Researchers discovered that photoaging can be reversed by understanding how UV radiation affects skin fibers. Polina Mamoshina's study using Geroscope software platform analyzed pathway dysregulation in chronologically-aged and photoaged skin.
Scientists from InSilico Medicine have developed an approach to screen and rank geroprotective drugs using big data analysis, identifying compounds with potential geroprotective properties. The Geroscope software was applied to gene expression data derived from stem cells to select five drugs that displayed geroprotective action.
A new biomarker, PAS, has been identified to predict cetuximab response in colorectal cancer (CRC) patients with wild-type K-ras. This finding could help physicians make better treatment decisions, improving patient outcomes.
A team of researchers from InSilico Medicine has successfully mapped the molecular pathway for myeloid-derived suppressor cell (MDSC) cancer progression. The study identifies several proliferation and invasion-related pathways that are key to MDSC's immune-suppressive effects, opening up new avenues for therapy targeting these cells.
GeroScopeTM is a system that evaluates age-related changes in human tissue and predicts the efficacy of drugs with known molecular targets. The technology will be presented at the FEBS-EMBO 2014 Conference, allowing delegates to learn about its functionality.