Researchers develop molecular jackhammers that use aminocyanine molecules to create plasmons, which rupture melanoma cell membranes with high efficiency. The method showed a 99% success rate against lab cultures of human melanoma cells and cured half of the mice with melanoma tumors.
The study found three distinctive acoustic features - roughness, mean, and period entropy of mel-frequency cepstral coefficients - that are associated with healing music's emotional responses. These features were consistently present across various genres, suggesting a universal language of music.
Recent studies in JDS Communications have found that paired housing can build behavior skills, shape calf personalities, and set up animals for success in the herd. Early socialization has been shown to boost competitive skills, increase time drinking from a bottle, and make calves bolder towards novel objects and unfamiliar calves.
JMIR Medical Education has been accepted for inclusion in MEDLINE, the US National Library of Medicine's premier bibliographic database, following a thorough review by the Literature Selection Technical Review Committee. This achievement validates the journal's commitment to exploring innovative and unusual ideas in medical education.
A study of 13,000 patients reveals few completed preoperative life-sustaining treatment documentation, with gaps in rates based on patient characteristics. The disparity affects veterans from different racial, ethnic, and rural backgrounds, as well as those with access to high-volume facilities.
A team at Peking University developed an analog in-memory computing module for one-step matrix-matrix-vector multiplication, solving compressed sensing recovery in real-time. The circuit outperforms digital approaches and has been demonstrated to recover various types of signals and images.
A malaria drug combination could counteract the negative effects of malnutrition on the female digestive tract, leading to improved birth outcomes. The research used a human organ chip model to demonstrate the potential benefits of this treatment.
A monoclonal antibody treatment increased food-allergic children and adolescents' tolerance to common foods, reducing allergic reactions. Omalizumab, approved for other indications, is being reviewed for a new indication based on the trial's interim analysis.
A study in Nature uncovers new insights into the human LINE-1 ORF2 protein's structure and mechanisms, shedding light on its evolutionary history and innate immune activation. The research also identifies potential targets for therapies to prevent cancer, autoimmune disease, and neurodegeneration.
A team of researchers at Tohoku University has developed a novel visualization method to study the behavior of hydrogen atoms in alloys. They successfully filmed the flow of hydrogen atoms in pure nickel, revealing that they preferentially diffuse through grain boundaries with large geometric spaces.
A study published in Nature Communications found that planting diverse crops reduces the number of microorganisms in the soil that eat plants, leading to higher yields. This is because specialized pathogens are suppressed in diverse communities, allowing for greater use of biomass.
Researchers will produce a comprehensive report on nonprofit employment in the US and collaborate with nonprofit leaders to improve federal database information. Funding from the Charles Stewart Mott Foundation will support the transfer of the Nonprofit Works interactive database application.
Researchers found that despite interest differences, gender gaps in career opportunities are substantial, particularly at lower education levels. The study suggests a need for gender diversity efforts to focus on professions that don't require a college degree.
A study found polycyclic aromatic hydrocarbons (PAHs) in Southern Resident killer whales and Bigg's killer whales off the coast of B.C., with contaminants from oil spills and wildfire smoke. The presence of PAHs suggests recent exposures to toxic chemicals, emphasizing the need for improved pollution management.
A new University of Maryland School of Medicine review article published in the New England Journal of Medicine finds nearly 16 million Americans have cannabis use disorder, with young adults disproportionately affected. The review emphasizes the need for doctors to screen and treat patients experiencing symptoms of cannabis use disorder.
Scientists have identified a core set of genes required by commensal bacteria to colonize plant hosts, enabling more efficient colonization and potential benefits for plant health. The discovery may lead to the development of beneficial bacteria for sustainable agriculture and medical applications.
A research group reconstituted autophagosome formation in vitro, showing that Atg8 protein and enzymes play a central role in shaping the membrane structure. High-speed atomic force microscopy and nuclear magnetic resonance analysis revealed flexible complexes on membranes, which work together to form autophagosomes.
Researchers found that plant genetic variation affects the core microbiome, a collection of microbes playing a crucial role in organizing associated microbes and helping host growth. The study highlights the importance of recruiting nitrogen-fixing bacteria for more sustainable bioenergy crops.
A team of researchers found that predicting snowflake movement is surprisingly simple, with patterns emerging based on a parameter called the Stokes number. This discovery has implications for weather forecasting and climate change, as it can affect precipitation patterns and cloud lifetimes.
A multicenter randomized clinical vignette survey study found that AI models, when systematically biased, reduced diagnostic accuracy. The study involved hospitalist physicians, nurse practitioners, and physician assistants from 13 states.
A research team led by Professor Yuan Lin has made a major breakthrough in showing how plastic strain develops in individual cells and propagates within the tissue. The study reveals the biophysical mechanisms behind cellular and tissue plasticity at different scales, providing critical insights for regenerative medicine.
Researchers found that one group of vervet monkeys exhibited more affiliative behavior and reciprocated grooming, suggesting a social tradition. This discovery challenges the idea that ecological differences explain behavioral variations and highlights the importance of social influence in shaping primate cultures.
Research reveals that fish from the same species can evolve unique sense of smell and display individual foraging 'personalities' to successfully find food. The study highlights the importance of behavioral studies in understanding how sensory systems evolve and resulting fish behavior.
A new oral treatment, E-52862, has been found to reduce the severity and duration of mild COVID-19 symptoms. The study involved 120 volunteers and showed that the drug can be administered on an outpatient basis.
A groundbreaking clinical trial found that hip-focused physical therapy outperforms spine-focused therapy in reducing disability from low back pain in adults aged 60-85. The study's results suggest a tailored approach can lead to faster improvements in low back pain disability, walking speed, and chair-rise performance.
Researchers have developed a novel microfluidic magnetic detection system that enables rapid and highly sensitive detection of tumor-derived exosomes, potential biomarkers for cancer diagnosis. The system's serpentine design enhances TDE capture efficiency, while DNA probes augment specificity.
A genomic analysis of seized pangolin scales reveals that they were sourced from West and Central Africa, highlighting the complex pathways of illegal trade. The study's findings can inform conservation efforts and support enforcement measures to protect endangered species.
Researchers found that intense fires in the region were more likely caused by human activities like war than climate change. The study used sediment cores to analyze black carbon and soot deposits from Tianchi Lake, dating back 6,000 years.
Researchers at the University of Tübingen discovered a novel antibiotic substance called epifadin produced by specific strains of Staphylococcus epidermidis. Epifadin has an antimicrobial effect against various pathogens, including Staphylococcus aureus, and could be used as a lead structure for developing new antibiotics.
Scientists have identified a population of progenitor cells that strongly promote new blood vessel growth in ischemic limbs, showing promise as a treatment for preventing amputations. The discovery was made through single-cell transcriptomics and confirmed in mice with limb ischemia, where the treatment rescued limbs from amputation.
Researchers at Politecnico di Milano have designed a hydrogel with specific characteristics using supramolecular chemistry and crystallography. The study showed that the interactions between an amino acid and bioactive molecules can be identical in both solid and aqueous states.
Flori Corpodean, a postdoctoral researcher at Pennington Biomedical, has been selected as the sole recipient of the 2024 Resident Research Award. She is exploring how the brain and intestinal tract communicate through her research on altered nutrient delivery.
George Mason University researchers Dhafer Marzougui and Cing-Dao Kan have received a $749,954 grant to develop a crashworthy tangent end treatment for low-speed and curbed roadways. The project aims to improve safety on these types of roadways, which are prone to accidents.
Scientists at Kyoto University have discovered two gene clusters associated with anxiety disorders that have distinct spatial and temporal expression patterns and functional profiles within the human brain. These findings provide new insights into the underlying causes of ADs and may lead to novel therapeutic strategies.
Research on the ancient landscapes of Sahul reveals an extensive archipelago that existed during Marine Isotope Stage 4, potentially supporting populations ranging from 50,000 to 500,000 people. Sea level rise events led to the inundation of approximately 50% of the Northwest Shelf, triggering changes in human life spans and cultural d...
Researchers discovered that eutypine activates plant defense mechanisms, primarily due to its phenolic moiety, which triggers a rapid calcium influx and increases the expression of defense-related genes. The study also found that different chemical groups in these compounds play varying roles in plant defense mechanisms.
Researchers at Bar-Ilan University have developed a novel approach to combat sleeping sickness by damaging the trypanosome parasite's ribosome, which is essential for protein production. The findings suggest that deleting just one pseudouridine from the ribosome impairs its ability to produce proteins and inhibit growth.
A team of researchers has discovered a new inactive form of the p38a protein, which is regulated by the cellular redox state. This finding opens up new avenues for developing therapeutic compounds that modulate the activity of p38a more precisely.
A new study by ICTA-UAB shows that pursuing higher economic growth may jeopardise the Paris goals and leave no viable pathways for humanity to stabilise the climate. Slower growth rates make it more feasible to achieve the Paris goals, with lower economic growth reducing CO2 emissions by 10-13% by 2030.
Researchers have discovered that analyzing changes in sweat metabolism can help diagnose the severity of sleep apnea. The study, published in the Journal of Sleep Research, found that sweat samples can provide valuable insights into energy production and oxidative stress associated with the disease.
The study identifies FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A, regulating its activity and cellular location. This finding may provide potential clinical insights into treating Down syndrome and related diseases.
A 12-week beetroot juice supplement reduced systolic blood pressure by 4.5mmHg and increased walking distance by 30 meters in COPD patients. The nitrate-rich supplement improved cardiovascular risk markers, suggesting potential benefits for everyday life and heart disease prevention.
A phase-one human clinical trial shows that Omadacycline causes a distinctly different effect on the gut microbiome than Vancomycin, making it a safe drug option for patients at high risk for C diff infection. The antibiotic achieves high concentrations in the gut quickly, reducing the risk of long-term colonization.
Nanoparticles loaded with antibiotics and antimicrobial compounds inhibit TB progression and overcome resistance without cell damage. The technology shows promise for a shorter treatment strategy against multidrug-resistant strains of Mycobacterium tuberculosis.
Researchers found that less than two percent of patients in Medicaid and commercially insured plans received Z-codes to document Social Determinants of Health. The study highlights the need for improved tracking and documentation of SDOH in healthcare settings, with recommendations for policy changes and provider education.
The scientific community must create a flexible governance framework to ensure equity, prevent unintended consequences, and maximize positive impact. To achieve this, the authors suggest advancing AI infrastructure, democratizing access to research and outcomes.
A systematic review and meta-analysis found that individuals exposed to childhood trauma are at an increased risk of experiencing chronic pain and pain-related disability in adulthood. The study highlights the urgent need for targeted interventions to address adverse childhood experiences.
Researchers at KIT have developed a method that uses radiation more efficiently to produce images of micrometer resolution, allowing for longer observation times of small living organisms. The method combines X-ray phase contrast with a Bragg magnifier and photon-counting detector.
Researchers at HKUMed successfully cured stage 4 liver cancer by reducing it to stage 1 using a combination of stereotactic body radiation and immunotherapy, followed by successful removal through living donor liver transplantation. An 85-year-old patient with two liver cancers was also treated and recovered well.
A study found that clinicians can be fooled by biased AI models even with provided explanations, leading to serious declines in accuracy. While accurate AI models improved diagnostic decisions for some demographics, biased models worsened decisions for others.
Researchers analyzed gene expression and single-nucleotide polymorphisms in two modern Japanese malting barley cultivars to uncover the 150-year history of Japanese beer barley breeding. They found unique features related to malting quality and BaYMV resistance, highlighting the importance of preserving genetic diversity.
A joint research team has reported the discovery of buried palaeo-polygonal terrain beneath Utopia Planitia on Mars using the Zhurong rover's radar. This finding suggests that ancient Mars experienced a cold polar region and significant climate changes.
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
Deep learning models have been developed to analyze X-ray diffraction data, improving the search for new materials. The models can sift through large amounts of data generated by X-ray diffraction techniques, providing valuable insights into material structure and properties.
Researchers have analyzed mollusk shells from polar expeditions to gain insights into the ocean's natural chemistry before significant nuclear testing in the 1960s. The findings suggest that the tests disrupted the balance of carbon-14 in the atmosphere, making it challenging to date fossil samples using traditional methods.
The use of 'trip-killers' to shorten psychedelic drug trips is a growing concern among doctors, with benzodiazepines and antipsychotics being the most frequently recommended options. However, warnings about their potential side effects are rarely included, highlighting a need for greater awareness.
Patients screened in emergency departments (ED) are more likely to screen positive for Social Determinants of Health (SDOH) needs compared to primary care patients. Primary care may be better optimized to address SDOH needs, with lower screening rates.
Researchers have discovered the oldest known fossils of the Frankincense and Myrrh family in Indian chert, dating back to the Cretaceous period. The fossils were preserved in pyrenes, which are woody dispersal pods that protect seeds from digestion.
A systematic review and meta-analysis of 20 observational studies found a significant association between sedative-hypnotic medication use and an increased risk of fractures. The study estimates that users have a 30% higher risk of fractures compared to non-users, with the highest risk associated with benzodiazepine and z-drug use.
A new long-term study has found that vervet monkeys in neighboring groups have distinct social traditions, with some exhibiting more affiliative behaviors than others. The researchers observed that males adapted their social style to match their new group, suggesting a phenomenon akin to social conformity driven by peer pressure.