Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
A recent study by Pacific Northwest National Laboratory researchers reveals a previously unknown atmospheric phenomenon over the Amazon rainforest, driven by plant-foliage-derived gases. These gases condense to form fine particles that cool the planet and seed clouds, affecting precipitation and the water cycle.
Researchers analyzed breast milk samples from 15 nursing mothers to track gene expression changes in mammary gland cells. The study identified various changes linked to factors such as hormone levels, illness, and lifestyle changes.
Researchers have identified a gene mutation in ARID2 that signals the development of aggressively metastatic melanoma. The study suggests patients with this mutation may require different treatment approaches to manage their cancer effectively. Further research is underway to refine this understanding and improve patient outcomes.
Researchers found that cereal fiber, but not fruit or vegetable fibers, was associated with lower inflammation and cardiovascular disease risk in older adults. The study used data from a large cohort of elderly individuals and confirmed previous associations between dietary fiber and CVD.
The American Association for Cancer Research (AACR) has announced the recipients of its 2022 Scientific Achievement Awards and Lectureships, recognizing Tony Hunter, Christina Curtis, John E. Dick, Kevan M. Shokat, and Lee M. Ellis for their groundbreaking contributions to cancer research.
Researchers used X-ray computed microtomography to produce stunning 3D reconstructions of the proteus' head, revealing extensive changes in sensory organs and physical appearance. The study provides detailed information about evolutionary-designed adaptations for surviving in lightless caves.
Researchers propose an open platform to integrate data collection, processing, and publication, ensuring FAIR (findable, accessible, interoperable, reusable) data and enabling machine-learning algorithms to learn from failed experiments. The platform aims to bridge the gap between data and machine learning in chemistry.
A study using the nation's largest COVID-19 data resource found that the vaccine protects most cancer patients from getting COVID, but those with certain types of cancer have a higher risk of breakthrough infections. The research also highlights the importance of continued vaccination efforts to protect cancer patients.
Ira Mellman, PhD, is being honored with the 2022 AACR-CRI Lloyd J. Old Award in Cancer Immunology for his seminal work on dendritic cell function and its impact on atezolizumab and neoepitope vaccines. His research has made a major impact on cancer immunology and has the potential to stimulate new directions.
Researchers use DNA to program metal nanoparticles to assemble into new configurations, resulting in the discovery of three new crystalline phases. The approach enables symmetry breaking and creation of complex colloidal crystal structures with unique optical and catalytic properties.
Researchers at CU Anschutz Medical Campus discovered a reactivated protein, Hand2, in certain cases of mesothelioma, which may lead to new treatments. The study aims to investigate the cause and effect of this reactivation.
Researchers discovered that obesity changes molecular underpinnings of allergic inflammation in both mice and humans. The treatment in obese mice makes their skin worse instead of healing, but a specific drug can 'de-fatten' obese mice without changing body weight.
A new app called Metaboseek has been developed to streamline the analysis of comparative metabolomics data, helping researchers identify valuable compounds. The app was created by a postdoctoral research associate and is now essential to his lab's work.
Researchers have discovered two distinct classes of cancer-associated fibroblasts that accumulate in the pancreatic tumor microenvironment and play opposing roles. The study suggests that targeting these unique cell populations may improve treatment outcomes for pancreatic cancer patients.
Researchers observed rapid electron precipitation from low-Earth orbit using the ELFIN mission, which was caused by whistler waves affecting electrons in the Earth's magnetosphere. The findings demonstrate that whistler waves are responsible for far more electron rain than current theories and space weather models predict.
Researchers found a persistent 20% reduction in carbon dioxide seeping up from the ground during the spring of 2017, coinciding with intense drought and record-high Sierra Nevada snowpack. The study suggests that changes in Earth's hydrology due to climate change can impact volcanic emissions.
A new study found that warmer summer nights are associated with an increased risk of cardiovascular disease deaths in men aged 60-64, but not women or older men. A 1°C rise in temperature is linked to a 3.8% higher risk of male death, highlighting the need for preventive population health initiatives and novel urban policies
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
A newly discovered small molecule, N-0385, has been found to inhibit entry of the virus into cells, protecting mice from infection prior to exposure and providing effective treatment up to 12 hours after. The treatment holds promise for preventing disease and reducing severity with a few single daily doses.
Researchers developed an AI-driven image analysis pipeline that identified novel cellular hallmarks of Parkinson's disease from images of over a million skin cells. The platform can distinguish between patient cells and healthy controls, revealing new signatures for potential therapeutic targets.
Research reveals that ASMR enthusiasts are hypersensitive to their environment, easily overstimulated by noise and movement. They also possess heightened bodily awareness, noticing physical changes when experiencing emotions.
Researchers at Argonne National Laboratory have discovered a key reason for the performance decline of sodium-ion batteries, which are promising candidates for replacing lithium-ion materials. By adjusting synthesis conditions, they can fabricate far superior cathodes that will maintain performance with long-term cycling.
Dr. Tony Hunter's groundbreaking work on protein tyrosine phosphorylation has led to the development of targeted cancer therapies and a deeper understanding of cancer biology. His discovery has been recognized with numerous awards, solidifying his legacy in cancer research.
Researchers developed a novel approach to diagnose, monitor, and predict the course of myocarditis using CMR parameters and AI. The goal is to provide personalized counseling for athletes and optimize treatment options.
Researchers discovered that by four days after mating, close to 20% of fruit fly sperm proteins are female-derived. Female proteins bind to sperm inside the female, potentially supporting their viability.
A study suggests that smartwatch heart rate measurement algorithms are less effective in people with darker skin tones due to increased melanin absorption. Researchers emphasize the need for diverse population inclusion and explore alternative light wavelengths for more accurate readings.
A new study using subsurface imaging sheds light on the geological connection between Yellowstone's iconic hydrothermal features and deeper heat sources. The research team detected hydrothermal alteration and found a remarkable similarity in deep structure beneath areas such as Norris Geyser Basin and Lower Geyser Basin.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
Researchers found that suspected amygdala neurons producing corticotropin-releasing factor are not necessary for alcohol withdrawal or dependence. Instead, the CRF is believed to come from other neurons in the brain, with potential implications for human treatment options.
The American Association for Cancer Research (AACR) announced its newly elected class of Fellows of the AACR Academy, recognizing distinguished scientists who have propelled innovation and progress against cancer. The 2022 class consists of 33 luminaries from various scientific disciplines.
Researchers develop novel therapeutic approach for treating tuberculosis using phosphatase inhibitors, offering potential benefits for TB research and basic biology exploration. The discovery provides a promising alternative to traditional antibiotic-based treatments and has significant implications for combating antimicrobial resistance.
Researchers at Colorado State University have discovered that anti-malaria drugs can effectively treat a pulmonary disease similar to tuberculosis. The study found that these drugs target the bacterium's defense mechanism, preventing it from responding to stresses and reducing its ability to form biofilms.
Researchers developed a computational approach called CellTrek to combine parallel gene-expression profiling methods, creating spatial maps at single-cell resolution. The tool provides detailed information on individual cell types' location within tissues, enabling unique biological insights.
Researchers at UNLV's Nevada Extreme Conditions Lab have discovered a new form of ice with unique properties. The team found that the transition to Ice-X occurs at much lower pressures than previously thought.
A new rice rat species, possibly arboreal, was discovered in Ecuador through detailed skull analysis. The species, Mindomys kutuku, has distinct characteristics that distinguish it from its sister species.
Researchers found data analysis, accounting, cleaning, and banking to be the most boring jobs, while religion, watching TV, and bird watching were among the dullest hobbies. Stereotypically boring people are often disliked and avoided due to preconceptions, leading to social ostracization and increased loneliness.
A new research project led by Professor Edze Westra aims to uncover the mechanisms of molecular communication in viruses, which coordinate their infections and replicate in infected cells. The team will use a combination of theoretical, experimental, and observational approaches to address key questions about viral communication systems.
Researchers at the University of Huddersfield have identified a key mechanism by which the coronavirus causes inflammation in the brain's immune cells, potentially explaining some symptoms experienced by COVID-19 patients. The study suggests that adequate funding is needed to further develop this research and its potential applications.
Researchers have discovered a streamlined method for synthesizing novel neuroactive compounds found in the bark of Galbulimima trees, which may lead to new psychiatric and neurological drugs. The new approach enables easy synthesis at scale, paving the way for further study of these compounds' biological effects.
Researchers from NTU Singapore and KIMM create chemical-free printing technique to fabricate semiconductor wafers with nanowires. The method produces highly uniform and scalable wafers, leading to improved performance and high chip yield.
Intermittent fasting produces mild to moderate weight loss and improves cardiometabolic risk factors, comparable to traditional calorie-restricted diets. The review also dispels myths about intermittent fasting, including the misconception that it leads to weakness and decreased concentration.
A new study confirms that abnormalities in the GDF15 gene are involved in hyperemesis gravidarum, a condition causing severe nausea and vomiting during pregnancy. The discovery may lead to targeted treatments and improved care for women with HG.
Research found that adult howler monkey play increases when faced with competition over fruit, a valuable resource. This playful behavior helps regulate relationships within the social group and avoid conflict, unlike collective grooming used by some other primates.
Two clinical trials will report groundbreaking data on adjuvant olaparib for germline BRCA1/2 associated breast cancer and pembrolizumab for early-stage non-small cell lung cancer. These treatments aim to improve survival rates and reduce recurrence.
Researchers have designed a fast-acting injectable insulin based on the venom of the Conus kinoshitai marine snail, which doesn't form clusters like human insulin. The new hybrid insulin holds promise for better diabetes control with faster action and reduced clustering.
A research team at the Advanced Science Research Center has identified peptidoglycan as the most powerful actuator material. The new water-responsive muscles can quickly expand and contract in response to water absorption and evaporation, enabling rapid actuation of micro and macro structures.
A new virtual ligand-assisted screening method enables efficient searching of ligands for optimal catalysis, accelerating reaction design. By simplifying ligand description with two metrics, researchers identify promising ligands and focus on real testing.
A WVU postdoctoral researcher has made a groundbreaking discovery in the field of magnetic reconnection, which can be used to predict space weather events that affect satellite and power grid systems. The study uses advanced laser diagnostics to measure electron speeds, providing new insights into plasma physics processes.
Researchers from Purdue University and other institutions have discovered a supermassive black hole binary system, consisting of two black holes that orbit each other. The system is significant due to its close separation, which may lead to a merger releasing massive energy in gravitational waves.
Researchers at the University of Bath have developed a new coating method for soft robots that allows them to change shape and movement through human-controlled activity. This breakthrough in active matter could lead to the creation of machines governed by individual units that cooperate to determine movement and function.
A CHOP-led study found bortezomib significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma. The trial also showed that intensifying the chemotherapy regimen allowed for elimination of radiation in nearly all patients, resulting in excellent outcomes.
Researchers discovered that plant volatile signals can warn neighboring plants of herbivore attacks, activating defense genes and increasing resistance. The team found epigenetic mechanisms, including histone acetylation, play a key role in this process.
Researchers discovered that an inorganic polyphosphate released by nerve cells contributes to the death of motor neurons in people with ALS and frontotemporal dementia. The study found that lowering levels of this toxin may be an innovative therapeutic strategy for diverse types of ALS/FTD.
Researchers at the University of Virginia Health System have identified a potential way to treat obesity and type 2 diabetes in women by targeting a specific gene called KLF14. Increasing KLF14 abundance in fat cells may help alleviate metabolic abnormalities, including slower metabolic rates and less efficient triglyceride management.
A University of South Florida study suggests targeting kappa-opioid receptors may alleviate working memory deficits and improve executive function in individuals with severe alcohol use disorder. A compound blocking these receptors alleviated working memory deficits and restored normal executive function.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
Aging egg cells accumulate damage to genetic material, preventing maturation and fertilization. Researchers have identified a key process causing this damage and found that anti-viral drugs can reverse it.
Researchers at Tel Aviv University have developed a unique detector using compressed xenon gas to detect axion-like particles, promising a breakthrough in finding dark matter. The new technology enables the exploration of previously inaccessible masses, constraining the properties of axion-like particles.
Researchers have demonstrated control of graphene's relaxation time, allowing for novel functionalities in devices such as light detectors and modulators. This work paves the way for the development of ultrafast optical devices with potential applications in photonics and telecommunications.