Researchers found that the skin relies on TRPM8 sensor for cold detection, while internal organs primarily use TRPA1 sensor. This difference explains variations in external and internal cold perception, and has implications for understanding thermal homeostasis and pathologies related to cold sensitivity.
A research team discovered a counter-ion competition mechanism that explains the superiority of negatively charged nanofiltration membranes in separating lithium and magnesium ions. This finding provides critical insights for designing next-generation NF membranes with tailored ion selectivity.
Researchers at Johns Hopkins Medicine have identified TRPM7, a cation channel in carotid bodies and bloodstream, as a promising therapeutic target for sleep apnea. Blocking or eliminating this channel may offer a new treatment option for obesity-related breathing disorders.
Scientists have developed a new tool for controlling brain circuit activity using light pulses, allowing for precise control over neuron function. The breakthrough, funded by the NIH, could lead to future therapeutic applications in managing pain and understanding mental illnesses.
University of Illinois researchers used a high-resolution single-molecule study technique to see subtle differences between two branches of neurotransmitter-gated ion channels. They found that changing the position of an amino acid changes its properties, allowing cation-selective channels to regulate excitation.
Contributors from different disciplines discuss ion selectivity using crystal structures, electrophysiology, and computational methods. The series provides an ongoing forum for experts to discuss scientific questions and controversies.