News on early, curiosity-driven science that opens new directions. Covers materials discovery, AI-guided research, pediatric research standards, and energy science.
A team of scientists discovered that over half of known 3D materials in nature exhibit at least one topological state, challenging the long-held idea that these materials are rare. The study also introduces a new concept called 'supertopological' and makes its data freely available to researchers.
Researchers have discovered that 90% of known crystalline structures contain at least one topological property, and more than 50% exhibit some sort of topological behavior. The newly identified materials are stored in a freely accessible database, allowing scientists to quickly search for materials with robust electronic properties.
Researchers at Institute of Physics Chinese Academy have discovered new zirconium polyhydrides that exhibit superconductivity with a high transition temperature (Tc) of ~71 K. The compounds can be synthesized under high pressure conditions and may lead to the discovery of new superconducting materials.
Researchers from Edith Cowan University, CSIRO, and WEHI have decoded the genome of oats, revealing why they may be a suitable alternative to wheat for those with coeliac disease. The study found that oats contain fewer gluten-like proteins, making them a potentially healthier option.
A study published in Nature Communications sheds light on dopamine transporter (DAT) function, which regulates brain reward centre communication. The researchers discovered DAT depends on potassium, not just sodium, rewriting textbooks on its mechanism.
A new study published in PNAS reveals that a specific bacterial compound, lipopolysaccharide, induces larval marine tubeworms to settle on the seafloor and undergo metamorphosis. The discovery offers hope for coral reef restoration, mariculture, and biofouling prevention.
The discovery of a 164,000- to 131,000-year-old Denisovan tooth in Laos provides significant insights into the species' geographic range. The ancient tooth's shape and similarity to teeth found on the Tibetan Plateau suggest that Denisovans inhabited Southeast Asia, particularly northern Laos.
Researchers at the Beckman Institute found a direct link between high-fat diets and heightened nitric oxide levels, which can lead to increased risk of inflammation and cancer development. The study used a molecular probe to visualize changes in the tumor microenvironment.
A new screening tool has been developed to identify pregnant women at risk of eating disorders, allowing for early intervention and treatment. The Prenatal Eating Behaviors Screening (PEBS) tool, created by WVU researchers, uses a 12-question screener to assess symptoms and emotions associated with eating disorders.
A new species of Phalotris snake was discovered in Paraguay's Cerrado forests, characterized by its unique red head, yellow collar, and black lateral band. The species is considered Endangered due to its extreme rarity and limited distribution.
A team led by Flinders University archaeologist Dr Martin Polkinghorne is reuniting ancient ceramics with their ships of origin, developing a narrative of ancient global trade. The research project will also promote cultural value and awareness among communities in Indonesia and Australia.
Researchers at the University of Colorado School of Medicine have found that histone deacetylase 6 (HDAC6) regulates heart stiffness by acting on titin protein. This discovery could lead to novel treatments for heart failure, a condition affecting millions worldwide.
Two new species of Amazonian fish have been discovered and described by Smithsonian researcher Murilo Pastana, one with vibrant red-orange fins and another that is technically a miniature fish. The species are at risk of extinction due to deforestation in the region where they inhabit.
Plazi receives EUR 1.5 million grant from Arcadia Fund to develop Biodiversity Literature Repository (BLR), providing access to over 750,000 taxonomic treatments, figures, and material citations. The project aims to liberate data from scientific publications, making it FAIR and open for researchers.
A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.
Researchers at Johns Hopkins Medicine have designed nanobodies derived from llama antibodies to target specific sodium ion channels in human muscle cells. This breakthrough could lead to safer and more efficient treatments for pain during surgery and irregular heart rhythms, as well as seizure control.
Researchers suggest a novel neuroimaging technique can unveil Alzheimer's disease secrets and predict symptom risk. The 'neuromelanin-sensitive MRI' method provides insights into the brain's noradrenergic system, linked to aggressive behavior and cognitive decline.
Private companies like GlaxoSmithKline and Imperial College London have carried out high-risk breaches, handling sensitive patient data outside of agreed contracts. NHS Digital's audits show that many organisations have failed to protect patient confidentiality, with no consequences for those who breach agreements.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
Researchers from Clemson University have discovered a promising therapy for toxoplasmosis, a disease caused by the microscopic protozoa Toxoplasma gondii. The team has enlisted an unlikely ally - the herbicide oxadiazon - in the fight against the single-celled parasite.
Researchers from McGill University and Italy found that blocking neutrophils can prolong pain, even with anti-inflammatory drugs. The study suggests reconsidering acute pain treatment, and findings are supported by a large UK analysis.
A study by Hebrew University researchers reveals that individuals overestimate the presence of minority groups in social settings. This 'diversity illusion' can hinder policies promoting diversity and leads to less support for related initiatives. The research team suggests that awareness and education are key to addressing this bias.
Scientists have developed a machine learning algorithm that can accurately predict the lifetimes of different battery chemistries using as little as a single cycle of experimental data. The technique could reduce costs and accelerate the development of new battery materials, enabling researchers to quickly evaluate and test multiple ma...
A $66,000 NIH grant will support Karry Weston's two-year study on the lack of breastfeeding in rural Missouri. The goal is to identify cultural factors influencing mothers' decisions, with a focus on improving maternal care in rural communities.
Researchers at the University of Birmingham call for more diverse patient groups in clinical trials and practice to ensure representative data collection. The team identifies barriers such as access to technology, disability, language, and cultural requirements that hinder participation.
A study by Kobe University researchers has illuminated the characteristics of Myeloid immune cells in coronary plaque, a major contributor to acute coronary syndrome. The findings suggest that macrophages and monocytes accumulate in the plaques of patients with acute coronary syndrome, leading to increased inflammation.
Researchers have discovered a unique mechanism called 'momentum-dependent spin splitting' that allows for strong spin currents and efficient magnetic switching. This discovery could lead to advances in magnetic random-access memory technologies.
Scientists at Scripps Research developed Pytheas, an open-source app that automates the analysis of modified RNA molecules using mass spectrometry. The tool speeds up the process of characterizing and quantifying RNAs in basic research and drug-development settings.
Researchers have used a data-sharing innovation to categorise 16 uncertain BRCA variants as benign or likely benign, potentially allowing women with these variants to skip invasive surgeries. This could lead to thousands of people avoiding difficult treatments for no reason.
Researchers find that black holes go through a 'hard' and 'soft' state during outbursts, with the final flash possibly indicating a brief expansion of the corona. The findings help scientists understand how supermassive black holes shape galaxy formation.
Researchers from the US and Japan have discovered the mechanism of GTP recognition by a tumor-promoting kinase, leading to the evolution of a GTP sensor kinase. This finding could lead to the development of a new cancer-treating drug that targets PI5P4Kβ using GTP instead of ATP.
The May issues of American Psychiatric Association journals explore the cognitive impacts of long-term cannabis use, the intersection of climate change and mental health, and tools to address children's mental health. The American Journal of Psychiatry and Psychiatric Services feature research reports on these topics.
An international team of scientists has discovered 30 exocomets in the β Pictoris planetary system, determining their size range and estimating a similar size distribution to those orbiting the Sun. This discovery sheds new light on the origin and evolution of comets in planetary systems.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
Researchers at MIT developed an AI method that constrains machine-learning models to suggest molecules with producible chemical structures. The approach guarantees quality and speed, outperforming existing methods in proposing high-quality molecular structures.
A new study published in Management Science journal found that considering chronic conditions when developing screening guidelines can significantly alter disease screening recommendations. This approach has been shown to reduce the misuse of limited screening resources, particularly for patients at risk of developing chronic conditions.
Researchers at Nanyang Technological University, Singapore have successfully used recycled glass as a replacement for sand in 3D printing concrete mixtures. The new method offers a more environmentally sustainable way of building and construction, reducing waste and pollution.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
A new study estimates the national economic burden of PTSD at $232.2 billion for 2018, with civilians accounting for 82% of the total costs. The study calls for increased awareness, effective therapies, and expanded evidence-based strategies to reduce the clinical and economic burden of PTSD.
A new study from Boston Medical Center found that COVID-19 infection during pregnancy is associated with elevated inflammatory markers in infants, potentially impacting growth and brain development. Researchers emphasize the importance of COVID-19 vaccinations for pregnant women to avoid long-term adverse consequences for their infant.
A new method predicts the starting materials and reaction paths of multi-step chemical reactions using only information about the target product molecule. The algorithm reduces the number of paths to explore, mitigating the combinatorial explosion that occurs in single-step reactions.
Researchers have discovered new evidence that sheds light on the initial expansion of the Lapita people throughout Papua New Guinea, revealing a more extensive dispersal than previously thought. The study found distinct markings on pottery, new tool technologies, and animals such as pigs introduced to the region by Lapita people.
Researchers have identified a new oxygen sensing mechanism in spinal cord neurons capable of triggering activation of the sympathetic and respiratory nervous system. This discovery suggests that SOS are critical for autoresuscitative reflexes and contribute to physiological regulation in health and disease.
Researchers from The University of Texas Health Science Center at San Antonio have identified 33 genes associated with Alzheimer's disease, doubling the known list. This discovery adds 42 new genetic variants to the existing gene list, shedding light on emerging pathways of Alzheimer's biology and potential treatment targets.
Researchers at Case Western Reserve University discovered that altering macrophage metabolism influences their relationship with T cells, suppressing tumor growth and reducing overall tumor size. The study found PERK protein's involvement in key metabolic pathways and identified a potential clinical drug inhibitor to target it.
A new study by Scripps Research analyzed sensor data from wearable devices to track physiological responses to the COVID-19 vaccination. The findings show that resting heart rate increased significantly after vaccination, with stronger effects in younger individuals and those who had prior COVID-19 infection.
Researchers at Virginia Tech discovered 17 new species of twisted-claw millipedes, including Nannaria swiftae, named after singer-songwriter Taylor Swift. The millipedes play a valuable role in decomposing leaf litter and have unique characteristics such as shiny caramel-brown bodies with white spots.
Researchers at Clemson University and SSSIHL discovered a novel way to combine curcumin and gold nanoparticles to create an electrode that efficiently converts ethanol into electricity. The discovery brings replacing hydrogen as a fuel cell feedstock one step closer, with potential applications in sensors and supercapacitors.
Researchers found that vitamin E boosts immunotherapy responses by stimulating dendritic cell activity, leading to improved antigen presentation and enhanced antitumor immunity. Vitamin E treatment also showed promise in combining with cancer vaccines and immunogenic chemotherapies.
Researchers at UT Health San Antonio have identified a novel mechanism by which tau protein causes neurons to die, which can be altered pharmacologically. This discovery provides a new framework for studying vertebrate models of tauopathy and eventually clinical trials.
Scripps Research scientists have discovered a special cell type called 'ionocyte' that maintains healthy concentrations of ions in saliva, producing growth factor FGF10. This ionocyte might hold the key to repairing salivary glands and treating conditions like Sjögren's syndrome and dry mouth.
Scientists have identified a potential new antibiotic candidate from the rare soil microbe Lentzea flaviverrucosa. The discovery was made using genomics-based approaches and shows that this actinomycete produces two different bioactive molecules that are active against various types of cancer cells.
A team of NYU Tandon researchers investigated the variability of mortality prediction models when applied to different hospitals and geographic regions. They found that these models exhibit a lack of generalizability due to dataset shifts in race and clinical variables, leading to disparities in performance across racial groups.
Researchers found that fighters who rapidly cut weight before bouts are more likely to suffer concussions or be misdiagnosed with head trauma. The study also discovered that the practice may not offer a competitive advantage and can leave fighters at a disadvantage more often than not.
A new strain of algae has been identified that can produce green hydrogen gas via photosynthesis on an industrial scale. This breakthrough could accelerate the transition to environmentally friendly green hydrogen and reduce pollution. The researchers also plan to develop methods to increase production rates and reduce costs.
A new study using 50 years of data from the University of Otago's Dunedin Multidisciplinary Health & Development Study found that vaccine resistance is linked to adverse childhood experiences. The research suggests that individuals who develop a history of mistrust during childhood are more likely to become resistant to vaccinations.
Scientists at the University of Bath have developed a new technique called Transcription Block Survival (TBS) to accelerate the discovery of cancer-fighting drugs. TBS identifies molecules that can shut down dangerous proteins before they wreak havoc, by blocking their interaction with cell DNA.
A team of astronomers led by Dr Marcin Glowacki have detected the most distant megamaser ever observed, with light traveling 58 trillion kilometers from its location at five billion light years from Earth. The megamaser is thought to be created when two galaxies collide, triggering a beam of concentrated light.
Researchers at the University of Illinois Chicago are studying licorice-derived substances for their potential to prevent or stop prostate cancer growth. The study suggests that these compounds, such as glycyrrhizin and its derivatives, may have anti-inflammatory and anti-cancer effects.
A study found a shift in the profile of specialized lipid mediators from pro-resolving to pro-inflammatory in patients with cognitive impairment, correlating with severity of cognition impairment. The researchers identified novel mechanisms of brain health and potential therapeutic targets for slowing down Alzheimer's disease onset.