Researchers at Ochsner Health have developed SRP-001, a novel medication that leverages unique biological mechanisms to alleviate pain without typical side effects. The first-in-human Phase 1 trial confirms SRP-001's safety and tolerability, paving the way for its progression to further clinical stages.
A study published in Circulation found that revascularization significantly enhances the health-related quality of life (HRQoL) for patients with chronic limb-threatening ischemia. Patients who underwent endovascular intervention (Endo) showed slight statistical superiority over those who received surgical bypass (Bypass) in some HRQoL...
The study found that neoadjuvant chemotherapy increased median overall survival to 37 months and progression-free survival to 26 months. 57.2% of patients showed an objective response, with nearly one-fourth experiencing lymph-node pathologic complete response.
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
A groundbreaking study published in JAMA found that excluding aspirin from the antithrombotic regimen for patients with a fully magnetically levitated left ventricular assist device (LVAD) resulted in a significant decrease in major nonsurgical bleeding events. This approach is safe and beneficial, challenging conventional practice and...
A recent study in JAMA Cardiology analyzed data from 15,000 patients and found that enteric coating on aspirin does not change its effectiveness or safety for secondary prevention of cardiovascular events. The study suggests that patients can choose the aspirin formulation that suits them best.
A recent case study highlights the challenges faced by families seeking venom immunotherapy for fire ant allergies, particularly in low-income communities. Despite proven safety and effectiveness of treatment, access remains a significant issue due to transportation barriers, lack of childcare, and work constraints.
The new Southern Center for Maternal Health Equity will develop innovative approaches to reduce pregnancy-related complications and deaths in the Gulf South. The center aims to promote maternal health equity and address disparities in maternal mortality rates, particularly among Black pregnant and postpartum people.
A new study published in Annals of Surgery reveals promising results for normothermic machine perfusion in liver transplantation. The randomized controlled trial found that this technology showed particular promise in marginal donors and those with higher risk factors, demonstrating a lower incidence of dysfunction and cardiovascular s...
A recent study published in JAMA demonstrates the effectiveness of a minimally invasive procedure called renal denervation (RDN) to treat uncontrolled hypertension. RDN uses ultrasound energy delivered through a small balloon to denervate the renal artery, reducing sympathetic nerve activity and decreasing blood pressure.
Research recognizes significant association between unhealthy behaviors and conditions like obesity, diabetes, smoking, leading to poorer COVID-19 outcomes. Experts emphasize promoting healthy lifestyles to combat syndemics, particularly impacting underserved communities.
A new study by Ochsner pharmacist Kevin Lin suggests that oral cephalosporins are as safe and effective as fluoroquinolones for treating acute kidney infections. The study's findings support the use of narrower-spectrum antibiotics to reduce antimicrobial resistance, a growing concern in healthcare.
A new study has identified the genes that become active in carotid arteries when plaque rupture causes a stroke. The researchers sequenced the RNAs in plaques from patients who had experienced a stroke within two to five days, revealing increased inflammation and loss of protective cap.
A new study published in the Journal of the American College of Cardiology suggests that carotid artery stenting can be just as effective as surgery in preventing long-term stroke and improving durability. The research recommends expanding insurance coverage for this minimally invasive procedure, which can improve blood flow to the brain.
A large clinical trial conducted at Ochsner Health found that social determinants of health, including financial stress and lack of health literacy, have a significant impact on blood pressure control rates among patients with uncontrolled hypertension. The study suggests that these barriers can eliminate racial disparities in hyperten...
Researchers at Ochsner Health and MD Anderson have discovered that blocking interleukin-6 (IL-6) in lab models improves cancer responses while minimizing inflammation in healthy tissue. By targeting this cytokine, immune checkpoint inhibitors may become more targeted on tumors with fewer side effects.
A new study published in the New England Journal of Medicine found that treating even mild forms of high blood pressure during pregnancy is safe and beneficial for both mother and developing baby. The study's results demonstrated a significant decrease in pregnancy complications, including severe preeclampsia and preterm births.