Articles tagged with Free Radicals
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A new study found that 42% of women treated with uric acid therapy had little to no disability after 90 days compared to 29% of those treated with a placebo. Uric acid also helped reduce dead tissue resulting from lack of blood supply.
Korean scientists have successfully created a new class of radical compounds by reacting nitric oxide with N-heterocyclic carbenes. The resulting nitric oxide compounds show potential for targeted NO delivery, which could lead to new therapeutic applications in various human diseases.
Researchers have identified and corrected defects in diseased cells, restoring normal activity in Cockayne syndrome patients. The study reveals the role of an enzyme, HTRA3 protease, in mitochondrial defects that contribute to premature aging. Therapeutic strategies using HTRA3 inhibitors or antioxidants may soon be tested in patients.
Monash researchers, in collaboration with Illycaffè, conducted a comprehensive study on the behavior of free radicals and antioxidants during coffee brewing. They discovered that under certain conditions, coffee can act as an antioxidant, providing a deeper understanding of its potential health benefits.
Researchers found that e-cigarettes compromise the immune system in mice, increasing susceptibility to respiratory infections and impairing lung function. The study also identified 'free radical' chemicals in e-cigarette vapors, previously thought only to be found in tobacco cigarettes and air pollutants.
Researchers found that A1M stops the oxidation of blood fats and repairs damaged molecules, protecting against atherosclerosis. The protein can also clean and reduce oxidised blood fats from LDL and take care of dangerous substances from MPO.
Researchers at Temple University discovered that oxygen free radicals bind to a protein receptor in the brain called the thromboxane receptor, transmitting signals that increase amyloid beta and tau production. Blocking this receptor has shown promise in neutralizing Alzheimer's disease symptoms.
A recent study aimed to determine the role of free radicals in aging, but was refuted due to limitations with the measurement tool used. The researchers found that changes in pH levels inside mitochondria, rather than free radical release, were responsible for the signals detected by the probe.
Researchers found that moderate levels of free radicals are necessary for proper skin wound healing in laboratory roundworms. Increased ROS can even accelerate wound closure, suggesting a potential therapeutic target for improving wound healing in humans, particularly the elderly and those with diabetes.
Researchers at the University of Missouri have discovered a molecule that effectively treats oxidative stress, which is linked to cancer, Alzheimer's, and Parkinson's disease. The compound, HPP-4382, has shown promise in fighting free radicals and could eventually be developed into a drug.
Researchers at McGill University found that free radicals stimulate a molecular mechanism that increases cell defenses and promotes longevity. The study used the roundworm C. elegans as a model organism and found that elevating free radical generation induced a substantially longer life.
A new UK study published in Free Radical Biology and Medicine found that a diet low in vitamin D causes free radical damage to the brain, leading to decreased cognitive performance. The researchers also discovered that vitamin D deficiency is linked to Alzheimer's disease, certain cancers, and heart disease.
Researchers found that disabling a circadian clock gene blocks the brain's antioxidant surge, allowing free radicals to cause more damage. This can lead to neurodegeneration and age-related brain cell injury, similar to Alzheimer's disease.
Researchers aim to prevent diabetes-related damage to blood vessels in the retina by modulating the arginase enzyme. By stabilizing arginase levels, they hope to restore a healthy relationship between enzymes and reduce oxidative stress. This new approach may not only protect sight but also have broader benefits for cardiovascular health.
A scientist is working to bolster the body's natural antioxidant system to interrupt a vicious cycle of inflammation and free radicals that cause vision loss in diabetes. The goal is to use a selenium supplement to improve the thioredoxin system, which helps neutralize excess free radicals.
Researchers believe blocking the sodium transporter HVI may stop the vicious cycle of excessive sodium, free radicals, and hypertension. If successful, targeted treatment could help reduce cardiovascular disease risk.
Researchers at USC's Keck School of Medicine found that liver mitochondria in mice improve and increase after chronic alcohol feeding, suggesting a possible mechanism for liver damage. The study's findings could help pinpoint targets for therapy if observed in human mitochondria.
Researchers employed a high-powered laser to dramatically enhance electron paramagnetic resonance (EPR) spectroscopy, allowing for the study of tiny molecules at high resolution. This breakthrough will facilitate discoveries in fields such as new drug development and efficient plastic solar cells.
A diet high in vegetables may help prevent acute pancreatitis by reducing oxidative stress. The study found that individuals who consumed the most vegetables daily were 44% less likely to develop the condition than those who ate the least. This protective effect was strongest among heavy drinkers and overweight individuals.
A Mexican study found that avocado oil's properties can increase yeast cell resistance to harmful free radicals. The antioxidants in avocado oil allow it to thrive even in high concentrations of iron, which produces a large amount of free radicals.
Researchers found that avocado oil protects yeast cells from damage caused by free radicals, increasing their resistance to oxidative stress. The study suggests that avocado oil may have a similar protective effect on human health, particularly for individuals with chronic degenerative diseases.
Researchers at Northwestern University discovered that squeezed polymers can generate significant amounts of energy for chemical reactions. However, they also found that certain polymer-based medical implants release harmful free radicals under moderate pressure, raising concerns about their safety.
Researchers have discovered that toxins released by diseased brain cells trigger a vicious circle of immune system activation, leading to high levels of free radicals that attack healthy nerve cells. The discovery may lead to targeted therapies to slow down these diseases.
Researchers from Cornell University created a healthier cigarette filter with lycopene and grape seed extract, drastically reducing toxic free radicals. The study demonstrates the potential for an alternative type of cigarette filter with a free radical scavenging additive.
Researchers at Max Planck Institute discovered a mechanism that allows cells to coordinate respiratory activity and degrade toxic oxygen radicals. This discovery may have significant implications for cancer research, as it could be used to target nutrition deficiency in tumour cells and render them more vulnerable.
Researchers found that elevating free radical levels suppresses appetite in obese mice by activating satiety-promoting neurons. This process is driven by hormones leptin and glucose, which signal the brain to modulate food intake.
A new study reveals that free radicals act as signal substances that increase the heart's contractions with the correct force. Persistent stress can lead to chronic levels of free radicals, potentially contributing to heart failure.
Researchers found that statin drugs can prevent free radicals from killing nerves important to maintaining vision in people with diabetes. The study suggests that oral treatment with atorvastatin can restore proper levels of nerve growth factor and preserve neurons in the retina.
Scientists have found that free radicals contribute to the damage in patients with Fuchs Endothelial Corneal Dystrophy (FECD), a hereditary disease impacting nearly four percent of the population over age 60. The discovery holds promise for early and preventative treatments, such as a diet rich in leafy green vegetables and multivitamins.
A BYU research team found that eating an orange is better for you than its components when taken separately due to the specific mixture of antioxidants. The study identified several combinations, with hesperidin and naringenin appearing to contribute significantly.
Researchers found that oxygen therapy can increase peroxynitrite levels in the lungs, leading to inflammation, hemorrhaging, and swelling. A new compound, peptide 326, has been developed to interfere with this process, offering hope for reducing lung damage.
Researchers from the University of Montreal have identified an enzyme called NOX2 that generates highly reactive oxygen derivatives to activate defense genes and molecules against viral invasions. The study reveals how these free radicals serve a critical role in mounting an immune response to viral infections.
Researchers found that sub-lethal doses of antibiotics trigger DNA mutations, producing germs resistant to multiple drugs. The study highlights the dangers of incomplete antibiotic treatment and calls for stricter regulations on its use.
Researchers discovered a way to reduce free radicals and oxidative damage in genetically altered fruit flies, leading to increased lifespan. The finding could lead to the development of new anti-aging treatments without genetic manipulation.
Researchers question the long-held free radical theory of ageing, suggesting that oxidative stress is not a major cause of ageing. The study found no significant impact on lifespan when controlling superoxide levels in nematode worms.
A previously unrecognized group of air pollutants has been discovered that can cause life-threatening conditions similar to those found in tobacco smoke. Inhaling these pollutants exposes individuals to potentially lethal amounts of free radicals, with the average person inhaling 300 times more daily than from smoking one cigarette.
Brain plays a key role in appetite regulation by using fat as fuel, with oxygen-free radicals playing a crucial role. The study suggests that antioxidants could help control weight, and taking them at the right time may affect satiety.
A genetic disorder linked to fatal muscle contractions during anesthesia may also be connected to heat stroke, according to new research. The study found that antioxidants could protect against heat stroke in genetically prone individuals.
A UCLA study found that broccoli's sulforaphane can switch on antioxidant genes and enzymes in immune cells, combating oxidative tissue damage. This could lead to a decline in age-related decline in immune function.
New research reveals that button mushrooms have equivalent anti-oxidant properties to pricey maitake and matsutake mushrooms. The study found that the body of the mushroom has a higher concentration of anti-oxidants than the stalk.
Researchers discover mechanism by which rosemary's carnosic acid fights off free radical damage in the brain, potentially leading to new treatments for stroke and neurodegenerative diseases. The active compound activates a novel signaling pathway, providing a 'pathological-activated therapeutic' approach with reduced side effects.
The study found that females have higher levels of nitric oxide synthase, which may contribute to their lower risk of kidney disease. In contrast, males have more AT1 receptors that enable angiotensin 2 to cause damage, leading to a greater risk of hypertension and kidney injury.
Researchers found that a combination of vitamins A, C, and E and magnesium effectively prevented permanent noise-induced hearing loss in guinea pigs. The study's lead author suggests that similar nutritional bars could provide adequate daily protection for people exposed to loud noises, such as soldiers or concertgoers.
Researchers at Dana-Farber Cancer Institute found that a regulatory protein PGC-1a switches on the brain's anti-oxidant system when free radicals accumulate. Increasing PGC-1a activity in brain cells protects against nerve toxins and oxidative stress.
A new drug has been shown to improve blood flow in diseased arteries by reactivating a damaged enzyme, reducing the risk of high blood pressure and heart attacks. The discovery is a significant development for the treatment of cardiovascular disease and aims to challenge orthodox thinking on heart health.
Researchers found children with autism have abnormal blood vessel function and high levels of oxidative stress, which may contribute to the disorder's symptoms. The study suggests that targeting this imbalance could lead to new therapies for autism.
A study identifies Protein Disulphide Isomerase as a marker for neurodegenerative diseases, while also showing its potential as a therapeutic target. The research reveals that NO attacks PDI via S-nitrosylation, altering its function and leading to nerve cell injury.
Researchers discovered that amphetamines are converted into free radicals in the brain, leading to long-term neurodegeneration and oxidative stress. The study suggests a novel mechanism for how amphetamines may contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Scientists have found that melanin, a pigment in the body, acts as a sponge to absorb and destroy free radicals that damage retinal cells. This discovery offers hope for preventing macular degeneration, a leading cause of blindness.
A new UF study suggests that mitochondrial mutations leading to programmed cell death could be a central mechanism driving aging in mammals. The research finds no correlation between oxidative stress and increased mortality, contradicting the previously believed 'vicious cycle' theory of aging.
Scientists have extended the lifespan of mice by protecting against free radicals, providing evidence for the free-radical theory of aging. The study found that delivering catalase to mitochondria increased average and maximum lifespan by up to 20%.
Researchers discovered that inserting human UCP2 into fly nerve cells extended lifespan by 28% in females and 11% in males. The increased mitochondrial uncoupling led to reduced ROS production and oxidative damage, without affecting reproductive or physical activity levels.
A study published in Neuroscience found that calorie restriction had mixed effects on the brains of mice, improving grip strength, coordination, and flexibility, but having no effect on cognitive performance. The researchers suggest that free radical damage may contribute to age-related cognitive impairments, which could be prevented o...
A high-fat fast-food breakfast causes a surge in inflammatory factors in the blood stream, overwhelming the body's natural anti-inflammatory mechanisms. Repeated exposure may lead to chronic inflammation and increase the risk of heart disease.
Researchers question current disease treatment theory, suggesting new treatments targeting neutrophil leukocytes instead. The study's findings could lead to a re-evaluation of antioxidant therapies and a shift in medical practice.
Jacox, a leading expert on free radicals, has been recognized for her contributions to spectroscopy. Her work reveals the importance of free radicals in driving chemical reactions and understanding their role in various molecular processes.
Researchers have visualized the molecular structure of succinate dehydrogenase, a key enzyme in cellular respiration, revealing its anti-aging function. The study shows that the enzyme's three-dimensional shape prevents the formation of destructive oxygen atoms, which can cause cellular aging.
A UC Irvine study found that adding antioxidants to insulin therapy can improve its ability to reduce blood sugar and prevent organ damage. Treating rats with insulin alone only partially succeeded, but vitamins C and E spared sugars, proteins, and nitric oxide from attack.
Grape seed extract enhanced wound healing in mice and human skin cells by promoting epidermal tissue formation and connective tissue deposition. It also increased levels of VEGF, a compound that helps rebuild blood vessels.
Researchers found that a synthetic antioxidant, AEOL 10150, significantly reduced brain tissue destruction and neurological deficits in mice after stroke. The compound protected potentially salvageable tissue surrounding the damaged cells.