Researchers have created a mouse model of A-T, a disorder characterized by severe motor coordination loss and premature death, to test a promising new therapy. The study demonstrates that the therapy restores ATM production in tissues from A-T mutant mice.
Researchers found that the therapeutic effects of MSCs are due to the recipient's immune cells responding to dying MSCs undergoing apoptosis, promoting anti-inflammatory effects. This understanding may lead to new therapeutic strategies targeting the responding immune cell population.
A KU study reveals that individuals' political ideologies play a crucial role in shaping their health behaviors during the COVID-19 pandemic. The research, conducted using two surveys and a review of existing data, found that ideology was a significant predictor of health behavior, especially when compared to other factors such as age,...
Researchers discovered inhibiting or genetically deleting the MTHFD2 enzyme reduced disease severity in various inflammatory disease models. This suggests that MTHFD2 function is important for immune cell regulation, particularly for T cell subsets involved in inflammation.
The study analyzes how Sex Education fills the gap in sex education for teenagers, offering a more nuanced understanding of their needs. The show represents sex education as a conversation between teens, parents, and experts, challenging traditional gatekeeper ideas about adult protection.
A new study from the University of Eastern Finland reveals that Finnish parents regard assessment as primarily a tool for supporting pupils' learning and growth. They hope for diverse forms of assessment, including numerical evaluations, to motivate children and facilitate comparison. The researchers propose that schools engage in clos...
A study found that children with autism tend to have less diverse diets and lower gut microbiome diversity compared to their non-autistic peers. This suggests that dietary preferences may contribute to the development of autism-related traits.
A new Illinois study compares performance of static and dynamic nitrogen recommendation tools, finding that complex dynamic tools do not consistently increase profits but offer a 15% reduction in nitrogen leaching. The researchers highlight the need to refine these tools and prioritize environmental outcomes over economic gains.
Researchers have developed a novel sensor that can detect and track the movement of nanoparticles in space, providing insights into biological processes. The sensor uses an optical resonator to capture light interactions with nanoparticles, allowing for the measurement of their three-dimensional motion.
Researchers discovered regulation of cytokinin is central to balancing nitrogen acquisition. Legumes restrict nodules when nitrogen is abundant, acquiring instead from the soil.
Scientists at SLAC National Accelerator Laboratory recreated deep-Earth conditions to study iron's atomic structure. They observed 'twinning,' a common pressure response in metals and minerals, which allows iron to be incredibly strong before flowing plastically.
A new study reveals that marine species in the Mediterranean are migrating tens of meters deeper to survive warmer temperatures. The research found that cold-water species deepen significantly more than warm-water species, with an average depth increase of 55 meters across the region.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Research suggests women with lingering COVID-19 symptoms experience heart rate irregularities during physical exertion, leading to delayed recovery and reduced exercise tolerance. Targeted rehabilitation programs are needed to manage these consequences in women with persistent heart and lung problems.
Researchers have developed a new method of stem cell transplantation that does not require chemotherapy or radiation. The approach uses immunotherapeutic drugs to eliminate cancer cells and prevent immune rejection. This technique has the potential to be curative for blood cancers and treat other diseases like sickle cell anemia.
A research team developed a treatment for myocardial infarction using mussel adhesive proteins, promoting cell proliferation and migration in damaged heart tissue. The MAP-based microneedle bandage alleviated fibrosis and restored the damaged myocardial wall.
A study published in JAMA Pediatrics found that mothers with disease-acquired immunity and those with vaccine-immunity produced high levels of antibodies in their breast milk, providing neutralization against SARS-CoV-2. The antibodies, including IgA and IgG, existed for three months after infection or vaccination.
Researchers at the Missouri School of Journalism explored how people value digital news, finding that print newspapers moved to digital platforms without understanding the differences between mediums. The study identified eight affordances of digital news readers, including the importance of design elements like color and hyperlinks.
Using next-generation sequencing, researchers identified four major regulatory pathways and specific molecular effectors behind COVID-19 symptoms. The study may pave the way for a more personalized approach to diagnosis and treatment.
A study led by Georgia State University researchers found that increased salt intake can lead to a decrease in blood flow to the hypothalamus, a key region for regulating body functions. This 'inverse neurovascular coupling' mechanism may play a role in hypertension and could have implications for developing new treatments.
Researchers discovered two new exoplanets using AI-powered image recognition, which can predict the effect of interactions between planets on a star's luminosity. This technique improves detection rates for terrestrial-type planets and provides insights into their mass, density, and composition.
Researchers developed a hybrid membrane using graphene oxide and tungsten trioxide nanoparticles to reduce vanadium ion permeation in VRFBs. The new membrane shows high ion selectivity, improving Coulombic and energy efficiency compared to commercial membranes.
Whale-watch vessels with louder petrol engines significantly disrupt short-finned pilot whale resting and nursing, according to a study. The researchers found that mothers who were approached by the vessel with the petrol engine spent on average 29% less time resting and 81% less time nursing their calves.
A new study found that orgasmic meditation produces a distinctive pattern of brain function, affecting areas associated with sexual stimulation and traditional meditation. The practice was correlated with alterations in the autonomic nervous system and reported profound spiritual experiences among participants.
Researchers identified a high-pressure calcium silicate perovskite, named davemaoite, trapped inside a deep-earth diamond. This discovery confirms the existence of a new mineral that concentrates elements incompatible in the upper mantle, including rare-earth elements and radioactive isotopes.
A global study of nearly half a million students found that repeated grades increase the risk of bullying victimization. Girls who repeated grades faced higher risks of being bullied in various ways, including being made fun of and having possessions taken away.
A study published in the New England Journal of Medicine found that chlorthalidone significantly lowered blood pressure by 11mmHg in patients with stage 4 chronic kidney disease. The results also showed a 50% reduction in albuminuria, suggesting potential benefits for reducing kidney failure progression and hospitalizations.
Researchers found that low-to-moderate caffeine intake was associated with a reduced risk of developing gestational diabetes. Drinking up to 100mg of caffeine per day during the second trimester showed a 47% reduction in diabetes risk.
A Rutgers-led study found that conflicting health information can lead to confusion, errors, and negative feelings towards experts. Those exposed to conflicting messages performed slower on attention tasks and reported more effort, despite accurate performance.
Scientists at KAUST have created catalysts that can convert CO2 into valuable hydrocarbons, such as gasoline-grade isoparaffins, with high selectivity rates. The development paves the way for a circular carbon economy and drop-in fuels from CO2.
A new study at Boston Medical Center found that individuals experiencing unstable housing and homelessness are more likely to be re-infected with SARS-CoV-2 due to increased exposure. Despite having antibodies from the first infection, individuals in unstable housing were still at a higher risk of re-infection.
Researchers propose that crushing large olivine crystals reduces plate resistance, allowing it to bend into segments. Simulations support observations from nature, including fault patterns and seismic velocity structure.
Researchers at The Wistar Institute identified a glyco-immune checkpoint interaction that allows HIV-infected cells to evade immune surveillance. They developed a novel approach to selectively target these interactions, enabling killer cells to attack and kill infected cells in a selective manner.
A team of astronomers from the University of Arizona suggests that near-Earth asteroid Kamo`oalewa could be a miniature moon, with its spectrum matching lunar rocks from NASA's Apollo missions. The asteroid's orbit is similar to Earth's but with a slight tilt, making it unlikely to have originated from a typical near-Earth asteroid.
Researchers at the University of Cambridge have developed a sustainable, non-toxic, and vegan glitter made from cellulose nanocrystals. The material is biodegradable, plastic-free, and free from carcinogenic effects, offering a promising alternative to traditional cosmetics.
A study by West Virginia University researcher Sunil Sharma found that rural COVID patients who end up in an intensive care unit are more likely to die within 30 days compared to their urban counterparts. The researchers also discovered that rural patients with COVID-linked ARDS have a higher mortality rate, even when controlling for d...
Researchers have successfully imaged the spin of an individual molecule using electron spin resonance in a scanning tunneling microscope. This achievement allows for precise control of spin states and investigation of magnetic interactions between molecules.
A new study found that low-dose CT scans are as accurate as standard-dose scans in diagnosing appendicitis and differentiating between uncomplicated and complicated cases. This breakthrough could lead to reduced radiation exposure for young patients, improving treatment outcomes.
Research from the University of Vienna found that athletes with a pre-performance routine outperform those without, regardless of sport task complexity or athlete age/gender. A meta-analysis of 800 athletes across 15 sports revealed significant performance improvements after learning and applying a PPR.
A global study reveals that industrial fishing has drastically altered the size spectrum theory in oceans, leading to a drastic loss of large fish and whales. Researchers estimate that losses caused by industrial fishing and whaling over the past century are greater than potential biomass losses due to climate change scenarios.
A genomic analysis of Pacific Ocean rockfish reveals genetic drivers of their extreme lifespan, including DNA repair pathways and inflammation control. The study identifies 137 longevity-associated genes that affect life span in these fish, providing potential strategies for human health improvement.
A recent study analyzed 59 US stem cell clinics and found that most rely on weakly scientifically credible marketing tactics, including technical descriptions of stem cells and patient testimonials. Only a minority invokes stronger forms of evidence, such as registered clinical trials or scientific peer-reviewed articles.
A new study found that tumors with one mutant copy of the PIK3CA gene tend to have lower PI3K activity, while those with two or more copies often have higher PIK3α activity, leading to more aggressive tumors and poorer prognosis. The research also discovered a counterintuitive relationship between PI3K mutations, PI3K activity, and ste...
A study by Colorado State University found that singing produces 77% more aerosols than talking, with older males emitting the most particles. The study's findings suggest that measuring carbon dioxide levels and noise levels can be used to gauge transmission risk in enclosed spaces.
A group of Harvard scholars, including David Keith and Joseph Aldy, argue that more thorough social science research is needed into solar geoengineering to understand its potential risks and benefits. They suggest pursuing three research themes: assessing costs and benefits, understanding deployment incentives, and evaluating SG in a p...
A new study in mice found that PFAS exposure reprograms the metabolism of benign and malignant human prostate cells to a more energy efficient state. Consuming a high-fat diet significantly accelerated development of tumors in PFAS-exposed mice, suggesting a synergistic interaction between the two.
Researchers used a combination of RoseTTAFold and AlphaFold to identify over 1,500 pairs of yeast proteins likely to interact. These complexes play roles in almost all key processes in eukaryotic cells, providing broad insights into biological function.
Researchers provide first direct measurement of overall impact of ocean eddy killing, finding a continuous loss of 50 gigawatts of kinetic energy. This phenomenon, known as 'eddy killing,' counterintuitively reduces the most energetic components of ocean currents.
A new predictive tool has been developed to identify patients most at risk of experiencing a delayed discharge from hospital. The eight-variable model uses data collected when patients are admitted to hospital and is currently being piloted at Royal Stoke University Hospital.
Researchers have sequenced the Arabidopsis genome at unprecedented detail, shedding light on centromere evolution and revealing genetic and epigenetic topography. The findings provide insights into the genomic equivalent of black holes, a region that has long been challenging to analyze.
A new study by USC researchers uses a genetic technology to analyze gene expression signatures of individual cancer cells from patients with leukemia. The findings show that cancer cells with distinct gene expression profiles tend to grow in different organs, while those with specific genes are more resistant to chemotherapy.
New research by the universities of Kent, Warwick and Notre Dame has found that sex-selective abortion is lower in India districts with a Muslim state legislator. This is due to stronger stated preferences against abortion among Muslims compared to Hindus, making Muslim legislators more effective at reducing abortion rates.
Researchers found that digital fencing technology makes goat farming easier by eliminating the need for physical fences. The system also enables farmers to monitor their goats' movements and prevent animal welfare concerns.
A year-long study found that few veterans were able to obtain permanent housing despite living near the region's major VA service center. The study highlights the need for outreach efforts to be expanded to engage unhoused veterans, with mobile services potentially being a key solution.
New guidelines recommend using nerve blocks to select patients with chronic neck pain who may benefit from radiofrequency ablation. Only one nerve block is required, rather than two, and patients must experience meaningful pain relief from diagnostic blocks. This approach aims to reduce unnecessary procedures and improve patient outcomes.
A clinical trial found that a drug combination of all-trans retinoic acid and arsenic trioxide is highly effective in treating standard- and high-risk acute promyelocytic leukemia in children, with nearly all patients surviving for two years without relapse. The treatment reduces the need for conventional chemotherapy, offering fewer s...
Research highlights the intersection of poverty and racism in exacerbating US public health disparities. The US has a high rate of poverty despite collective wealth, disproportionately affecting communities of color. Beech emphasizes the need for policies to increase access to care and address institutionalized racism.
Researchers analyzed a statewide survey in Pennsylvania to identify experiences of autistic individuals and their caregivers across interactions with the criminal justice system. Positive and negative experiences were reported, highlighting an increased risk for male autistic individuals with co-occurring psychiatric diagnoses.
A study by University of Cologne researchers found that COVID-19 has a particularly negative impact on young people from economically disadvantaged and less educated backgrounds. They exhibit decreased prosocial behavior, including lower generosity, altruism, and cooperation, as well as reduced trust in others.
New research reveals humans played a significant role in the extinction of woolly mammoths, contributing to population declines and range collapses. The study shows that human hunting, combined with climate change, led to the species' demise in Eurasia thousands of years earlier than previously thought.