Articles tagged with Fusion Genes
Researchers have identified a previously unknown gene fusion event in lung adenocarcinoma cases in never-smokers, suggesting that this fusion could serve as a therapeutic target. The study found the KIF5B-RET fusion to occur in about 6% of all lung adenocarcinoma cases.
Dr. Andrés Finzi's 'Reverse Fusion' project aims to deliver toxic genes to HIV-infected cells to eliminate them. The approach targets the virus's unique key and lock, using modified envelope glycoproteins and receptors to deliver a Trojan horse that eradicates infected cells.
Researchers at Stanford University School of Medicine have identified a unique gene fusion in ovarian cancer that could enable early detection and targeted therapies. The fusion, involving genes ESRRA and C11orf20, was found in 15% of aggressive ovarian cancer cases.
U-M scientists identified a genetic anomaly in the KRAS gene, known for its role in numerous cancers, that may promote tumor progression in a rare subset of prostate cancers. This finding suggests different subtypes of prostate cancer will need targeted treatment strategies.
Researchers have identified a pattern of DNA sequence called microhomology that plays a key role in the formation of gene fusions in pediatric brain tumors. This discovery sheds light on how these genomic rearrangements form in the early stages of cancer and may have implications for understanding other types of cancers.
A U-M study found that exposure to androgen hormone relocates pieces of chromosome near each other, setting the scene for gene fusion in prostate cancer. This finding may lead to new screening tools or prevention strategies.
Researchers have discovered a new gene fusion, NDRG1-ERG, that produces a protein potentially targeted by drug therapies. This finding may improve prostate cancer testing and treatment options.
A novel gene fusion, SLC45A3-ELK4, is highly expressed in prostate cancers and detectable in urine. This biomarker may help distinguish clinically significant from indolent disease.
A doctoral thesis reveals that three FET genes involved in cell maturation and stress response can lead to rapid cancer development in children. The study's findings suggest that these genes' rearrangements may cause cancer cells to lose normal control mechanisms, resulting in uncontrolled growth.
Researchers at U-M Comprehensive Cancer Center identified recurrent gene fusions that drive certain cancers to develop. New gene sequencing technology enabled quicker and easier detection of these fusions.
Researchers identified SPINK1 as a biomarker for an aggressive type of prostate cancer that accounts for 10% of cases. The discovery could lead to a simple urine test to diagnose this variation, which tends to recur quickly.
Researchers found that gene fusions trigger cancer growth and could impact treatment choices, with some genes regulated by androgen. The discovery may lead to better diagnostics and targeted therapies for prostate cancer.
Researchers at the University of Utah Health have made a significant breakthrough in understanding the origins of synovial sarcoma, a deadly cancer that affects young adults. By engineering mice to develop this cancer, scientists discovered that it originates from muscle cell precursors known as myoblasts.
Eugenio Schuster, a controls engineer at Lehigh University, has received a five-year NSF CAREER Award to develop active control systems for nuclear fusion reactors. The goal is to regulate the density, current, and temperature of plasmas in fusion reactors to achieve self-sustaining fusion reactions.
Turbulence has been observed to generate its own self-regulating flows that destroy turbulent eddies, according to recent experiments at DIII-D. These flows, predicted theoretically and seen in computer simulations, create a 'shearing' or tearing action that destroys turbulent eddies.