Researchers at Children's Hospital Los Angeles will recruit 120 children with autism who also have chronic constipation for a year-long study. The goal is to determine if successful GI treatment improves behavioral symptoms in children with ASD.
Researchers at Children's Hospital Los Angeles developed a tissue-engineering technique to grow an entire esophagus from human cells on a biodegradable scaffold. This breakthrough may lead to new treatments for children born with missing portions of the organ, as well as patients who have had esophageal cancer or damaged tissue.
Researchers discovered that mice with Fragile X Syndrome exhibit perceptual learning deficits when using their whiskers to navigate through sensory-rich environments. This study may provide an effective model for investigating brain circuitry alterations and testing drugs to improve symptoms in children.
Researchers at Children's Hospital Los Angeles discovered the origin of retinoblastoma tumors in young children, revealing a single genetic change in the RB1 gene. This finding holds promise for developing novel therapies and advancing understanding of cancer development.
Researchers at Children's Hospital Los Angeles discovered a protein in breast milk called neuregulin-4 (NRG4) that appears to protect against necrotizing enterocolitis (NEC), a potentially lethal intestinal disorder. Formula feeding is a known risk factor for NEC, highlighting the importance of breastfeeding.
Researchers at Children's Hospital Los Angeles have developed a method to multiply natural killer cells from patients with leukemia in the lab. These autologous NK cells can be used to destroy cancer cells, potentially providing a less toxic and more effective treatment for pediatric leukemia.
Researchers at Children's Hospital Los Angeles found that prenatal alcohol exposure can alter brain activation over time, leading to persistent cognitive and behavioral problems in individuals with FASD. The study suggests a possible neural mechanism for the attention problems seen in FASD, highlighting the importance of early developm...
A team of investigators at Children's Hospital Los Angeles is award $4 million to create a high-resolution, four-dimensional map of alveolar development in humans and mice. The LungMAP project will provide unprecedented insights into the formation of the gas exchange surface in the human lung.
Researchers at Children's Hospital Los Angeles found that infants treated with inhaled hypertonic saline had lower rates of hospital admission compared to those receiving normal saline for bronchiolitis. The study, published in JAMA Pediatrics, suggests a promising and inexpensive treatment option to reduce healthcare costs.
Researchers at Children's Hospital Los Angeles have discovered a novel target, B-cell activating receptor (BAFF-R), for chemotherapy-resistant leukemia cells. By targeting this receptor, the team was able to selectively kill cancer cells in mouse models and increase killing of leukemia cells by natural killer cells and macrophages.
A team of researchers has developed a tool to accurately identify the biogeography of worldwide individuals using genetic distribution and geographical distance. This method, called GPS, is sensitive and specific, allowing it to identify place of origin even in ethnically diverse regions like the US.
A study by Children's Hospital Los Angeles found strong correlations between seasonal ambient air pollutants and pregnancy loss in Ulaanbaatar, Mongolia. The researchers discovered a striking seasonal pattern of variation in miscarriage incidence, with increases in December due to increased hours of darkness and coldest temperatures.
Researchers at Children's Hospital Los Angeles successfully created a tissue-engineered small intestine in mice that replicates the intestinal structures of natural intestine. The study paves the way for long-term, durable solutions for children with intestinal failure.
A cancer specialist at Children's Hospital Los Angeles has been awarded $1.7 million by the NCI to develop a new strategy to overcome resistance of cancer cells to radiation therapy. The goal is to create personalized radiation therapy regimens with fewer side effects.
Researchers at Children's Hospital Los Angeles have discovered Eya1 protein phosphatase as a crucial regulator of embryonic lung epithelial stem cells. The correct functioning of these stem cells is essential for healthy lung development, and dysregulation has been linked to developmental disorders and cancer.
Researchers have created a bioengineered protein called CD19-L that selectively targets and destroys leukemia cells, including those resistant to chemotherapy. This breakthrough discovery offers new hope for treating childhood leukemia.
Researchers found that early puberty is associated with greater bone mass, while later puberty results in less, increasing the risk of fracture. This discovery has significant implications for adolescence growth and development, highlighting the importance of timing in shaping adult bone health.
The hospital has established a Diagnostic, Clinical & Research Center for Autism to support clinical and translational research. Participation in the ATN will enable them to engage in cutting-edge clinical and translational research.
Dr. John Wood will investigate energy production mechanisms in red blood cells to determine if glutamine supplementation improves physiology in athletes with sickle cell trait. The goal is to develop an easy and safe therapy to incorporate into athletic training regimens.
A study found that living within 309 meters of a freeway at birth was associated with a two-fold increase in autism risk. Air pollution exposure during pregnancy has been linked to physical and developmental effects on the fetus in other studies.
A pediatric trauma research network is crucial to develop evidence-based recommendations for improving standard of care for children injured in traumatic events. The establishment of such a network could minimize the occurrence and severity of pediatric trauma.
Researchers at Children's Hospital Los Angeles identified PDGF as a key factor in epicardial cell proliferation and transformation. Blocking PDGF signaling impaired epicardial cell proliferation and coronary blood vessel development.
Researchers at Children's Hospital Los Angeles have discovered a way to overcome radiation resistance in leukemia cells by targeting the SYK tyrosine kinase molecular target. This breakthrough could improve treatment outcomes for children with relapsed leukemia, who currently face poor survival rates.
Researchers at Children's Hospital Los Angeles found that obesity increases the risk of acute lymphoblastic leukemia in both mouse models and older animals, suggesting an association between excess weight and cancer progression.
A research consortium at Children's Hospital Los Angeles has received a $410,000 grant to study targeted therapy for children with relapsed or refractory acute leukemia. The Phase I study aims to determine a safe and biologically-active dose of a new drug in young patients with FLT3 and c-Kit genetic mutations.
Researchers at Children's Hospital Los Angeles will investigate how a type of white blood cell called macrophages help bacteria like E. coli accumulate in the blood and enter the brain. This understanding could lead to the development of treatments to prevent meningitis buildup and infection.
The award aims to support Dr. Brown's research on radiation damage and its effects on the immune system. Childhood cancer survivors often suffer long-term health consequences due to radiation therapy, which can cause organ damage and increase the risk of secondary cancers.
A new NIH-funded study will investigate the effects of spina bifida on bone development in children and adolescents, potentially informing prevention strategies for leg fractures. The research aims to understand whether adolescence with spina bifida leads to differences in bone mass or reduced activity due to physical limitations.
A recent study found that naturally occurring protein IL-10 can prevent and reverse brain damage caused by meningitis in newborns. The research suggests that IL-10 acts to clear antibiotic-sensitive and antibiotic-resistant E. coli from the circulation, thereby preventing or restoring damaged brain tissue.