This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
A new study found that people with Alzheimer's dementia who were treated with lipid-lowering statins showed slower cognitive decline compared to those not treated. The researchers emphasize caution due to the observational nature of the study and initial concerns about statins' effects on patients with dementia.
Researchers have discovered a protein called NEMO that prevents the formation of toxic protein aggregates in Parkinson's disease. By labeling proteins for degradation and interacting with autophagy machinery, NEMO promotes the breakdown of harmful aggregates, potentially leading to new therapeutic strategies.
Scientists have discovered the protein that enables poison dart frogs to accumulate and store potent toxins in their skin for self-defence against predators. The findings may suggest potential therapeutic strategies for treating humans poisoned with similar molecules.
Brazilian researchers developed a 3D zinc oxide photocatalyst that efficiently degrades sertraline, an emerging pollutant contaminating groundwater. The material's high photocatalytic activity and stability make it suitable for wastewater treatment.
Researchers at Boston Children's Hospital developed a predictive model for accessing prenatal care services in rural Amhara, Ethiopia. The model incorporated data on education, income source, diet, and history of previous pregnancies, identifying factors that predict failure to attend prenatal care visits.
The AGA releases its first comprehensive evidence-based guideline for managing pouchitis, a complication of ulcerative colitis surgery. The guideline recommends treatment with antibiotics and multi-strain probiotics to prevent recurrent pouchitis.
A new study by Southern Methodist University's Neely Myers found that young people with early-onset psychosis are ambivalent about stopping substance use. Participants offered feedback on ways to improve care, including more information about substance use and strategies for addressing psychological and physical pain.
A study found that patients with refractory large B-cell lymphoma who received bendamustine before CAR T-cell therapy had a shorter progression-free survival and overall response rate compared to those who did not receive bendamustine. The use of bendamustine should be avoided in these patients when possible.
A 15-year-old girl developed bilateral vocal cord paralysis after a COVID-19 diagnosis, highlighting the potential for nervous system complications. The case report suggests that vocal cord paralysis may be a neuropathic complication of SARS-CoV-2 infection.
Researchers at the University of Bath and University of Surrey have developed a method to introduce degradable bonds into thermoset polymers, making them more easily recyclable. The study found that gels with breakable bonds retained their properties better when reformed after degradation.
A diabetes drug called dulaglutide may significantly lower a woman's risk of substantial weight gain after giving up smoking. In contrast to men, women are five times as likely to experience substantial weight gain after stopping smoking, according to the study.
Researchers are leveraging AI/ML to improve health outcomes, but human judgment is still crucial for model selection and data quality. Explainable AI can enhance transparency and acceptance in clinical practice.
A University of Limerick study examined the association between adverse childhood experiences and premature mortality. The research found that self-acceptance and purpose in life are crucial factors explaining why childhood adversity is linked to future longevity.
A new study investigates how people perceive and claim authorship of artificially generated texts, revealing that perceived ownership does not always align with declared authorship. Researchers found that participants who wrote the text themselves felt a stronger sense of ownership, while those who relied on AI ghostwriters did not.
New research reveals that Black women are more likely to develop endometrial cancers called serous carcinoma and carcinosarcoma, which are more aggressive than those found in white women. The study also showed that Black patients have a higher risk of having copy number-high or TP53 abnormal tumors, which have worse outcomes.
Researchers have found a superconducting material that can be controlled to switch its properties on and off, potentially leading to more efficient large-scale computing. The discovery could enable the creation of energy-efficient switchable superconducting circuits, revolutionizing industry electronics.
Research at Washington State University found that nurse aides with more consistent schedules and co-workers had lower turnover rates. The study estimated a 1.9% reduction in turnover for each additional hour worked.
Researchers at the University of Surrey studied dog owners' motivations and behaviors when traveling with their pets. The study highlights the importance of providing clear information and welcoming services for dogs, which can enhance the travel experience for both humans and animals.
The giant bacterium Epulopiscium viviparus has modified its metabolism to make the most of its environment, using a rare method to produce energy and harvest nutrients from its host's gut. This unique approach allows it to thrive in extreme conditions, with similarities to how mitochondria function in more complex organisms.
A comprehensive review challenges traditional trust and distrust mindsets, instead advocating for an alternative Cartesian mindset. This evaluative approach has shown promise in distinguishing between true and false information, reducing the propagation of disinformation.
A new genetic atlas details the gene expression programs that drive zebrafish development, revealing insights into human embryonic growth and the origins of diseases such as gastrointestinal disorders. The atlas provides a comprehensive resource for studying cell development and differentiation in vertebrates.
Researchers identified Elovanoid-34, a molecule that modulates the activity of TXNRD1 protein, which regulates antioxidant defenses. This discovery opens new therapeutic avenues for degenerative brain and eye diseases, as well as promoting healthy aging.
Scientists simulated the runaway greenhouse effect, transforming habitable climates into hostile environments, with significant changes in atmospheric structure and cloud coverage. The study provides key insights for the search of life elsewhere, as it demonstrates a critical water vapor threshold beyond which a planet cannot cool down.
A new study explores the intensity of impatient emotion during different phases of a waiting period. The research found that people experience the highest levels of impatience as the end of the wait approaches, driven by their desire for closure.
A Yale study finds that per- and polyfluoralkyl substances (PFAS) promote cancer migration by increasing cell motility and altering metabolic profiles. The study suggests that these 'forever chemicals' could contribute to cancer metastasis in living organisms.
Researchers have made significant strides in understanding the relationship between hydrogen partial pressure and PEMFC performance, revealing a pronounced decline in performance as hydrogen partial pressure decreased. The study aims to simplify fuel cell quality testing, cost reduction, and reduced safety requirements.
Researchers found that pre-zygotic germline variants and post-zygotic hypermethylation at 11p15.5 predispose patients to bilateral Wilms tumor. This study provides new insights into the genetic and epigenetic mechanisms underlying the disease, with potential implications for treatment decisions and clinical trials.
A study published in The BMJ analyzed Barbie's medical and scientist dolls and found they largely depicted white, adult, female doctors with limited specialties. The research highlights the need for more diverse and accurate representations of medical professionals and scientists in toys to inspire young girls.
A new method can help estimate the prevalence of disease in free-ranging wildlife by accounting for animal clustering. This approach may reduce the number of samples needed to detect a disease. The researchers focused on Chronic Wasting Disease (CWD) in deer, which tends to cluster in family groups, making this method particularly useful.
Researchers found apes recognize photos of friends they haven't seen in over 25 years and respond more enthusiastically. The study demonstrates the longest-lasting social memory outside humans, suggesting a common ancestor link and potential for great ape culture evolution.
New ASU research models the benefits of combining heat adaptation strategies with mitigation efforts to lessen extreme heat exposure in major US cities. The study finds that Northeast and Midwest regions can expect greater benefits, while Sun Belt cities face limited reductions.
Researchers found that pancreatic enzymatic replacement improved behavioral function in preschoolers with ASD, including reduced irritability, hyperactivity, and lethargy. The treatment had minimal side effects and demonstrated potential for addressing co-occurring maladaptive behaviors.
A team of researchers has identified the allosteric control sites found in the protein KRAS, providing a comprehensive map for controlling its effects. The study offers promising targets for safer and more effective drugs, with potential implications for cancer treatment.
Only 4.1% of hospital encounters for opioid overdoses led to opioid agonist therapy (OAT) initiation within a week of discharge from hospital, highlighting missed opportunities to prevent future mortality and morbidity related to opioid use disorder. Studies show that prompt OAT initiation in the emergency department is crucial to redu...
The study of 146 ancient Balkans reveals a diverse, cosmopolitan Roman Empire with African and Eastern European immigrants. The team identified three individuals of African origin and a large demographic influx from the Anatolian Peninsula during Roman rule.
A new study on the role of polls in South Korea highlights the limitations of polling in a democratic society. The research finds that technology, methodology, intentions, and reporting can affect poll results, leading to a social construction of public opinion influenced by pollsters and media.
A recent study using AI to analyze registry data on people's residence, education, income, health, and working conditions can predict life events such as personality and time of death. The model outperforms other advanced neural networks and provides precise answers despite ethical concerns about sensitive data and bias.
The study aims to refine and validate a set of remote-testing methods called R-CARE Toolbox to assess older adults with dementia in diverse populations. Participants will undergo comprehensive assessments both in-person and remotely, followed by follow-up assessments at 18 and 36 months.
A new study analyzing data spanning over three decades finds a concerning trend of increasing wildfires in the eastern United States. The research highlights the need for proactive forest management and individual preparedness for people living in the region, particularly in areas with the highest risk from wildfire.
A new study reveals that international recognition played a crucial role in shaping Libya's conflict, with contact and support from other countries affecting political actors' identity, resources, and legitimacy. The study argues that non-recognition can create change and is geopolitically inevitable.
A novel lexical simplification (LS) method, PaGeLS, is proposed to simplify sentences by generating substitute words without altering meaning. The method achieves state-of-the-art results, surpassing previous LS methods in candidate ranking and word substitution accuracy.
A new study published in Frontiers in Artificial Intelligence found that training in Interlingual Respeaking, a new practice combining human collaboration with speech recognition software, can improve language professionals' cognitive abilities. The research, conducted by the University of Surrey, showed significant enhancements in wor...
PSI researchers develop antibody-like proteins that accelerate Botox's effects on nerve signals, suggesting faster pain relief. The discovery opens new options for therapeutic use of botulinum toxin A1 in treating conditions like cramping muscles and faulty nerve signals.
Researchers have identified sST2 and suPAR in the blood of dengue patients, which could accurately predict patients at risk of severe dengue. The test kits would improve patient outcomes by distinguishing between non-life-threatening cases and severe dengue, requiring hospitalization.
Researchers revisited melatonin's effects on cancer in mice, finding that nighttime administration inhibits chemically induced mammary tumor development. The study highlights the importance of timing in using this freely available compound for cancer prevention and treatment.
Researchers found that Ebola virus creates tunneling nanotubes to transfer particles to new cells, evading treatments and spreading infection. The discovery suggests a new route of dissemination for the deadly virus.
A new study examines the impact of public benefit programs on child maltreatment rates across different racial and ethnic groups. The research suggests that these programs may exacerbate existing disparities, with white children facing lower rates of investigation compared to their Black and Hispanic counterparts.
A new Doctor Who episode aired during the festive period is associated with lower death rates in the subsequent year across the UK. The study highlights the positive effect doctors can have when working during the holiday season, suggesting that watching a doctor care for people may encourage health-seeking behavior.
Researchers at Lancaster University find that the 'r' sound is becoming weaker in England, with most young speakers softening it to an elongation of the vowel. This decline is predicted to continue, potentially erasing traditional dialects and linguistic homogenization.
Out-of-hospital care digital solutions offer flexible, convenient, and personalized healthcare options with higher accessibility. The integration of technologies and the health system is crucial to navigate multi-stakeholder collaboration in out-of-hospital care.
The new platform, Arras Energy, simulates how all parts of an electric grid work together, making it easier to understand and apply the results. The tool can help utilities harden their distribution systems against extreme weather and integrate renewable energy sources.
Researchers identified key proteins involved in the process, including mTOR and TSC2, which can be targeted to slow or halt disease progression. The study's findings suggest new therapeutic strategies to save dopaminergic neurons and alleviate motor and cognitive symptoms.
A new study found that daily toothbrushing among hospitalized patients is associated with lower rates of hospital-acquired pneumonia and ICU mortality. The study, which analyzed data from over 2,700 patients, also showed that toothbrushing was linked to shorter durations of mechanical ventilation and ICU length of stay.
A team of researchers from Okayama University discovered the recognition mechanism behind the repair of damaged photosystem II protein D1 by FtsH protease. Oxidized tryptophan amino acid residues play a critical role in this process, and understanding their function is essential for improving crop tolerance.
A comprehensive digital database has been created to document over 20,000 species known to produce sounds underwater, including 729 confirmed and 21,911 likely producers. This inventory can revolutionize marine science by providing valuable insights into species interactions and environmental impacts.
A systematic analysis by researchers at Boston University School of Medicine finds that funding for key TB risk factors, such as undernutrition and alcohol use, is significantly lacking. The study highlights the need for increased NIH funding to address these comorbidities and realize global TB elimination goals.
A study published in Nature predicts that climate change will lead to a 9% loss of ecosystem services by 2100, with the poorest 50% of countries expected to bear 90% of the damages. The study's findings highlight the importance of accounting for natural systems and human well-being within economic frameworks.
A recent VCU-led study found that rising temperatures can make it harder for dragonfly nymphs to control mosquito larvae populations. As a result, there could be nearly twice as many mosquito larvae reaching adulthood in warmer temperature pools.
Scientists at the University of Washington School of Medicine developed a novel protein design approach using AI, creating proteins that bind to challenging biomarkers with exceptionally high affinity and specificity. The breakthrough has implications for drug development, disease diagnosis, and environmental monitoring.