A new study suggests that not enough women with breast cancer are being offered the chance to undergo treatments that may conserve their breasts. Despite high response rates to neoadjuvant therapy, only around 40% of patients receive breast-conserving surgery. The studies call for a clear consensus on the role of breast conserving surg...
Research reveals activation of PI3K-Akt signaling pathway induces mammary gland cells to produce prolactin, triggering Stat5 activation and milk production. Prolactin's role in human breast cancer is reevaluated, with potential implications for treatment.
Researchers at Stanford University School of Medicine discovered that blocking the action of a specific protein called DUSP6 can restore an important class of immune cells' response to vaccines. This finding holds long-term therapeutic ramifications and could potentially counter aging's effects on the immune system.
A phase III trial shows that crizotinib is more effective than standard chemotherapy in response rates and progression-free survival, with improved quality of life. The study compared 347 patients with previously treated ALK-positive lung cancer and found significant benefits for those on the crizotinib arm.
The proposed algorithm generates feature sensitive non-uniformly distributed discrete sample points for underlying point sets. It uses a Gaussian sphere-based sampling scheme to simplify the point set surfaces, and then applies an adaptive re-sampling framework to generate the desired samples.
A new study projects a 14-20% decline in maximum fish body weight by 2050, with the tropics being most impacted. The research highlights the need to curb greenhouse gas emissions and monitor changes to ocean ecosystems.
Studies presented at ESMO 2012 Congress reveal that a large proportion of people overestimate the cancer risk attributable to genetics and underestimate the risks associated with obesity, alcohol, and sunlight exposure. Increasing awareness of primary cancer prevention is crucial to reduce incidence rates.
New research reveals that women with HER2 positive breast cancer that is also hormone (estrogen and progesterone) receptor negative have an increased risk of early death and less likely to recur in bone compared to those with hormone-sensitive cancer. The study suggests HR status defines two different subsets of HER2 positive cancers.
A study published in Clinical Epigenetics found that individuals with a specific genetic variation in SIRT1 are more likely to develop vibration-induced white finger disease. The research suggests that testing for this variant before starting work with vibrating machinery could prevent years of pain and disability.
A molecule called p110delta regulates immune cells to control inflammation, preventing excessive reactions that can damage the organism. Temporarily interfering with p110delta activity could lead to new therapeutic avenues for treating diseases such as cancer, asthma, and multiple sclerosis.
Several new first-in-human studies for drugs targeting a range of cancers have shown promising results, including the development of MEK-, MET- and HSP90 inhibitors as well as immunotherapeutic strategies. Studies have demonstrated significant activity in ALK-positive lung cancer resistant to crizotinib and other targeted therapies.
A recent study reveals a common RNA pathway that contributes to the degeneration of motor neurons in both ALS and dementia. The discovery provides a potential target for developing new treatments and offers insights into the normal function of key proteins involved in these diseases.
A new study reveals the emergence and spread of invasive non-Typhoidal Salmonella disease in sub-Saharan Africa, which has a significant mortality rate of up to 45% in infected people. The disease is caused by a rapidly evolving form of Salmonella Typhimurium that acquired resistance to multiple front-line drugs.
Researchers at the University of Cincinnati have identified a genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1. The discovery of the CIB2 protein provides new insights into the mechanism of mechano-electrical transduction, which converts mechanical energy into sound.
The study reveals that southwestern forests face significant challenges due to climate change, including increased drought stress and mortality. The researchers developed a Forest Drought-Stress Index that shows a strong correlation with tree growth, death from drought, and area burned by forest fires.
Researchers from the University of North Carolina School have established a connection between histone H3 lysine 9 methylation and DNA methylation, implicating protein UHRF1 in their maintenance. This finding may provide clues to the underlying causes of disease and cancer.
Scientists discovered Lepidopteris baodensis, a 251-million-year-old seed fern with subepidermal swellings that may have allowed it to survive in hot, arid environments. The finding expands knowledge of the genus' biology and taxonomy, as well as its relationship to other plant species.