Articles tagged with Molecular Mechanisms
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers used single-cell transcriptogenomics to study the cell's defense mechanisms and found that DNA-directed RNA transcription can exclude ENU-mutated alleles, preventing them from being expressed. This novel mechanism may provide a new approach to understanding aging and disease.
Researchers have identified KLF transcription factors as key regulators of axon growth and regeneration in the central nervous system. The study found that these factors suppress axon regeneration in neurons, highlighting the complex genetic programs involved in this process.
Researchers at Stanford University are studying light harvesting mechanisms in photosynthetic organisms to improve solar cell efficiency. They have discovered new states of light harvesting complexes with different degrees of quenching, which may be a molecular mechanism for photoprotection.
Researchers have discovered that neuronal RNA granules are highly heterogeneous and dynamic in their composition, containing proteins that repress protein synthesis. This uncoupling of mRNA transport from protein production is essential for learning and memory, and has implications for understanding neurodegenerative diseases.
A recent study conducted at Marshall University investigated the effects of cadmium on the prostate, revealing molecular mechanisms that induce carcinogenesis. The research, published in PLOS ONE, may lead to new therapies for prostate cancer.
Researchers aim to identify mechanisms that define embryonic olfactory epithelium stem cells, which are linked to neurological and psychiatric diseases such as Parkinson's and Alzheimer's. The goal is to harness these mechanisms for brain repair and regeneration.
Differences in jet lag severity may be rooted in how the circadian clock sets itself, with advanced and delayed mechanisms differing at a molecular level. This finding could provide clues for understanding jet lag and offer potential remedies.
A new study identifies a mutation underlying accelerated-aging disease, providing key insights into normal human aging. The research highlights the importance of the nuclear envelope in the aging process.
Researchers at IRB Barcelona discovered 200 new protein interactions that could be linked to Alzheimer's disease, bringing the total number of interactions to 6000. The study reveals new molecular mechanisms, including oxidative stress and inflammation, which may play a role in the development of the disease.
Researchers have discovered that ROCK2 protein is involved in regulating the production of IL-17 and IL-21, which are linked to autoimmunity. Administration of a ROCK inhibitor has shown promise in reducing disease symptoms and ameliorating conditions in mice models.
Scientists at EMBL identified two proteins, PRC1 and kinesin-4, that control the formation and size of microtubule overlaps in the spindle. This adaptive mechanism ensures the overlap remains constant without affecting microtubules elsewhere in the cell.
Researchers have found distinct changes in white matter and protein markers of brain pathology after mild traumatic brain injury (mTBI), which can induce problems with sodium channels on neurons
Researchers at the Institut de recherches cliniques de Montréal have identified a new molecular pathway required for the guidance of retinal axons within the optic chiasm. This guidance relies on the Boc receptor, which could lead to therapies stimulating axonal growth after injury or in neurodegenerative disorders.
Researchers have identified a molecular mechanism underlying the harmful effects of DES on male testis development and function. Neonatal exposure to DES leads to reduced fertility in mice, with NR0B2 deficiency protecting against these effects.
A Yale team found a crucial molecular mechanism for mixing neurons in columns of the cerebral cortex. This intermixing is essential for normal cognitive processing and disruption can lead to severe problems like autism and mental retardation.
Researchers at Vanderbilt University Medical Center have discovered a new molecular mechanism that increases the risk of arrhythmias. They found that calcium-sensitizing drugs can cause arrhythmias by making heart muscle cells more prone to irregular rhythms.
Researchers from the University of Bristol have identified a key molecular mechanism controlling synaptic plasticity, which is vital for visual recognition memory and learning. Blocking this mechanism prevents visual recognition memory in rats, demonstrating its importance in brain function.
Researchers at Stanford University have uncovered a novel mechanism of the tumor suppressor ING2, which regulates gene expression programs to prevent cancer formation. The findings highlight a new approach to understanding DNA damage responses in normal cells and potential therapeutic targets for cancer prevention and treatment.
Researchers found that low temperatures trigger a specific splicing mechanism in frq mRNA, excluding the l-FRQ translation initiation site and modulating circadian rhythmicity. This temperature-dependent inhibition of translation by uORFs effectively regulates FRQ levels and circadian rhythms.
Virginia Tech biologist Virginia Tyson earns top scientist award for his work in computational cell biology and mathematical models of molecular mechanisms controlling cellular growth and division. His research aims to understand and treat medical problems caused by molecular dys-regulation, such as cancer and nerve-cell regeneration.