A chemical tool was developed to manipulate liquid-liquid phase separation (LLPS) reversibly and dynamically within living cells. The compound pairs BI-3802 and BI-3812 can readily modulate LLPS of fused proteins, enabling the study of their functions in vivo.
Researchers explore subduction initiation process with varying geological records, proposing two contrasting regimes: hot and cold. High-temperature ophiolites and metamorphic sole are characteristic of hot subduction initiation, while cold subduction zones lack these records.
Scientists used a new method to analyze zircon minerals, providing insight into the oxidation state of crustal magmatism and the supercontinent cycle. The study found that the redox state of magmas rose at 3.5 billion years ago, followed by a consistent average oxidation state over the last 3 billion years.
The Tibetan Plateau's pre-Cryogenian sedimentation records reveal the formation and evolution of early supercontinents. The study found three basement types: Tarim-, Yangtze-, and Lhasa-type, with distinct characteristics.
Researchers have developed a novel 'In−N−Out' strategy to mitigate safety issues in flammable electrolytes. The design allows for high-phosphate-content electrolytes without compromising Li+ insertion at the graphite anode. Excellent ion conductivity is achieved, making it suitable for extended battery application.
Researchers designed and synthesized raloxifene analogues, exhibiting dual-emission properties with blue fluorescence and orange phosphorescence. The crystals' RTP behavior is influenced by packing modes, allowing for multilevel stimuli-responsiveness to mechanical force, solvent vapor, and heat.
Researchers have discovered the most active Cu facet for ZnO-Cu interfacial catalysis, leading to improved efficiency in CO2 hydrogenation to methanol and reverse water-gas shift reactions. The study suggests that engineering Cu nanoparticles with minimized exposed bare Cu surfaces can lead to highly active and selective catalysts.
Scientists have identified a new oil-flower/oil-bee pollination mutualism in tropical Asia, where male bees collect oil from orchid flowers. This discovery highlights the challenge of maintaining natural orchid populations, which rely heavily on male oil-bees for reproduction.
A review article highlights the potential of AI in improving battery performance, safety, and lifespan through enhanced electrolyte design and interface mechanics. The technology combines machine learning models to gain deeper insights into battery formation processes and extract key descriptors from large data sets.
The study found that sintilimab was efficacious and well-tolerated in treating advanced NSCLC, with a confirmed ORR of 51.4% in the monotherapy arm. Treatment-related adverse events were consistent with previous phase III studies, but sintilimab had a higher incidence of rash compared to pembrolizumab.
Researchers have discovered that tailoring the morphology symmetry of bismuth vanadate (BiVO4) photocatalysts enables efficient charge separation and improved water oxidation activity. This is achieved by spatially separating photogenerated electrons and holes between different facets.
This study explores the emergence of a machine language using neural networks, allowing AI to generate variable-length, discrete representations. The research demonstrates potential advantages in interpretability, generalization, and robustness across diverse datasets.
Recent advances in solar-driven photo(electro)chemistry enable environmentally-friendly synthesis of epoxides, reducing reliance on hazardous oxidants and fossil fuels. Emerging systems promote efficient epoxide production with improved catalytic selectivity.
Researchers developed a novel method to quantify information loss caused by mutual coupling in digital metasurfaces. The study found that the probability distribution of current on the metasurface is a set of dependent normal distributions, indicating significant information loss when converting digital signals into electromagnetic waves.
The VPNVax platform utilizes a modular approach to create viromimetic polymer nanoparticle vaccines with enhanced surface valence, demonstrating improved immune stimulatory effects. The research offers new insights into designing the next generation of VLP vaccines with increased durability and versatility.
New research reveals that solar radiation, atmospheric humidity, and ecosystem processes significantly affect the oxygen concentration over the Qinghai-Tibetan Plateau. Vegetation is found to have a substantial contribution rate of 16.7-24.5%, contradicting existing estimates.
Between 1990 and 2022, China's urban FVC increased by 27.31% due to ecological construction policies and urban expansion, particularly in megacities.
The study assesses sustainable food system thresholds and proposes management strategies to reduce resource input and environmental impacts. Current indicators show that global cropland area has surpassed the upper boundary, while agricultural water use and fertilizer applications have also exceeded sustainability limits.
Researchers developed two complexes with five coplanar M–C σ bonds using a carbon chain ligand, exhibiting exceptional stability at high temperatures and in moist environments. The unique structures expand the record for coplanar M–C σ bonds to five.
This study elucidates the molecular mechanism governing TRIM71's RNA-binding property, revealing a specific nucleotide sequence and key residues essential for interaction with stem-loop structured RNAs. Mutations impairing these interactions are also identified, providing insights into TRIM71-related diseases.
Researchers have developed an efficient photothermal catalyst for CO2 methanation, achieving high conversion rates and selectivity without external heating. The NiFe alloy nanoparticles exhibit enhanced localized surface plasmon resonance effect, allowing for stable operation over 100 hours.
The article reviews the benefits of in-situ solidification in improving the safety and adaptability of high-energy-density lithium metal batteries. The technology enhances conformal contacts, reduces interfacial impedance, and improves electrochemical performance.
A team of scientists has identified two key proteins involved in a plant's ability to cope with nighttime heat stress, shedding light on the circadian clock's role in regulating this process. The discovery reveals that these proteins control mRNA alternative splicing and contribute to improved thermotolerance.
Researchers review recent progress in zirconium-based MOF development, highlighting reticular chemistry's role in designing targeted structures and properties. Future directions include exploring new design strategies, emerging synthesis techniques, and commercialization of multifunctional Zr-MOFs.
Researchers enhance electrochemical performance of Prussian blue analogues by applying ammonia etching, improving specific capacity and cycle stability. The method yields superior results, increasing discharge capacity from 76.8 mAh g-1 to 83.5 mAh g-1.
Prime editing is a genome editing technology that enables precise correction of pathogenic mutations in human diseases, showing great promise as a therapeutic strategy. The technology has rapidly progressed in the past four years, with advancements in architecture, targetability, and specificity.
Researchers have developed a novel approach to regulate perovskite film crystallization by introducing chiral molecules under magnetic-field control. This method significantly improves interaction energy between chiral molecules and perovskites, resulting in high-quality uniform films with enhanced crystal orientation.
Researchers explore opportunities for ionic liquid-based electrolytes to enhance the performance and safety of rechargeable lithium batteries. The study discusses various IL-based electrolyte types, including liquid, polymer, and composite polymer electrolytes.
Researchers developed a hydrogel fiber pattern that increases condensation rates by 85.9% and improves water collection efficiency in solar evaporative water purification. The pattern steers droplets using chemical wetting gradients and Laplace pressure difference.
Research found continuous vegetation greening and slight increase in land carbon sink during the maturation phase of the 2015/2016 El Niño event. The study attributed this to seasonal compensation effects that countered negative impacts on vegetation growth.
Experiments found that silica decreases olivine hydrothermal alteration rates and hydrogen production at lower temperatures. However, higher temperatures counteract this effect, suggesting a complex interaction between silica and the system.
Scientists reconstructed the history of great floods in the lower Pearl River area, finding seven flood deposits with an average return period of approximately 855 years. The floods were triggered by weakening Asian summer monsoons and enhanced ENSO frequency.
Researchers have updated the lunar time scale to reflect advances in understanding the Moon's evolution after the Apollo era. The new scheme divides the Moon's history into three distinct phases: Eolunarian Eon, Paleolunarian Eon, and Neolunarian Eon.
Artificial intelligence (AI) is being applied to coronary CT angiography to improve image quality and automate calculations. This enables more accurate diagnoses and personalized treatments for cardiovascular diseases.
Modern semantic communication optimizes information transmission and error correction using natural redundancy, enabling end-to-end system-wide optimization. The Seb-based framework provides a new basic model for semantic information representation, with potential applications in Intellicise networks and various industries.
Researchers discovered a novel mechanism where iron catalysts modulate reactivity and selectivity through spin state changes. The study found that spin-delocalization interactions between iron and the ligand regulate the spin and oxidation states of the iron center.
This integrated study applies a new plate tectonics model to interpret major geological phenomena on Archean cratons, eliminating the illusion that continental crust did not originate from plate tectonics. The results provide insights into the evolution of early Earth and the origin of continental crust.
This study highlights the essential role of Mettl3 in regulating CD8 T cell response during acute infection, where its absence impairs effector differentiation and memory formation. The results show that Mettl3-dependent m6A modification sustains T-bet protein expression, allowing normal production and function.
Researchers successfully created a single-domain protein catenane that exhibits improved anti-aggregation properties and thermal resilience. The enzyme retains over 70% of its activity even after being heated to 70°C for 10 minutes.
Modern semantic communication technology has been developed to utilize natural redundancy in information transmission, enabling source compression and channel transmission optimization. This technology has potential applications in emerging fields like Intellicise networks and the metaverse.
Climate change will exacerbate heat-related work hours lost in China, with provinces like the south and east most affected due to higher temperatures and larger populations. Limiting global warming to 1.5°C can avoid substantial labor losses, equivalent to 0.6-1.4% of annual GDP.
The study reveals over 10,000 viral species in global supraglacial environments, driving biogeochemical cycling and ecosystem sustainability. These viruses interact with host microbes to promote metabolism, adaptation, and phenolic carbon use in hostile conditions.
The convergence of automation and AI in organic chemistry has led to a paradigm shift, enabling the development of self-evolving chemistry assistants. This integration is poised to unlock new possibilities in understanding reaction mechanisms and teaching organic chemical reactions.
Scientists create novel concept for all-weather CO2 utilization by mimicking natural photosynthesis, enabling round-the-clock and solar-driven CO2 conversion.
The FASHI survey has detected a total of 41741 extragalactic HI sources in the frequency range 1305.5-1419.5 MHz, covering approximately 35% of the total sky observable by FAST.
The convergence of automation and AI is revolutionizing organic chemistry research, introducing generative AI assistants that can learn and evolve. This shift enables new possibilities in understanding reaction mechanisms and heuristics.
A long-term study found that green manuring strengthens core microbiomes in soils, promoting organic C mineralization, N fixation, and N2O release. Keystone phylotypes were key to unlocking these functions across vertical soil profiles.
The study reconstructs the thermal and tectonic evolution of regional metamorphism at convergent continental margins, focusing on the East Tethys tectonic domain. The research reveals three types of regional metamorphism and associated geothermal gradients, shedding light on the tectonic transition from cold subduction to hot rifting.
Researchers successfully created a C4-like vein pattern in rice by modulating SHORT ROOT and auxin levels. This breakthrough sheds light on the antagonistic interplay between SHR and auxin, providing critical insights into C4 vein formation.
The study connects Tethyan plate tectonic movements to changes in Earth's surface environment, influencing global temperature and mineral resource distribution. Subduction-driven plate tectonics altered ocean-sea land distribution, affecting solar energy absorption and subsequent environmental shifts.