Rapastinel, an antidepressant-turned-opioid-reversal-drug, has shown promising results in reducing withdrawal signs in rats, potentially leading to a new treatment option for opioid dependence. The drug binds to the same receptor as ketamine but with a milder effect, offering a safer alternative to existing treatments.
A study suggests that tert-butylhydroquinone (tBHQ) impairs immune function and makes flu shots less effective in mice. The findings could explain why seasonal influenza poses a major global health threat.
Researchers discovered female bottlenose dolphins have well-developed clitorises with erectile tissue similar to humans. The location of the clitoris near the vaginal opening suggests it can be easily stimulated during copulation.
Children born to women with preeclampsia have higher blood pressure during childhood and increased stroke risk. Treating preeclampsia with sildenafil citrate may help protect offspring's cardiovascular health.
A study found that capsaicin, a compound in chili peppers, inhibits invasion and metastasis of lung cancer cells, slowing disease progression. The researchers also identified the protein Src as a key player in suppressing lung cancer metastasis.
Researchers discovered a protein called neuronostatin that protects against low blood sugar and causes the pancreas to release less insulin. By understanding how neuronostatin works, scientists may develop new ways to treat and prevent hypoglycemia, potentially saving lives.
A new study has uncovered important differences in the biological pathways that lead to cancer for alcoholic fatty liver disease compared to non-alcoholic fatty liver disease. The findings could benefit the more than 3 million people diagnosed with fatty liver disease each year, potentially leading to new cancer prevention strategies.
A study found that breast cancer patients who don't respond to targeted therapy have distinct patterns of epigenetic modifications compared to those who do respond. The researchers identified 879 genes with higher methylation levels in resistant patients, suggesting potential targets for new treatments.
A new study suggests that increasing thrombospondin-1 levels may aid liver recovery after acetaminophen overdose. Mice with higher thrombospondin-1 levels showed improved liver function and reduced cell death compared to those without the protein.
Cancer research highlights canine sniffing detection, spicy compound slowing lung cancer progression. Neurodegenerative diseases examined via gum bacteria link to Alzheimer's and Parkinson's. New therapies target diabetes complications and liver failure.
Recent studies have shed light on the impact of environmental toxins, food additives, and pain management on human health. Research has found that certain antioxidants can protect cells from harm caused by hexavalent chromium, while other substances may weaken the immune system or cause dental damage.
Researchers found kefir supplementation reduced endotoxins, blood pressure, and improved intestinal permeability in hypertensive rats. Kefir restored the natural balance of bacteria and an enzyme essential for normal nervous system function, suggesting a gut-brain axis connection.
Researchers developed an 'Am I Stoned' app that helps users understand their impairment through phone-based tasks. The app showed promise in detecting THC-induced impairments in a natural setting, paving the way for future use in assessing individual performance.
Researchers have developed a platform for 3-D printing food with customized texture and body absorption characteristics, enabling personalized nutrition. The technology has the potential to reduce food waste and meet the increasing demands of a growing world population.
Research suggests that mental fatigue, rather than physical fatigue, has a significant impact on older adults' walking ability. Volunteers performed physically and mentally tiring tasks, with their gait speed and stride length decreasing significantly in those who reported more cognitive fatigue.
Researchers found improved measures of cardiovascular health, beneficial changes in fat tissue, and reduced risk of diabetes in obese women with PCOS who used a hot tub regularly. Heat therapy may reverse some of the inflammation in fat that causes metabolic health impairment.
Researchers used a rocket scanner to take the first whole-body CT scan of a minke whale, revealing insights on whale communication. The team modeled how whales hear low-frequency sounds using custom-developed computer simulation tools.
Researchers found mice with induced heart failure fared better after being treated with antibiotics for five weeks, which sterilized the gut. This suggests that modulating the microbiota could modulate T cell activation and changes in the heart that lead to heart failure.
Researchers at the University of Michigan have developed a new compound that could offer pain-relieving properties without the risk of addiction. The compound interacts with two types of opioid receptors, one responsible for pain relief and another that can reduce addiction liability.
A single mindfulness meditation session has been shown to reduce anxiety and stress on the arteries, with participants reporting reduced anxiety scores even a week later. The study suggests that this brief intervention may help reduce cardiovascular risk in individuals with moderate anxiety.
Researchers found that hemp extract slowed cell migration and reduced inflammation in ovarian cancer cells, suggesting a possible biological mechanism behind its anti-cancer effects. The study's results are comparable to or even better than current ovarian cancer drug Cisplatin, with potential for fewer side effects.
A new study suggests that probiotics can improve liver health by reducing oxidative stress caused by acetaminophen. Researchers found that mice treated with the probiotic Lactobacillus rhamnosus GG suffered less liver damage when exposed to a high dose of acetaminophen.
Research suggests that human-like bipedalism emerged around 3.6 million years ago, allowing for more efficient energy expenditure during long-distance travel. This shift likely responded to climate and habitat changes, enabling ancestral hominins to cover longer distances while foraging.
Researchers have discovered that certain genes are shared between salamanders and humans, which could lead to new therapeutic targets for treating spinal cord injuries. By studying the molecular mechanisms at work in salamanders, scientists hope to understand why humans cannot regenerate nerves after injury.
Researchers have developed biomarkers to detect harmful environmental contaminants in wildlife, enabling faster development of diagnostic tools. Additionally, scientists have created a more sustainable method for producing biodiesel from low-cost cooking oil waste using nanoparticles.
Researchers are using cutting-edge techniques to shed new light on the intricate circuitry behind our thoughts, feelings, and behaviors. Innovative nanocapsules could improve drug delivery for Autism Spectrum Disorder, while mapping brain circuits with rabies and herpes viruses provides insights into learning and memory.
Researchers discovered that fluctuations in estrogen levels affect cells in the brain, making women more susceptible to migraines. The study found higher NHE1 expression levels in male rats and lower levels in female rats with high estrogen levels.
Researchers report four new insights into diet and health: time-restricted eating reduces tumor growth in mice, adults who eat breakfast gain less weight, and alternate-day fasting enhances weight loss. New studies also reveal the importance of taste perception in modulating hunger and fullness cues.
Researchers developed a vaccine to blunt bath salts' stimulant effects on the brain, which could aid recovering drug users experiencing relapse. The vaccine showed promising results in reducing MDPV-induced movement and activity in rodents.
New research finds sugar replacements can cause health changes associated with diabetes and obesity, suggesting switching from regular to diet soda may not be a healthier option. Artificial sweeteners alter the body's processing of fat and energy, increasing the risk of negative health outcomes.
Researchers have identified new treatments for liver diseases, including the use of melatonin receptors to slow disease progression. Additionally, scientists have discovered potential therapeutic targets for acetaminophen-related liver damage and a link between non-coding RNA and alcoholic liver disease.
Scientists have found that a specific protein called thrombospondin-2 (TSP2) is elevated in wounds of patients with diabetes and contributes to delayed wound healing. Removing or inhibiting TSP2 from mice with diabetes led to improved wound healing, suggesting it could be a target for new treatments.
Researchers have made significant breakthroughs in treating pancreatic, colon and breast cancers, as well as developing new pain treatments for chemotherapy-induced peripheral neuropathy. A new compound has shown promise in targeting cancer cell death pathways, while indomethacin has been found to inhibit colon cancer growth.
Janardan K. Reddy, a world-renowned pathologist, has been awarded the ASIP Gold-Headed Cane Award for his significant research contributions to liver biology, particularly peroxisomes and carcinogenesis. He is also recognized for his exceptional teaching and mentoring skills.
The American Association of Anatomists has awarded its Young Investigator Awards to Bhart-Anjan Bhullar, Elçin Ünal, Maksim Plikus, and Helen Bateup for their groundbreaking contributions to cell biology, neuroanatomy, and developmental biology. These young scientists have made significant advancements in understanding the structural f...
Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
The American Association of Anatomists presented its 2018 Award Recipients to recognize outstanding achievements in human anatomy education, scientific research, and leadership. The recipients included Valerie D. O'Loughlin, Kurt Albertine, Jeffrey Laitman, and Jason Organ for their contributions to the field.
Dr. Michael A Gimbrone, Jr has made significant contributions to the field of vascular biology through his research on endothelial cells and the development of methods for culturing these cells. His work has led to a paradigm shift in our understanding of vascular diseases and has paved the way for countless studies and discoveries.
New research suggests that inhaling lavender oil can reduce stress in competition horses by lowering cortisol levels. This study found a small decrease in heart rate after exposure to lavender oil during transport.
Dr. Chad M. Walesky receives the ASIP Young Scientist Leadership Award for his contributions to liver cancer pathogenesis, including a novel function of HNF4α as a tumor suppressor. His work has been published in top journals such as The American Journal of Physiology and Hepatology.
A new study suggests that applying an ice bag to the face could help prevent a sudden drop in blood pressure after blood loss, potentially saving lives among first responders. The technique was tested on healthy volunteers and showed promising results.
Dr. Katerina A. Politi has made significant contributions to the understanding and treatment of EGFR mutant lung cancer. Her research has led to a paradigm-shift in the diagnosis and treatment of lung cancer, including the early adoption of molecular profiling.
Researchers found that the p53 protein plays a key role in preventing acetaminophen-induced liver damage and promoting regeneration. Activation of p53 helps prevent injury progression while inhibition stimulates liver repair, offering hope for new treatment options.
Dr. Xiao-Ming Yin's pioneering research has significantly impacted our understanding of cellular degradation pathways, leading to novel cancer treatment approaches and potential therapeutic strategies for non-alcoholic fatty liver disease.
Transplanted fetal rat liver cells multiply and give rise to new cells in injured adult liver. This breakthrough has implications for treating liver failure without organ transplants.
Research suggests that vitamin A within a high-fat diet can negatively affect liver gene expression associated with glucose and fat metabolism. Rats fed with normal and deficient vitamin A levels showed significant differences in body mass, liver fat content, and insulin signaling pathways.
A new study found that elite rowers who engage in intense training sessions without adequate recovery periods may experience decreased osteoprotegerin levels and increased inflammation, leading to potential bone loss. The research suggests that very intense training without sufficient rest can compromise bone health.
Researchers discovered that inhibiting myostatin production in mice significantly enhances muscle mass and improves markers of heart and kidney health. The findings suggest a promising pathway for protecting against obesity-derived cardiometabolic dysfunction, potentially leading to the development of an 'exercise pill'.
A new 16-year study found that consuming less sodium was associated with higher blood pressure in men and women, challenging the current recommended limits. Potassium, calcium, and magnesium intake showed a significant association with lower blood pressure.
Researchers are using gene-editing platform Crispr-Cas9 to investigate the poisoning power of ancient silver remedy. They aim to create effective antimicrobials and avoid antimicrobial resistance pitfalls.