About The Study: No unexpected reactions were identified in this analysis of reactions to COVID-19 vaccines among children. Similar to this study, data from clinical trials and V-safe found that irritability was the most common systemic reaction among children ages 6 months to younger than 2 years, followed by fever and fatigue or sleepiness. In contrast to other studies observing a higher prevalence of reactions after the second COVID-19 vaccine dose, this study observed a higher prevalence after the first dose. This difference may reflect maternal vaccination; the first COVID-19 vaccination in this cohort may be some children’s second immunological encounter with a COVID-19 vaccine.
Corresponding Author: To contact the corresponding author, Andrea J. Sharma, PhD, MPH, email aec4@cdc.gov .
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(doi:10.1001/jamanetworkopen.2024.47492)
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