A Mayo Clinic study found that intermediate-risk patients with unstable angina who underwent exercise treadmill testing could be safely discharged from the emergency room without significant events. In contrast, those not eligible for testing were more likely to receive costly stress imaging and hospital admission.
Dr. Piero Rinaldo calls for improved newborn screening due to inconsistent use of existing technology and variability in quality parameters. He highlights the success of secondary analysis in reducing false positives and improving screening value.
Researchers have discovered a potential link between protease inhibitor drugs and heart rhythm irregularities in HIV patients. The study, published in The Lancet, found that certain drug combinations could trigger adverse heart effects, highlighting the need for closer monitoring of vulnerable individuals.
A retrospective study of over 500 patients found that obese kidney donors experienced similar short-term outcomes to non-obese donors, despite prior cardiovascular disease risks. The study highlights the need for longer follow-up periods to assess potential long-term differences in obese donors.
Researchers at Mayo Clinic have identified a new mechanism by which cancerous cell growth occurs, revealing that Skp2 degrades FOXO1, a tumor suppressor. This degradation abolishes FOXO1's ability to suppress tumors and can be reversed using chemicals that inhibit protein destruction.
A study found that induction at 32 weeks pregnancy can significantly lower infections in both mom and baby, as well as shorten hospital stay for newborns. This approach may be a viable option for women with prolonged premature membrane rupture to minimize potential infection risks.
Researchers found that magnesium treatment delayed labor long enough for steroid therapy to work in about half the cases, reducing repeat preterm labor risk. Babies born after 34 weeks showed better health outcomes, with most doing well despite preterm delivery.
Patients with rheumatoid arthritis are at a higher risk for heart failure soon after the onset of symptoms and throughout their disease course. The elevated risk is not attributed to traditional cardiovascular factors like diabetes or high cholesterol.
Researchers found that rheumatoid arthritis patients are three times more likely to have been hospitalized for an acute heart attack during the two years before diagnosis. They were also twice as likely to experience unrecognized heart attacks and sudden cardiac deaths after diagnosis.
Researchers at the Mayo Clinic have successfully created an 'obedient virus' that can specifically target and destroy cancer cells, paving the way for potential use in human therapies. The virus was engineered to seek out cancer cells instead of healthy cells, and has been shown to be effective in laboratory tests.
Researchers used APACHE III to identify patients with low predicted likelihood of survival and found that those with unrealistic family expectations used more ICU resources. However, one-year survival rates were similar, and survivors often had severe disabilities.
The study reveals that obese individuals have low non-exercise activity thermogenesis (NEAT), a biological need to sit more, which is linked to brain chemical differences. Encouraging NEAT-seeking behaviors can help obese patients overcome this defect and achieve weight loss.
A new study identifies a genetic variant associated with increased MS risk in women, suggesting that interferon gamma production plays a key role in the disease. The findings provide potential targets for future research and treatments, as well as insights into gender differences in disease susceptibility.
Researchers at Mayo Clinic have identified a new form of muscular dystrophy in adults, linked to specific gene mutations that can be targeted for treatment. The study combines laboratory and clinical data to provide a deeper understanding of the disease process and its genetic basis.
Researchers at the Mayo Clinic have developed a new method to repair cleft palates using distraction osteogenesis, which gradually lengthens bone and soft tissue. The technique has shown promising results in animal studies, with some degree of bony closure observed in most treated animals.
The study identified specific characteristics of tissues removed during surgery as risk factors for endometrial cancer recurrence. Approximately one-third of patients with endometrial cancer in the US may benefit from enrollment in clinical trials addressing new treatment approaches.
The new technique uses gamma camera technology to detect smaller breast lesions and improve cancer diagnosis, particularly in women with dense breast tissue. The study found a high sensitivity rate of 86% for detecting small breast tumors, outperforming conventional gamma cameras.
Researchers identify specific T cells and staining methods that improve detection and treatment of RA lung disease. The study suggests therapies targeting T cell function may succeed in treating RA lung disease, while early detection could lead to prolonged lives for patients.
A Mayo Clinic study analyzed data from the Rochester Epidemiology Project and found a stable incidence of autism until 1988-1991, then increased with new diagnostic criteria and special education laws. Researchers identified 124 children meeting current diagnostic criteria for autism out of 3,000 with related diagnoses.
A Mayo Clinic study found that children with restless legs syndrome have a higher risk of family history and iron deficiency, which may be linked to the condition. The study examined 538 children and found that 72% had a family history of restless legs syndrome, with mothers being three times more likely to be affected.
Researchers tested devices outside of the body and found no interference, but warn that technology advances require continual testing for clinical safety.
A new blood test can accurately diagnose neuromyelitis optica (NMO), a debilitating inflammatory disease that destroys the protective myelin sheath around the optic nerve and spinal cord. Early diagnosis with this biomarker enables optimal therapies to be started sooner, potentially lessening the impact of the disease.
A population-based study of nearly 2,300 US adults found a significant link between gastrointestinal disorders and insomnia. The study suggests that irritable bowel syndrome is more common among people with sleep disturbances than those without.
Researchers found that a combination of thalidomide and dexamethasone is as effective as standard intravenous chemotherapy in treating newly diagnosed multiple myeloma. A newer analog, CC-5013 (lenalidomide), showed promise with fewer side effects.
Researchers used reactive hyperemia peripheral arterial tonometry (RH-PAT) to assess coronary endothelial dysfunction in patients. The study found a strong correlation between fingertip test results and coronary endothelial dysfunction, suggesting the fingertip test could be an effective screening tool for early heart disease.
Researchers at the Mayo Clinic have identified a potential biomarker for aggressive kidney cancer, which can help improve treatment outcomes by identifying patients at high risk of disease progression. The study found that high levels of B7-H1 molecule are associated with increased risk of cancer spread and mortality.
Urinary incontinence and abdominal pain are key symptoms of ovarian cancer, with crampy abdominal pain being the most common symptom. The study found that women often ignore or downplay these symptoms, leading to delayed diagnosis.
A new hysteroscopic sterilization technique has been shown to be less expensive than traditional laparoscopic tubal ligation, with patients typically leaving the hospital within an hour and recovering quickly. The method requires minimal sedation and no surgical incision, resulting in significant cost savings for patients.
A Mayo Clinic study found that patients with well-controlled epilepsy have a very low risk of injury from seizures. The study examined records of 247 patients and found that 80% of injuries were cuts or bruises that did not cause serious health consequences.
Researchers found that testosterone impairs T-lymphocyte function, leading to a weakened immune response in men. In contrast, females' immune systems are more active without significant levels of testosterone, making them more prone to autoimmune diseases.
A new study by Mayo Clinic suggests that the ketogenic diet can be safely initiated as an outpatient treatment for children with epilepsy, offering improved acceptability and comfort. The study found no significant differences in long-term seizure control or mental improvement between inpatient and outpatient groups.
A Mayo Clinic study found that physical training is more effective than amphetamine use in improving motor function after a stroke. The research team's experiment used brain-damaged rats to demonstrate the power of physical training in recovery.
The new Mayo Clinic research indicates that mycophenolate mofetil could help many more lupus patients, offering a potential alternative to existing treatments with fewer side effects. Currently, there is no curative treatment for SLE, and many medications used to treat this disease have considerable side effects.
Weight-reduction surgery patients are at risk of developing peripheral neuropathy, a condition causing pain, numbness, and weakness. Following nutritional guidelines and attending post-surgical care programs can help prevent nerve damage.
Researchers found that certain species of airborne fungus trigger abnormal immune responses, leading to congestion and inflammation in patients with chronic rhinosinusitis. The study suggests that reducing fungal exposure through treatments like nasal irrigations or antifungal medicines could provide relief.
Researchers at Mayo Clinic found that pyridostigmine improved patients' standing blood pressure and reduced symptoms without elevating blood pressure while lying down. The study showed significant results in reducing the need for other medications, particularly in those over age 70 with common causes like diabetes and Parkinson's disease.
Mayo Clinic has been awarded a major NIH contract to conduct genomic research on smallpox vaccination, utilizing its advanced genomics technology center and biostatisticians. The study aims to identify gene polymorphisms affecting susceptibility to infection and response to vaccination.
According to Dr. Broughton, most children reported missing are runaways or taken by noncustodial parents, not strangers. Children need to learn skills and confidence, not fear and avoidance. Parents can teach personal safety without causing unwarranted fear.
A new study by Mayo Clinic researchers demonstrates that eosinophils are required for mucus accumulation and lung dysfunction associated with asthma. Transgenic mice without eosinophils showed reduced or eliminated disease symptoms following allergen exposure, paving the way for novel therapies to treat and prevent asthma.
A new study published in Mayo Clinic Proceedings found that males are at a higher risk for ADHD than females, with low maternal and paternal education levels increasing the risk. Researchers analyzed birth certificates of children born between 1976 and 1982 and identified those with ADHD using medical and school records.
A study by Mayo Clinic researchers found that high-sensitivity C-reactive protein (hs-CRP) is associated with the presence of atherosclerotic plaques in the arteries, even if symptoms are absent. Elevated hs-CRP levels may indicate an increased risk of cardiovascular events like heart attacks.
Researchers successfully delivered a phosphorescent green protein from jellyfish to the eyes of laboratory cats, producing a permanent effect. The study demonstrates a potential gene therapy approach to treat glaucoma, a chronic disease affecting 70 million people worldwide.
A study led by Mayo Clinic cardiologist Veronique Roger found that cardiac rehabilitation can improve survival rates for heart attack patients by almost 50%. However, women and elderly patients were less likely to participate in exercise programs due to factors such as lack of transportation and support networks.
A recent study found that immediate statin therapy in hospitalized heart attack patients significantly reduced the risk of death and additional heart attacks. The study, which involved 3,605 patients at 260 medical centers, confirms earlier findings that early statin treatment is beneficial for heart health.
A recent study by Mayo Clinic researchers suggests that patients with minimal or no disability after 10 years of multiple sclerosis (MS) are unlikely to progress and may not need medication. However, those with higher disability scores may still experience worsening symptoms over time.
A study published in Mayo Clinic Proceedings found that intensive glucose management in ICU patients resulted in a significant reduction in mortality rates, with a decrease of 29.3% and the prevention of 49 deaths. The treatment involved monitoring blood glucose levels and administering insulin to prevent elevations.
A study reveals the tobacco industry's extensive efforts to shape journalists' coverage of secondhand smoke, a public health issue with significant mortality rates. The research highlights the need for increased scrutiny of media articles on this topic to ensure accurate public information.
MayoClinic.com empowers people to manage their health with useful and up-to-date information and tools from a team of over 2,000 physicians and scientists. The site is owned by Mayo Foundation for Medical Education and Research and serves as a dependable source of health information.
Scientists at Mayo Clinic develop novel approach to cancer vaccine that leverages inflammatory cell death to trigger a strong anti-tumor immune response, eradicating skin cancer tumors without triggering autoimmune disease. The breakthrough sheds light on a major obstacle in advancing cancer vaccine research from lab to human trials.
A new phase 2 study shows that combining cetuximab with irinotecan can resensitize tumors resistant to irinotecan, offering patients a new treatment option. The study's modest benefits in stopping cancer growth and improving patient response are seen as a step forward in treating colorectal cancer.