A recent study from Michigan Medicine researchers reveals that specific 'junk' RNA genes, known as microRNA34, work with the protective gene p53 to regulate cell growth and prevent cancer. The loss of these microRNAs is linked to common lung cancer.
A team of U-M researchers, including gynecologists and engineers, will use the grant to examine damage to pelvic muscles during vaginal deliveries. They aim to develop preventive strategies to reduce injury rates, which affect up to 300,000 women per year.
A vaccine against anthrax has been developed using nanoparticles, which triggers a strong immune response and induces immunity on mucous membranes, providing protection after bioterror attacks. The new vaccine is easy to store and administer without needles, making it a valuable tool for health authorities.
A Michigan Medicine study found that half of seniors have geriatric conditions affecting daily living, such as falls and incontinence. The study highlights the need for clinicians to address these common conditions, which can lead to disability if left untreated.
A Michigan-CDC study analyzed 43 US cities during the 1918-1919 Spanish flu pandemic and found that sustained non-pharmaceutical interventions (NPIs) like quarantine, isolation, school closures, and public gathering cancellations significantly reduced mortality rates. The study's findings challenge conventional wisdom on the effectiven...
A new study found that emergency angioplasty treatment for heart attacks has increased dramatically over the last decade, with a notable decline in patients going without crucial care. However, 10% of eligible patients still do not receive this urgent treatment, highlighting gaps in care for certain subgroups.
Researchers found that gene fusions trigger cancer growth and could impact treatment choices, with some genes regulated by androgen. The discovery may lead to better diagnostics and targeted therapies for prostate cancer.
University of Michigan scientists are creating nanoparticles that can deliver morphine to wounded soldiers faster and more safely. The goal is to develop tiny drug-bearing particles that a fellow soldier could inject with a pen-like device, even in combat.
Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene, FOXP3, that suppresses tumor growth in breast cancer. The study found that when FOXP3 is normal, it keeps HER-2 levels low; however, when FOXP3 is missing or mutated, HER-2 levels are likely to rise.
Researchers propose new model for predicting post-hospital death risk in aortic dissection patients based on blood clotting in the false lumen. Partial clotting is associated with a much greater risk of death, while those with patent or completely thrombosed false lumens have intermediate and lower risks respectively.
A large study of over 17,000 men found that finasteride caused a small decrease in sexual function, but this effect diminished over time. The researchers concluded that finasteride is unlikely to cause significant sexual dysfunction for most men taking the drug.
A new study found that people's responses to placebo treatments are linked to their brain's dopamine activity, particularly in the nucleus accumbens. The study used two types of brain scans to investigate this phenomenon and suggests that individual expectations play a significant role in determining the effectiveness of placebos.
Researchers found a strong correlation between tumor responses during treatment and three months after completion, suggesting PET scans can be performed earlier to modify treatment plans. This could lead to better tumor control and survival rates, potentially changing standard practice guidelines.
Researchers found a significant link between genetic variation on chromosome 8 and the risk of colorectal cancer, with individuals carrying the specific marker being 23% more likely to develop the disease. The study suggests that this single genetic variation might account for 14% of colorectal cancer cases in Israel.
Scientists have identified a gene mutation causing one form of Charcot-Marie-Tooth disorder, a common inherited neurological disease. The discovery enables a genetic test for people with this subtype, which was previously unidentified and lacked an unknown genetic basis.
Researchers at Michigan Medicine are studying the impact of a Mediterranean diet on colon cancer risk. The study will compare the diet with a standard healthy eating plan and investigate its effects on protein levels and antioxidant compounds in the body. Participants who complete the six-month study will receive $270.
A new University of Michigan study shows that pill-splitting, slicing high-dose pills in half, can save Americans thousands of dollars on prescription drugs. Most participants said they would continue splitting pills if given a 50%-co-pay reduction, but some reported no issues with the practice.
U-M researchers found that a gene called Brahma is silent in some cancer cells but can be reactivated using inhibitor drugs. The study shows promise for developing new targeted therapies to slow or stop cancer progression.
Researchers have successfully implanted a tiny electrode array in the auditory nerve of cats, enabling them to hear a wide range of sounds. The device has several advantages over cochlear implants, including more precise activation of specific frequency signals and reduced electrical current requirements.
A University of Michigan study found that 86% of patients with follicular lymphoma survived after 8 years of treatment with Bexxar, a radioimmunotherapy drug. This success rate compares favorably to state-of-the-art chemotherapy regimens, making Bexxar an attractive option for patients.
A study reveals that genetic differences in Japanese and US patients with non-small cell lung cancer affect how well they respond to chemotherapy drugs like paclitaxel and carboplatin. The research found that specific gene variations, such as CYP3A4 and ERCC2, influence treatment outcomes.
A study published in Aging Cell found that male mice fed a normal diet and NDGA showed significantly longer survival than control mice. However, no significant difference was observed in female mice. The researchers are now conducting further studies to confirm the results and determine the potential of NDGA as an anti-aging agent.
A new study from Michigan Medicine found that up to 17% of physicians in a single state who claim to be pediatricians are not board certified by the American Board of Pediatrics (ABP). The researchers also discovered that another 12% of pediatricians did not complete a medical residency training program in pediatrics. Parents can check...
A new international study involving over 10,700 people with high blood pressure found that single-tablet combinations of drugs can bring blood pressure under control for up to 80% of US patients. The six-month treatment period saw a near-doubling of the proportion of patients achieving controlled blood pressure.
Researchers tested retinol-containing lotions on elderly patients, finding significant reductions in wrinkles, roughness, and overall aging severity. The study also showed increased collagen production, making the skin more resistant to injury and ulcer formation.
A new study from the University of Michigan Stroke Program finds that ICH patients who had a do-not-resuscitate order issued in the first 24 hours or had care withdrawn were twice as likely to die. Early limitations on care may be an overlooked factor in calculating ICH survival odds, according to researchers.
A new international study found that patients who received modern treatments after a heart attack or severe chest pain had significantly lower death rates, stroke risks, and heart failure. The study shows improved outcomes due to increased use of guideline-based treatments such as drugs, tests, and procedures.
Researchers found that rats fed tart cherries had lower cholesterol, blood sugar, fat storage in the liver, oxidative stress, and improved fat handling. The study suggests a potential benefit from anthocyanin-rich foods like tart cherries for heart disease and diabetes prevention.
A new study suggests that green tea compound epigallocatechin-3-gallate (EGCG) inhibits production of molecules that cause destruction of cartilage and bone in people with rheumatoid arthritis. EGCG also suppresses inflammatory products in connective tissue.
A study of retired NFL players found nearly 15% experienced moderate to severe depression, with chronic pain levels nearly half of the population. The study also highlighted connections between depression, pain, and other issues like sleep, fitness, and social support.
A new study finds that higher doses of statins are cost-effective for patients with recent heart attacks, but may not provide significant benefits for those with stable coronary artery disease. The analysis could help evaluate the cost-effectiveness of other medications and treatments.
A new imaging method measures water diffusion in tumors to detect early response to treatment for advanced prostate cancer. Researchers found that changes in water diffusion could predict tumor response to chemotherapy as early as seven days after treatment began.
Researchers have discovered that bacteria can enter immune system cells through a pore in the cell membrane, triggering an immune response without activating Toll-like receptors. This finding offers new perspectives for developing human vaccines and drugs that target inflammatory responses in autoimmune diseases like rheumatoid arthritis.
Researchers develop genetically engineered mice with defects in Wnt/â-catenin and PI3K/Pten signaling pathways, leading to rapid tumor development and metastasis. The study aims to improve early detection and treatment of ovarian cancer.
The program, which teaches healthy habits and offers hope for a healthier future, has been successful in lowering diastolic blood pressure, total cholesterol, and LDL cholesterol levels among participants. With a significant drop in systolic blood pressures and blood glucose levels, the program aims to fight childhood obesity.
Researchers found that a combination of vitamins A, C, and E and magnesium effectively prevented permanent noise-induced hearing loss in guinea pigs. The study's lead author suggests that similar nutritional bars could provide adequate daily protection for people exposed to loud noises, such as soldiers or concertgoers.
Researchers at the University of Michigan have made significant progress in cardiac tissue engineering, with promising results in growing pulsing heart muscle and tri-leaflet valves. However, challenges such as determining optimal cell types and finding effective methods to grow viable tissue still need to be addressed.
A study of 365 surgeons found that only 24% referred three-quarters or more of their patients for reconstruction, citing patient barriers such as inadequate knowledge, cost concerns, and availability of plastic surgeons. The researchers suggest improving decision aids and multidisciplinary care to increase reconstruction rates
Researchers found a significant link between smoking and skin damage in non-facial areas, such as the inside of the upper arm. Smoking was associated with an increased degree of skin aging, with smokers showing more severe fine wrinkling than nonsmokers.
Researchers found that measures of spirituality increased significantly in recovering alcoholics, with daily spiritual experiences and feeling of purpose in life strongly linked to sobriety. This suggests that including spirituality into recovery services may be beneficial, regardless of the individual's faith or belief system.
A new study from Michigan Medicine reveals that obese patients have a higher risk of post-operative complications, including heart attack, wound infection, nerve injury, and urinary tract infection. The study found that morbidly obese patients had a death rate nearly twice as high as non-obese patients.
A new study found that lung-derived mesenchymal stem cells reside in transplanted lungs, challenging the assumption that they originate from bone marrow. These cells have been shown to differentiate into multiple connective tissue cell types and may hold the key to understanding therapeutic options using MSCs that reside in adult organs.
A team of researchers has identified more than 70 markers unique to ovarian tumor blood vessels, which could lead to new screening and treatment tools. The finding suggests that these markers may be a sign of an aggressive tumor and could help inform treatment decisions.
A new study reveals that specialty heart hospitals are associated with a significant rise in heart procedures, such as bypass surgery and angioplasties. The study found that the opening of a new specialty cardiac hospital is linked to a regional increase in these procedures, particularly among patients without heart attacks.
A new study published in Pediatrics found that higher body mass index scores in girls as young as age 3 and large increases in BMI between ages 3 and first grade are associated with earlier puberty. The study suggests that childhood obesity may contribute to an earlier onset of puberty in girls.
A special section in The Lancet examines the intersections between medicine and society, highlighting the impact of direct-to-consumer drug advertising on patients' expectations and doctors' professional clout. The essays explore how pharmaceutical ads create new societal perceptions of disease, normalcy, and wellness.
Researchers at the University of Michigan have discovered that Restylane works by stretching fibroblasts, causing them to create new collagen. This natural collagen then contributes to reducing wrinkle appearance. The study also found that Restylane inhibits the breakdown of existing collagen.
A study published in Archives of Ophthalmology confirms the effectiveness of genetic testing in diagnosing complex retinal diseases. The research found that genetic testing confirmed a clinician's diagnosis in half of the tested cases, providing crucial information for healthcare professionals.
Researchers identified a small number of cells in pancreatic cancer capable of fueling tumor growth, which are thought to be the cancer stem cells. These cells can replicate and produce new tumors, making them a crucial target for therapy.
A study found a strong connection between muscle damage during vaginal deliveries and pelvic organ prolapse, which causes the uterus, bladder, or bowel to fall down. The research suggests that preventing these injuries can help reduce the rate of pelvic organ prolapse.