Graz researchers investigate homocysteine's impact on the aorta, finding elevated levels lead to stiffer and less elastic vessels. This discovery contributes to understanding of cardiovascular diseases like atherosclerosis.
Researchers create nanoparticles shaped like bottlebrushes with antibodies guiding them to tumor sites, delivering a large range of chemotherapy drugs directly to cancer cells. This approach reduces the need for potent drugs and enhances customizability of treatment options.
Virginia Tech researchers create method combining MRI, fluid dynamics, and algorithm to identify hidden glioblastoma cells. The technique uses fluid flow patterns to predict tumor re-growth, allowing for more aggressive surgical approaches. This technology has potential to improve cancer treatment outcomes
Researchers at Harvard Medical School have designed an AI model that identifies treatments for diseases by pinpointing genes and drug combinations. The new tool, PDGrapher, shows superior accuracy and efficiency compared to other similar tools.
Researchers used advanced X-ray imaging to track how tiny defects in stainless steel respond to hydrogen exposure. The study revealed three key changes once hydrogen was introduced, allowing internal defects to move more easily and leading to unexpected failure in metals.
The PALOMA-2 study found that subcutaneous amivantamab every 4 weeks, combined with daily oral lazertinib, yields a high objective response rate in patients with previously untreated EGFR-mutated advanced non-small cell lung cancer. This dosing regimen offers fewer administration-related reactions and improved convenience for patients.
A new study suggests that low-dose CT screening may be effective for detecting lung cancer in Asian women who have never smoked. The Female Asian Nonsmoker Screening Study found a lung cancer detection rate of 1.3% among the screened population.
A large-scale survey by Lung Cancer Europe identified critical communication barriers affecting information access and understanding among lung cancer patients and caregivers. The study found that complex medical language was a major obstacle to shared decision-making, with only 56% of respondents feeling their opinion was considered i...
A study of 40,000 users over 15 years found that musical taste becomes more refined and personal with age, with younger listeners exploring a wide range of contemporary music and older listeners returning to their youth favorites. Nostalgia is a strong driving force in middle age and beyond.
A new study suggests that the high prevalence of Autism Spectrum Disorder in humans is linked to the rapid evolution of specific brain cell types and genes. The research found that human brains contain a unique array of neuronal cell types that evolved rapidly compared to other primates.
Dr. Gerhard Andersson's pioneering work in internet-delivered cognitive behavioral therapy has produced over 200 controlled trials and transformed mental healthcare accessibility across continents.
Dr Oliver Pain develops GenoPred platform advancing personalized mental healthcare worldwide through accessible genetic tools, democratizing access to cutting-edge genomic methodologies. His work aims to reduce global health inequities by developing inclusive polygenic scoring methods that perform accurately across all ancestry groups.
A new technique uses ground-based observations and DART data to calculate safe asteroid deflection spots. The method takes into account asteroid shape, surface topology, rotation, and mass to minimize the risk of pushing the asteroid through a 'gravitational keyhole'.
Researchers successfully etched hafnium oxide films at atomic-level precision and smoothness without halogen gases. The new method uses nitrogen and oxygen plasmas to form volatile byproducts, resulting in reduced surface roughness and improved device performance.
A study by Dr. Esther Sternberg highlights the importance of social engagement, intellectual stimulation, purposeful activity, humor, and spiritual exploration in achieving exceptional cognitive and social functioning in advanced age. Dr. Reichlin's example challenges conventional assumptions about aging trajectories.
New research questions the origin of organic molecules in Enceladus's plumes, suggesting they could be formed by radiation on Saturn's surface rather than originating from the sub-surface ocean. This challenges astrobiologists' assumptions about the moon's habitability.
A new survey across seven large countries in the Global South reveals both depth of climate knowledge and trade-offs citizens face when weighing climate policies against other urgent needs. Strong support is found for earmarking revenues from carbon taxes for health and education programs.
A new review warns that strobilurin fungicides, widely used in farming, are contaminating staple foods, water, and human bodies. Small amounts can cause harm, interfering with cell energy production and potentially disrupting hormones.
Six Japan-led programs will be presented at the Science Summit UNGA80, addressing global challenges such as food and water security, rare diseases, inclusive education, and research ethics. The programs are open to a global audience and offer free registration.
The Global RETFound initiative aims to develop the world's first globally representative AI foundation model in medicine, addressing health inequalities and AI bias. The project involves a diverse dataset of over 100 million fundus photographs sourced from 65+ countries.
A comprehensive study assesses decarbonization's ramifications on global poverty and inequality, revealing the potential for redistributing domestic carbon revenues to alleviate poverty. However, careful policy design and international cooperation are crucial to address social development issues in developing countries.
Scientists have synthesized organic compounds that exhibit universal magnetic behavior attributed to linear band dispersion (LBD). The discovery accelerates understanding and application of quantum materials for advanced IT technologies.
This article introduces post-quantum cryptography, emphasizing its mathematical foundation in lattice theory and positive definite quadratic forms. The study explores the shortest vector problem (SVP) and closest vector problem (CVP), crucial problems for further development of lattice-based cryptography.
The International Telecommunication Union is strengthening its collaboration with academia to gather insights on emerging technology trends. The new Academic Advisory Body will produce informative policy briefs and forward-looking analyses on the evolving role and impact of innovation.
Researchers have created face-/edge-shared 3D perovskitoid single crystals with suppressed ion migration, providing a new pathway for stable and high-sensitivity X-ray detection. The team's design addresses the long-standing issue of ion migration in traditional perovskites.
A novel, low-cost catalyst made from peanut shell-derived biochar and BiFeO₃ achieves rapid inactivation of antibiotic-resistant bacteria (ARB) within minutes. The system demonstrates high efficiency and durability, offering a potential solution to tackle antibiotic resistance pollution in aquaculture wastewater.
A nationwide study of secondary school pupils in England found that bright children from poorer backgrounds are twice as likely to be admitted to hospital with mental health problems. They are also more likely to be treated for alcohol and drug use, self-harm, and pregnancy-related issues.
The new textbook bridges the gap between traditional divisions in teaching and practicing tectonics, seismology, geodesy, and geodynamics. It provides a basis to explore fundamental connections between the planet's deep interior and surface.
Developing fly embryos use different strategies to prevent 'tissue tectonic collision', a fundamental engineering problem during development. The cephalic furrow forms and disappears without leaving a trace, but its evolutionary significance was unclear until now.
A new study found that Australian women of reproductive age taking GLP-1 receptor agonists are not using effective contraception, despite known risks during pregnancy. The research revealed a higher risk of pregnancy among younger women with diabetes and those without diabetes in their early thirties.
Researchers developed photo-inducible binary interaction tools (PhoBITs) to precisely control gene expression, cell signaling, and immune responses. PhoBITs enable targeted treatment with minimal side effects, opening new avenues for cancer therapy, immunotherapy, and regenerative medicine.
A new study found that the end of COVID-era federal funding led to a significant increase in uninsured children visiting emergency departments in Texas, with 45.2% more visits than before. The share of commercially insured patients also rose 12.5%, while Medicaid-insured visits declined by 11.7%.
A review analyzes strategies for energy-level alignment in perovskite solar cells, including perovskite absorber engineering and ETL/HTL optimization. Real-world case studies validate the effectiveness of these approaches.
A large portion of people with diabetes remain undiagnosed or receive suboptimal care. The study found that 44% of those aged 15 and older with diabetes are unaware of their condition, with substantial regional diagnosis and treatment disparities.
A multilayer film developed by University of California engineers reflects heat while letting through light needed for photosynthesis. This could make greenhouses more water- and energy-efficient, with minimal impact on crop yields. The film reduces near-infrared light passing through by almost 90%.
Researchers have developed a game-changing solution for wastewater treatment, delivering unprecedented performance in electrochemical oxidation of persistent pollutants. The 3D-printed electrodes reduce reliance on critical raw materials and cut fabrication costs by 30%, offering a scalable, metal-free path to sustainable water treatment.
Researchers have developed an artificial cartilage material that responds to pH changes in the body, releasing anti-inflammatory drugs precisely where and when needed. This approach could improve arthritis treatment outcomes by continuously delivering pain-relieving medication.
As Arctic permafrost thaws, geochemical reactions unleash metals like cadmium, harming fish and disrupting ecosystems. The Salmon River's transformation poses indirect threats to Indigenous communities and other species.
Researchers developed a novel zwitterionic electrolyte additive using anionic group design to eliminate hydrogen evolution reactions and zinc dendrite growth. MPC emerged as the most effective additive due to its dual functionality, offering promising solutions for ultra-stable and long-life aqueous zinc-ion batteries.
Researchers used AI models with integrated clinical and claims data to predict chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). The study found that the models outperformed single data source models and reduced racial bias. The findings can inform likelihood and management of CKD, supporting targeted interven...
Researchers have developed a new approach to manufacturing multicolour lenses using metamaterials, overcoming major limitations of metalenses. The design enables polarisation independence and scalability through mature semiconductor nanofabrication platforms.
Stefan Kappe, a leading expert in genetic engineering of parasites, has been appointed as the new Director of the Center for Vaccine Development and Global Health at UM School of Medicine. He will focus on developing genetically engineered live-attenuated pathogens to combat malaria infection.
Researchers developed an AI tool to assess tambaqui fish stress levels based on their lower half body coloration. The study found that stressed fish became darker, and the trait is heritable, impacting animal welfare and farming practices.
The article explores the fundamental principles and applications of current oral anti-tumor and anti-infective vaccines, discussing considerations necessary for designing future oral vaccines. Oral vaccines can be used for tumor therapy and prevention of various infectious diseases, improving immune defense.
Researchers explore FtsZ's potential as a therapeutic target for bacterial cell division, highlighting current advances and future directions. Despite progress, challenges persist, including weak binding affinities and evolving drug resistance.
A 14-year study highlights the importance of diagnosing and treating obstructive sleep apnea in people with type 2 diabetes. The research suggests that continuous positive airway pressure (CPAP) treatment can reduce mortality risk by up to 26%.
Researchers found that neutrophil protein Relmy pokes holes in heart cells, promoting dangerous heart rhythms and cell death. The study suggests targeting immune cells may help prevent sudden cardiac death and arrhythmias.
Resistance mutations and the blood-brain barrier pose significant hurdles to targeted treatment efficacy in NSCLC patients with brain metastases. Emerging evidence suggests that ABCB1 and ABCG2 drug transporters play a crucial role in differential efflux of targeted inhibitors at the BBB.
The Lung Cancer Genetics Study has launched an open-source data platform, offering no-cost access to de-identified data from consenting participants. Researchers can conduct analyses on germline genotyping, self-reported health and exposure data, and cancer-causing driver mutations, with longitudinal datasets to be added over time.
A population-based study found that CT radiation exposure before conception may increase the risk of spontaneous pregnancy loss and congenital anomalies. Women with prior CT scans were more likely to experience miscarriages, ectopic pregnancies, or stillbirths, as well as birth defects in their offspring.
Keith Cole has received a five-year grant from the National Institute on Aging to conduct integrated research on dual decline, mobility, cognition and aging. This research aims to identify predictors and treatment targets for older adults at risk of physical and cognitive decline.
A research team at DGIST has successfully developed a drop-and-spread inkjet printing technique to fabricate high-sensitive biosensors. The technology enables precise sensor fabrication without expensive equipment, showing potential for early diagnosis and real-time monitoring of neurological diseases.
Researchers at Penn State developed CitraBoneQMg, a biodegradable scaffold that combines magnesium and glutamine with citric acid to promote bone growth. The implant increased bone growth by 56% in rats compared to traditional implants, demonstrating its potential for treating complex fractures.
Researchers used multiple agronomic models to examine the effects of climate-smart agricultural practices on carbon sequestration and greenhouse gas emissions. The study found positive effects in both studied locations under a baseline scenario, but negative effects in a worst-case scenario.
A new study reveals cancer cells can convert a ketone into acetyl-CoA through an alternative pathway, reshaping the relationship between diet and cancer. This finding suggests that glucose may not always be the primary nutrient source for cells, adding to the complex understanding of cellular metabolism.
Researchers at Indiana University School of Medicine have developed a novel candidate drug that shifts the behavior of immunosuppressive regulatory T cells, turning them from cancer protectors into tumor fighters. The study shows promising results in clearing triple-negative breast cancer tumors and treating other aggressive cancers.
A study found that fine particulate matter air pollution exposure is associated with increased dementia severity and Alzheimer disease neuropathologic changes. Population-based studies are needed to better understand this relationship.
Researchers discovered a new reductive uric acid pathway that functions without oxygen, which builds upon current knowledge of uric acid degradation. The study found that this pathway produces a metabolite called yanthine, which is elevated in patients with gout and could serve as a biomarker for diagnosing or monitoring the condition.
Researchers developed a novel optical sieve method to detect, classify and count nanoplastic particles in real-world environments. The innovation provides hope for scalable monitoring of global plastic pollution with far-reaching implications for human health and the environment.
Researchers developed a mathematical framework that shows economic growth and environmental sustainability are compatible in developing countries. A 'kindergarten rule' level of pollution abatement is necessary for successful implementation, depending on factors like clean technology availability and foreign aid.