A recent Mayo Clinic study found a significant association between benign prostate obstruction and chronic kidney disease in older men. BPH can cause bladder outlet obstruction, leading to increased risk of death, hospitalization, and cardiovascular events.
Researchers at Mayo Clinic discovered a therapy that removes immune system blockages without harming the immune system, boosting its natural ability to reject breast cancer. T-regulatory cells play a disease-promoting role in breast cancer, and blocking them boosts natural immunity.
A Mayo Clinic case series reveals a link between long-term welding and neurological impairment, including Parkinsonian syndrome, multifocal myoclonus, vestibular-auditory dysfunction, and mild cognitive impairment. The study emphasizes the importance of adequate fume protective measures to prevent damage from manganese exposure.
Research from Mayo Clinic Proceedings reveals that patients traveling long distances prior to surgery are at increased risk of postoperative blood clots, which can be life-threatening. The study also found a threshold for anesthesia duration that increases the risk of blood clots in veins after surgery.
A recent study at Mayo Clinic found that transplanting kidneys with small stones does not significantly affect the kidney's function. The study followed 44 donor kidneys, of which 86% had stones smaller than 2mm, and reported a 97% graft survival rate after 26 months, comparable to national averages for living kidney donation.
A nationwide collaboration of transplant specialists is reviewing kidney allocation guidelines, soliciting public input, and exploring changes to improve patient access and outcomes. The review process aims to balance justice, utility, and efficiency in the allocation system.
Researchers found a risk of cardiac toxicity ranging from 2.2 to 3.3 percent among patients receiving chemotherapy and trastuzumab. The study documented less than 1 percent of patients experiencing heart muscle damage alone during chemotherapy.
A recent study by Mayo researchers suggests that using results from clinical trials for one and two years can be as predictive of long-term outcomes in cancer patients as three-year data. The goal of this new approach is to make promising new therapies available more quickly to help patients.
Researchers at Mayo Clinic have developed a new treatment for recurrent glioblastoma multiforme, a form of adult brain cancer with dismal prognosis. The 'smart' drug CCI-779 showed significant response in 36 percent of patients, suggesting potential improvement in treatment outcomes.
New research from Mayo Clinic reveals that adding trastuzumab to chemotherapy reduces breast cancer recurrence by 52% and death risk by 33%. The study's findings could change the standard of care for thousands of women with HER-2 positive breast cancer.
A Mayo Clinic-led study has found a genetic biomarker that can predict which patients are most likely to experience unwanted side effects from oxaliplatin-based chemotherapy regimens. This biomarker could enable early identification and alternative treatments for patients at risk of nerve damage.
Researchers found no improvement in hot flash symptoms when women took black cohosh compared to placebo. In contrast, a progestational agent reduced hot flashes by up to 90% and improved sleep quality, with benefits lasting at least six months.
The Mayo Clinic study found that DNA from group A beta-hemolytic streptococci is concentrated in the tonsil tissue and cannot be detected towards the front of the mouth. The researchers hope to develop a more child- and adult-friendly test for diagnosing strep throat.
Researchers at Mayo Clinic have developed a pharmacogenetic test to determine the best dose of three-drug chemotherapy treatment for various cancers. By analyzing a patient's genetic makeup, they can identify individuals with a higher risk of toxicity from irinotecan and tailor their treatment plan accordingly.
A broader range of treatments for hyperhidrosis has been found to be effective, including botulinum toxin type A (Botox) and surgery. The study also highlights the importance of understanding the sympathetic nervous system in treating this condition.
A Mayo Clinic study found that bypass grafting surgery significantly improves symptoms of hypothenar hammer syndrome in 78% of patients. The condition affects laborers and can cause pain, cold intolerance, and limited hand function due to damaged ulnar artery blood flow.
Mayo Clinic researchers found that green laser pointers can cause irreversible damage to the retina's pigment layer. Longer exposures and higher-powered lasers increase the risk of vision damage.
A study by the Mayo Clinic found that arm lift surgery is generally safe, with a complication rate of relatively low numbers. The most common complications were fluid collections under the skin, poor scarring, skin infection, and nerve injuries. These complications can include numbness in the forearms or pain in the hand and forearm.
Exposure and response prevention therapy is shown to be effective in reducing OCD symptoms in children, with benefits lasting after treatment ends. Medication therapy also reduces symptoms but does not provide a cure for the disorder.
Researchers discovered a genetic link between a mutation and vitamin B6 responsiveness, enabling a genetic test for guiding treatment. The disease causes kidney stones or failure if left untreated, but early diagnosis with this test can maximize successful treatment outcomes.
Mayo researchers identified a genetic glitch in the heart's electrical system, which can lead to sudden and unexpected drownings. The study found two cases of proficient swimmers who died unexpectedly while swimming, highlighting the importance of further research into this phenomenon.
A study by Mayo Clinic investigators found that pessimism and depression are associated with a higher risk of dementia. The research, which analyzed data from over 3,500 individuals, suggests that personality traits may play a role in the development of cognitive impairment 30-40 years later.
A Mayo Clinic study showed that donepezil treatment may slow the progression from mild cognitive impairment to Alzheimer's disease. Patients with a specific genotype had a longer response to the treatment, which could lead to new horizons in early treatment and prevention.
A study at Mayo Clinic found an association between anxious and pessimistic personality types and the future development of Parkinson's disease. Individuals with these personality traits have a higher risk of developing the disease, but the exact reason for this link remains unclear.
A study published by Mayo Clinic researchers found that removing the ovaries elevates the risk of Parkinson's disease and parkinsonism in women. The study, which analyzed data from over 2,500 women, suggested that a reduction in estrogen levels after ovary removal may contribute to this increased risk.
Patients with obstructive sleep apnea are at much higher risk of cardiac death during sleep, with peaks occurring between 10pm and 6am. The general population's lowest risk period is actually the most vulnerable time for those without sleep apnea.
Researchers at Mayo Clinic discovered a new pathway against pancreatic cancer by targeting the GSK-3 Beta molecule, which regulates NF Kappa B activity. This finding may lead to new drug development strategies for other cancers and improve treatment options for pancreatic cancer patients.
A study found that young coronary artery disease patients have a high prevalence of hostility symptoms, with improvements in risk factors and quality of life seen after cardiac rehabilitation. The researchers suggest that reducing hostility should be emphasized in rehabilitation following a heart attack to improve long-term prognosis.
A Mayo Clinic study found that spit tobacco use can cause dramatic increases in heart rate and blood pressure, blunting the body's natural protective mechanisms. This raises concerns for both short-term users and individuals with established heart disease, suggesting a link to long-term cardiovascular risks.
Rheumatoid arthritis patients with swelling in large joints, vasculitis, lung disease, or high ESR levels have a significantly increased risk of dying from heart conditions. The study suggests that systemic inflammation promotes this risk and hypothesizes that closely monitoring and controlling inflammation may decrease the risk.
Researchers at the Mayo Clinic have identified a specific genetic variation associated with a 10-fold increased risk of a ruptured brain aneurysm. This discovery could lead to the development of a fast and inexpensive blood test to predict stroke risk, saving thousands of lives annually.
A Mayo Clinic study establishes a threshold for valve repair surgery in patients with severe mitral regurgitation, indicating that those with large regurgitant orifice areas are at high risk of death if treated medically. The study suggests that valve surgery can restore normal life expectancy and reduce mortality by up to five times.
A Mayo Clinic study found that intermediate-risk patients with unstable angina who underwent exercise treadmill testing could be safely discharged from the emergency room without significant events. In contrast, those not eligible for testing were more likely to receive costly stress imaging and hospital admission.
Dr. Piero Rinaldo calls for improved newborn screening due to inconsistent use of existing technology and variability in quality parameters. He highlights the success of secondary analysis in reducing false positives and improving screening value.
Researchers have discovered a potential link between protease inhibitor drugs and heart rhythm irregularities in HIV patients. The study, published in The Lancet, found that certain drug combinations could trigger adverse heart effects, highlighting the need for closer monitoring of vulnerable individuals.
A retrospective study of over 500 patients found that obese kidney donors experienced similar short-term outcomes to non-obese donors, despite prior cardiovascular disease risks. The study highlights the need for longer follow-up periods to assess potential long-term differences in obese donors.
Researchers at Mayo Clinic have identified a new mechanism by which cancerous cell growth occurs, revealing that Skp2 degrades FOXO1, a tumor suppressor. This degradation abolishes FOXO1's ability to suppress tumors and can be reversed using chemicals that inhibit protein destruction.
A study found that induction at 32 weeks pregnancy can significantly lower infections in both mom and baby, as well as shorten hospital stay for newborns. This approach may be a viable option for women with prolonged premature membrane rupture to minimize potential infection risks.
Researchers found that magnesium treatment delayed labor long enough for steroid therapy to work in about half the cases, reducing repeat preterm labor risk. Babies born after 34 weeks showed better health outcomes, with most doing well despite preterm delivery.
Patients with rheumatoid arthritis are at a higher risk for heart failure soon after the onset of symptoms and throughout their disease course. The elevated risk is not attributed to traditional cardiovascular factors like diabetes or high cholesterol.
Researchers found that rheumatoid arthritis patients are three times more likely to have been hospitalized for an acute heart attack during the two years before diagnosis. They were also twice as likely to experience unrecognized heart attacks and sudden cardiac deaths after diagnosis.
Researchers at the Mayo Clinic have successfully created an 'obedient virus' that can specifically target and destroy cancer cells, paving the way for potential use in human therapies. The virus was engineered to seek out cancer cells instead of healthy cells, and has been shown to be effective in laboratory tests.
Researchers used APACHE III to identify patients with low predicted likelihood of survival and found that those with unrealistic family expectations used more ICU resources. However, one-year survival rates were similar, and survivors often had severe disabilities.
The study reveals that obese individuals have low non-exercise activity thermogenesis (NEAT), a biological need to sit more, which is linked to brain chemical differences. Encouraging NEAT-seeking behaviors can help obese patients overcome this defect and achieve weight loss.
A new study identifies a genetic variant associated with increased MS risk in women, suggesting that interferon gamma production plays a key role in the disease. The findings provide potential targets for future research and treatments, as well as insights into gender differences in disease susceptibility.
Researchers at Mayo Clinic have identified a new form of muscular dystrophy in adults, linked to specific gene mutations that can be targeted for treatment. The study combines laboratory and clinical data to provide a deeper understanding of the disease process and its genetic basis.
Researchers at the Mayo Clinic have developed a new method to repair cleft palates using distraction osteogenesis, which gradually lengthens bone and soft tissue. The technique has shown promising results in animal studies, with some degree of bony closure observed in most treated animals.
The study identified specific characteristics of tissues removed during surgery as risk factors for endometrial cancer recurrence. Approximately one-third of patients with endometrial cancer in the US may benefit from enrollment in clinical trials addressing new treatment approaches.
The new technique uses gamma camera technology to detect smaller breast lesions and improve cancer diagnosis, particularly in women with dense breast tissue. The study found a high sensitivity rate of 86% for detecting small breast tumors, outperforming conventional gamma cameras.
Researchers identify specific T cells and staining methods that improve detection and treatment of RA lung disease. The study suggests therapies targeting T cell function may succeed in treating RA lung disease, while early detection could lead to prolonged lives for patients.