A new approach uses mouse tests to predict which chemotherapy drugs work best for each patient, offering a promising way to individualize therapy earlier in treatment. The method involves implanting tiny bits of patient tumor into mice, allowing researchers to test multiple drugs simultaneously.
Researchers at Johns Hopkins have found that lung cancer cells exploit the NRF2 gene to detoxify chemicals, including chemotherapy agents, rendering them ineffective. This discovery may lead to new treatment strategies by blocking NRF2 activity, potentially improving standard chemotherapy drug efficacy.
Researchers at Johns Hopkins Medicine have identified a critical protein player in cell communication, which controls calcium flow into cells. This finding sheds new light on the rare cognitive disorder Williams-Beuren syndrome, associated with overly social behavior and spatial learning defects.
Researchers developed a DNA-based vaccine to protect against ragweed allergies, showing a 60% reduction in symptoms. The vaccine works by suppressing acute reactions and helping the body regulate chronic inflammation.
A Hopkins study reveals that T lymphocytes, part of the immune system, play a dual role in organ damage after transplantation. While they produce toxic chemicals that contribute to IRI, they also appear to protect transplanted kidneys from damage. The findings could lead to new strategies for preventing or rapidly treating IRI.
Researchers discovered that fruit flies missing the Gr66a protein consume caffeine as if it were not bitter due to their inability to detect its taste. This finding sheds light on how animals perceive bitterness and has implications for understanding caffeine-induced behavior in other organisms, including humans.
In a study led by Johns Hopkins Medicine, researchers discovered that patients with chronic sinusitis who failed to respond to treatment had severely decreased immune function and lower production of key proteins. The findings suggest new treatment targets for this condition affecting an estimated 32 million Americans.
Researchers at Johns Hopkins Medicine found a link between mild anemia and impaired thinking in elderly women. Those with anemia were four to five times more likely to perform poorly on executive function tests, compared to those with normal blood hemoglobin.
Researchers at Johns Hopkins Kimmel Cancer Center have identified close to 200 mutated genes linked to breast and colon cancer. The genetic code reveals distinct pathways for the development of each cancer type, with some genes crucial for tumor formation. The findings provide a foundation for future comprehensive genetic studies.
Researchers at Johns Hopkins Medicine have identified four mutations in the Desmoglein-2 gene as a significant contributor to arrhythmogenic right ventricular dysplasia (ARVD), a condition that causes sudden cardiac death in young athletes. The findings should increase the accuracy of tests to identify those at risk for ARVD.
Researchers found that a gene for an anti-insect enzyme is up to 250 times more active in people with severe sinus inflammation. The enzyme's presence was linked to chronic sinusitis, which affects an estimated 32 million Americans.
A Hopkins-led study of over 600 people and their families found that siblings, parents, or children of those diagnosed with chronic severe unipolar depression before age 31 have a 2.52-to-1 chance of also having the disorder. This suggests the value of searching for contributory genes.
Johns Hopkins researchers have created an online tool to help advance the search for causes and treatment of rare illnesses, known as 'orphan diseases'. The new database consolidates knowledge on genes contributing to cilia operations in the body, shedding light on their role in various common disorders.
Scientists at Johns Hopkins have identified a previously unknown way the trypanosome parasite that causes African sleeping sickness makes fatty acids. The discovery of this unique biochemical pathway could lead to the development of new drugs to treat the illness.
A large follow-up study of over 50 families has identified more genetic perturbations in Loeys-Dietz Syndrome, providing clearer picture for diagnosis. The study emphasizes the importance of comprehensive clinical evaluations when diagnosing the disease.
Researchers found neural changes in children with untreated sleep apnea, damaging critical brain structures tied to learning ability. Children with severe obstructive sleep apnea showed deficits in neuropsychological performance, including lower IQ test scores.
A Hopkins study shows that combining curcumin and quercetin greatly reduces the size and number of colorectal polyps in patients with familial adenomatous polyposis. The average number of polyps dropped 60.4 percent, and the average size dropped by 50.9 percent.
A national study of 304 physicians reveals primary care doctors often fail to diagnose and refer patients with chronic kidney disease, a condition affecting an estimated 10 million Americans. The study suggests that early detection and referral can slow the progression of kidney disease in high-risk patients.
A Johns Hopkins study shows that moderate exercise has no negative impact on the heart's ability to pump blood or increase in size. Exercise improves heart function and reduces abdominal fat, benefiting those who make gains in physical fitness.
A 'domino' transplant program can effectively double the benefit of altruistically donated kidneys by serving multiple recipients, according to researchers at Johns Hopkins Medicine. The domino-donation model has been shown to increase the likelihood of good outcomes for patients and prioritize those in greatest need.
Researchers will follow over 540 children with mild to moderate kidney disease for four years, collecting blood, urine, and genetic samples. The study seeks to refine an existing method to measure glomerular filtration rate (GFR), a precise indicator of kidney function.
Scientists at Johns Hopkins believe that heat therapy can selectively target and kill cancer cells by disrupting their nuclear protein scaffolding. Preliminary research suggests that this approach could be effective in treating solid tumors, with the goal of improving cure rates.
Hopkins researchers have created a biosensor that allows them to see multiple, real-time chemical reactions in living cells. The sensor can locate where an enzyme is being turned on or off within the cell, providing valuable insights into how chemicals interact with enzymes.
Researchers at Johns Hopkins Medicine found a surprising connection between the energy usage of yeast cells and their genetic material. Removing an enzyme involved in energy production led to the shutdown of 70% of genes and cell death. This study could lead to new strategies for slowing aging and treating cancer.
Scientists at Johns Hopkins have successfully blocked the advance of retinal degeneration in mice with antioxidants, including vitamin E and alpha-lipoic acid. The study found that high oxygen levels in the retina kill cone photoreceptors, which are critical to central vision.
Researchers at Johns Hopkins Medicine found that seniors who give up driving are less likely to enter nursing homes or assisted living centers than those who have never driven. The study included extensive interviews with 1,593 seniors between 65 and 84 years old.
Researchers at Johns Hopkins and the University of Michigan have developed a treatment that helps spinal cord nerves regrow after injury. Using an enzyme called sialidase, they increased the number of new nerve fibers in injured rats by more than twice, compared to untreated controls.
Researchers developed a gene screening method that can detect breast cancer with high accuracy, spotting 15 out of 21 samples positive for cancer. The test uses methylation-specific PCR to identify abnormal levels of chemical tags in DNA, which can be missed by pathologists' naked eye.
Johns Hopkins researchers show that psilocybin can induce mystical/spiritual experiences descriptively identical to those reported for centuries. Subjects who underwent the experience reported positive changes in behavior and attitude, lasting several months. The study's results have significant implications for our understanding of hu...
Researchers at Johns Hopkins have discovered protein machinery essential for maintaining chromosome integrity in cells. Removing sirtuin proteins causes yeast cells to become hypersensitive to chemical agents and spontaneously break chromosomes.
Researchers identified VCP/pr 97 as the protein responsible for destroying defective CFTR in cells, and used RNA interference to block its production. This approach restored chloride transport function and reduced inflammation, offering new hope for cystic fibrosis treatments.
A new guideline called SCRATCH helps pediatricians recognize the source of a rash by considering symmetry, clusters, age, target/time, confused, and household factors. The tool aims to prevent misdiagnoses and costly tests by providing a simple and memorable acronym.
A study by Johns Hopkins Medicine found that tracking computer-based error reports can improve patient safety. The researchers analyzed 1,010 medication errors and found that nearly one-third of all errors occurred with anti-infective medications.
Researchers created a 'cookbook recipe' to restore lost nerve function using mouse embryonic stem cells, growth factors, and specific agents. The approach showed promising results in recovering paralysis in treated rats, with some regaining muscle strength and mobility.
A whole-genome scan for OCD has identified six potentially significant regions in the genome linked to the condition. These regions are found on five different chromosomes and may hold the key to understanding the genetic basis of OCD.
Researchers at Johns Hopkins Medicine have discovered a protein called GCN5 that plays a crucial role in controlling blood sugar levels. By altering the activity of another protein, PGC-1alpha, GCN5 can turn off pathways leading to glucose release from liver cells.
The study suggests that motor learning involves different time scales and implies that slow learning is key to maintaining motor skills in stroke patients. The research team hopes to tailor therapy strategies to target slow-learning systems, improving recovery of muscle control after brain injuries.
Researchers at Johns Hopkins Medicine have developed a surgery to plug the superior canal in the inner ear, stopping severe symptoms of superior canal dehiscence. The procedure has been successful in treating patients with severe dizziness, loss of balance, and hearing loss.
A study published in Nature sheds light on how the body repairs wounds, revealing that a 'scaffolding' protein plays a crucial role in signaling proteins that lead to new protein manufacture and cell growth. Additionally, research in Genes and Development reveals a novel role for this protein in promoting hair follicle growth.
Researchers will test 400,000 SNPs in 552 patients to clarify the role of genes in sporadic ALS. The study's results could strongly shape the search for a cure if it finds gene associations or suggests an environmental cause.
A new study suggests that an individual's unique genetic makeup can affect their risk of developing severe anemia from malaria. Researchers have identified specific genes and DNA sequences that control the production of MIF, a protein linked to malarial anemia.
A Hopkins study found that pediatricians rarely screen patients for Autism Spectrum Disorder (ASD), with 62% citing a lack of knowledge about screening tools. Screening for ASD is crucial to prevent poorer outcomes in children with developmental disorders, but current national efforts may not be effective.
Developed by Johns Hopkins Medicine, online calculators and computerized drug ordering systems significantly reduce medication errors in children. Studies show that these systems can prevent up to 17-18 errors per 100 chemotherapy orders, particularly in pediatric oncology centers.
A newly discovered enzyme in the brain, CPT1c, plays a crucial role in managing hunger and satiety. Mice lacking this gene eat less but gain more weight on high-fat diets due to their brain's inability to regulate energy balance.
A survey of operating room personnel found that general surgical nurses and certified registered nurse anesthetists (CRNAs) consistently rated high for teamwork, while surgeons received the lowest scores. The study used the Safety Attitudes Questionnaire to assess safety attitudes in the OR.
A three-year study of pediatric residents found that working 80 hours per week led to less fatigue and better patient care. Reduced work hours had the most pronounced effect on first-year residents, who reported fewer issues with patient care, communication, and procedures.
A whole-genome study at Johns Hopkins reveals a new gene, NOS1AP, associated with abnormal heart rhythm and increased risk of sudden cardiac death. Approximately 60% of European descent individuals carry a variant of this gene linked to QT interval length.
A new gene, Lazaro, has been discovered to reduce retinal degeneration in fruit flies by enhancing the production of diacylglycerol, a key player in controlling TRP channels. This discovery may have implications for understanding sensory signaling in mammals.
The lizard's parietal eye photoreceptors contain two pigments, allowing it to respond to blue and green light in the same cell. This unique mechanism may have been an economical way to detect changes in sunlight during dawn and dusk. The study proposes a 'missing link' between the light-sensing apparatus of lower animals and humans.
Researchers found that both self-monitoring of blood glucose and precise physician testing of hemoglobin A1c can help diabetics manage their disease. Consistent communication between patients and healthcare professionals is also crucial.