A new study from EMBL researchers has identified 'mechanotypes' as the physical links between genes and body shapes in animals like corals and sea anemones. The study shows how mechanical tissue properties determine shape diversity, providing a framework for understanding how diverse forms arise in animals.
The journal focuses on advancing scientific understanding and expanding engineering horizons through rigorous peer-reviewed, open-access research. ASI aims to be the preeminent hub for pioneering next-generation scientific tools and fostering global collaboration.
Researchers discovered that alpine grasslands could amplify climate feedbacks as warming and wetting stimulate moisture-driven denitrification. Irrigated croplands also exhibited strong N₂O emissions, highlighting the need for improved nitrogen management.
A case-control study found that insurance churn is associated with poorer diabetes management, increased insulin use, and acute complications. Continuous insurance coverage for low-income diabetic patients may lower risk of costly preventable complications.
A team of scientists has identified a novel octameric resistosome formed by an activated wheat CC G10 -NLR immune receptor. The study reveals that the resistosome induces Ca 2+ influx and immune responses through a unique channel architecture, providing new insights into plant immunity.
A study identified metabolic subgroups in diabetes-free Chinese adults to predict 3-year risk of developing diabetes and related complications. The low-risk subgroup had favorable metabolic profiles, while the high-risk subgroup showed poor glycemic control and increased risks of fatty liver disease and cardiovascular events.
Researchers at Harvard University have discovered a way to fully regenerate skin in mice by unblocking an embryonic healing mechanism. The study suggests that removing the block on this mechanism may be sufficient to allow regeneration to occur, potentially leading to new therapies for human patients.
Researchers have developed ultra-lightweight water materials that retain water's inherent thermal advantages while overcoming its density constraints. These materials enable passive thermal management without energy-intensive active cooling systems, addressing the weight burden limitation of conventional hydrogels.
Researchers found that ants continually update their sense of nestmate identity and tolerance for outsiders through repeated exposure, revealing a flexible behavioral foundation for studying social recognition. This discovery opens the door to exploring the neural circuits behind ant social behavior.
Researchers at KAIST discovered that skyrmions can spontaneously emerge from magnetism and lattice deformation in most magnetic materials. This finding could lead to the development of next-generation spintronics technology with higher data storage densities and lower power consumption.
A randomized crossover pilot study found that pre-chemotherapy exercise can reduce cancer-related fatigue and attenuate symptoms. High-intensity interval exercise performed before treatment showed significant benefits on Day 5 post-chemotherapy.
Researchers analyzed electronic health records from over 39,000 adults with diabetes, finding that those who lost insurance had poorer blood sugar control and needed more intensive medications. The study suggests that coverage gaps pose a direct threat to health, particularly for low-income patients.
A Finnish clinical imaging study found that rest tremor in Parkinson's disease is associated with relatively well-preserved dopamine function, challenging the long-held assumption of greater dopamine loss. The study analyzed data from 414 patients and demonstrated a clear correlation between higher dopamine transporter binding and tremor.
Researchers analyzed electronic health records to determine heat exposure thresholds associated with emergency department use in vulnerable older patients. They found that heat-associated ED use among these patients spikes at around 90 F, not 95 F, and that targeted interventions can enhance their heat adaptive capacity.
Scientists create functional machines using DNA, adapting macro-scale robotics principles for nanoscale performance. Control strategies use biochemical methods and physical stimuli to direct movement.
Recent scientific review highlights Ga-LMs' natural fluidity, high electrical conductivity, and biocompatibility, making them suitable for wearable health monitoring systems, soft robots, and implantable medical devices. Advanced patterning techniques enable precise fabrication of Ga-LM-based circuits for high-performance HMIs.
Researchers from Xiamen University have developed a new method to measure coral reef photosynthesis using passive acoustic technology. The study found that the rate of oxygen bubble formation varies systematically with seasons and environmental conditions, providing a way to track reef health and productivity. This non-invasive approac...
The Erhai Lake Basin is a substantial net exporter of atmospheric reactive nitrogen, with annual emissions exceeding local deposition by over 8,200 tons. Agriculture is the primary driver of ammonia emissions, while transportation sector emissions are dominated by nitrogen oxide emissions.
A new questionnaire has been developed to reliably measure patients' anxiety about their cancer progression, with results showing that it provides accurate scores for clinical use. The tool assesses a single dimension of cancer-related anxiety, which has a direct impact on patients' emotional and functional well-being.
Research suggests significant heat-health risks observed among socioeconomically vulnerable populations. This study underscores the importance of developing targeted heat warning strategies to mitigate these risks and prevent emergency department visits among older adults.
Researchers at HKUST developed CarGAP, a chemo-optogenetic tool that uses vitamin B₁₂ and green light to control gap junctions. This innovation allows precise regulation of cell communication, with far-reaching potential for understanding disease mechanisms and advancing regenerative medicine.
A recent study has uncovered a dynamic spleen-to-lung neutrophil axis that operates during antiviral defense, challenging traditional views of pulmonary neutrophil origin. The study found that splenic neutrophils migrate to the lung, replenishing local pools and participating in innate immune defense.
A study published in Nitrogen Cycling reveals that future air pollution controls will reshape oceanic nitrogen deposition, influencing marine productivity and climate feedbacks. Reducing one nitrogen pollutant alone may increase the deposition of another, emphasizing the need for coordinated NH3 and NOx management.
Researchers developed in vitro and in vivo models to track cartilage-to-bone transition, identifying key signaling pathways and transcription factors involved. The study found that some cartilage cells can transition into bone-like cells, challenging the traditional view of bone cell origin.
Researchers have discovered a promising active substance, bemnifosbuvir, that inhibits hepatitis E virus replication and liver inflammation. The study found that bemnifosbuvir effectively blocked the replication of the virus in cell cultures and animal experiments.
A study found that biochar's climate benefits vary by land-use type, with suppressed denitrification-driven N₂O in upland soils and enhanced multi-pathway N₂O production in flooded paddy soils. Precision soil management practices are crucial for scaling up biochar applications.
Researchers developed an AI model that forecasts river flows accurately even with limited local hydrological records. This approach can improve flood warnings and drought planning in regions with sparse monitoring data, addressing a pressing need for accurate water resource management.
Researchers at King's College London have been awarded £191,000 to enhance the prediction of aortic coarctation by adapting their established biomarker from MRI to ultrasound. The goal is to improve the accuracy of CoA diagnosis before birth using routine 2D scans.
A study by European Society of Cardiology found that AI-based ECG interpretation outperformed standard pathways in detecting occlusive myocardial infarction (MI) without ST elevation. The AI tool correctly identified obstructive MI in 84% of cases, with high sensitivity and specificity rates.
Researchers identified SHP protein as a key regulator protecting cartilage from degeneration in osteoarthritis. Restoring SHP levels slowed cartilage damage and improved joint function in mice.
Michael Franklin, former Liew Family Chair of Computer Science, has been appointed Deputy Dean for Computational and Mathematical Sciences. He will lead strategic planning to advance these disciplines and foster collaborations across campus.
A research team led by Prof. Wang Zuankai has discovered the mechanism behind mechanoelectrical perception in sea urchin spines, which allows them to detect water flow instantly. The team has developed a bionic metamaterial sensor using gradient porous structure and 3D printing, holding promise for sensing technology breakthroughs.
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
Researchers found the brain's internal compass, tracking direction and spatial information, remains structurally intact despite changes in memory structures, suggesting it acts as an anchor for memory. This stability could help clarify why spatial abilities deteriorate in Alzheimer's disease.
Scientists have created the first lab-grown oesophagus that safely replaces a full section of the organ and restores normal function in growing animals without immunosuppression. The technology has shown promising results, providing a blueprint for human treatment and offering hope for families affected by life-threatening oesophageal ...
Researchers analyzed genetic data from over 2.2 million individuals to understand how genes shape vulnerability to alcohol, tobacco, cannabis, and opioid use disorders. They found that genetic risk operates along two main pathways: one related to brain wiring and the other specific to each substance.
Researchers have developed programmable 2D material–organic molecule hybrids with high efficiency and nanoscale spatial precision using DNA origami triangles. This approach enables the creation of arrays of solid-state single-photon-emitter ensembles with excellent spectral and intensity stability, opening a route toward miniaturized h...
A comprehensive study reveals substantial declines in many South African raptor and large terrestrial bird species over the past 16 years. Researchers detected sharp declines in threatened and iconic raptors, including the Endangered Secretarybird, highlighting the vulnerability of species dependent on multiple regions.
A computer simulation improved understanding of refugees among Swedish teenagers who experienced simulated migration journeys. The study found that students exhibited increased social understanding and empathetic attitudes towards immigrants.
A deep neural network model has achieved global precision in predicting nuclear charge density distributions, surpassing traditional methods by over 50% accuracy. The model's innovative approach combines physical mechanisms with artificial intelligence to provide a unified description of charge density and charge radius.
A study found that sleep apps can have negative effects on people with insomnia symptoms, causing more worries and stress. While the apps helped some users, younger adults reported stronger effects, while older individuals responded less.
Researchers at the University of South Florida used fluorescent imaging to map out Toxoplasma gondii's cell cycle, revealing its unique growth stages and potential weak points. The study aims to develop safer and more effective treatments for toxoplasmosis, a parasite that infects nearly one-third of the global population.
LazySlide enables systematic whole-slide image analysis using AI models and links visual patterns to text concepts. The study demonstrates its potential in analyzing tissue samples, identifying biological pathways, and reducing the barrier for applying advanced image analysis methods.
A new study calls for dedicated research to guide the sustainable and commercially viable development of Via Ferrata tourism. The sport, which combines elements of hiking, mountaineering, and rock climbing, has experienced rapid growth globally, but lacks a consolidated evidence base.
The study investigated the link between heart attack-induced inflammation and cognitive decline, as well as the potential of PET-based metabolic tumor volume to predict CAR T-cell therapy outcomes. Additionally, researchers combined advanced imaging with genetic profiling to explore hidden metabolic patterns in recurrent brain cancer.
A biomimetic smart insole system integrates high-resolution sensing, autonomous energy supply, and AI-assisted gait diagnosis to monitor lower limb function and disease progression. The system achieves ultra-low detection limits and maintains mechanical stability, addressing existing bottlenecks in wearable gait monitoring.
Climate warming significantly increases plant growth in permafrost regions by altering growing seasons and root penetration, but its impact depends on nitrogen supply. A new study reveals that moss-associated biological nitrogen fixation is a critical factor in sustaining plant growth under warming conditions.
Dr. Chun Li has been awarded the SNMMI Mars Shot Research Fund Award to investigate the PET radiotracer 64Cu-DbCD11b for detecting vulnerable atherosclerotic plaques. The study aims to assess the non-invasive assessment of vulnerable plaques and aid in patient risk identification and treatment.
Researchers Ansel Hillmer and Eric Webb have received the $100,000 Drs. Jane & Abass Alavi Mars Shot Research Award to advance imaging research in infection and inflammation for Alzheimer's disease. They aim to develop a PET radiotracer targeting CSF1R to diagnose and monitor brain inflammation.
Researchers discovered a metabolite called pTOS in pythons that increases appetite suppression in obese mice, leading to significant weight loss. The study sheds light on the power of studying extremes in the animal kingdom and may lead to new weight-loss treatments.
A study of over 340,000 British adults found that low to moderate wine consumption was associated with a significantly lower risk of death compared to spirits, beer, and cider. Moderate wine drinkers had a 21% lower risk of dying from cardiovascular disease, while even low intake of spirits, beer, or cider was linked to a 9% higher risk.
A decrease in colorectal cancer incidence was observed among individuals with negative screening colonoscopy results, particularly men, suggesting risk-based follow-up strategies. Nonadherence to scheduled colonoscopies increased the risk of CRC, highlighting the need for targeted interventions to improve early detection.
A team of ETH Zurich researchers developed a process to convert sawdust into a recyclable and environmentally friendly composite using struvite. The material exhibits excellent fire resistance due to the mineral's non-combustible properties and cooling effect, making it suitable for internal fittings.
The 'leaky pipeline' metaphor oversimplifies the systemic barriers faced by women and marginalized scholars in archaeology. New research highlights multiple forms of inequity that diminish productivity, limit collaborations, and reduce future generations of archaeologists.
Researchers tracked mouse groups during cold exposure and found that individual brain activity influences collective behavior, leading to self-correction when one member is compromised. The study highlights the importance of considering the whole group in understanding brain function.
The Hefei Botanical Garden is a key institution for biodiversity research in East China, with over 5000 plant species preserved, including rare and endangered species. The garden promotes sustainable resource utilization, ecological education, and rural revitalization through its 'Botanical Garden + Agriculture' model.
A study found that the aquatic plant Salvinia auriculata can act as a sink for antibiotics in the Piracicaba River, reducing bioaccumulation and genotoxicity. The plant was able to remove high concentrations of enrofloxacin and chloramphenicol from the water, but its effectiveness varied depending on the compound.
Research reveals postpartum GBS strains with mutations that allow them to survive in the birth canal and resist treatment. Identifying these mutations is crucial for understanding how GBS is evading antibiotic treatment and finding new drug targets.
Streptococcus mitis bacteriocins selectively target S. pneumoniae, highlighting potential as antimicrobial strategies. DNA exchange between species facilitates bacterial adaptation and shapes evolution in human respiratory environments.
Scientists at Osaka Metropolitan University developed high-performance lead-free piezoelectric thin films directly on standard silicon wafers. The films achieved the highest piezoelectric response ever reported for bismuth ferrite, enabling a fivefold improvement in energy conversion efficiency.