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Subtract a gene and feasting mice add no fat

Scientists have created mice that can eat rich, high-fat diets without accumulating fat or risking diabetes. The mice lack the SCD-1 gene, which produces an enzyme required for fat tissue production. Instead of storing excess fat, the mice metabolize it, increasing energy expenditure and oxygen consumption.

SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateAug 12, 2002

Foxo1 and the insulin resistance of cultured kidney cells

Researchers discovered that Foxo1 is involved in regulating glucose metabolism and promoting insulin resistance in cultured kidney cells. Increased Foxo1 activity was linked to decreased insulin sensitivity, highlighting its potential as a therapeutic target for treating related disorders.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateOct 31, 2001

GLUT4 in membrane ruffles

Researchers found GLUT4 inserted into plasma membranes at regions of membrane ruffling. High insulin and glucose levels impede this process, suggesting a novel explanation for muscle glucose homeostasis loss in diabetes. This study provides insight into the role of membrane-cytoskeletal interactions in regulating glucose uptake.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 1, 2001

New and painless way for diabetics to measure glucose levels

Researchers have developed a new and painless way to measure glucose levels in diabetics using low-frequency ultrasound. The method, described in a recent study, involves making the skin permeable with ultrasound waves, allowing glucose to cross the skin and be measured continuously for up to 12 hours.

SourcePenn State·JournalNature Medicine·DateFeb 29, 2000

Women With PCOS Also Have Higher Rates Of Diabetes

A study of 254 women with Polycystic Ovary Syndrome (PCOS) found that 7.5% had undiagnosed diabetes, compared to 1% in the general population. Insulin resistance is a key factor in PCOS-related glucose intolerance and diabetes risk.

SourcePenn State·JournalThe Journal of Clinical Endocrinology & Metabolism·DateJan 28, 1999

Cancer Cells Self-Destruct When "Sweet Tooth" Is Thwarted

Researchers found cancer cells self-destruct when glucose is cut off, suggesting a potent new way to fight cancer with few side effects. The discovery was made using a compound that disrupts glycolysis, the process that produces energy from sugar, and could be used in combination with existing treatments.

SourceJohns Hopkins Medicine·JournalProceedings of the National Academy of Sciences·DateFeb 17, 1998