Articles tagged with Immunology
Researchers uncover the placenta distinguishes between antibodies and albumin, allowing for the design of long-acting biologic medicines with reduced fetal exposure. Fusion of IgG antibodies to albumin inhibits transport across the placenta, enabling the development of safer treatments during pregnancy.
The DKMS John Hansen Research Grant supports innovative cell therapy approaches and transplant immunology. The grant enables young researchers to build a network and advance lifesaving therapies for blood cancer.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
Research at UT MD Anderson Cancer Center has identified biomarkers to identify patients with resectable NSCLC who benefit most from perioperative immunotherapy. The center also found that the composition of donor cord blood may influence CAR NK cell therapy outcomes.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
Researchers identified two immune cell populations present in both initial and recurrent arthritis flares, suggesting an immune-memory disease. These cells may serve as biomarkers for high-risk patients or to guide targeted therapies to reduce side effects.
A single-cell atlas reveals that a balance between two macrophage states, with lipid-fueled immunesupressors, tracks clinical outcomes in gastric cancer patients. Tumors with a more permissive immune state respond better to immunotherapy and have longer progression-free survival.
A protein known for sensing cellular stress also acts as a cholesterol sensor in specialized immune cells, enabling them to process dying cells and maintain immune homeostasis. IRE1's removal leads to cholesterol accumulation, negatively affecting cell survival and immune function.
National Jewish Health researchers identified disease-associated gene activity in macrophages and changes in immune cell communication in lung tissue. These findings may lead to targeted therapies and improved diagnosis of pulmonary sarcoidosis.
Researchers explore bacterial extracellular vesicles as a tool for cancer diagnosis and treatment, with potential for targeted delivery of therapeutic molecules and immunotherapy. However, consistency and safety remain major challenges in this emerging field.
Researchers found that infected tadpoles preferred cooler temperatures and regulated their body temperature to slow viral replication. The study suggests that behavioural cooling may help animals combat viral infections, providing a physiological advantage over the detrimental effects of low temperatures.
Recent research found that D-serine accelerates gastric cancer growth by suppressing cytotoxic T-cell activity and promoting immunosuppressive macrophages. High serum D-serine concentrations were linked to ICI therapy resistance in patients, suggesting its potential as a biomarker for disease progression.
Cancer cells' ability to evade the immune system is linked to changes in their surrounding environment, including nearby nutrients and conditions. Researchers discovered that altering these factors can thin the cancer cell's protective sugar coating, allowing the immune system to recognize and eliminate them.
Researchers have uncovered a key mechanism explaining how allergic inflammation in the skin can progress to a body-wide allergic response. IL-13 acts on dendritic cells, enhancing their ability to present allergens and promoting immune responses that produce antibodies.
Researchers discovered how cancer cells exploit palmitate to suppress neutrophils' anti-tumor activity, allowing tumors to survive and grow. By disrupting this process, the researchers restored neutrophil function and reduced metastatic growth in liver metastases.
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center are developing drug-based strategies to enhance cancer immunotherapy for melanoma and potentially other cancers. They identified two promising compounds that could strengthen T cell interaction with cancer cells or make tumor cells more susceptible to destruction by T cells.
A study by King's College London has identified an immune pathway that prevents a normally harmless fungus from developing into a fatal infection. The IL-1 family signalling plays a critical role in containing the fungus, suggesting it may be a broader defence mechanism against other fungal species.
A $3.2 million NIH grant will support a five-year study investigating the role of thymulin, a hormone produced by the thymus, in age-related inflammation and cancer. The research aims to explore whether thymulin can improve cancer immunotherapy outcomes, particularly in older individuals.
A new study has identified over 100 genes in rare immune cells that may contribute to Crohn's disease risk. The researchers used a novel method to map long-range DNA interactions in these cells, revealing unexpected connections between genetic variants and gene regulation.
A study published in the Journal of Cachexia, Sarcopenia and Muscle reveals that deleting transforming growth factor-beta 1 (TGF-β1) from macrophages enhances muscle regeneration and mitochondrial function. The research found that this approach protected against obesity-related muscle wasting and improved exercise performance.
A major Australian study of twins will investigate why two genetically similar people respond differently to infections, diseases, and treatments. The Snow Centre for Immune Health and Twins Research Australia are recruiting 100 pairs of identical and non-identical twins to track immune cell behavior over time.
Researchers found that tumor cells use DDB1 to ubiquitinate PD-L1, allowing it to enter the nucleus and drive immune suppression. A new compound, thalidomide, disrupts this process, restoring sensitivity to immunotherapy in preclinical breast cancer models.
Researchers at La Jolla Institute for Immunology discovered that immune cells in lung tissue express genes associated with autoimmune disease risk. These tissue-resident immune cells may actively drive the development of autoimmune diseases, particularly in women.
Researchers developed a flexible, battery-free hydrogel bioelectronic patch that wirelessly monitors periodontal inflammation and delivers localized miRNA therapy. The system successfully distinguished MMP-9 levels between healthy volunteers and patients with periodontal disease.
New research from Memorial Sloan Kettering Cancer Center sheds light on leukemia resistance to promising new drugs and the role of bone hardness in the immune battle against metastasis. A telehealth tobacco treatment program also shows promise in helping cancer patients quit smoking.
The Alliance QUANTUM trial is testing whether post-transplant consolidation therapy with teclistamab improves survival in patients with primary plasma cell leukemia. Plasma cell leukemia is a rare but aggressive blood cancer with poor long-term survival rates.
Researchers will examine whether online support strengthens brain development linked to emotional and mental health in prematurely born infants. The scalable intervention could transform how families receive support after discharge from the neonatal intensive care unit, bringing evidence-based support into the home.
Researchers developed a quantum machine learning framework to predict which tumor mutations will trigger an immune response. The Q-CHIPP model outperformed classical computing methods and achieved a significant technical milestone by scaling to full-length peptide modeling on quantum hardware.
The PIEM concept introduces a new framework for studying persistent intracellular extraintestinal microbes, which reside within internal tissues and cells. Microbiome research has long focused on barrier surfaces, but PIEMs offer fresh perspectives on host–microbe relationships and the pathogenesis of complex diseases.
Researchers at Tulane University discovered that vesper bats have two distinct copies of genes producing antibodies, which helps them recognize and fight infections. This finding opens up new areas of study on the evolution of immunity and how animals respond to diseases.
A recent study found that exposure to specific bacteria in barn air can protect against allergies, asthma, and hay fever. Researchers identified two key bacteria, Romboutsia timonensis and Glutamicibacter arilaitensis, which mediate the farm effect through certain receptors.
Researchers at Baylor College of Medicine and Houston Zoo have developed the world's first mRNA vaccine against elephant endotheliotropic herpesvirus (EEHV), a deadly disease affecting young Asian elephants. The vaccine has shown promising results in clinical trials, providing protection against severe hemorrhagic disease.
Researchers discovered that blocking autophagy in high endothelial venules reduces inflammation in mice with psoriasis, offering a promising new approach for treating chronic inflammatory and autoimmune diseases. This strategy targets the blood vessels rather than the immune system, preserving normal immune function.
A new study reveals that USP22 regulates B-cell activation and differentiation through the CHD4-CD19 axis. Inhibiting USP22 partially reversed B-cell hyperactivation in Kawasaki disease patients.
A recent study found that human lung tissue contains a vast reservoir of tissue-resident memory T cells (T RM cells) capable of targeting a range of viruses, bacteria, and fungi. These cells reside only in the lungs and can live for years, providing a vital line of defense against severe respiratory infections.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
A study by North Carolina State University researchers found that an AVP stimulation test can reliably diagnose endocrine dysfunction in sick foals. The test, which involves administering arginine vasopressin to stimulate the release of hormones, showed promising results in detecting hypothalamic-pituitary-adrenal gland axis (HPAA) dys...
Researchers found that CRISPR-Cas systems regulate the expression of innate immunity genes to defend against bacteriophages. This layered regulatory hierarchy provides a layer of protection, making it challenging for phages to evade the defense mechanisms.
A three-year project aims to create a new formulation that supports the targeted and less invasive regeneration of injuries affecting intimate tissues. The researchers focus on extracellular vesicles, tiny particles released by cells, to facilitate intercellular communication and tissue regeneration.
Scientists at UVA have developed a new method to target glioblastoma, the most common and deadly brain cancer, by delivering microRNAs through the brain's natural barrier. The approach shows promise in slowing tumor growth and extending survival in animal models.
A new study reveals that hepatocytes release soluble Tim-3 protein to limit immune-mediated damage in response to drug-induced liver injury. The protein binds to Galectin-3 and Galectin-9 to regulate immune cell infiltration, providing protection against subsequent damage.
Researchers from the Keck School of Medicine of USC identified a hormone produced by the thymus that keeps inflammation under control. As we age, levels of this hormone decrease, allowing diseases like cancer to progress. Increasing this hormone improved cancer survival and made immunotherapy more effective in older mice.
A new framework integrates all stages of carbohydrate vaccine development, from antigen production to clinical evaluation. The framework highlights emerging technologies like automated glycan assembly and AI-driven glycoscience to transform vaccine design.
Research reveals that blood vessel endothelial cells produce lipoprotein lipase (LPL), guiding activated T cells to enter tumors and fight cancer cells. LPL enables endothelial cells to present tumor-derived components, acting like a 'wanted poster' to alerting T cells to the presence of cancer cells.
University of Minnesota researchers found that certain immune cells, regulatory T cells, prevent helpful T cells from eliminating hidden cancer cells. By combining treatment strategies, they improved the immune response and reduced cancer spread in preclinical models.
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Researchers at Tohoku University have discovered a previously unknown pathway for B-cell development in chickens, bypassing the bursa of Fabricius. The discovery reveals that B cells originate in the bone marrow and migrate to the cecal tonsils, establishing an IgA-mediated intestinal barrier.
Dr. Rui Yang receives a Burroughs Wellcome Fund Career Award for Medical Scientists to uncover genetic causes of life-threatening immune disorders and identify new treatment paths. The research aims to advance diagnosis and understanding of rare diseases while fostering the next generation of scientists.
A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, researchers reveal. The study found that replenishing beneficial bacteria or treating patients with FDA-approved bile acid sequestrants may reduce breast cancer metastasis.
Scientists at MD Anderson Cancer Center have identified a previously unknown mechanism by which T cells attack and eliminate acute myeloid leukemia (AML) cells. The discovery reveals that AML cells use a CD64-dependent pathway to evade traditional MHC recognition, potentially explaining why AML is sensitive to immune-based treatments.
A specific subgroup of neutrophils signals the immune system to dial down its response, allowing regeneration. The study shows that the fine regulation of inflammation is crucial for healing and that unleashing the right signals can reactivate nerve regeneration.
Researchers developed a new way to uncover differences in how viruses infect and destroy individual microbial cells. The study used a mathematical modeling framework to analyze infection outcomes in individual cells, revealing striking accuracy and new insights into viral behavior.
Researchers developed a new allergen-specific IgE test to detect functional antibodies capable of triggering immune responses in food allergies. The improved AlphaCL method overcomes limitations of conventional tests, maintaining strong signal responses even with serum components present.
Eight Fred Hutch researchers will receive funding for projects guiding pancreatic cancer treatment decisions, improving CAR-T effectiveness, and stopping acute myeloid leukemia development. The Evergreen Fund, an internal grant program, aims to accelerate translational discoveries to commercial viability.
A new study by University of Notre Dame economist Santosh Kumar Gautam found that India's universal immunization programme significantly reduced infant and under-five mortality rates. However, the programme had mixed effects on educational attainment, with some regions seeing increased primary school completion while others experienced...
Researchers at Technion-Israel Institute of Technology discovered that mature, aged cells can revert into active stem cells that regenerate damaged tissue. This finding challenges the prevailing view on tissue regeneration and implies the possibility of therapies promoting natural healing mechanisms.
Researchers created a comprehensive single-cell map of the tumor immune microenvironment in multiple myeloma and its precursor conditions. The study identified five distinct subtypes, or 'ecotypes,' that capture meaningful insights into signaling pathways and genetic programs not fully explained by disease stage alone.
This review highlights metabolic crosstalk between tumor cells and immune cells, shaping the immunosuppressive tumor microenvironment and limiting immunotherapy efficacy. Emerging metabolic intervention strategies aim to overcome therapeutic bottlenecks in skin cancer treatment.
Recent studies have challenged the classical view of immune checkpoints as local suppressive molecules only active in tumor immunity. Instead, ICs participate in systemic immune homeostasis and are embedded in broader inflammatory and metabolic networks.