Articles tagged with Publishing Industry
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
The How to Do Research and Get Published webinar series, offered by Sage, has been recognized for its excellence in publishing education and training. The award highlights Sage's commitment to providing accessible and actionable insights to support researchers worldwide.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
A new PLOS report proposes a 'knowledge stack' publishing model to better support open science. This model connects articles with associated outputs like data, code, and methods to create a structured, open record of research. The report highlights the need for coordinated action beyond publishing to address challenges in existing models.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
The Bulgarian Society of Endocrinology's open-access journal, Endocrinologia, has moved to the ARPHA publishing platform developed by Pensoft. The platform provides a fast-track system for authors, reviewers, and editors, improving management and increasing international integration.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
New research reveals that see-through or cut-out product packaging on a shelf increases the psychological desire to own it. Customers rely on various cues when making purchasing decisions, with visibility of a product influencing choices.
The study found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species. MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair.
Fayetteville State University and Taylor & Francis have partnered to provide FSU researchers with free access to over 2,500 journals. This three-year agreement eliminates costs associated with open access publishing, enabling FSU scholars to share their research globally and increase its visibility.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
A rare case of a small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation showed a strong response to high-dose imatinib, despite the presence of the SDHC mutation. Integrated molecular interpretation is crucial in GIST management.
The merger will enable significant operating efficiencies and combined scale with Project MUSE, while maintaining BioOne's flagship aggregation of bioscience research journals as a discrete product within Hopkins Press. The integration is expected to expand services, shared infrastructure, and sustain revenue for the nonprofit community.
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
The University of California and JMIR Publications have extended their institutional membership agreement, reinforcing a commitment to advancing open science. The multi-year extension supports over 450 articles published under the agreement, making open access publishing more equitable for UC researchers.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
Research finds PDX1 gene plays a tumor-promoting role in human PCa cells by influencing metabolic pathways. The study identifies PDX1 as differentially hypermethylated in prostate cancer tissues, contributing to its aggressive characteristics.
The extension of the partnership aims to refine SnapShot's performance for live manuscript submission, providing enhanced author feedback and guidance on data sharing. The collaboration also focuses on iterative product development, expanding assessment graphs to accommodate additional data policies.
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
The Oncotarget Editorial Board discusses the journal's evolving approach to scientific integrity, highlighting the importance of modern image forensics tools. The article emphasizes the need for independent analytical and AI-based tools in journal evaluation.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
The study found that immune checkpoint inhibitors significantly improved key clinical outcomes, including disease-free survival and distant metastasis-free survival. However, no clear improvement in overall survival was observed across studies, highlighting the need for careful patient selection and monitoring.
The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.
A new review analyzes how glioma classification research has evolved across clinical, molecular, and social domains. The study highlights the prominent role of DNA methylation profiling and advanced imaging techniques in molecular biomarker-based classification models, while finding social factors to be relatively scarce.
The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
The renewed agreement allows eligible researchers at participating UK institutions to publish unlimited articles across JMIR's portfolio of journals without APCs. This simplifies the publication workflow and increases equity for researchers at all career stages.
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
Dr Amy Shirong Lu joins JMIR Serious Games as Editor-in-Chief with extensive research on digital health technologies and their impact on physical activity and cognitive health.
Between 2021 and 2024, government organizations accounted for around one-tenth of the estimated $336 million spent on advertising to news websites publishing health misinformation. Pharmaceutical companies also made notable contributions.
Researchers found that the three-drug combination increased autophagosome formation and autophagic flux in uveal melanoma cells, killing them via enhanced autophagy. The study suggests a potential therapeutic approach for treating metastatic uveal melanoma, particularly in liver-targeted disease.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
The company has announced an expansion of its innovative diamond open access (OA) model, Collective Pathway to Open Publishing, through agreements with Jisc in the UK and CAUL in Australasia. Six new journals will make their 2026 volumes open access without charging authors an article publishing charge.
A systematic review of experimental studies found exergames to be associated with better mood outcomes, including reductions in tension and depressive symptoms. The evidence base remains small and heterogeneous, but the study calls for longer-term interventions and larger samples to determine the durability of benefits.
JMIR Publications and the University of Nevada, Las Vegas announce a new Flat-Fee Unlimited Open Access Publishing Agreement. The agreement eliminates financial obstacles for researchers, reducing administrative workload for library staff and ensuring research findings are available via immediate open access in JMIR's high-impact journ...
The review emphasizes surgical excision as the cornerstone of curative treatment, with recommended margins depending on tumor risk stratification. Reconstruction should be individualized according to defect size, anatomic subunit involvement, and patient factors.
A study found CREB5 regulates basal and SCL transcriptional programs and tumor-forming phenotypes in prostate cancer, suggesting a central role in aggressive prostate cancer. Disrupting CREB5-regulated pathways may improve therapeutic responses in advanced disease.
Over 11,000 Cambridge Scholars eBooks are now globally accessible through the Taylor & Francis eBooks platform. The partnership expands the reach of Cambridge Scholars titles, enhancing visibility and discoverability for rigorous academic scholarship.
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.