Articles tagged with Discovery Research
Epidemiologists have developed a new blood test, DunedinPACE, to measure biological aging. The test uses DNA methylation marks to track changes in organ-system integrity over time, predicting future disease and mortality.
Researchers at the University of Surrey have successfully demonstrated the use of multimodal transistors in artificial neural networks, achieving practically identical classification accuracy as pure ReLU implementations. The study paves the way for thin-film decision and classification circuits, which could be used in more complex AI ...
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
A recent study found that the number of stage 3 AKI kidneys transplanted in the US has increased significantly over the last decade, yet 44% are still discarded. This highlights the need for further efforts to optimize the use of these organs and reduce waste.
Researchers at La Jolla Institute for Immunology found that macrophages in artery walls can sense octanal, leading to inflammation and atherosclerosis. By blocking this detection, they reversed disease progression. Further research is needed to explore the role of olfactory receptors in cardiovascular diseases.
Researchers have developed a new text-based analytics model that analyzes firms' tailoring of investments to their portfolio of products, using the four-stage product cycle. This framework provides insights into how firms exploit investment opportunities, including disclosure patterns and strategic alliances.
Researchers have discovered that heart disease causes early brain dysfunction, leading to reduced blood flow and increased risk of dementia. A combination of heart disease and a genetic predisposition for Alzheimer's Disease also trebles the amount of beta-amyloid protein in the brain.
Researchers at Cardiff University found that medical face masks increase facial attractiveness more than cloth masks, with blue masks being the most attractive. The study suggests that people associate masks with healthcare workers and find them reassuring, leading to a positive perception of the wearer.
Barrett's esophagus is caused by long-term GERD, which leads to changes in cells where the stomach and esophagus meet. Researchers found that stomach cells adopting intestinal cell qualities may be a key factor in its development.
Research led by Diego Bohórquez at Duke University has identified the cells responsible for sensing sugar in the gut. These neuropod cells produce neurotransmitters that transmit signals to the brain, allowing animals to distinguish between real sugar and artificial sweetener.
UCLA researchers found that removing brain cells linked to wakefulness and addiction reduces both physical and emotional symptoms of opioid withdrawal. The study suggests that drug therapies regulating hypocretin production may be an effective treatment for opiate addiction and withdrawal.
Astronomers have discovered a binary system consisting of a rapidly spinning neutron star and the precursor to an extremely-low-mass white dwarf, dubbed a 'cosmic spider'. The system emits powerful gamma-rays and has been observed using the SOAR Telescope in Chile.
A study reveals a powerful subset of vascular macrophages expressing CLEC4A2 fosters 'good' macrophage behavior, limiting plaque build-up. This discovery challenges the widely held belief that macrophages only play a harmful role in cardiovascular disease.
A team of Australian and international scientists has discovered a valuable new fossil site in New South Wales, containing exceptional examples of fossils from the Miocene epoch. The site, named McGraths Flat, provides insights into the history of the Australian continent and its ecosystems.
Researchers from Singapore-MIT Alliance for Research and Technology (SMART) have discovered a way to perform 'general inverse design' with high accuracy. This breakthrough enables the creation of materials with specific characteristics and properties, paving the way for revolutionizing materials science and industrial applications.
Researchers have discovered that certain microorganisms, such as Nitrosopumilus maritimus, can produce oxygen in the absence of sunlight, possibly deep below the ocean surface. These microbes play a crucial role in the nitrogen cycle and remove bioavailable nitrogen from the environment.
Researchers have solved the mystery of how praziquantel works, a key to treating schistosomiasis. The discovery highlights new opportunities for drug development and may help combat this debilitating disease affecting over a billion people worldwide.
Scientists have created the world's lightest version of magnesium, a record-setting isotope that helps refine theories on atomic structure. The unstable isotope was produced using particle accelerators and decays within tenths of a second, making it impossible to measure directly.
Researchers discovered that bacterial biofilms employ a developmental patterning mechanism similar to plants and animals. The 'clock and wavefront' mechanism creates intricate composite patterns of repeating segments of distinct cell types.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
A new study analyzing the rock record rules out atmospheric oxygen before the Great Oxygenation Event, potentially rewriting our understanding of Earth's past. The research team used high-resolution techniques to inspect specimens of the rock, finding evidence that chemical data suggesting early oxygen may have been introduced later.
Plants respond to heat stress by activating a molecular defense pathway involving brassinosteroids, which increase heat stress resistance. Researchers at TUM discovered the role of transcription factor BES1 in this process.
A study from Weill Cornell Medicine and Cornell University reveals that targeting protein ATF4 and its related metabolic protein SIRT3 can trick lymphoma cells into starving themselves, slowing their growth.
Researchers at Lawrence Berkeley National Laboratory developed a method to stabilize graphene nanoribbons and directly measure their unique magnetic properties. By substituting nitrogen atoms along the zigzag edges, they can discretely tune the local electronic structure without disrupting the magnetic properties.
Researchers find that toxic aggregates form inside brain cells, causing axon damage and neuronal death. Silencing specific proteins can block the aggregation process, potentially preventing or treating prion diseases and other neurodegenerative disorders.
Researchers found that certain bacteria in the human microbiome can produce an enzyme called acarbose kinase, which renders acarbose inactive. This enzyme is present in three major categories of oral and gut bacteria and may make people resistant to the antidiabetic drug.
Researchers at Weill Cornell Medicine discovered that deleting the EtfD Mtb enzyme renders Mycobacterium tuberculosis unable to sustain an infection in mice. The enzyme plays a critical role in fatty acid breakdown, making it an attractive target for TB treatment.
A new study reveals that New Caledonian crows prioritize the storage of complex and efficient foraging tools over basic ones. The research suggests that these birds have an understanding of the relative value of different tool types, similar to humans when handling valuable items.
The newly discovered dinosaur Vectiraptor greeni, from the Early Cretaceous period, was a large, heavily built relative of Velociraptor with powerful claws and serrated teeth. It is believed to have hunted larger prey, using its strength rather than speed.
A NTU study found that entrepreneurs quickly build trust in work-related situations and adapt to dishonesty. They also recover more easily from losing trust, making them valuable assets for organisations in negotiation and trust-building roles.
A University of Guam professor emeritus has discovered a new species of diatom, Licmophora complanata, that produces an estimated one-fifth of the oxygen in the air we breathe. The discovery was made using advanced microscopy techniques and builds on previous finds by UOG students.
Researchers confirm that skin infections, not just throat infections, trigger acute rheumatic fever, with Māori and Pacific children at highest risk. The study's findings have huge implications for prevention, suggesting a new focus on addressing skin infections to reduce the risk of rheumatic fever in New Zealand and internationally.
Researchers are part of a five-year global study examining the behavioral and long-term health impacts of different regulatory approaches to e-cigarettes and other new nicotine products among youth and adults in seven countries. The study aims to inform US public policy based on evidence, maximizing population health.
Researchers at Louisiana State University have identified 14 new endemic species of shrews on the Indonesian island of Sulawesi, a significant milestone in understanding the island's extraordinary biodiversity. This discovery highlights the importance of taxonomy in understanding and preserving life.
Researchers have published an extensive 7T fMRI dataset to study how humans perceive and interpret naturalistic photographs. The Natural Scenes Dataset provides a massive scale of brain data for training complex deep-learning models that predict brain activity.
Researchers developed a material that automatically responds to changing temperatures, switching between heating and cooling. The glass can regulate both solar transmission and radiative cooling, reducing energy consumption up to 9.5% or ~330,000 kWh per year.
The MDI Biological Laboratory has been awarded a grant to promote cloud computing among researchers in Maine, aiming to level the playing field by providing access to sophisticated computing resources. The program will provide training on Google Cloud Platform and assist institutions in implementing cloud computing services.
A study published in the Futures journal found that people attending mass 'raves' during the Covid-19 lockdown broke fewer pandemic guidelines than single vaccinated 80-year-olds. The researchers suggest this is linked to the outlook of ravers, who tend to have a slower-life history strategy and are more future-oriented.
Researchers from Duke-NUS Medical School found that Zika virus infection disrupts the glucose metabolism pathway in infected foetuses, leading to birth defects and death. A potential supplement, pyruvic acid, may protect foetuses from these impacts.
Researchers at Stanford University have demonstrated that measuring the physics of just a small portion of a coral reef can reveal insights about the entire reef system. This new approach provides low-cost methods for scaling up monitoring efforts, which are crucial for understanding the impact of climate change on these ecosystems.
Researchers found that our concept of self becomes increasingly indistinct as we think about ourselves farther in the past or future, affecting decision-making and memory recall. The 'temporal self-compression' effect challenges traditional notions of identity and time perception.
Researchers found fecal transplants increase IL-25, reducing tissue inflammation and boosting immune system response to C. difficile infections. The transplants also promote beneficial microbial diversity, helping patients heal from life-threatening diarrhea.
Researchers at Trinity College Dublin have developed mathematical equations explaining how individual randomness can give rise to synchronisation, applicable to systems like clocks, fireflies and metronomes. The findings provide a basis for new types of computer technology using light signals.
Cancer cells secrete type III collagen to stay dormant, and when levels decrease, they wake up and create metastatic cancer. Researchers found that enriching the environment with collagen can force cells to remain in a dormant state and prevent tumor recurrence.
Researchers predict existence of split photons, a new phase of light that behaves like a coin with two distinct halves. The finding advances fundamental understanding of light and its behavior, challenging long-held beliefs.
A study led by LSU Health found how late-onset retinal degeneration develops and identified a surprising potential therapeutic, metformin. The research suggests that an enzyme called AMPK activates the protein CTRP5 to regulate fatty acid metabolism and energy stability.
Researchers at Weill Cornell Medicine are studying breast cancer as a series of inflection points to identify potential intervention points and develop therapeutics for triple negative breast cancer. The goal is to create a large repository of organoids from tissue samples to study gene expression, epigenetic changes, and immune response.
A groundbreaking study confirms the timing of the Chicxulub asteroid impact, which occurred during the spring-summer growth phase, leading to the extinction of dinosaurs and 75% of life on Earth. The research team used multiple lines of evidence, including fossil pollen, index fossils, and radiometric dating, to pinpoint the exact time...
Scientists found that seven genes associated with bright-light vision are absent in burrowing snakes, demonstrating extensive vision gene loss over millions of years. This challenges the hypothesis that all modern snakes evolved from extreme burrowers, suggesting a different evolutionary path for these subterranean snakes.
A large earthquake off the coast of south-central Chile in 1737 may have caused a substantial tsunami that was absent from historical records. Researchers analyzed sediments and found evidence of widespread sandy layers, dating to the same time as the earthquake, similar to deposits made by tsunami waves in other areas.
Researchers have found that sharks acquire their microbiome through three methods: the mother passing on microbes to her offspring via egg case, social interactions with other sharks, and recruiting microbes from their environment. This study provides new insights into the development of animal microbiomes and their importance in under...
A study by University of New South Wales has found that one in five future thyroid cancers in Australia is attributable to current levels of overweight and obesity. The prevalence of obesity has doubled in the last two decades, with 75% of Australian men and 60% of women being overweight or obese.
Researchers have designed porous, carbon-based crystals that can stretch to more than twice their length, making them suitable for nanofiltration and pollutant removal. By adding 'soft joints' into the crystal's scaffold, they can be disrupted by specific chemicals, causing the crystal to expand and contract rapidly.
Researchers have identified a specific gene signature associated with severe COVID-19, enabling early detection of high-risk patients through non-invasive blood tests. The breakthrough could revolutionize patient triage and improve healthcare outcomes during future pandemics.
A new study reveals how design bias can affect medical data used in artificial intelligence tools and personalized healthcare. The research highlights the need for more inclusive recruitment strategies to ensure diverse patient populations are represented.
A special form of four-stranded DNA has been found to interact with the gene that causes Cockayne Syndrome when faulty. G-quadruplexes, which form knot-like structures in DNA, specifically bind to a protein called CSB, affecting its function and potentially leading to premature ageing.
A new study led by York University reveals that Western Honey Bees originated in Western Asia, with genetic data suggesting a strong connection to this region. The research highlights the importance of understanding the origin and evolution of these vital pollinators to inform their management and conservation.
Scientists at La Jolla Institute for Immunology and MIT have discovered a new adjuvant called SMNP, which combines saponin and TLR agonist to boost the protective power of vaccines. The study found that SMNP triggers a strong immune response in mice, promoting lymphatic drainage and activating multiple parts of the immune system.
Scientists at Chalmers University of Technology discovered a way to create a stable resonator using two parallel gold flakes in a salty aqueous solution. The structure can be manipulated and used as a chamber for investigating materials and their behavior, with potential applications in physics, biosensors, and nanorobotics.
Astronomers have discovered an ultra-short-period planet GJ 367 b, which orbits its star in just eight hours and has a radius of 72% that of Earth. The planet's mass is 55% of the Earth's, indicating it likely has an iron-rich core, similar to Mercury's interior.