Scientists at the Oklahoma Medical Research Foundation have redefined how the gut microbiome operates and coexists with bacteria. The findings show that the microbiome controls the creation of mucus, which acts as a barrier between bacteria and immune cells in the colon.
Researchers identified a compound that disables abnormal blood vessels, potentially reversing vision loss in patients with retinopathy of prematurity and diabetic retinopathy. The treatment targets only the abnormal vessels, sparing healthy ones.
Researchers at Oklahoma Medical Research Foundation have identified the signaling molecules that activate the Wnt signaling pathway in the lymphatic vascular system. This discovery could lead to better therapeutic options for lymphedema and associated disorders, including cancer and atherosclerosis.
Researchers found that a high-carb diet, particularly with high sugar and low fiber content, increased signs of joint inflammation and altered cartilage genes in laboratory mice. The study suggests that dietary carbohydrates may be a contributing factor to osteoarthritis risk, even in the absence of obesity.
Researchers at the Oklahoma Medical Research Foundation have made a groundbreaking discovery about colon cancer, revealing that certain hidden polyps may be responsible for up to 30-40% of cases. The study also found that these polyps are caused by a mutation in the BRAF gene and could potentially be detected through fecal samples.
Researchers at Oklahoma Medical Research Foundation found that an enzyme thought to be beneficial can pose significant danger to developing embryos. They discovered excessive plasmin activity can lead to liver blood vessels becoming fragile and prone to bleeding.
A new study has found that certain sugars produced by the body play a crucial role in the development of colitis and colon cancer. The researchers genetically modified mice to lack these sugars, revealing that their mucous layer vanished and they developed colitis and a form of colon cancer.
A recent study published in Nature Genetics has identified 10 new genes linked to lupus, an autoimmune disease affecting millions worldwide. The research analyzed over 17,000 DNA samples from Asian populations and found that these genes play a significant role in the development of lupus.
Researchers pinpoint cell that triggers scarring in fatty tissue, leading to insulin resistance and diabetes. The study reveals a potential new target for treating metabolic disorders.
The Oklahoma Medical Research Foundation will receive a two-year $280,000 grant to investigate the role of BAFF and APRIL molecules in multiple sclerosis progression. This project aims to understand how inhibiting these molecules affects disease symptoms in experimental models.
The Oklahoma Medical Research Foundation has received a five-year, $14.5 million grant from the National Institutes of Health to continue its research on anthrax and its effects on humans. The project aims to identify new vaccines and drug targets by studying the human immune response to anthrax bacteria.
Researchers found CaM Kinase II plays a significant role in controlling neuropeptide release from neurons, affecting learning, memory, social behaviors, and mood. The study's findings could lead to future therapies targeting altered mood and memory in humans.
Researchers have identified six new disease-related genes for Sjögren's syndrome, an autoimmune disease that affects moisture-producing glands. The findings provide a first step towards understanding how genetic variants alter immune system functions and may lead to the development of therapeutics.
Researchers found that platelets activate a screening process allowing lymphocytes to exit the bloodstream without causing bleeding. This discovery opens avenues for further research into the role of platelets in vascular health and inflammation.
Researchers have identified how two genes, Ipl1 and Mps1, work together to correct mistakes in chromosome distribution during cell division. This understanding could lead to targeted cancer treatments by controlling these master regulator genes.
Researchers identify IRF8 and TMEM39a as associated with lupus in European-American, African-American, Gullah, and Asian patients. The study's findings also suggest that the genes may not be universal, highlighting the need for further research.
Researchers at the Oklahoma Medical Research Foundation have made a groundbreaking discovery that could help treat traumatic injuries and severe diseases. They found an antibody that can counteract histones' deadly effects on blood vessels, potentially preventing uncontrolled bleeding and fluid buildup.
Scientists have obtained visual evidence of how deadly 'superbugs' acquire and disseminate antibiotic resistance. The discovery sheds light on the role of conjugative pili in spreading antibiotic resistance.
Researchers have discovered a new way that organisms sense light, which may lead to insights into human sensory perception. The study found that exposing paralyzed worms to ultraviolet light restored normal movement levels in the animals.
A newly discovered gene variant in TNFAIP3 may cause the immune system to continue attacking healthy tissues and organs, leading to damage. This discovery adds to a growing list of genes associated with lupus and holds promise for diagnosis and treatment.
A new study found that mice immunized with an MS-like condition were protected from the disease when consuming six to eight cups of coffee daily. Caffeine stopped adenosine from binding to a receptor, preventing certain T cells from triggering the disease.
Researchers develop new process to identify and clone human antibodies tailored to fight specific infections, offering rapid and effective treatments for influenza and other diseases. The technology has the potential to provide therapy for existing infections or passive immunity against future infection.
A new research study from Oklahoma Medical Research Foundation demonstrates that immunization could blunt or prevent Alzheimer's disease by targeting the build-up of protein plaques. The vaccinated mice showed a significant reduction in plaque accumulation and improved cognitive performance compared to control mice.
A new study published in EMBO Reports found that the order of authors on a scientific paper significantly affects perceived contribution and credit. Middle authors tend to receive less recognition and credit compared to those listed at the beginning or end of the list.
Researchers at Oklahoma Medical Research Foundation discovered that ApoE4 attaches to a receptor on brain cells, leading to protein fragment formation and cell death. This finding may lead to new pathways for developing Alzheimer's therapeutics.
Researchers found that marrow stem cells have receptors that detect bacteria and viruses, triggering a response to fight pathogens. This discovery could lead to new treatments for leukemias and autoimmune diseases like lupus and rheumatoid arthritis.
Scientists have successfully reversed cell division, a process essential to life, and may use this discovery to control cancer development and metastasis. The research holds promise for preventing and treating birth defects and other conditions.
A new study by Oklahoma researchers has identified autoantibodies years before the clinical features of lupus and found specific autoantibodies close to disease onset. The study, published in the New England Journal of Medicine, holds important clinical value and may lead to new therapies for the disease.