A study published in the Journal of the National Cancer Institute found that rats fed whole tomato powder had a 26% lower risk of prostate cancer death compared to those on control diets. The researchers suggest that whole tomato products and energy balance may offer independent benefits against prostate cancer.
Commentaries question the benefit of early breast cancer screening for women aged 40-49, citing higher mortality rates among screened women. Experts highlight possible biologic explanations and the importance of informed consent, while also warning of potential harms such as false positives and overtreatment.
A study analyzed patterns of SNB use in academic comprehensive cancer centers and found that its use was associated with breast-conserving surgery. The procedure's popularity increased over time, from 8% in 1997 to 58% in the last half of 2000.
A recent study of early-stage breast cancer patients found that tamoxifen is effective in reducing recurrence and mortality regardless of body mass index. However, obesity was linked to increased risks of second cancers and all-cause mortality.
A recent study found that men aged 55-74 who received regular prostate cancer screenings every 4 years had a low rate of interval cancers. The screening procedure showed an 85.5% high sensitivity rate for detecting cancers, suggesting that very few aggressive prostate cancers escape screening.
A new study found that adjuvant chemotherapy did not improve survival rates for patients with surgically removed non-small-cell lung cancer. Additionally, a study on selenium supplementation revealed that it may increase the risk of squamous cell carcinoma and total nonmelanoma skin cancer in individuals at high risk.
A recent study found that North American mammographers are more likely to interpret mammograms as abnormal, leading to higher rates of false positives and unnecessary follow-up procedures. The study analyzed data from 32 community-based screening programs in North America and compared outcomes with those in other countries.
Patients who traveled farther for cancer treatment had improved overall and progression-free survival rates, suggesting that access to information and resources plays a crucial role in cancer outcomes. The study's findings highlight the importance of considering travel distance as a potential factor in phase II clinical trial results.
A new study found that a rapid increase in the incidence of esophageal and gastric cardia adenocarcinomas is linked to modifiable risk factors such as smoking, being overweight, and gastroesophageal reflux. High serum levels of vitamin E are associated with reduced risk of upper gastrointestinal cancers.
Measuring DNA repair enzyme OGG activity found a significant association with lung cancer risk. Smokers and nonsmokers with low OGG activity had higher lung cancer risk compared to those with normal activity levels, with smokers being at greater risk due to smoking alone.
A clinical trial found that oral sodium clodronate reduced the risk of symptomatic bone progression by 21% and mortality by 20% compared to placebo, but with limited statistically significant results due to small population size. However, side effects were common, particularly in older patients.
The Annual Report to the Nation on Cancer statistics shows stabilized cancer rates. A study found carboplatin-paclitaxel is better tolerated in ovarian cancer patients than cisplatin-paclitaxel. Another study linked blood transfusions with HHV-8 seropositivity, while HPV status may predict cervical lesion prognosis
Researchers found that postmenopausal women with a higher body mass index have an increased risk of breast cancer due to elevated estrogen levels. In contrast, heavier men under age 60 or those with family history of prostate cancer may experience lower risks of developing the disease.
A study examined whether limited-field radiation therapy could be an effective alternative to whole-breast radiation therapy for patients at low risk of recurrence. The results showed no significant difference in local recurrence rates or overall survival between the two groups after five years of follow-up.
Researchers found that patients with smoking-related cancers had shorter telomeres than those without cancer, and that short telomeres were associated with a greater cancer risk. Smoking status significantly influenced the effect of short telomeres on cancer risk.
Research suggests that cervical cancer vaccines may be less effective in women who are ovulating, due to fluctuations in antibody levels triggered by sex hormones. The study found higher antibody levels during the proliferative phase and lower levels around ovulation.
Consuming phytoestrogens found in plant foods like soy is associated with a reduced risk of endometrial cancer. Imiquimod has been shown to induce apoptosis in skin cancer cells, while an integrin polymorphism may increase cancer progression. The study on breast cancer survivors also found increased numbers of circulating T lymphocytes.
Researchers found that a paclitaxel combination improved median and long-term survival rates for patients with early-stage SCLC. The treatment also reduced side effects compared to standard chemotherapy.
Research highlights the link between high animal fat intake and increased breast cancer risk, as well as the benefits of gynecologic surgeries in reducing ovarian cancer risk. Protein overexpression is also linked to esophageal cancer development, suggesting a potential target for prevention.
Research identifies three SNPs in PSA gene promoter that increase serum PSA levels, suggesting genotyping may improve prostate cancer detection sensitivity. The findings suggest a lower cutoff value for PSA testing for men with reduced PSA promoter genotype.
Researchers found that HPV16 is less associated with immune status than other HPV types, suggesting it can skirt the immune system. This discovery raises hypotheses about why cervical cancer rates are only moderately increased in HIV/AIDS-affected women.
Women treated with radiation therapy and chemotherapy had a 61% lower risk of developing breast cancer compared to those who received only radiation. The authors suggest that ovarian hormones play a role in promoting tumor growth after radiation, which may explain the increased breast cancer risk in young women exposed to radiation.
Studies on prophylactic surgery for women with BRCA1/2 mutations show a significant reduction in breast and ovarian cancer risk. However, potential biases in study designs, such as confounding by indication and familial-event bias, may lead to underestimation of risk reduction.
Researchers found that high zinc intake was associated with an increased risk of advanced prostate cancer, but not with lower doses. The studies also failed to find evidence of simian virus 40 (SV40) DNA in non-Hodgkin's lymphoma samples.
Researchers found that increasing RKIP expression in metastatic prostate cancer cells decreased their invasiveness and reduced lung metastases in mice. The study suggests that RKIP may be a suppressor of prostate cancer metastasis, offering new targets for cancer control.
A study found that acrylamide triggers mutagenesis by damaging DNA in mammalian cells. Low concentrations of acrylamide increased mutations in a transgene, similar to those caused by the known carcinogen BPDE.
A study suggests that extending screening intervals could reduce lead-time bias and overdetection rates associated with prostate cancer screenings. The research estimates a potential 60-90% increase in prostate cancer incidence, highlighting the need to weigh benefits against risks.
Research suggests that frequent consumption of miso soup and high intake of isoflavones may lower breast cancer risk. Vitamin D analog paricalcitol also demonstrates antitumor activity against myeloid leukemia, myeloma, and colon cancer cells.
A new study found that tamoxifen is effective in reducing breast cancer cell proliferation at lower doses, with decreases in biomarkers associated with cardiovascular disease and blood clots. The results support a potential dose reduction for tamoxifen therapy without compromising its effectiveness.
A study of over 78,000 women found that those who worked rotating night shifts for years had a 35% greater risk of developing colorectal cancer. Additionally, research on melanoma suggests two separate pathways may lead to its development, and polymorphisms in certain genes may be associated with prostate cancer risk.
Researchers found NRAS mutations in 95% of primary hereditary melanomas, but only 10% of sporadic melanomas. The study suggests a link between UV light exposure and the activation of NRAS mutations in early stages of melanoma development.
A study of 7,257 patients with rectal cancer found that those treated at high-volume hospitals had lower mortality rates and higher survival rates compared to those treated at low-volume hospitals. Patients at high-volume hospitals also experienced a lower risk of permanent colostomy.
A new study found that beta-carotene supplementation increased colorectal adenoma recurrence risk among smokers and heavy drinkers. Randomized trials showed a significant decrease in adenoma recurrence risk without smoking or drinking, but paradoxical results when exposed to these lifestyle factors.
Researchers have discovered a second mechanism by which LPA promotes ovarian tumor growth through increased cyclin D1 protein levels. Additionally, the identification of PEP, a peptide fragment with vasopermeability activity, may help reduce toxicity in cancer immunotherapy. A new study also suggests that p16 inhibitors play a role in ...
Researchers identified a strong association between EZH2 and ECAD biomarkers and prostate cancer recurrence. Moderate or strong expression of EZH2 coupled with at most moderate expression of ECAD is most strongly associated with biochemical recurrence.
Researchers identified a link between specific genetic mutations and increased risk of osteosarcoma, a type of bone cancer. They also developed a non-invasive method to measure thymidylate synthase inhibition using carbon-labeled thymidine PET scanning.
A modified adenovirus, Delta-24-RGD, has shown improved infectivity and replication efficiency compared to the unmodified Delta-24. This leads to increased cytopathic effects and prolonged survival rates in mouse models of human glioma. The authors conclude that Delta-24-RGD may be an effective agent in treating gliomas.
A study found that sigmoidoscopy screening significantly reduces distal colorectal cancer incidence, with a four-fold reduction in incidence for individuals who had ever had a screening. This reduction was sustained for more than 15 years, supporting longer screening intervals.
A decision aid called Decision Board improved patients' understanding of their disease, risk of recurrence, and treatment options. Women who used the board were more satisfied with decision making and preferred a more active role in their care.
A study published in the Journal of the National Cancer Institute found that only 40% of patients with superficial bladder cancer had regular follow-up examinations, despite recommended guidelines. Patient characteristics such as age, ethnicity, and socioeconomic status were independently associated with low-intensity surveillance.
According to a new study, nearly 10 million US women aged 35-79 could benefit from tamoxifen chemoprevention for breast cancer. White women are more likely to benefit than black or Hispanic women due to differences in risk factors and comorbidities.
A recent study found that genes determining breast density are associated with an increased risk of breast cancer. Additionally, researchers discovered a compound called YC-1 that slows tumor growth in mice by blocking angiogenesis, potentially leading to new cancer treatments.
A Danish study found that individuals exposed to contaminated poliovirus vaccine had no increased risk of cancer compared to those not exposed. The findings contradict previous laboratory and epidemiologic evidence suggesting a link between SV40 contamination and human cancer.
Research on STI571 and paclitaxel shows potential in controlling prostate cancer metastasis to bone. Lung cancer risk varies widely among smokers, with accurate prediction models helping individuals decide on screening. Non-BRCA mutations may be linked to high breast cancer risk in younger women.
Researchers found that 68% of invasive low-grade ovarian tumors and 61% of precancerous lesions carried one of the three common mutations in BRAF or KRAS. Blocking KRAS-BRAF signaling may provide more effective therapy for these cancers, which generally do not respond well to conventional chemotherapy.
A new study examines the incidence of breast cancer among postmenopausal women with 'probably benign' mammographic findings. The research suggests that short-interval follow-up may not be necessary, and a 1-year follow-up may be as effective as a 6-month follow-up in identifying early-stage breast cancers.
High levels of AIB1 expression in breast cancer tumors are associated with poorer tamoxifen treatment outcomes. Patients with both high AIB1 and HER-2 expression have significantly worse disease-free survival compared to other patient groups.
A study found that higher plasma folate levels were associated with lower risk of breast cancer, while higher plasma vitamin B6 levels increased breast cancer risk. Plasma vitamin B12 levels inversely associated with breast cancer risk among premenopausal women. Cystic fibrosis patients may have an increased risk of digestive tract can...
A Phase III randomized trial found that a combination of vinorelbine and gemcitabine did not improve overall and progression-free survival in elderly NSCLC patients. However, the study suggests that certain chemotherapy combinations, particularly cisplatin-based regimens, may be more effective than single-agent therapy. The results als...
A study found that recent radiologists interpreted screening mammograms more accurately than those with less training, while facilities with higher diagnostic volume showed improved accuracy. The researchers suggest additional studies to clarify the complex relationship between radiologist experience and mammogram interpretation.