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New statistical model predicts which cities could become 'superspreaders'

A new statistical model identifies potential superspreader cities by incorporating both connectivity between cities and their varying suitability for infection. The risk of a city becoming a superspreader increases with infection suitability only up to a certain extent, but risk increases indefinitely with increased connectivity.

SourcePLOS·JournalPLOS Computational Biology·DateMar 18, 2021

Parasites may make dogs smell good to insect vector

A study found that infected dogs emit an odor attractive to female sand flies, which transmit Leishmania infantum, the parasite causing visceral leishmaniasis. The researchers suggest parasites manipulate their host's scent to improve transmission opportunities.

SourcePLOS·JournalPLOS Pathogens·DateMar 18, 2021

Honey bee behavior from within the hive

A study published in PLOS ONE reveals rare honey bee behaviors, including mouth-to-mouth larval feedings, using video recordings from within the hive. The research provides new insights into individual honey bee behavior, revealing complex social interactions and processes previously undocumented.

SourcePLOS·JournalPLOS ONE·DateMar 17, 2021

SARS-CoV-2 jumped from bats to humans without much change

The study found that SARS-CoV-2 underwent little significant genetic change in the first year of the pandemic, suggesting a 'generalist' nature and rapid transmission. This is attributed to human population immunity and lack of containment, allowing the virus to spread quickly.

SourcePLOS·JournalPLOS Biology·DateMar 12, 2021

Standard vital signs could help estimate people's pain levels

A new study shows that machine-learning strategies can be applied to routinely collected physiological data to provide clues about pain levels in people with sickle cell disease. The researchers found that these vital signs give clues into the patients' reported pain levels, outperforming baseline models.

SourcePLOS·JournalPLOS Computational Biology·DateMar 11, 2021

Openly available toolkit to help lab-based coronavirus research

A new, openly available SARS-CoV-2 laboratory research toolkit was published in PLOS Biology. The toolkit includes a 'single plasmid reverse genetics' system allowing researchers to manipulate the coronavirus genome and study individual mutations. This will fast-track investigation of COVID-19 research, including novel variants, drug d...

SourcePLOS·JournalPLOS Biology·DateFeb 25, 2021

Two new genes linked to Alzheimer's disease discovered

Researchers identified two new genes linked to Alzheimer's disease, PTPN9 and PCDHA4, in a study of gene expression in the hippocampus. The findings suggest that these genes contribute to the progression of the disease through pathways related to plaque formation and cell death.

SourcePLOS·JournalPLOS Genetics·DateFeb 25, 2021

Effects of face masks on speech recognition

Respirator and cloth masks increase difficulties in recognizing speech amidst background noise. Surgical masks have no negative effect on communication., Researchers found face masks negatively affect speech recognition in noisy settings.

SourcePLOS·JournalPLOS ONE·DateFeb 24, 2021

Captive chimpanzees may unite against a common enemy

Captive chimpanzees display cohesive behaviors such as physical closeness and play when exposed to recorded calls of unknown chimp species. This response indicates an innate ability to form alliances, suggesting a complex social structure in captive chimps.

SourcePLOS·JournalPLOS ONE·DateFeb 24, 2021

Pre-existing immunity protects against airborne spread of flu viruses

A study found that pre-existing immunity against previous flu infections can protect individuals from airborne transmission of seasonal flu viruses. The researchers used the ferret model and discovered that even short exposure times can lead to efficient transmission, but prior immunity provides a significant barrier to infection.

SourcePLOS·JournalPLOS Pathogens·DateFeb 18, 2021