The study found that Rev/Dex reduced myeloma cancer protein levels by over half in 91% of patients, with manageable side effects and a rapid response time. This oral treatment offers an attractive alternative to traditional intravenous therapies.
A Mayo Clinic study found acupuncture significantly improves symptoms of pain, fatigue, and anxiety in patients with moderate to severe fibromyalgia. The treatment showed promise as an additive therapy to existing medications.
Researchers at the Mayo Clinic have discovered that measuring C-reactive protein levels can help identify patients with stiffened arteries, which increases the risk of heart attack and stroke. The study suggests that suppressing low-grade inflammation may be a potential target for improving arterial health.
A recent study by Mayo Clinic researchers found that patients with high levels of heparin antibodies during hemodialysis have higher rates of adverse outcomes. The study suggests that detecting these antibodies may help identify patients at risk for complications, leading to potential improvements in treatment.
A new study from the Mayo Clinic found that smokers with a history of alcoholism can quit smoking using customized nicotine replacement therapy. The study, which adjusted nicotine patch dosages based on serum cotinine levels, resulted in a tobacco abstinence rate of 51 percent.
The study suggests that different patterns of tissue damage in MS patients require different treatment approaches. Plasma exchange treatment was found to be most helpful for severe attacks in patients with pattern II MS lesions, which contain large quantities of immunoglobulins and complement activation.
Researchers found improved patient outcomes in open nephron-sparing surgery (NSS) over time, attributed to increased surgeon experience and perioperative care. Open NSS showed benefits compared to laparoscopic NSS, particularly in complex tumor cases.
A Mayo Clinic study found that basal cell carcinoma (BCC) tumors are increasing in younger adults, with a significant surge in women over 30. Squamous cell carcinoma (SCC) diagnoses also rose sharply, especially among men and women in their late 30s. Long-term sun exposure and tanning bed use are major contributors to this trend.
A new study suggests that surgical myectomy can significantly improve symptoms in patients with severe obstructive hypertrophic cardiomyopathy (HCM), resulting in comparable life expectancies to those who never had the condition. By correcting blood flow obstructions, surgery offers a better quality of life for these younger patients.
A study by Mayo Clinic found that 72% of discharged patients couldn't list their medications or 58% couldn't recall their diagnosis. Dr. Friedman recommends improving communication through language, practicality, and time to avoid noncompliance.
Researchers have developed a way to engineer an alternative outer covering for the measles virus, allowing it to recognize and target only cancerous cells. The 'virus in stealth' approach uses pieces from an animal virus that cannot infect humans to disguise the measles virus, enabling it to evade the immune system and reach tumors.
A new study has identified older Americans with new-onset diabetes as a high-risk group for pancreatic cancer. The research found that patients with type 2 diabetes are at a significantly higher risk of developing pancreatic cancer compared to those without the condition, highlighting the need for early detection and screening.
Researchers at the Mayo Clinic Translational Ultrasound Research Unit have developed a new ultrasound technique that can detect subtle changes in heart muscle motions, potentially predicting heart problems. The technology uses high-resolution imaging to measure transitional tissue deformations and analyze their impact on cardiac function.
Researchers discover that toxic proteins are released into nasal and sinus mucus, not the diseased airway tissue, leading to a radical change in treatment for chronic sinus infections. This finding has far-reaching implications for treatment targeting inflammation and bacterial infection.
Researchers found a link between certain benign breast lesions and increased risk of breast cancer, particularly proliferative and atypical types. Women with non-proliferative forms had no increased risk as long as they didn't have a strong family history.
A study by Mayo Clinic researchers found a rare link between dopamine agonist drugs and pathological gambling in Parkinson's patients. The behavior can be reversed by stopping the medication, but it affects only a small number of patients.
Mayo Clinic researchers report a new mechanism behind thiopurine metabolism, a protein deficit caused by misfolded proteins that disrupts enzyme function. The discovery offers promising new directions for predicting genetic changes and altering drug effects.
A study by Mayo Clinic researchers found that an exercise program with a special weighted back support improved balance and reduced back pain in women with kyphosis. The intervention, which included shifting the center of gravity and improving back strength, was effective in reducing the risk of falls and fractures.
A recent Mayo Clinic study found a significant association between benign prostate obstruction and chronic kidney disease in older men. BPH can cause bladder outlet obstruction, leading to increased risk of death, hospitalization, and cardiovascular events.
Researchers at Mayo Clinic discovered a therapy that removes immune system blockages without harming the immune system, boosting its natural ability to reject breast cancer. T-regulatory cells play a disease-promoting role in breast cancer, and blocking them boosts natural immunity.
A Mayo Clinic case series reveals a link between long-term welding and neurological impairment, including Parkinsonian syndrome, multifocal myoclonus, vestibular-auditory dysfunction, and mild cognitive impairment. The study emphasizes the importance of adequate fume protective measures to prevent damage from manganese exposure.
Research from Mayo Clinic Proceedings reveals that patients traveling long distances prior to surgery are at increased risk of postoperative blood clots, which can be life-threatening. The study also found a threshold for anesthesia duration that increases the risk of blood clots in veins after surgery.
A recent study at Mayo Clinic found that transplanting kidneys with small stones does not significantly affect the kidney's function. The study followed 44 donor kidneys, of which 86% had stones smaller than 2mm, and reported a 97% graft survival rate after 26 months, comparable to national averages for living kidney donation.
A nationwide collaboration of transplant specialists is reviewing kidney allocation guidelines, soliciting public input, and exploring changes to improve patient access and outcomes. The review process aims to balance justice, utility, and efficiency in the allocation system.
Researchers found a risk of cardiac toxicity ranging from 2.2 to 3.3 percent among patients receiving chemotherapy and trastuzumab. The study documented less than 1 percent of patients experiencing heart muscle damage alone during chemotherapy.
A recent study by Mayo researchers suggests that using results from clinical trials for one and two years can be as predictive of long-term outcomes in cancer patients as three-year data. The goal of this new approach is to make promising new therapies available more quickly to help patients.
Researchers at Mayo Clinic have developed a new treatment for recurrent glioblastoma multiforme, a form of adult brain cancer with dismal prognosis. The 'smart' drug CCI-779 showed significant response in 36 percent of patients, suggesting potential improvement in treatment outcomes.
New research from Mayo Clinic reveals that adding trastuzumab to chemotherapy reduces breast cancer recurrence by 52% and death risk by 33%. The study's findings could change the standard of care for thousands of women with HER-2 positive breast cancer.
A Mayo Clinic-led study has found a genetic biomarker that can predict which patients are most likely to experience unwanted side effects from oxaliplatin-based chemotherapy regimens. This biomarker could enable early identification and alternative treatments for patients at risk of nerve damage.
Researchers found no improvement in hot flash symptoms when women took black cohosh compared to placebo. In contrast, a progestational agent reduced hot flashes by up to 90% and improved sleep quality, with benefits lasting at least six months.
The Mayo Clinic study found that DNA from group A beta-hemolytic streptococci is concentrated in the tonsil tissue and cannot be detected towards the front of the mouth. The researchers hope to develop a more child- and adult-friendly test for diagnosing strep throat.
Researchers at Mayo Clinic have developed a pharmacogenetic test to determine the best dose of three-drug chemotherapy treatment for various cancers. By analyzing a patient's genetic makeup, they can identify individuals with a higher risk of toxicity from irinotecan and tailor their treatment plan accordingly.
A broader range of treatments for hyperhidrosis has been found to be effective, including botulinum toxin type A (Botox) and surgery. The study also highlights the importance of understanding the sympathetic nervous system in treating this condition.
A Mayo Clinic study found that bypass grafting surgery significantly improves symptoms of hypothenar hammer syndrome in 78% of patients. The condition affects laborers and can cause pain, cold intolerance, and limited hand function due to damaged ulnar artery blood flow.
Mayo Clinic researchers found that green laser pointers can cause irreversible damage to the retina's pigment layer. Longer exposures and higher-powered lasers increase the risk of vision damage.
A study by the Mayo Clinic found that arm lift surgery is generally safe, with a complication rate of relatively low numbers. The most common complications were fluid collections under the skin, poor scarring, skin infection, and nerve injuries. These complications can include numbness in the forearms or pain in the hand and forearm.
Exposure and response prevention therapy is shown to be effective in reducing OCD symptoms in children, with benefits lasting after treatment ends. Medication therapy also reduces symptoms but does not provide a cure for the disorder.
Researchers discovered a genetic link between a mutation and vitamin B6 responsiveness, enabling a genetic test for guiding treatment. The disease causes kidney stones or failure if left untreated, but early diagnosis with this test can maximize successful treatment outcomes.
Mayo researchers identified a genetic glitch in the heart's electrical system, which can lead to sudden and unexpected drownings. The study found two cases of proficient swimmers who died unexpectedly while swimming, highlighting the importance of further research into this phenomenon.
A study by Mayo Clinic investigators found that pessimism and depression are associated with a higher risk of dementia. The research, which analyzed data from over 3,500 individuals, suggests that personality traits may play a role in the development of cognitive impairment 30-40 years later.
A Mayo Clinic study showed that donepezil treatment may slow the progression from mild cognitive impairment to Alzheimer's disease. Patients with a specific genotype had a longer response to the treatment, which could lead to new horizons in early treatment and prevention.
A study at Mayo Clinic found an association between anxious and pessimistic personality types and the future development of Parkinson's disease. Individuals with these personality traits have a higher risk of developing the disease, but the exact reason for this link remains unclear.
A study published by Mayo Clinic researchers found that removing the ovaries elevates the risk of Parkinson's disease and parkinsonism in women. The study, which analyzed data from over 2,500 women, suggested that a reduction in estrogen levels after ovary removal may contribute to this increased risk.
Patients with obstructive sleep apnea are at much higher risk of cardiac death during sleep, with peaks occurring between 10pm and 6am. The general population's lowest risk period is actually the most vulnerable time for those without sleep apnea.
Researchers at Mayo Clinic discovered a new pathway against pancreatic cancer by targeting the GSK-3 Beta molecule, which regulates NF Kappa B activity. This finding may lead to new drug development strategies for other cancers and improve treatment options for pancreatic cancer patients.
A study found that young coronary artery disease patients have a high prevalence of hostility symptoms, with improvements in risk factors and quality of life seen after cardiac rehabilitation. The researchers suggest that reducing hostility should be emphasized in rehabilitation following a heart attack to improve long-term prognosis.
A Mayo Clinic study found that spit tobacco use can cause dramatic increases in heart rate and blood pressure, blunting the body's natural protective mechanisms. This raises concerns for both short-term users and individuals with established heart disease, suggesting a link to long-term cardiovascular risks.
Rheumatoid arthritis patients with swelling in large joints, vasculitis, lung disease, or high ESR levels have a significantly increased risk of dying from heart conditions. The study suggests that systemic inflammation promotes this risk and hypothesizes that closely monitoring and controlling inflammation may decrease the risk.
Researchers at the Mayo Clinic have identified a specific genetic variation associated with a 10-fold increased risk of a ruptured brain aneurysm. This discovery could lead to the development of a fast and inexpensive blood test to predict stroke risk, saving thousands of lives annually.
A Mayo Clinic study establishes a threshold for valve repair surgery in patients with severe mitral regurgitation, indicating that those with large regurgitant orifice areas are at high risk of death if treated medically. The study suggests that valve surgery can restore normal life expectancy and reduce mortality by up to five times.