchers found therapeutic potential in a rare kidney disease treatment for some mitochondrial disorders, improving mitochondrial metabolism and reducing oxidative stress. However, dosages must be carefully controlled due to narrow therapeutic windows.
Scientists propose using microalgae biomarkers to detect environmental pollution, which is triggered by oxidative stress and reactive oxygen species. The use of microalgae as an indicator can provide early warnings of environmental problems.
A study published in Scientific Reports found that fasting increases metabolic activity, generates antioxidants, and may reverse some aging effects. Researchers discovered 30 previously unknown substances whose quantity increases during fasting, indicating various health benefits.
Research at Cornell University found that green tea brewed with bottled water contains double the amount of antioxidant EGCG as tap water, making it more bitter. In contrast, consumers prefer the sweeter taste of tea brewed with tap water.
Researchers at Penn State developed a technique to extract and purify alkylresorcinols (ARs) from rye bran, which can act as antioxidants in emulsions. The study found that ARs were not as effective as synthetic or natural antioxidants but showed promise for future development.
Research suggests that metabolic syndrome patients require higher amounts of vitamin C to counteract the effects of antioxidant depletion. A diet high in saturated fat leads to chronic inflammation, which can trigger metabolic syndrome and impair gut function. Eating fruits and vegetables daily can help restore balance.
Researchers explored umbelliferone-based derivatives as potent monoamine oxidase inhibitors. The compounds exhibited significant MAO-A and hMAO-B inhibitory potential, with some also showing antioxidant properties.
Researchers found that cooking spinach for short times minimizes lutein loss, while microwaving partially compensates. Adding fat to spinach releases more lutein, making smoothies a best way to consume it.
A new study suggests that antioxidants can reduce cognitive impairments caused by low blood sugar in diabetic patients. The research found that stimulating antioxidant defenses with sulforaphane improved cognitive ability in mice, indicating potential benefits for humans.
Researchers identified a small molecule that activates the antioxidant response, a key mechanism to protect cells from oxidative stress. The discovery targets the glycolysis pathway, opening new strategies for treating diseases involving oxidative stress.
Researchers at Thomas Jefferson University found that hot-brewed coffee contains higher levels of antioxidants than cold-brew coffee. This contradicts the popular perception that cold brew is less acidic and thus less likely to cause gastrointestinal problems.
Research led by Salk Institute scientist Gerald Shadel found that short-term stress can trigger sustained production of antioxidants and increase mitochondria efficiency, potentially extending lifespan. Cells exposed to brief stress showed higher antioxidant levels, more mitochondria, and less superoxide buildup than unstressed cells.
A recent study published in Science Signaling reveals that the ATM protein plays a dual role in sensing cellular threats and repairing damage. It forms dimers when exposed to ROS, triggering an increase in cellular antioxidant capacity through the pentose phosphate pathway.
Researchers synthesized tetrapeptide PAGY and its analogues using solid phase peptide synthesis, screening their antioxidant properties. The results showed that PSGY exhibited the highest DPPH inhibition activity, while modifications in amino acid sequences increased or decreased antioxidant activity.
A randomized, controlled trial found that supplemental antioxidants decreased the risk of time to first exacerbation requiring antibiotics in patients with CF. The study also showed increased circulating antioxidant concentrations and transiently decreased inflammation in the antioxidant-treated group.
A large US clinical trial found that an antioxidant supplement taken daily by the male partner for three months made no difference to sperm concentration, motility, or morphology. The study also showed no significant differences in natural conception rates between the antioxidant and placebo groups.
Researchers found antioxidants from SkQ ions slow down plant cell death and senescence, but not photosynthesis or respiration. They also contain plastoquinone, which influences plant cells and chloroplasts.
New research finds that certain cancers express high levels of the neural calcium channel TRPA1, which helps them tolerate toxic oxidative stress. Blocking TRPA1 activity in mice curbs tumor growth and makes cancer cells more sensitive to chemotherapy.
Researchers found that an antioxidant-enriched multivitamin may decrease respiratory illnesses in people with CF by prolonging the time between illnesses and reducing inflammation. The study, led by Children's Hospital Colorado and the University of Colorado School of Medicine, involved 73 patients with pancreatic-insufficient CF.
Researchers found that hunting dogs fed a test diet with added antioxidants and nutrients performed similarly to those on a commercial diet, but showed improved indirect measures of oxidative stress. The study suggests that athletic dogs may benefit from supplementation of vitamin E and taurine to minimize oxidation.
Researchers found that taking a mitochondrial-specific antioxidant supplement improved blood vessel dilation by 42%, making them appear younger. The improvement was due to reduced oxidative stress and associated with a 13% reduction in heart disease risk.
Researchers found two compounds effective in prolonging lifespan and protecting against brain damage in animal models of mitochondrial disease. These findings suggest that N-acetylcysteine and vitamin E may be viable leads for clinical trials to treat mitochondrial disease, which has no proven effective treatments.
Researchers have identified useful commercial applications for grape waste, such as prolonging the shelf life of fatty foods. Grape pomace is rich in natural antioxidants like proanthocyanidins, anthocyanins, and ellagic acid, which can be used to substitute artificial antioxidants in food products.
Researchers have developed biocompatible microcapsules that can scavenge reactive oxygen species, potentially aiding in antioxidant therapy or industrial applications. The novel microcapsules show improved scavenging rates compared to previous versions and do not degrade with exposure to reactive oxygen species.
Scientists discover that pain medicine pentazocine preserves vision in a model of severe retinal degeneration by activating the Nrf2-Keap1 antioxidant pathway. The drug normalizes Nrf2 levels, potentially restoring its protective function and preventing oxidative stress.
A study by Loma Linda University Health researchers found that consuming nuts regularly strengthens brainwave frequencies associated with cognition, healing, learning, memory, and other key brain functions. Pistachios produced the greatest gamma wave response, while peanuts stimulated the highest delta response.
A recent study published in Diabetologia found that a diet rich in antioxidants, particularly from fruits and vegetables, tea, and moderate alcohol consumption, is associated with a lower risk of type 2 diabetes. Women with the highest antioxidant scores had a 27% reduced risk compared to those with the lowest scores.
Researchers found that mushrooms are the highest dietary source of ergothioneine and glutathione, two antioxidants that may protect against oxidative stress and age-related diseases. The amounts of these compounds vary greatly between mushroom species, with porcini being the richest source.
A new chemical compound has been found to significantly improve the survival of cells during transplantation, a process used in cell-based therapies for various conditions. The antioxidant, Proxison, was tested on lab-grown cells and shown to be 10 times more effective than natural antioxidants in protecting cells from damage.
Reactive oxygen species are crucial signals that start muscle repair processes. Proper mitochondrial function is necessary for energy production and repairing injured myofibers. Excess antioxidants can inhibit this signaling process, exacerbating muscle damage.
A new portable sensor developed by American Chemical Society researchers can detect food spoilage, contaminants and authenticate products. The sensor uses nanostructures to bind to compounds of interest, changing color with intensity indicating concentration.
Researchers developed ceria-zirconia nanoparticles to treat sepsis by removing harmful oxygen radicals and reducing inflammatory responses. The nanoparticles improved survival rates by 2.5 fold in mice with sepsis, offering a new therapeutic strategy for this deadly disease.
Researchers have found that SkQ1, a mitochondria-targeted antioxidant, significantly enhances wound healing in a mouse model of diabetes mellitus type II. The study improves wound epithelization, granulation tissue formation, and vascularization, restoring disturbed blood circulation.
Researchers found that increasing roasting levels reduced antioxidant and anti-inflammatory activities in coffee extracts, with chlorogenic acid varying by roast level. The study suggests some beneficial compounds may be affected by the roasting process.
Researchers found that methylene blue slowed signs of aging in human skin cells, improving cellular health and reducing damage from reactive oxygen species. The antioxidant also increased cell division rates and reduced senescence markers in older donors.
Grilled and microwaved cooking methods are best for preserving the nutritional properties of mushrooms. Microwaving and grilling improve the antioxidant activity of cooked mushrooms compared to boiling and frying. Grilling also offers additional benefits, including enhanced polyphenol content.
Researchers found that cinnamon supplements reduced belly fat, improved sugar and insulin levels, and increased antioxidant molecules in rats fed a high-fat diet. This suggests that cinnamon may mitigate the negative effects of a high-fat diet on cardiovascular health.
Phenolic compounds exhibit antioxidant activity through two distinct mechanisms: breaking free radical chains and chelating abilities. The ANN model identified chemical features contributing to high DPPH* scavenging activity, including alcohol groups, molecular size, and flexibility.
Researchers discovered that hawkmoths harness the pentose phosphate pathway to create antioxidants, reducing muscle damage from high-intensity flight. This metabolic strategy allows them to process sugary diets without succumbing to oxidative stress.
A new study reveals that nectar-feeding moths can avoid oxidative damage to their muscles by converting carbohydrates into antioxidants. The researchers found that the moths rely on the pentose phosphate pathway to produce antioxidants, a mechanism that may be shared with other animals, including humans.
Researchers at Rice University have created single-molecule compounds that quench damaging reactive oxygen species, offering a new basis for antioxidant therapies. The molecules, called PEG-PDI, are true mimics of superoxide dismutase enzymes and show promise for treating cancer, traumatic brain injuries, and chronic diseases.
Termite queens have higher antioxidative enzyme levels and lower oxidative damage than other termites, suggesting an anti-aging mechanism that enables their longevity. This efficient antioxidant system allows the queens to live longer despite high fertility.
New research published in The FASEB Journal suggests that pyrroloquinoline quinone (PQQ) may prevent the development of nonalcoholic fatty liver disease in offspring. PQQ, a naturally occurring antioxidant found in soil and foods, was shown to protect against liver damage and inflammation in mice fed high-fat diets.
Researchers found that PQQ reduced fat in livers and inflammation, protecting adult mice from fatty liver even after stopping supplementation. The antioxidant may work by impacting pathways critical to early onset of diseases associated with maternal obesity and high-fat diets.
A Japanese research team has found that 2-aminobutyric acid (2-AB) can effectively increase glutathione levels in the body, a major antioxidant component. The study suggests that 2-AB could be used as a biomarker for early detection of oxidative stress and potentially treat conditions such as Alzheimer's disease and heart failure.
A new clinical trial found that consuming milk with only A2 protein increased the concentration of glutathione, a critical antioxidant, in healthy adults. This may help strengthen the body's disease-fighting power and reduce the risk of degenerative diseases.
Researchers found that patients with amyotrophic lateral sclerosis (ALS) who consumed more fruits and vegetables experienced better function around the time of diagnosis. The study suggests that a diet high in antioxidants and carotenoids may help minimize ALS severity.
Researchers developed a method to infuse peanut skin extracts into maltodextrin powder, which was then incorporated into milk chocolate. The resulting product had antioxidant properties comparable to dark chocolate without affecting the taste. Consumer testing showed that the fortified chocolates were liked as well as untreated samples.
A new study found that antioxidant nutrients, fruits, and vegetable intake are associated with better ALS function at baseline. The analysis of 302 ALS patients suggested promoting fruit and vegetable intake to support nutritional care.