Articles tagged with Messenger Rna
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A case series found that a fourth dose of an mRNA-based vaccine increases antispike IgG titers in kidney transplant recipients with weak serologic response after three doses. The researchers noted no safety concerns with the additional dose and suggested its use for such patients.
Researchers have created an mRNA-based approach to reprogram immune cells to attack specific targets, with promising results in treating heart failure. The technique, which is simpler and more temporary than current CAR T cell technology, holds potential for addressing a range of fibrotic diseases.
A new study reveals that mRNA vaccines activate a type of helper cell called T follicular helper cells, which assist in creating powerful antibodies and drive the development of immune memory. This strong response helps prevent severe disease and death, even against highly mutated variants like omicron.
Researchers developed nanoparticles that activate key cancer fighters by driving up immunity at the tumor site, improving interactions with antibody therapies. The technique left six of 10 mice with lymphoma tumor-free and was effective in melanoma when combined with existing immune response amplifiers.
A study by University of Seville researchers reveals that messenger RNA modifying factors play a crucial role in the repair of DNA breaks. The discovery could lead to better understanding of rare diseases and cancer. Messenger RNA editing facilitates the removal of trapped RNA molecules, allowing for proper DNA repair.
The study found that the Moderna vaccine offered a lower risk of documented infection (21% reduced), symptomatic COVID-19 (44% reduced), hospitalization (55% reduced), ICU admission (10% reduced), and death (2% reduced) compared to the Pfizer vaccine. The results suggest that either vaccine is effective, but Moderna may be slightly mor...
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
A study of 77 lactating parents found a higher prevalence of anti-SARS-CoV-2 antibodies in breast milk among unvaccinated mothers, suggesting potential protection against COVID-19. The study also identified a link between vaccine-induced immunity and increased neutralizing activity in human milk.
A recent study published in the American Journal of Roentgenology found a link between COVID-19 mRNA vaccination and myocarditis in adolescent males. Cardiac MRI was used to assess suspected myocarditis post-vaccination, with late gadolinium enhancement persisting in two patients undergoing repeat MRI.
Researchers found that mRNA COVID vaccines reduced symptomatic illness risk by 89% and 96% for Pfizer-BioNTech and Moderna vaccine recipients respectively. The vaccines' effectiveness was lower in immunocompromised individuals.
A population-based study of 2.4 million people found rare cases of acute myocarditis after COVID-19 mRNA vaccination in young men. The study suggests that the signal of increased myocarditis warrants further investigation into the relationship between COVID-19 vaccines and cardiac complications.
Researchers at MUSC have discovered that hnRNP E1, a tumor suppressor protein, not only binds RNA but also DNA to maintain genome integrity and sense or prevent DNA damage. The protein's binding is sequence- and structure-specific, suggesting its potential role in preventing cancer metastasis.
Researchers aim to produce enough mRNA vaccines from spinach and lettuce to rival traditional shots. They're exploring chloroplasts as a key to making plant-based mRNA vaccines that can be stored at room temperature.
A new study from La Jolla Institute for Immunology shows that the Moderna COVID-19 vaccine generates durable T cell memory and antibodies, even in people over 70. The researchers found strong CD4+ and CD8+ T cell responses to the vaccine, comparable to those seen in recovered COVID-19 patients.
A new software, ModTect, identifies RNA modifications using pre-existing sequencing data, revealing associations with cancer survival outcomes. The study found dysregulation of the epitranscriptome in patients across multiple cancer types, associated with cancer progression and survival.
A recent study found that breastfeeding mothers who received Pfizer-BioNTech or Moderna COVID-19 vaccines experienced temporary symptoms such as pain and swelling at the injection site, chills, muscle/body aches, fever, and vomiting. The study also reported no serious side effects in breastfed infants.
A comprehensive study of 6.2 million patients found no serious health effects linked to mRNA COVID-19 vaccines, with some early findings previously reported at CDC meetings. The Vaccine Safety Datalink's COVID-19 rapid cycle analysis will continue tracking vaccinated patients for at least 2 years.
The study found that the first dose of mRNA vaccine primes the immune system, while the second dose boosts the T-cell response, which can last for years. In people with a history of COVID-19, the T-cell response was already robust after the first dose, with no significant increase after the second dose.
A study found that mRNA vaccine recipients with prior SARS-CoV-2 infection experienced more severe symptoms after vaccination. The study suggests vaccine type may influence symptom severity in individuals with a history of COVID-19 infection.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Researchers investigated SARS-CoV-2 BNT162b2 mRNA vaccine response in cancer patients and healthy controls. The study found that the vaccine's antispike IgG antibody response wanes over time in patients on active anticancer treatment.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
A multi-hospital analysis of patients who experienced allergic reactions to their first mRNA COVID-19 vaccine dose found that all patients who received a second dose tolerated it without complications. The study suggests it's safe for most individuals to receive a second dose, despite initial concerns.
Researchers discovered APA's function in allowing certain mRNAs to reach specific sites of protein synthesis, shedding light on mRNA metabolism. APA impacts the connection between mRNAs and the endoplasmic reticulum, enabling signaling proteins to be encoded in specific cellular locations.
A computerized decision model found that mRNA vaccines (e.g., Pfizer) provide a net gain of 7.4 days in quality-adjusted life expectancy compared to not vaccinating at all, while adenovirus vector vaccines (e.g., J¼hnson ⚠ Johnson) yield virtually equivalent results.
A patient with no previous history of facial nerve palsy developed two episodes of Bell's palsy after receiving Pfizer-BioNTech COVID-19 vaccine doses. The author suggests a potential link between the vaccine and Bell's palsy, emphasizing cautious use for those at risk.
Researchers discovered that the protein SPT6 is essential for the arrival of RNA polymerase at the end of a gene, producing functional mRNA. Without it, the polymerase destroys obstacles, making it impossible for functional RNA polymerases to find their way.
A study found no detection of COVID-19 vaccine-associated messenger RNA (mRNA) in breast milk samples from vaccinated mothers. Researchers analyzed 13 human milk samples and concluded that the mRNA was not detectable.
A nationwide study found mRNA COVID-19 vaccines significantly reduce the risk of infection by up to 91% in fully vaccinated individuals. For those who develop breakthrough cases, vaccines also shorten symptom duration and severity.
A breakthrough in tracking RNA with fluorescence allows researchers to follow messenger RNA molecules in real time, enabling the development of new RNA-based medicines. This method provides crucial information for optimising drug discovery and understanding how mRNA is taken up into cells.
A recent study reports four cases of acute myocarditis following mRNA COVID-19 vaccination. The condition can lead to serious heart problems, highlighting the need for cautious monitoring and research into vaccine safety.
A study found 23 cases of myocarditis in US military members following mRNA COVID-19 vaccination, highlighting a potential risk factor for the condition.
Researchers have developed a method to control the degradation of messenger RNA, which could lead to more efficient biotechnological functions and improved medical outcomes. This breakthrough has potential applications in vaccine development, genome engineering, and therapeutic treatments.
Researchers found that extracellular mRNA is taken up by natural killer cells and transported to the nucleus, enhancing migration activity and interferon gamma production. This mechanism inhibits cancer metastasis in animal experiments.
Researchers found that COVID-19 vaccines pre-prepared in syringes can be safely transported under minor precautions, with messenger RNA remaining stable for at least three hours. The study aims to streamline vaccination processes, particularly in rural and less developed areas.
Researchers will examine regulation and disease relevance of alternative splicing in different types of heart cells. The project aims to map the path from splicing factor discovery to drug development.
Researchers developed a novel technique to study viral structure and evolution, revealing hallmarks of natural viruses in an artificial system. The findings suggest that these 'containers' efficiently package genetic cargo, potentially leading to new gene therapeutic applications.
Dr. Katalin Karikó's groundbreaking research on modifying nucleosides in mRNA led to the development of mRNA vaccines with over 94% efficacy against COVID-19. The Vilcek Prize for Excellence recognizes her contributions to science and medicine.
Scientists at Helmholtz Zentrum München developed a new bioengineered reporter system called EXSISERS, enabling non-invasive observation of fundamental cellular processes. The system detects specific protein isoforms being translated, with potential applications in neurodegenerative diseases like Parkinson's.
A recent study found that up to a third of patients taking methotrexate had inadequate antibody levels after receiving the Pfizer-BioNTech COVID-19 vaccine. This is compared to healthy participants and those on other immunomodulatory drugs, who showed an adequate immune response.
Researchers Lynne Maquat and Joan Steitz recognized for elucidating key functions of RNA, a workhorse molecule in cell function. Their discoveries inform RNA-based therapies for diseases like COVID-19 and muscular dystrophy.
A new study reveals how Ebola virus's VP40 protein uses human mRNA to transform into different shapes, adapting to various functions. This discovery sheds light on the fundamentals of genome-encoded information and highlights VP40 as a key vulnerability for effective therapies.
Researchers at Tokyo Medical and Dental University have developed an mRNA delivery system that effectively produces BDNF protein in rat brain to protect neurons from ischemia. The system, known as an mRNA nanomicelle, increases the survival of hippocampal neurons and shows long-term therapeutic benefits.
Researchers developed a tamper-proof temperature indicator to monitor mRNA vaccine storage conditions. The system can alert healthcare workers when the vaccine reaches an unsafe temperature for a certain period, ensuring effective distribution and use of the vaccine.
A Mayo Clinic study found that vaccinated patients without symptoms had an 80% lower adjusted risk of testing positive for COVID-19 after their last dose. The Pfizer-BioNTech and Moderna messenger RNA vaccines showed efficacy in limiting the spread of COVID-19 among asymptomatic individuals.
Researchers at Brigham and Women's Hospital have developed a novel urine test to diagnose human kidney transplant rejection. The study, published in the Journal of the American Society of Nephrology, demonstrates that exosomes isolated from urine samples can serve as a viable biomarker for kidney transplant rejection.
The article proposes reserving Johnson & Johnson vaccines for younger, healthier populations and boosting them with mRNA vaccinations for better efficacy. Boosting people with prior SARS-CoV-2 infection also enhances their immune response.
Researchers have developed a hydrogel that slowly releases mRNA nanoparticles, activating T cells and stimulating antibody production in mice with melanoma. The treatment causes tumors to shrink and prevents metastasis, demonstrating great potential for long-lasting cancer immunotherapy.
Researchers at Seoul National University developed a synthetic protein quality control system in bacteria to increase the efficiency of protein production. This technology enhances full-length translation, leading to up to 250% increase in protein yield and over two-fold increase in target metabolite production levels.
A new study reveals that retrogenes, which are inserted into the genome via reverse transcription of mRNA molecules, can have a profound impact on genetic diversity. These retrogenes can act as regulatory mutations, negatively influencing the original gene's mRNA and causing harm to organisms.
Researchers have identified a mechanism that allows Trypanosoma brucei to express only one surface protein variant, avoiding detection by the immune system. This finding has implications for understanding and potentially inhibiting antigenic variation in pathogens.
Researchers developed a new mRNA delivery platform using ZIF-8 nanoparticles that exhibit high mRNA loading capacity, successful endosomal escape, and synergistic GSH depletion. This approach upregulates mRNA translation and improves delivery efficiency compared to existing methods.
Researchers developed an mRNA vaccine that restored tolerance to self-proteins in mice with autoimmune encephalomyelitis, a mouse model for multiple sclerosis. The vaccine suppressed immune responses and promoted regulatory T cells to control the disease.
Researchers at Uppsala University developed a new AI-based method for analyzing gene activity in tissues using graph neural networks. This approach enables the detection of new cell types and intra- or intercellular functions without prior knowledge of expected cell types, greatly expanding our understanding of cellular behavior.
A specific region of messenger RNAs plays a crucial role in brain cell function. The study reveals an unusual EXAR (EXon-Activated Rescue) mechanism that secures this process, using ELAV and FNE proteins to determine neuronal transcript signatures.
Researchers at the University of South Carolina have identified a biological trigger that promotes quicker nerve regeneration. The discovery highlights the importance of protein phosphorylation and Casein kinase 2-alpha (CK2α) in breaking down stress granules, allowing nerves to regrow faster.
A newly discovered quality control system in protein production prevents the translation of faulty messenger RNA fragments, thereby preventing the formation of toxic incomplete protein products. The discovery has implications for understanding neurodegenerative diseases and may shed light on the underlying causes of such conditions.
Researchers at Eötvös Loránd University have identified molecular differences in brain neurons that may support drug development for psychiatric disorders. The study focused on the mRNA set of two types of cortical neurons, revealing cell surface proteins that can be targeted to treat certain conditions.
A novel optical switch enables precise control over the lifespan of genetic copies by attaching aptamers to molecular markers. This method can be used to specifically switch off practically every mRNA molecule in a cell in a controlled manner, opening up new avenues for investigating dynamic processes in living cells.
A team of scientists has made a breakthrough in understanding the complex process of photosynthesis by discovering that mRNAs transport proteins to thylakoid membranes. This finding opens up new avenues for research into photobiotechnology.