Research team discovers Gulf Stream thermal fronts are essential for forming North Atlantic subtropical mode water. Suppressing this feedback can significantly reduce STMW formation by up to half, highlighting the importance of frontal-scale air-sea interactions in climate systems.
Researchers designed a novel chimeric peptide, Pal-DMPOP, to simultaneously block CD47/SIRPα and PD-1/PD-L1, leading to enhanced antitumor activity. The peptide improved phagocytosis of macrophages on tumor cells and restored T cell killing effects.
Researchers have developed an electrochemical method to synthesize 15N-labeled amino acids from 15N-nitrite and ketonic acids, achieving high yields and recycling the byproduct. The method uses a commercial nickel foam cathode under ambient conditions, showing great potential for synthesizing various 15N-amino acids.
A study in squamates reveals the genetic mechanism behind limb loss, associating conserved non-coding elements and lineage-specific insertions with regulatory signals during early limb development. These findings provide insights into the importance of these regulatory elements in phenotypic evolution.
Researchers create CuI nanodots with favorable facets and stable Cu+ state for selective CO2 reduction to C2H4. The high thermodynamic potential of Cu2+/CuI benefits formation of stable CuI, achieving a high Faradaic efficiency of 72.4%.
Researchers found that endothelial extracellular vesicles, including follistatin-like protein 1, play a crucial role in inducing acute lung injury after cardiac surgery. The study showed that inhibition of certain signaling pathways can reduce the occurrence of ALI/ARDS, providing new therapeutic targets.
Researchers found a U-shaped association between low-density lipoprotein cholesterol (LDL-C) levels and all-cause mortality risk in acute ischemic stroke patients. The lowest mortality risk was at an LDL-C level of 2.67 mmol/L, mediated by post-stroke infection.
A DNA methylation map of four Chinese populations, including Tibetans, has been released, showing that epigenetic variation is associated with high-altitude adaptation. The study reveals ethnic-specific and non-ethnic-specific DNA methylation variations correlated to global genetic divergence and high-altitude adaptation genes.
A study finds that China's aerosol reductions under carbon neutrality will cause temperature increases of 0.2-0.5 K over eastern China in the near-term future, with annual mean precipitation enhanced over southern China. In the long-term future, air temperature is projected to increase by up to 0.5 K due to clean air actions.
This study reconstructs long-term clay mineral records to show the progressive aridification of Asia's interior since late Oligocene, driven by Tibetan uplift and global cooling. Clay mineral evolution reveals strengthened continental weathering and erosion in Asia.
The COATS experiment revealed new insights into the physical mechanism and spatial structure of the atmospheric boundary layer (ABL) during haze pollution in the North China Plain. The study found that mountain-induced vertical circulations can promote the formation of elevated pollution layers.
Researchers studied cation effect on CO coupling reaction using ab initio simulations and found correlations between ion hydration energy, double layer capacitance, and surface reaction energies. Different cations influence selectivity of C2 products in CO electro-reduction.
Researchers create stacked tungsten disulfide – zinc oxide thin film heterostructure to amplify trion formation, increasing the probability of radiative recombination. This leads to enhanced information storage and potential applications in quantum devices.
This study predicts land use changes in the Tibetan Plateau during three periods, highlighting a decrease in grassland area and an increase in urban, forest, and bare land. By the end of the 21st century, grassland will decline by 6.1-21.7%, while woodland areas are expected to significantly increase.
The study developed multi-valent mRNA vaccines targeting monkeypox enveloped or mature viron surface antigens, inducing dynamic immune responses with robust IgG and neutralizing activities. The vaccines protected a mouse model from lethal VACV challenge.
Researchers have discovered anomalous quantum oscillations in twisted double bilayer graphene, which exhibit periodic behavior with the inverse of magnetic field. The oscillations are tunable by electric field and qualitatively reproduce calculations based on a phenomenological model.
Researchers discovered a new mechanism by which senescent cells resist redox stress, involving the hyperoxidation of peroxiredoxin 2, leading to decreased sensor activity and reduced RRC. This finding offers insights into aging and proposes delaying RRR as an effective strategy to intervene in aging.
Teleost fishes have developed distinct ways to generate heat, with mackerel tuna utilizing muscle differentiation and sailfish relying on ATP decomposition. These findings suggest that organisms adapt to achieve endothermy through different pathways, maximizing existing biological foundations.
A study found that circulation changes contribute to much of the inter-model differences in simulated amount of heat absorbed by the Southern Ocean. The team's analysis shows that prevailing westerly winds intensify toward the Antarctic, leading to accelerated melt of ice sheets and ice shelves.
Researchers identify three novel NPRL3 mutations in families with focal epilepsy, showing the mutant proteins lose ability to bind DEPDC5 and affect GATOR1 complex formation. This leads to decreased inhibitory effect on mTORC1 pathway activity.
Researchers developed a new type of hole-transporting material using boric acid, achieving high power conversion efficiency over 22% and long-term stability for perovskite solar cells. The study overcomes the acidity pitfall in existing SAMs, enabling a perfect contact between the substrate and perovskite layer.
Researchers developed graphene-confined ultrafast radiant heating to overcome the trade-off between ultrasmall size and high metal loading in meta cluster catalysts. The method achieved high metal loading up to 27.1 wt% in subnanometer Co cluster catalysts with fast pyrolysis times.
Researchers discovered the scale effect of ordered media on circularly polarized luminescence (CPL) signals, with measurement entropy being a dominant factor. Different luminescent materials were used to discuss macroscopic anisotropy's impact on CPL signals.
The study introduces a fluorinated cyclic carbonate as an SEI-forming additive, improving the interface between Li metal and electrolyte. The modified electrolyte enables high efficiency and long cycling stability in lithium metal batteries.
This study reveals two mechanisms of NiO electrocatalyst function, EOM-HAT and EOM-Cleavage of C-C bond, which synergize to electrooxidize primary alcohol and vicinal diol on NiO. A unified reaction mechanism is established for alcohol electrooxidation reaction on nickel-based electrocatalysts.
Scientists create a novel thermoelectric module composed of both n-type and p-type Mg3Sb2-based alloys. The modules exhibit excellent matching TE and mechanical properties, enabling efficient power generation at medium temperatures.
Researchers analyzed mobile phone signaling records to understand how people moved in response to the 2021 Zhengzhou flood. The study found that female, adolescent, and older adults were more vulnerable to flooding due to lower mobility resilience. It also identified four abnormal patterns of human mobility, which accounted for 50% of ...
The open-channel platform offers unique advantages for improving the efficiency and accuracy of trace biosensing through miniaturized reactors and easy accessibility to purification, mixing, and amplification. Various signal outputting approaches can be combined with the platforms to detect multiple targets.
This study explores the developmental regulatory mechanism of limb loss in squamates, finding lineage-specific insertions and deletions that affect limb bud formation genes. The research provides insights into the genetic basis for complex biological traits, contributing to our understanding of phenotypic evolution.
A novel 3D-NAND-based content addressable memory (CAM) design offers ultra-high density and low power consumption for data-intensive computing applications. The design achieves a cell density 157 times higher than conventional SRAM-based TCAMs, while consuming less energy per bit search.
Researchers have developed novel thermoelectric modules using the same parent materials, Mg3Sb2-based alloys. The modules show well-matched TE and mechanical properties, enabling optimal conversion efficiency. This achievement heralds widespread applications of thermoelectric devices in power generation.
Researchers in the Carassius complex discovered a unique reproduction mode that combines ameiotic oogenesis and sperm-egg fusion. This discovery enables the efficient synthesis of sterile allopolyploids, providing a promising approach for fish polyploidy breeding.
Researchers investigate structure-activity correlation for CO2 electrolysis in SOECs, revealing dynamic reconstruction of active sites. The study highlights the role of IrFe alloy nanoparticles on improving CO2 conversion performance.
The Atlantic Meridional Overturning Circulation (AMOC) has weakened since the late 19th century and continues to weaken, impacting surface air temperature in the northern hemisphere. Climate models predict that AMOC will weaken further under high emission scenarios, posing a significant risk of collapse before 2100.
A new nutrition-screening tool, AIWW, has been developed to improve diagnosis and treatment of malnutrition in cancer patients. The tool showed better screening ability than existing tools, NRS2002 and MST, using the patient-generated subjective global assessment as a gold standard.
Researchers found a sustained weakening trend in East Asian seasonal temperature difference since the 1870s, largely driven by human-induced warming. Climate models generally reproduce observed variability and trends but may underestimate seasonal differences.
This study discovers over 10,000 novel genes in cotton, including protein-coding and long non-coding RNAs, created by LTR insertions. The findings provide insight into the mechanisms of intergenic transcript expression and cotton fiber development.
The study defines the northern boundary of the Asian summer monsoon (ASM) over the Tibetan Plateau, indicating its position and variability. The results show that the northern boundary roughly coincides with the boundaries of endorheic and exorheic basins and is characterized by changes in wind patterns and precipitation.
The Zhurong rover has provided direct in-situ evidence of ancient oceans in the northern plains of Mars, with sedimentary structures forming during the regression of a paleo-ocean. The discovery sheds new light on the early history of Mars and its habitability.
Researchers fabricated 2D perovskite solar cells based on molecular ferroelectrics, achieving the highest open circuit voltage and best efficiency among 2D Ruddlesden-Popper perovskite solar cells. The introduction of ferroelectricity improved charge transport and device performance.
Researchers design Cu@FAU catalyst for selective hydrogenation of CO2 to methanol, achieving stable yields and selectivity. The study reveals a unique reaction pathway involving dihydrogen activation on copper-oxygen pairs.
The study investigates toxic effects of pesticides (chlorpyrifos, acetochlor, dicofol) on S. costatum growth and chlorophyll-a content, revealing varying toxicity levels among the pesticides. Marine microalgae partially degrade pesticides, with acetochlor showing stronger persistence.
Researchers explored AI applications in remote sensing, including multimodal imagery interpretation, hyperspectral image restoration, and semantic segmentation. These advancements are improving the analysis and processing of satellite data.
The study reports a positive magnetodielectric effect of up to 12% in the compound, with significant increase in electric polarization under magnetic field. Spin-polarized computational calculations reveal that the effect is mainly derived from spin-orbit coupling between Fe II and Cl2 An– under the magnetic field.
Gracilaria cultivation in China has shown a great annual growth trend, with predicted net carbon sink from 2021 to 2030 doubling that of the last decade. This could contribute significantly to achieving China's carbon peak goal.
Researchers observed two crystallographically independent radicals in a photoswitchable coordination polymer, showcasing a synergistic effect between valence tautomerism and semi-conductivity. This study presents the first example of dual-radical-based molecular anisotropy and charge-transfer-induced conductive anisotropy.
Researchers have designed a new intercalation-type Li-free cathode that achieves an energy density of >550 Wh kg−1, surpassing existing Li-free transition-metal-based electrodes. This breakthrough offers a solution to address energy density limitations and raw material availability concerns in all-solid-state batteries.
Researchers at ShanghaiTech University and Renmin University of China discovered superconductivity up to 32 K in MoB2 under pressure, exceeding previous records. The findings highlight the role of transitional metals in borides' superconductivity and pave the way for exploring high-Tc superconductors.
Researchers have developed a method to analyze regional turbulence structure and estimate turbulence spectra using long time series data from four-site observations. This approach overcomes previous assumptions of steady-state turbulence, horizontal uniform turbulence flux, and constant flux layer, providing more representative results.
A novel frameshift mutation in the SCNN1B gene has been identified as a causative factor for Liddle syndrome, a rare and serious form of hypertension. The study found that this mutation leads to an increase in sodium influx through the epithelial sodium channels, resulting in high blood pressure and low potassium levels.