News on early, curiosity-driven science that opens new directions. Covers materials discovery, AI-guided research, pediatric research standards, and energy science.
Researchers used submersibles to explore deep reefs, increasing the recorded number of deep-reef fishes by 9-fold. The study found that reef-fish faunas extend below the mesophotic zone and revealed a previously unknown reef ocean zone, the rariphotic.
A world-first discovery has identified a genetic mutation responsible for a lymphatic disorder that may cause stillbirth or severe chronic disease in affected children. The mutation, MDFIC, controls the growth and development of lymphatic vessels in the fetus, leading to fluid accumulation in critical organs.
The Precision ALS programme aims to provide new insights into Motor Neuron Disease through advanced data-driven prediction models and next-generation data analysis. The project will harness AI to analyse large amounts of data from a multimodal dataset, providing tools for clinical trials based on precision-medicine.
A new method using a thin oxide film has revealed that oxygen impurities in germanium are responsible for a surprising effect, creating holes in the material and eclipsing its semiconducting properties. This discovery has broad implications for understanding the role of thin oxide films in future semiconductor design.
Scientists have discovered a new therapeutic approach to aid the immune system in fighting cancer, offering hope for better solutions for patients. Researchers found that blocking the EP4 molecule can 'free' the immune system and restore its cancer-fighting functions.
A new study found that traditional Chinese medicine Shengmai Yin increases the sensitivity of cancer cells to radiation, reducing radioresistance. By altering DNA methylation status, SMY enhances the efficacy of radiation therapy and reduces side effects.
A Providence study confirms COVID vaccines are 94% effective at preventing hospitalization within 50-100 days of vaccination, but protection declines to 80.4% after 200-250 days. The study also identifies key risk factors for severe breakthrough infections, including advanced age, comorbidities, and vaccine type.
Researchers discovered a phase transition from charge-density-wave order to electronic nematicity in Kagome superconductor CsV3Sb5 at 35 Kelvin. This novel nematicity has Z3 symmetry, distinct from high-temperature superconductors.
Researchers at UVA Cancer Center have made a groundbreaking discovery about the EP300 gene and its role in small-cell lung cancer. The study found that the gene makes a protein with properties that can both foster and prevent tumor formation, providing a new potential target for treatment.
Researchers have found that SARS-CoV-2 variants can emerge more quickly than expected, driven by a short-lived increase in mutation rate. This phenomenon was observed in variants such as Delta, which emerged within six weeks of its ancestral form.
A new variant of the Hendra virus has been detected in Australian horses, emphasizing the need for ongoing disease surveillance. The discovery was made possible by a seven-year effort to create a network of frontline veterinarians and researchers aiming to detect new viruses.
Researchers discovered that mortars and pestles were preferred for processing rice and other plants in middle-late Neolithic China, while grinding slabs and rollers declined in use. The study provided solid evidence for the rise of mortar and pestle usage, revealing their high processing efficiency.
The 'Prize Papers' Project has made available online court documents related to the capture of approximately 1,500 ships between 1793 and 1815. Researchers can access digital copies of case books, trial records, and other materials, providing unique discoveries on global maritime history.
Researchers have created and detected dispersing excitons in a metal using angle-resolved photoemission spectroscopy, a breakthrough that could enable efficient data transmission. The discovery of mobile excitons in TaSe3 reveals their mobility and potential to revolutionize electronics.
Researchers at Arizona State University have developed a hybrid device that combines living organisms with bio batteries to produce stored energy under light conditions. The technology, known as microbial electro photosynthesis, has the potential to power a wide range of products, including transportation fuels and cosmetics.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Researchers have discovered a protein that plays a key role in the malaria parasite, leading to a potential new way to fight the disease. Deactivating this protein reduces the growth of the parasite by over 75%, making it a promising target for treatment development.
Scientists have discovered a new subtype of relapsed pediatric AML characterized by a specific gene mutation called UBTF exon 13 tandem duplication (UBTF-TD), which is associated with poor outcomes and an increased incidence of minimal residual disease. This mutation can be used to identify high-risk patients and guide treatment.
SMART researchers identified a novel phage lysin, Abp013, with promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae. The study demonstrated Abp013's ability to effectively target complex bacterial environments and could advance treatment methods for multidrug-resistant Gram-negative pathogens.
Researchers at Brigham and Women's Hospital discovered a new function of miR-10b, interacting with U6 snRNA to alter global splicing in glioma cells. This study highlights the potential for miRNA-based treatments in cancer therapy.
A Wayne State study reveals that communication between two key brain regions determines how we remember experiences. As these regions mature, their precise interactions improve our ability to form lasting memories. The research also found that age-related differences in fast and slow theta oscillations impact memory development.
Researchers found that epigenetic inheritance can affect the genetic composition of a population for multiple generations. Exposure to high temperatures accelerated the rate of evolution, increasing the spread of genes through mating.
A team of researchers found that many marine phytoplankton are voracious predators, consuming bacteria like Prochlorococcus and other primary production. This discovery reveals the complexity of ocean ecosystems and challenges traditional views of phytoplankton as solely photosynthetic organisms.
Researchers at the University of New Hampshire have made a groundbreaking discovery about the origin of lightning using radio telescopes. They found that the sources of lightning are indeed the streamers, or tiny spark-like discharges, supporting one of two competing theories on how lightning begins.
Researchers from Argonne National Laboratory have created a set of new practices to guide the curation of high energy physics datasets, making them more FAIR and reusable. The goal is to automate the finding and use of data for humans and streamline the development of AI tools for scientific discovery.
A research team discovered that human eggs are missing the protein KIFC1, which acts as a molecular motor to stabilize spindle poles during cell division. This finding opens up new avenues for therapeutic approaches to reduce chromosome segregation errors in human eggs.
Researchers developed a novel wearable soft robotic armband that conveys artificial sensations of touch to prosthetic hands, enabling users to control multiple grasp functions simultaneously. The study showed improved time efficiency and precision in transporting objects, with haptic feedback being crucial for tasks.
Researchers discovered a 150-million-year-old dinosaur with evidence of an avian-style respiratory infection, providing insight into ancient diseases. The study suggests that sauropod dinosaurs may have been susceptible to fungal infections similar to aspergillosis.
The ALS Canada Research Program has awarded nine Discovery Grants to investigate critical areas of disease processes and clinical care. The grants will support fundamental laboratory research, biomarker studies, and clinical trials.
A new study by the University of Arizona has identified a brain region and neural circuitry that mediate satiation, making it possible to create treatments with fewer side effects for eating disorders and weight management. The parasubthalamic nucleus plays a key role in regulating feelings of fullness after eating.
Researchers have discovered two new and unusual species of diatoms that fix nitrogen, a critical process supporting productivity in nutrient-poor open ocean waters. These diatoms harbor symbiotic cyanobacteria that convert dissolved nitrogen gas into ammonia, enabling them to thrive in nutrient-poor conditions.
Researchers at University of Maryland Center for Environmental Science found that marine snow particles help remove carbon dioxide from the atmosphere, contributing to a more efficient carbon cycle. The discovery sheds light on how oxygen deficient zones play a crucial role in the Earth's carbon cycle.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
Researchers at PSI's Laboratory for Muon Spin Spectroscopy have discovered strong evidence of exotic charge order and orbital currents in a correlated kagome superconductor. The findings provide a new insight into unconventional superconductivity and its relationship with the quantum anomalous Hall effect.
A national study found that states with higher labor underutilization, non-Hispanic white populations, and opioid prescriptions had higher SIM rates. States with centralized medicolegal death investigation systems detected more SIM cases due to toxicologic testing.
Researchers have confirmed an inhaled vaccine provides long-lasting protection against SARS-CoV-2 and its variants by targeting the lungs and upper airways. The vaccine induces broad respiratory mucosal immunity, outperforming traditional injected vaccines in terms of efficacy and dose requirements.
A comprehensive 'vertical map' of airborne microorganisms has been created, showing that temperature is the single most important factor influencing their composition. As global temperatures rise, this could lead to significant changes in the air microbiome, affecting human health and food security.
A team led by Case Western Reserve University discovered the novel repair properties of Gasdermin B protein, promoting restoration of epithelial layers and effective wound-healing. The findings have significant implications for designing therapeutics to enhance wound repair in various organs.
A new study using advanced radar technology has recorded Antarctic glaciers losing ice at unprecedented rates, threatening global climate risks. The research team plans to expand its findings to giant and fragile West Antarctica neighbors, including the Thwaites and Pine Island glaciers.
A recent study from Edith Cowan University found that even brief periods of weightlifting, such as three seconds a day, can increase muscle strength. The research involved 39 healthy university students performing isometric, concentric, or eccentric bicep curls for three seconds daily over four weeks.
Researchers at San Diego State University have discovered a novel way bacteria infect cells by producing long threads, which grows up to 100 times the size of a bacterium in 30 hours. This mechanism allows the bacteria to rapidly infect multiple cells and access more nutrients for growth.
Researchers at Wellesley College found that people frequently misinterpret bar graphs, with one in five graph readers categorically misunderstanding averages. The 'bar-tip limit error' occurs when viewers interpret the tip of the bar as the outer limit of the data, despite the average being the balanced center point.
A study by Academic Analytics Research Center found a significant increase in journal article publications (64%) and decrease in book publications (34-54%) across 12 Social Sciences disciplines from 2010 to 2020. This shift may impact library acquisitions strategies and affect humanities-related fields.
A new cloud-based data resource has been developed to help identify new subtypes of amyotrophic lateral sclerosis (ALS), a fatal neurological disorder. The tool, part of the Answer ALS collaborative effort, uses biological and clinical data from over 1,000 patients to better understand the disease.
Researchers discover unique bat-pollination system in Fiji's kuluva trees, highlighting co-dependence between species and urgent conservation needs. The novel chiropteropisteusis system sheds light on the evolution of flowering plants and threatens tree and bat species.
Research from the Dunedin Multidisciplinary Health and Development Study finds that prolonged cannabis use leads to over-inflated lungs and increased airway resistance, impairing oxygen extraction. This effect is distinct from tobacco use and may reflect early signs of a severe form of emphysema.
The collaboration aims to create an interoperable global data ecosystem for rare diseases, accelerating the development of new therapies. This partnership benefits patients, regulators, advocacy stakeholders, researchers, and industry, while expanding C-Path's global capabilities in collaborating on methodologies and technologies.
Researchers have discovered that a small protein called glucagon-like peptide-1 (GLP-1) couples the body's control of blood sugar and blood pressure. This finding could lead to new treatment strategies for patients with hypertension and/or diabetes.
Researchers discovered increased activity in the hippocampus during anesthesia and sleep, preceding Alzheimer's symptoms by years. This abnormality may enable early diagnosis and treatment of the disease.
Researchers from McGill University found that oxygen levels rose with complex eukaryotic ecosystems, indicating low oxygen was a significant limitation on evolution for billions of years. The discovery has implications for searching for biosignatures in other planets, focusing on ozone detection.
A new 'Goldilocks Zone' has been discovered in the Earth's crust, allowing critical metals like gold, copper, and tellurium to pass upwards. This finding sheds light on planetary cycles of metals and could enable more targeted mineral exploration, reducing environmental impact.
Researchers discovered a key growth factor protein, HB-EGF, produced by immune-regulating cells that protects the gut against inflammatory bowel disease. ILC3s produce HB-EGF to counteract TNF-induced inflammation and maintain gut barrier function.
A new global dataset reveals approximately 73,000 tree species, highlighting the vulnerability of global forest biodiversity to climate change and land use. The research, led by Professor Andy Marshall, also identifies a 'hot spot' of likely undiscovered species in northeast Australia and the Pacific Islands.
Scientists have identified a peripheral mechanism that allows fruit flies to quickly assess complex odors without costly synaptic computation. The fly's olfactory receptor neurons communicate through electrical interactions, enabling an energy-saving way to process meaningful odor blends.
A new study published in Clinical Nutrition found that drinking less than the UK's recommended 14 units of alcohol per week increases the risk of cardiovascular events. Moderate alcohol consumption is associated with a 23% increased risk of suffering a cardiovascular event for every additional 1.5 pints of beer consumed.
A new species of leafhopper, Phlogis kibalensis, has been discovered in the Kibale National Park in western Uganda. The insect belongs to a rare genus that was last recorded in Central African Republic in 1969.
A Rutgers study found measurable airborne SARS-CoV-2 RNA in the air of most homes where COVID-19 infected individuals were isolating, suggesting airborne transmission beyond isolation rooms poses a risk to other occupants. The study also showed that infected individuals often did not strictly adhere to self-isolation protocols.
Dr. John Pierce Wise leads a team to investigate chromosome instability in lungs caused by metal exposure, with hopes of preventing and reversing lung cancer in people. The research aims to understand why humans are more susceptible to metals-induced lung cancer than whales.
Researchers at Durham University have identified a medieval text written by Benedictine monk Gervase of Christ Church Cathedral Priory as the earliest known account of ball lightning in England. The description, composed around 1200, matches historical and modern reports of the phenomenon.
A new dataset examines publication patterns across 170 academic disciplines to provide more nuanced comparisons. The data reveals significant variation in publishing activity and venue preferences among scholars.