Articles tagged with Free Radicals
Researchers have visualized the molecular structure of succinate dehydrogenase, a key enzyme in cellular respiration, revealing its anti-aging function. The study shows that the enzyme's three-dimensional shape prevents the formation of destructive oxygen atoms, which can cause cellular aging.
A UC Irvine study found that adding antioxidants to insulin therapy can improve its ability to reduce blood sugar and prevent organ damage. Treating rats with insulin alone only partially succeeded, but vitamins C and E spared sugars, proteins, and nitric oxide from attack.
Grape seed extract enhanced wound healing in mice and human skin cells by promoting epidermal tissue formation and connective tissue deposition. It also increased levels of VEGF, a compound that helps rebuild blood vessels.
Researchers found that a synthetic antioxidant, AEOL 10150, significantly reduced brain tissue destruction and neurological deficits in mice after stroke. The compound protected potentially salvageable tissue surrounding the damaged cells.
A new study by University at Buffalo researchers found that insulin sensitizer rosiglitazone (Avandia) has a significant anti-inflammatory effect in Type 2 diabetes patients. The drug decreased levels of oxygen free radicals and inflammatory markers, reducing the risk of heart disease.
A gene mutation that affects antioxidant production is associated with a 50% increase in heart disease risk, even among those without traditional cardiovascular risk factors. Individuals carrying the mutation have an 80% higher risk of developing brain vessel disease.
A green tea extract has been shown to prevent primary graft failure after transplantation of fatty livers, increasing survival rates to 75%. This study confirms the association between increased free radical formation and graft failure, suggesting a potential therapy to prevent failure of previously rejected livers.
A combination of two compounds, acetyl-l-carnitine and alpha-lipoic acid, have been shown to improve physical and mental function in older rats. The study suggests that these compounds may have therapeutic potential for humans, with the goal of improving quality of life and health.
Research by UCLA chemists suggests that too much Coenzyme Q can be harmful to adult worms, extending their life span. The study, published in the journal Science, found that lower amounts of Coenzyme Q significantly extended the life span of Caenorhabditis elegans worms.
A study found that children from high-risk families have lower levels of enzymes that help dispose of free radicals, making them more susceptible to cellular damage. Increasing intake of fruits and vegetables can help build up these enzymes and prevent free radical damage.
Researchers at UNC Chapel Hill have discovered the chemical mechanism behind 'skunky beer' caused by light-sensitive hop compounds called isohumulones. These compounds break down into free radicals when exposed to light, producing a skunky thiol molecule with an extremely low taste and smell threshold.
Researchers found that antioxidants like vitamin C can significantly reduce free radical generation and skin damage. Vitamin C was the most effective quencher, accumulating in the skin to neutralize free radicals.
Researchers found that antioxidant treatment produced scattered blistering, lower inflammation, and extensive healing compared to no treatment or acid suppressants. Oxidative damage was a major cause of reflux oesophagitis, suggesting antioxidants should be considered primary treatment alongside acid suppressants.
A new study from the University at Buffalo reveals that obese individuals carry a massive oxidative load that increases their risk of heart disease. Severe calorie restriction decreases free radical production by over 50%, reducing the risk of developing heart disease without medication.
A new study reveals that free radicals, generated by the macrophage enzyme NADPH oxidase, are essential for the development of alcoholic liver disease. The researchers found that mice lacking this enzyme were resistant to liver injury and had lower levels of covalent adducts in their bile.
The NIH has awarded a grant to MetaPhore Pharmaceuticals to study potential new treatments for acute and chronic pain. The research aims to develop metal-based compounds that mimic the body's natural defense mechanism against oxidative damage, with the goal of creating non-opiate drugs for pain management.
A study published in The Journal of Clinical Endocrinology and Metabolism found that excess glucose consumption stimulates the generation of free radicals, which can damage cells lining blood vessels. The researchers also observed a decrease in levels of a-tocopherol, a powerful antioxidant.
Chemist Ned A. Porter of Vanderbilt University has discovered how free radicals attack molecules in the body, a process that may be critical to the development of arterial plaque and heart attacks. His work also reveals that antioxidants like vitamins C and E can affect and stop this reaction.
Researchers found that extracts from Scutellaria baicalensis significantly reduce cellular damage due to free radicals. The extract helped cells regain their ability to contract rhythmically after simulating cardiac arrest, reducing cell death by 47% compared to untreated cells.
Toxicologists have made a groundbreaking discovery that chemical compounds formed during the reaction of free radicals with human tissue can be detected in the urine within just a few days. This breakthrough has the potential to provide an earlier indication of the damaging effects of chemotherapy on cancer patients.
A University of Georgia study found that blood vessels from African Americans generate more free radicals than those from Caucasians, which may contribute to the higher incidence of cardiovascular disease in African Americans. The increased free radical production could be linked to reduced vasodilation and increased blood pressure.