Articles tagged with Antioxidants
Northwestern University professor Guillermo Ameer's team created a biodegradable, antioxidant biomaterial that reduces scarring and heals diabetic ulcers. The material is made from citric acid and vitamin C, and has potential applications in tissue engineering, medical device coating, and regenerative medicine.
The study found that melatonin treatment reduced decreased levels of antioxidant vitamins and enzymes in rats with traumatic brain injury, indicating a protective effect on cerebral cortex and blood toxicity. Melatonin also inhibited free radical formation and supported the antioxidant vitamin redox system.
Recent research suggests that antioxidant supplements and foods may not reduce cancer risk, but instead accelerate cancer development. The study proposes that antioxidants accumulate at distant sites in cells, leaving tumor-promoting ROS relatively unperturbed, which can stimulate cancer cell growth.
A study compared phenolic compounds in indigenous rose species to those of modern cultivars, revealing distinct differences in leaf phenolic content. Indigenous rose species are found to contain higher levels of phenolic antioxidants, making them a potentially suitable source for medicinal purposes.
Researchers discovered uric acid's role as a major intracellular antioxidant that prevents oxidative stress and its impact on cancer and aging. The p53-GLUT9 pathway is a mechanism to prevent ROS accumulation, which causes cell damage.
A new study by CU-Boulder reveals that an antioxidant called MitoQ can reverse the negative effects of aging on arteries, improving vascular function and reducing the risk of heart disease. MitoQ targets mitochondria, specific cell structures responsible for oxidative stress, and restores endothelial function in old mice.
Scientists at the University of Arizona have discovered a molecular pathway that could help create new therapies for end-stage liver disease. By understanding how Nrf2 is suppressed in cirrhotic livers, researchers have identified Hrd1 as a key player in exacerbating the disease process.
A recent study published in Neural Regeneration Research found that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. The study, led by Dr. Qiuyun Tu and colleagues, showed that atorvastatin reduces inflammation and oxidative stres...
Common edible flowers in China have excellent antioxidant capacity due to their high phenolic content, which has anti-inflammatory activity and a reduced risk of cardiovascular disease and certain cancers.
A new study found that antioxidants may increase DNA damage from omega-6 fatty acids, but reduce formation of another type of damage. Green tea polyphenol and alpha-lipoic acid showed mixed effects on these damages.
Researchers found that adding oligomeric procyanidins (PCs) from dark chocolate can reduce weight gain and improve glucose tolerance in mice. The study suggests that these compounds could be key to preventing type-2 diabetes and obesity.
Scientists have discovered that the antioxidant and anti-inflammatory properties of oat phenolic compounds, particularly avenanthramide, contribute to the heart health benefits of oats. These findings suggest that eating oats may go beyond fiber and provide additional cardio-protective effects.
Scientists at The University of Manchester discovered a rhythmic defence pathway in the lung controlled by our body clocks, essential for combating toxins and pollutants. The research found that timed administration of antioxidant compounds according to the lung clock time can increase their effectiveness and reduce side effects.
Researchers at Salve Regina University discovered that honey has multiple mechanisms to combat bacterial infections, including the osmotic effect, acidity, and polyphenols. The study found that honey inhibits biofilm formation and disrupts quorum sensing, making bacteria more susceptible to conventional antibiotics.
Researchers found that moderate exercise can stimulate stem cell regeneration in mice, but losing the antioxidant protein Nrf2 hinders muscle recovery. Sarcopenia, age-related muscle loss, occurs naturally and is linked to reduced antioxidant production.
Researchers identified compounds in hop leaves that could prevent bacterial adhesion and toxin release, potentially repurposing a discarded byproduct. The study found three new compounds and substantial amounts of proanthocyanidins, which are healthful antioxidants.
Researchers found that sprouted garlic had higher antioxidant activity than fresh bulbs and made different substances. This could be a way to improve the health benefits of garlic without wasting food.
Researchers have identified a potent antioxidant called Tiron that provides complete protection against UVA radiation and oxidative stress, offering potential benefits for anti-aging and sun-damaged skin. The study suggests that Tiron could be used to develop new skincare products or supplements, but further testing is needed.
Researchers at Oregon Health & Science University have discovered that an antioxidant called MitoQ can significantly reverse a multiple sclerosis-like disease in mice. The treatment reduced inflammation, demyelination, and neurological disabilities, showing promise for treating MS.
Researchers evaluated mangafodipir, an MRI contrast agent with antioxidant properties, for relief of oxaliplatin-induced neurotoxicity. Mangafodipir treatment reduced neurotoxicity and decreased neurological symptoms in both mouse models and human patients.
Researchers have found that controlling levels of reactive oxygen species can break the cycle of wounds that refuse to heal. Antioxidant supplements such as vitamin E and N-Acetyl cysteine were able to normalize conditions and promote healing in chronically infected wounds.
Chronic wounds affect millions of Americans at a high cost. Researchers found that reducing reactive oxygen species (ROS) levels can break the cycle of unhealing wounds. Antioxidant treatments can also reverse chronicity by disintegrating bacterial biofilms, leading to healthier tissue and wound healing.
Researchers identified a distinct Treg cell population expressing ICOS that predicts better clinical outcomes in melanoma patients treated with high-dose IL-2 therapy. A SOD1 pharmacological inhibitor reduced tumor growth in mice, suggesting inhibition of antioxidants as a viable chemotherapeutic option.
Researchers found that inhibiting antioxidant proteins reduced tumor growth and induced cell death in lung cancer cells. In a mouse model, the inhibitor ATN-224 also reduced tumor sizes when combined with another drug.
A team at the University of Geneva has generated a transgenic plant that constantly detects and responds to UV-B rays, producing high levels of antioxidants and flavonoids. This plant is equipped with an UVR8 mutated receptor, which remains active even without UV exposure.
The buffaloberry contains high amounts of lycopene and methyl-lycopenoate, making it an excellent source of antioxidants and nutrients. The fruit is also being considered as a natural food colorant and has potential applications in commercial wine production.
Researchers found that disrupting Nrf2 reduces reductive stress, cardiac protein aggregation, and extends survival in mice with heart failure. This study suggests restoring balance in reduction-oxidation chemical reactions can prevent heart disease.
Researchers from ETH Zurich found that vitamin niacin and its metabolite nicotinamide increase lifespan by promoting the formation of free radicals in roundworms. This contradicts common textbook opinion on antioxidants' role in health.
A recent study found that olive leaf extract can protect against lead-induced brain injury by increasing antioxidant capacity and reducing apoptosis. The study published in Neural Regeneration Research reveals the action mechanism underlying olive leaf extract treatment for lead poisoning.
Researchers found that defects in the NF1/Ras molecular pathway trigger production of harmful oxidative nitric oxide molecules in glial brain cells, leading to behavioral issues. Antioxidant treatment reversed symptoms in mouse models of NF1 and Costello syndrome, suggesting a potential therapeutic approach for related human conditions.
Scientists have identified several natural ingredients with potential health benefits, including curcumin, which inhibits cancer cell growth and induces apoptosis. Other compounds found in ginger, cranberries, and olive oil also show promise in reducing the risk of heart disease and cancer.
The American Chemical Society is hosting a symposium on the health benefits of polyphenols in plant-based foods, including dark chocolate, coffee, and nuts. Researchers will present their findings on the antioxidant properties of polyphenols and their potential role in reducing cardiovascular disease and certain forms of cancer.
Researchers have discovered a new generation of natural food colorings derived from purple sweet potatoes, which offer superior properties to traditional synthetic colors. These antioxidants-rich substances may also have health benefits, making them an attractive alternative for the food and beverage industry.
Excessive sunlight inhibits algae growth, leading to yellowish coloration and stress. The study found a direct relationship between solar radiation, antioxidant activity, and C:N ratio in the alga.
Researchers at Northwestern University discovered that plant polyphenols can be used to create antibacterial coatings with useful properties. These coatings, which are non-toxic and have antioxidant properties, were found to stick to various surfaces, including Teflon.
Research published in PLOS ONE reveals that native Brazilian fruits, including 'wolf apple', contain higher proportions of bioactive compounds and pigments than conventional Red Delicious apples, making them a potentially nutritious food source.
A recent study published in The Journal of Physiology found that high doses of the antioxidant compound resveratrol, commonly found in red wine and supplements, can block cardiovascular benefits of exercise in older men. This counterintuitive result highlights the complex relationship between antioxidants and exercise.
Researchers from Spain and the US have identified nine molecular hallmarks of aging, including genomic instability, telomere shortening, and epigenetic alterations. By understanding these hallmarks, they hope to develop treatments that can combat cancer and other diseases linked to aging.
Researchers at Norwich BioScience Institutes have developed a new method to breed GM tomatoes with enhanced flavor, health, and shelf life. By introducing a specific compound, they were able to prolong the lives of cancer-prone mice and extend the average shelf life from 21 days to 48 days.
A study published in Journal of Nutritional Biochemistry found that grapes reduce heart failure associated with hypertension by increasing antioxidant defense genes in the heart. Grapes are rich in antioxidants and polyphenols, which help improve glutathione levels and reduce oxidative stress.
Researchers found that injecting NAC prior to harvesting significantly improves graft survival, with suboptimal organ usage showing higher benefits. The study suggests using NAC during organ procurement to reduce damage and improve transplant outcomes.
A new study published in Neurology found no correlation between antioxidant intake and risk of developing stroke or dementia. The study suggests that individual antioxidants and food sources may be more important than total antioxidant levels in reducing the risk of these conditions.
Scientists at the University of Manchester have discovered that reactive oxygen species (ROS) play a crucial role in tadpole tail regeneration, which could lead to new therapies for human tissue repair. The team found that manipulating ROS levels may be essential to initiate and sustain regeneration processes.
Researchers found that filter and espresso coffeemakers leave more antioxidants in used coffee grounds, making most grounds a good source of useful substances. The extracted compounds can still be used as fertilizer after extraction.
Dr. James Watson suggests that antioxidants in late-stage cancer cells can promote cancer progression, and that reducing antioxidant levels may be key to developing new anti-metastatic drugs. He calls for a faster timetable for researching this proposition.
Researchers have designed a compound that suppresses symptoms of Huntington's disease in mice by targeting mitochondria, potentially leading to new treatments for neurodegenerative diseases. The synthetic antioxidant XJB-5-131 improves mitochondrial function and enhances neuron survival.
A new study published in Neurology suggests that a diet rich in tomatoes and lycopene may lower the risk of stroke. The research involved 1,031 Finnish men aged 46-65, who were followed for an average of 12 years, with those having higher levels of lycopene showing a 55% reduced risk of stroke.
A new study found that consuming one apple a day for four weeks lowered blood levels of oxidized LDL by 40 percent. The polyphenols in apples played a significant role in this effect.
A study by Berkeley Lab scientists found that older men who consume more vitamin C, E, folate, and zinc have less sperm DNA damage. This suggests that adequate micronutrient intake can help counteract the detrimental effects of aging on sperm genome health.
Researchers found that a commercially available acai berry product can triple the lifespan of fruit flies under oxidative stress conditions. Acai also protected normal flies against oxidative stress and neurotoxic effects of paraquat.
Scientists have discovered a way to increase antioxidant levels in sweet potatoes through an electric current treatment, which can help relieve hunger and improve nutrition. The study found that the treatment increased antioxidant activity and polyphenol content by 1.4 times and 1.6 times compared to untreated potatoes.
Research published in the journal Gut suggests that increasing dietary intake of antioxidant vitamins C, E, and selenium could cut the risk of developing pancreatic cancer. The study found a significant association between high antioxidant intake and reduced pancreatic cancer risk, with potential prevention of over one in 12 cases.
Researchers have discovered a powerful class of antioxidants that can block the development of Parkinson's disease by bolstering the natural antioxidant Nrf2. The synthetic triterpenoids increased Nrf2 activity, reducing oxidative stress and inflammation in brain cells, which are characteristic of Parkinson's.
A diet high in vegetables may help prevent acute pancreatitis by reducing oxidative stress. The study found that individuals who consumed the most vegetables daily were 44% less likely to develop the condition than those who ate the least. This protective effect was strongest among heavy drinkers and overweight individuals.
Researchers at Emory University School of Medicine have identified a new class of anti-inflammatory compounds that inhibit the Nox2 enzyme, which produces reactive oxygen species. This approach may be more effective than traditional antioxidants in treating conditions like stroke, heart failure, and neurodegenerative diseases.
Researchers found that rhSOD reduces ROP incidence and severity in newborns born earlier than 26 weeks, with a 22% reduction for those born earlier than 25 weeks. The study suggests that rhSOD could provide a preventive approach to ROP prevention, but further studies are needed to confirm the findings.
University of Minnesota researchers found that patients with high levels of good cholesterol but low levels of the GPx3 enzyme were six times less likely to develop cardiovascular disease. The study suggests that measuring this enzyme may become a common blood test to determine risk for cardiovascular disease.
A study by Joe Vinson found that popcorn has higher antioxidant levels than fruits and vegetables due to its high concentration of polyphenols. The hulls of the popcorn kernel have the highest concentration of these antioxidants, making them a nutritional gold nugget.
Researchers found that consuming two servings of salmon per week improves omega-3 fatty acid levels in both pregnant women and their babies. This increase in omega-3s enhances the body's antioxidant defenses, potentially helping to reduce oxidative stress associated with pregnancy.
A clinical trial examining the antioxidant effects of a vitamin E and C combination on Alzheimer's disease found no association with changes in cerebrospinal fluid biomarkers. However, the treatment was shown to reduce oxidative stress in the brain, but at the cost of faster cognitive decline.