Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered a unique mechanism called 'momentum-dependent spin splitting' that allows for strong spin currents and efficient magnetic switching. This discovery could lead to advances in magnetic random-access memory technologies.
Scientists at Scripps Research developed Pytheas, an open-source app that automates the analysis of modified RNA molecules using mass spectrometry. The tool speeds up the process of characterizing and quantifying RNAs in basic research and drug-development settings.
Researchers have used a data-sharing innovation to categorise 16 uncertain BRCA variants as benign or likely benign, potentially allowing women with these variants to skip invasive surgeries. This could lead to thousands of people avoiding difficult treatments for no reason.
Researchers find that black holes go through a 'hard' and 'soft' state during outbursts, with the final flash possibly indicating a brief expansion of the corona. The findings help scientists understand how supermassive black holes shape galaxy formation.
Researchers from the US and Japan have discovered the mechanism of GTP recognition by a tumor-promoting kinase, leading to the evolution of a GTP sensor kinase. This finding could lead to the development of a new cancer-treating drug that targets PI5P4Kβ using GTP instead of ATP.
The May issues of American Psychiatric Association journals explore the cognitive impacts of long-term cannabis use, the intersection of climate change and mental health, and tools to address children's mental health. The American Journal of Psychiatry and Psychiatric Services feature research reports on these topics.
An international team of scientists has discovered 30 exocomets in the β Pictoris planetary system, determining their size range and estimating a similar size distribution to those orbiting the Sun. This discovery sheds new light on the origin and evolution of comets in planetary systems.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
Researchers at MIT developed an AI method that constrains machine-learning models to suggest molecules with producible chemical structures. The approach guarantees quality and speed, outperforming existing methods in proposing high-quality molecular structures.
A new study published in Management Science journal found that considering chronic conditions when developing screening guidelines can significantly alter disease screening recommendations. This approach has been shown to reduce the misuse of limited screening resources, particularly for patients at risk of developing chronic conditions.
Researchers at Nanyang Technological University, Singapore have successfully used recycled glass as a replacement for sand in 3D printing concrete mixtures. The new method offers a more environmentally sustainable way of building and construction, reducing waste and pollution.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
A new study estimates the national economic burden of PTSD at $232.2 billion for 2018, with civilians accounting for 82% of the total costs. The study calls for increased awareness, effective therapies, and expanded evidence-based strategies to reduce the clinical and economic burden of PTSD.
A new study from Boston Medical Center found that COVID-19 infection during pregnancy is associated with elevated inflammatory markers in infants, potentially impacting growth and brain development. Researchers emphasize the importance of COVID-19 vaccinations for pregnant women to avoid long-term adverse consequences for their infant.
A new method predicts the starting materials and reaction paths of multi-step chemical reactions using only information about the target product molecule. The algorithm reduces the number of paths to explore, mitigating the combinatorial explosion that occurs in single-step reactions.
Researchers have discovered new evidence that sheds light on the initial expansion of the Lapita people throughout Papua New Guinea, revealing a more extensive dispersal than previously thought. The study found distinct markings on pottery, new tool technologies, and animals such as pigs introduced to the region by Lapita people.
Researchers have identified a new oxygen sensing mechanism in spinal cord neurons capable of triggering activation of the sympathetic and respiratory nervous system. This discovery suggests that SOS are critical for autoresuscitative reflexes and contribute to physiological regulation in health and disease.
Researchers from The University of Texas Health Science Center at San Antonio have identified 33 genes associated with Alzheimer's disease, doubling the known list. This discovery adds 42 new genetic variants to the existing gene list, shedding light on emerging pathways of Alzheimer's biology and potential treatment targets.
Researchers at Case Western Reserve University discovered that altering macrophage metabolism influences their relationship with T cells, suppressing tumor growth and reducing overall tumor size. The study found PERK protein's involvement in key metabolic pathways and identified a potential clinical drug inhibitor to target it.
A new study by Scripps Research analyzed sensor data from wearable devices to track physiological responses to the COVID-19 vaccination. The findings show that resting heart rate increased significantly after vaccination, with stronger effects in younger individuals and those who had prior COVID-19 infection.
Researchers at Virginia Tech discovered 17 new species of twisted-claw millipedes, including Nannaria swiftae, named after singer-songwriter Taylor Swift. The millipedes play a valuable role in decomposing leaf litter and have unique characteristics such as shiny caramel-brown bodies with white spots.
Researchers at Clemson University and SSSIHL discovered a novel way to combine curcumin and gold nanoparticles to create an electrode that efficiently converts ethanol into electricity. The discovery brings replacing hydrogen as a fuel cell feedstock one step closer, with potential applications in sensors and supercapacitors.
Researchers found that vitamin E boosts immunotherapy responses by stimulating dendritic cell activity, leading to improved antigen presentation and enhanced antitumor immunity. Vitamin E treatment also showed promise in combining with cancer vaccines and immunogenic chemotherapies.
Researchers at UT Health San Antonio have identified a novel mechanism by which tau protein causes neurons to die, which can be altered pharmacologically. This discovery provides a new framework for studying vertebrate models of tauopathy and eventually clinical trials.
Scripps Research scientists have discovered a special cell type called 'ionocyte' that maintains healthy concentrations of ions in saliva, producing growth factor FGF10. This ionocyte might hold the key to repairing salivary glands and treating conditions like Sjögren's syndrome and dry mouth.
Scientists have identified a potential new antibiotic candidate from the rare soil microbe Lentzea flaviverrucosa. The discovery was made using genomics-based approaches and shows that this actinomycete produces two different bioactive molecules that are active against various types of cancer cells.
A team of NYU Tandon researchers investigated the variability of mortality prediction models when applied to different hospitals and geographic regions. They found that these models exhibit a lack of generalizability due to dataset shifts in race and clinical variables, leading to disparities in performance across racial groups.
Researchers found that fighters who rapidly cut weight before bouts are more likely to suffer concussions or be misdiagnosed with head trauma. The study also discovered that the practice may not offer a competitive advantage and can leave fighters at a disadvantage more often than not.
A new strain of algae has been identified that can produce green hydrogen gas via photosynthesis on an industrial scale. This breakthrough could accelerate the transition to environmentally friendly green hydrogen and reduce pollution. The researchers also plan to develop methods to increase production rates and reduce costs.
A new study using 50 years of data from the University of Otago's Dunedin Multidisciplinary Health & Development Study found that vaccine resistance is linked to adverse childhood experiences. The research suggests that individuals who develop a history of mistrust during childhood are more likely to become resistant to vaccinations.
Scientists at the University of Bath have developed a new technique called Transcription Block Survival (TBS) to accelerate the discovery of cancer-fighting drugs. TBS identifies molecules that can shut down dangerous proteins before they wreak havoc, by blocking their interaction with cell DNA.
A team of astronomers led by Dr Marcin Glowacki have detected the most distant megamaser ever observed, with light traveling 58 trillion kilometers from its location at five billion light years from Earth. The megamaser is thought to be created when two galaxies collide, triggering a beam of concentrated light.
Researchers at the University of Illinois Chicago are studying licorice-derived substances for their potential to prevent or stop prostate cancer growth. The study suggests that these compounds, such as glycyrrhizin and its derivatives, may have anti-inflammatory and anti-cancer effects.
A study found a shift in the profile of specialized lipid mediators from pro-resolving to pro-inflammatory in patients with cognitive impairment, correlating with severity of cognition impairment. The researchers identified novel mechanisms of brain health and potential therapeutic targets for slowing down Alzheimer's disease onset.
Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
A recent study by Pacific Northwest National Laboratory researchers reveals a previously unknown atmospheric phenomenon over the Amazon rainforest, driven by plant-foliage-derived gases. These gases condense to form fine particles that cool the planet and seed clouds, affecting precipitation and the water cycle.
Researchers analyzed breast milk samples from 15 nursing mothers to track gene expression changes in mammary gland cells. The study identified various changes linked to factors such as hormone levels, illness, and lifestyle changes.
Researchers have identified a gene mutation in ARID2 that signals the development of aggressively metastatic melanoma. The study suggests patients with this mutation may require different treatment approaches to manage their cancer effectively. Further research is underway to refine this understanding and improve patient outcomes.
Researchers found that cereal fiber, but not fruit or vegetable fibers, was associated with lower inflammation and cardiovascular disease risk in older adults. The study used data from a large cohort of elderly individuals and confirmed previous associations between dietary fiber and CVD.
The American Association for Cancer Research (AACR) has announced the recipients of its 2022 Scientific Achievement Awards and Lectureships, recognizing Tony Hunter, Christina Curtis, John E. Dick, Kevan M. Shokat, and Lee M. Ellis for their groundbreaking contributions to cancer research.
Researchers used X-ray computed microtomography to produce stunning 3D reconstructions of the proteus' head, revealing extensive changes in sensory organs and physical appearance. The study provides detailed information about evolutionary-designed adaptations for surviving in lightless caves.
Researchers propose an open platform to integrate data collection, processing, and publication, ensuring FAIR (findable, accessible, interoperable, reusable) data and enabling machine-learning algorithms to learn from failed experiments. The platform aims to bridge the gap between data and machine learning in chemistry.
A study using the nation's largest COVID-19 data resource found that the vaccine protects most cancer patients from getting COVID, but those with certain types of cancer have a higher risk of breakthrough infections. The research also highlights the importance of continued vaccination efforts to protect cancer patients.
Ira Mellman, PhD, is being honored with the 2022 AACR-CRI Lloyd J. Old Award in Cancer Immunology for his seminal work on dendritic cell function and its impact on atezolizumab and neoepitope vaccines. His research has made a major impact on cancer immunology and has the potential to stimulate new directions.
Researchers use DNA to program metal nanoparticles to assemble into new configurations, resulting in the discovery of three new crystalline phases. The approach enables symmetry breaking and creation of complex colloidal crystal structures with unique optical and catalytic properties.
Researchers at CU Anschutz Medical Campus discovered a reactivated protein, Hand2, in certain cases of mesothelioma, which may lead to new treatments. The study aims to investigate the cause and effect of this reactivation.
Researchers discovered that obesity changes molecular underpinnings of allergic inflammation in both mice and humans. The treatment in obese mice makes their skin worse instead of healing, but a specific drug can 'de-fatten' obese mice without changing body weight.
A new app called Metaboseek has been developed to streamline the analysis of comparative metabolomics data, helping researchers identify valuable compounds. The app was created by a postdoctoral research associate and is now essential to his lab's work.
Researchers have discovered two distinct classes of cancer-associated fibroblasts that accumulate in the pancreatic tumor microenvironment and play opposing roles. The study suggests that targeting these unique cell populations may improve treatment outcomes for pancreatic cancer patients.
Researchers observed rapid electron precipitation from low-Earth orbit using the ELFIN mission, which was caused by whistler waves affecting electrons in the Earth's magnetosphere. The findings demonstrate that whistler waves are responsible for far more electron rain than current theories and space weather models predict.
Researchers found a persistent 20% reduction in carbon dioxide seeping up from the ground during the spring of 2017, coinciding with intense drought and record-high Sierra Nevada snowpack. The study suggests that changes in Earth's hydrology due to climate change can impact volcanic emissions.
A new study found that warmer summer nights are associated with an increased risk of cardiovascular disease deaths in men aged 60-64, but not women or older men. A 1°C rise in temperature is linked to a 3.8% higher risk of male death, highlighting the need for preventive population health initiatives and novel urban policies
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
A newly discovered small molecule, N-0385, has been found to inhibit entry of the virus into cells, protecting mice from infection prior to exposure and providing effective treatment up to 12 hours after. The treatment holds promise for preventing disease and reducing severity with a few single daily doses.
Researchers developed an AI-driven image analysis pipeline that identified novel cellular hallmarks of Parkinson's disease from images of over a million skin cells. The platform can distinguish between patient cells and healthy controls, revealing new signatures for potential therapeutic targets.
Research reveals that ASMR enthusiasts are hypersensitive to their environment, easily overstimulated by noise and movement. They also possess heightened bodily awareness, noticing physical changes when experiencing emotions.
Researchers at Argonne National Laboratory have discovered a key reason for the performance decline of sodium-ion batteries, which are promising candidates for replacing lithium-ion materials. By adjusting synthesis conditions, they can fabricate far superior cathodes that will maintain performance with long-term cycling.
Dr. Tony Hunter's groundbreaking work on protein tyrosine phosphorylation has led to the development of targeted cancer therapies and a deeper understanding of cancer biology. His discovery has been recognized with numerous awards, solidifying his legacy in cancer research.
Researchers developed a novel approach to diagnose, monitor, and predict the course of myocarditis using CMR parameters and AI. The goal is to provide personalized counseling for athletes and optimize treatment options.
Researchers discovered that by four days after mating, close to 20% of fruit fly sperm proteins are female-derived. Female proteins bind to sperm inside the female, potentially supporting their viability.