Articles tagged with Publishing Industry
The Journal of Applied Sports Sciences has transitioned to the ARPHA platform, enhancing accessibility and visibility of research in sports sciences. The journal operates under a Diamond Open Access model, allowing for free access to all research outputs without article processing charges.
The study found that EBV nuclear antigen 1 (EBNA1) significantly increases the expression of Derlin1 and PSMD10 genes in HeLa cells, both associated with enhanced cancer cell survival and proliferation. This suggests a potential mechanism by which EBV may contribute to cervical cancer progression.
Researchers found that cancer does not typically affect forensic age estimation accuracy, except for very aggressive forms of cancer. In contrast, blood cancers led to large errors, with ages overestimated by up to 50 years.
The platform update enhances the visibility of video and audio content, doubling readership of associated research articles. Dedicated multimedia pages and journal homepage sections showcase all content in one place, making it easy to access and discover.
A new study found a strong association between accelerated epigenetic aging and increased risk of colorectal cancer in postmenopausal women. Lifestyle factors like diet significantly influenced this risk, with healthy diets potentially reducing cancer risk associated with biological aging.
Researchers found that combining aramchol with regorafenib killed liver and colorectal cancer cells more effectively than either drug alone, triggering stress responses and disrupting survival pathways. The combination was especially effective in cells with a genetic variant called ATG16L1 T300.
The FDA-approved MI Cancer Seek test is a comprehensive molecular profiling assay that delivers accurate and reliable results from minimal tissue input. It identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers.
A 36-year-old woman was diagnosed with non-gestational ovarian choriocarcinoma, a rare and aggressive tumor that shares symptoms with pregnancy. She received chemotherapy and showed complete response to treatment.
A new study published in Aging-US found that frailty is associated with increased respiratory exacerbations and mortality in individuals with a history of cigarette smoking. Frail participants had a three- to five-fold higher chance of developing serious or frequent respiratory attacks, even if they had normal lung function.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
A new study suggests that regular exercise can influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan. Physical fitness is closely associated with slower epigenetic aging, and sedentary behavior may have detrimental effects on the body's internal aging process.
Researchers found that RSPO2 amplification is associated with poor outcomes in PC patients and promotes genes and signaling pathways associated with aggressive PC. The study highlights RSPO2 as a key driver of disease progression and opens new possibilities for treatment strategies.
The Georgian Reproducibility Network (GeoRN) aims to serve as a national hub for strengthening research quality and collaboration in Georgia. The Ukrainian Reproducibility Network (UARN) has already held its founding meeting with 26 researchers from across the country as its founding members.
An analysis of article views in Taylor & Francis medical journals found that extenders can increase readership by 144%. Plain Language Summaries of Publications and Clinical Trial Protocols with extenders attracted more views than those without these supplemental resources.
A new analysis of data on scientists with exceptional early-career success identified common characteristics, including affiliation with institutions in less developed countries and work in specific fields. These findings could aid efforts to distinguish stellar talent from problematic behaviors.
A new study uncovers coordinated efforts of paper mills, brokers, and infiltrated journals to fabricate research, pay for authorships, and citations. Millions of dollars are involved in these processes, with the problem so widespread that it's outpacing legitimate scientific publications.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
Bloomsbury is introducing Altmetric Explorer to track social attention and sharing of its publications, providing insights into reach, impact, and value. The tool will inform future editorial strategy and improve reader engagement.
A new research paper found that epigenetic aging is linked to cognitive decline in midlife, with twins experiencing a larger drop in IQ scores if they had grown up in families with lower socioeconomic status. This study provides new evidence for the impact of childhood adversity on brain aging.
Researchers analyzed data from over 10,000 solid tumor samples and found that more than 90 percent contained genetic changes that could guide treatment. The study identified biomarkers associated with approved therapies and rare mutations missed by simpler tests.
Researchers developed TraMA, an RNA-based measure of biological aging that predicts health risks and mortality. It captures distinct aspects of aging and health decline, including inflammation, immune function, and kidney and brain health.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
A study reveals that epigenetic changes associated with aging in adults do not occur before sexual maturity. In fact, rDNA copy numbers and methylation increase during childhood and adolescence, suggesting cells actively maintain a youthful state to ensure efficient protein production.
Researchers discovered that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, leading to lower levels of tumor-promoting proteins and cancer-suppressing cellular behaviors. Statins downregulate SATB1 while increasing SATB2, making cancer cells less able to grow and spread.
Researchers evaluated the Stem Cell Regenera treatment in 145 women with ovarian failure, showing nearly 70% oocyte activation and 14% conception through IVF after treatment. The therapy stimulates ovarian activity, increasing conception chances in selected patients.
A new case report documents a rare instance of lipoleiomyoma, a benign uterine tumor with characteristics similar to malignant liposarcoma. The diagnosis was confirmed through histopathological evaluation and imaging techniques, emphasizing the importance of careful assessment in elderly patients.
Researchers highlight microRNAs as crucial biomarkers for diagnosing and monitoring soft tissue sarcomas, with potential for precision medicine. MicroRNAs could help distinguish between tumor types and guide treatment decisions.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Researchers discovered a new monoclonal antibody, 2B010, that selectively targets regulatory T cells (Tregs) in tumors, boosting the activity of CD8+ T cells and improving anti-tumor immune responses. This unique mechanism could complement existing cancer therapies and lead to more effective treatments.
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
The Cambridge Elements series has reached a major milestone with the publication of over 2000 formats, offering original and peer-reviewed research from leading scholars. The series provides comprehensive coverage of key topics in various disciplines, filling the gap between journal articles and monographs.
Researchers found that prostate cancer cells store fats in lipid droplets under low oxygen conditions, making them less vulnerable to ferroptosis. This adaptation allows cancer cells to evade therapies designed to trigger cell death.
Researchers found that spermidine supplementation improves memory and preserves physical activity, while reducing protein intake boosts mitochondrial activity and extends lifespan. Combining the two interventions offers additive benefits, suggesting potential for synergistic effects.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.
This special collection aims to bring together cutting-edge research on cognitive aging, exploring its cellular and molecular underpinnings, as well as psychosocial and environmental factors. The collection seeks to foster a holistic understanding of how cognitive function changes with age.
Researchers found that waist-to-hip and waist-to-height ratios are strong predictors of physical performance in older adults. Individuals with higher abdominal fat tend to have poorer physical function, which can impair independence as people age.
A recent study discovered that the mutational landscape of blastic plasmacytoid dendritic cell neoplasm (BPDCN) is similar to other myeloid neoplasms. The researchers identified CCDC50 as a potential biomarker for this disease, which showed promising results in tracking disease activity and monitoring treatment success.
The International Society for Stem Cell Research has selected five distinguished early career scientists to serve as Early Career Editors for Stem Cell Reports. The new editors bring expertise in cell differentiation, tissue engineering, and precision therapies to the journal.
A new perspective on Peto's paradox highlights the importance of studying species that resist cancer naturally, which may offer insights into understanding cancer and aging. Understanding how cells interact with their environment could provide deeper insight into how cancer develops or is prevented.
A new research paper introduces DoliClock, a biological aging clock based on lipid profiles in the human brain, showing accelerated brain aging in individuals with autism, schizophrenia, and Down syndrome. The study found that dolichol levels serve as reliable biomarkers of aging.
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
A new study found diverse genetic patterns and treatment gaps in HER2-mutated non-small cell lung cancer (NSCLC) in Northeastern Brazil. The research highlights the importance of comprehensive molecular profiling and expanded access to targeted therapies for underrepresented populations.
A new study found that telomere shortening is not a shared characteristic of all progeroid syndromes, which cause individuals to display symptoms of aging far earlier than expected. The research suggests that the underlying biology of each syndrome plays a crucial role in determining whether telomere shortening occurs.
A new precision oncology paper presents a case of a 62-year-old man with metastatic colorectal cancer who underwent multiple lines of therapy. The WIN International Molecular Tumor Board proposed personalized treatment plans based on the tumor's unique genetic mutations, highlighting the growing role of precision oncology in guiding th...
A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.
Top ten errors identified by Dr Dan Green include incorrect causal language, poorly formatted abstracts, and statistical analysis sections with inaccurate or incomplete details. The article provides recommendations for researchers to avoid these common mistakes and advance a transparent and reproducible research world.
A new review identifies CHEK2 as a potential biomarker for predicting response to immunotherapy and suggests that combining CHEK2 inhibitors with existing therapies may enhance anti-tumor effects. This could lead to improved treatment outcomes in solid tumors.
Researchers found that low-cost genetic testing methods can effectively detect BRCA2 and HOXB13 mutations linked to increased prostate cancer risk. These findings support the adoption of precision medicine in prostate cancer care, enabling better diagnosis and personalized treatment plans.
A large-scale study identified early indicators of frailty decline in older adults, including health deficits such as sleep disturbances and muscle weakness. Early intervention programs addressing these modifiable health issues can contribute to disease control and slow frailty progression.
The Open Access Team, led by Sergei Kurenov, rides to support cancer research and honor Dr. Mikhail Blagosklonny's legacy through open-access publishing. Impact Journals is sponsoring the team in this year's Ride for Roswell event.
The MIT Press will acquire University Science Books' prestigious list of textbooks in the sciences, including bestsellers like John Taylor's Classical Mechanics and Don McQuarrie's Physical Chemistry: A Molecular Approach. The acquisition is set to take place on July 1, 2025.
A new perspective challenges current epigenetic clocks, which use DNA methylation patterns to estimate biological age, by failing to distinguish between different types of methylation changes. This could lead to inaccurate conclusions and potentially slow down progress in anti-aging research.
Researchers found that cigarette smoke and reduced DNA repair capacity combine to increase cancer risk, with normal lung cells showing extensive damage after smoke exposure. The study's findings support a 'double hit' model, highlighting the critical role of XPC protein in preventing DNA damage.
The Longevity & Aging Series has been honored with a Silver Award for 'Excellence in Video/Film' at the inaugural EPIC Awards celebration. The series is praised for its impactful storytelling and production quality, making it a trusted resource for scientists, clinicians, and the broader public.
Researchers found that CBR3-AS1 and PCA3 were significantly overexpressed in gastric cancer tissues, suggesting their involvement in GC development. The study supports the use of these lncRNAs as diagnostic biomarkers.
A new editorial proposes a transformative shift in healthcare focus from reactive disease management to proactive healthspan extension. The approach targets the root causes of age-related diseases through aging biology, aiming to prevent diseases before they emerge.
Researchers identified a novel region in AR that binds to PCNA, and developed a small peptide to mimic this region, blocking the AR-PCNA connection. This approach reduced cancer cell growth, particularly in patients with limited treatment options.
Researchers discovered that blocking PRDX1 protein can make ovarian cancer cells more responsive to DNA-damaging platinum therapies. The study suggests targeting PRDX1 could be a viable strategy to improve chemotherapy efficacy.
Researchers found that aging increases the brain's vulnerability to low oxygen levels, disrupting the blood-brain barrier and leading to inflammation and cognitive decline. The study identified specific oxygen levels that trigger BBB disruption, with older mice showing increased sensitivity even at mild hypoxic levels.
A study investigated immune-related adverse events (irAEs) in Latin American patients with advanced liver cancer treated with atezolizumab and bevacizumab. Most irAEs were mild or moderate and resolved within a month, without impacting overall survival.