Researchers propose a novel methodology for efficient and robust wireless-powering of deep-tissue implantable electronic devices. The technology uses ultra-low frequency magnetic energy focusing to penetrate deeper biological tissues with minimal energy loss and thermal damage.
Scientists have developed a new universal nanosystem to enhance the efficacy of tirapazamine (TPZ) in cancer treatment. The system combines a tumor microenvironment remodeling agent with a TPZ derivative, resulting in increased hypoxic cytotoxicity and improved targeting ability.
Researchers have successfully controlled the charge type and concentration of lead halide perovskite thin films using molecular remote doping, preparing n-type low-dimensional structures on the surface to promote carrier collection. This method has improved solar cell efficiencies up to 27% and tandem cells over 19%.
The new material exhibits a safe working potential, maximum lithium storage of 393 mAh g−1 at 0.02 A g−1, superior rate capability and outstanding long-term cycling performance.
This study introduces intrinsic chaotic dynamics into brain-inspired SNNs, boosting learning and generalization performance on various datasets. Chaotic dynamics improve optimization efficiency without adding extra loss functions.
Researchers have identified ALDH6A1's tetrameric architecture and unique binding model with NAD+, revealing potential for developing targeted therapies in diseases like MMSDH deficiency and severe cancer.
A Tibetan ice core shows dramatic centennial-scale fluctuations in isotopic compositions, suggesting multiple meltwater events during the early to mid-Holocene. These findings imply rapid sea-level rise and unstable climate due to fast polar ice retreat under anthropogenic global warming.
Scientists have created a new class of therapies targeting the accumulation of pathological tau protein in brain diseases. The treatment, called DEPTAC, uses chimeras to specifically dephosphorylate tau, reducing neurodegeneration and improving memory deficits.
Ferumoxytol, a superparamagnetic iron oxide nanoparticle, has significantly reshaped CE-MRI practices due to its excellent safety profile and higher relaxivity rates. Its clinical applications span various fields, including cardiovascular systems, tumors, inflammation, and cell transplantation evaluation.
Researchers developed a simple, efficient chemical leaching strategy to extract active lithium from retired batteries. The method optimizes solvent and process parameters for high recovery rates and minimal environmental pollution.
Household consumption in China drives distinct urban-rural air pollution-related mortality, with rural areas facing higher health risks. Indirect and direct consumption activities contribute to pollution, with urban households bearing more risk from indirect pollution, and less from direct pollution.
A comprehensive analysis of Triassic biostratigraphy, lithostratigraphy, and paleogeography of the Qinghai-Tibetan Plateau reveals a complex tectonic history. The study proposes a 'two continents and one basin' model, suggesting that the Indus-Yarlungzangbo Suture Zone served as a rift axis during Triassic time.
Research finds that watersheds in arid zones are more sensitive to underlying characteristics and less sensitive to climate variation, leading to a decline in water yield stability. This study provides insights for sustainable water resources development under climate change.
Researchers reconstructed spatiotemporal variations of rainy season precipitation on the Tibetan Plateau, identifying four distinct patterns and linking them to Westerly winds and monsoons. The study provides natural background support for understanding the coupling between these factors.
Researchers identified Slc43a2+ T cell subsets that expanded in both spleen and brain after virus infection, suggesting a homologous origin. Single-cell transcriptomic analysis revealed these cells matured and migrated from the spleen to trigger an immune response in the brain.
Researchers have synthesized a previously unknown iron cluster with an icosahedral [Fe@Fe12]16+ core and multicenter iron-iron bonding. The cluster's low oxidation states and unique bonding modes offer insights into the evolution of physical/chemical properties in transition metal clusters.
Researchers developed a technique to enrich circulating cell-free RNA in blood using MOF materials, achieving higher efficiency than commercial kits and preventing RNA degradation. The method identified potential serum biomarkers for non-invasive liver cancer diagnosis with high diagnostic accuracy.
A study on rice inversion variation reveals its impact on gene expression and phenotypic traits, including stress resistance. The research found that inversion genotypes are common in indica rice and contribute to heat resistance differentiation between indica and japonica rice populations.
A recent study found that China's insect species diversity is highest in the Southeast and Southwest regions, as well as the Hengduan Mountains and Hainan Island. The researchers also discovered a positive correlation between human population density and insect biodiversity on a regional scale.
The Chinese Society of Cardiology has released the first diagnostic and treatment guidelines for adult fulminant myocarditis, focusing on early identification, diagnosis, and immunomodulatory therapy. The new regimen aims to reduce mortality rates from over 50% to below 5% with life support-based comprehensive treatment.
Researchers propose a new strategy for converting waste heat into chemical energy through thermoelectrocatalysis, offering improved energy utilization efficiency and emission reduction. The study identifies four major working modes and explores ways to optimize thermoelectric properties for enhanced performance.
Researchers review developments in Si-based MOSFETs, focusing on device structure innovations and key challenges in fabricating cutting-edge stacked nano-sheet/nano-wire gate-all-around FETs. The authors also explore the potential of CFETs for scaling toward 1nm node and their integration with new channel materials.
Researchers developed a biomaterial scaffold that mimics the structure and function of a lymph node to boost CAR-T cell therapy for solid tumors. The scaffold, made from poly(lactic-co-glycolic acid), can accommodate up to 38,000 CAR-T cells and induce a remarkable 50-fold expansion in vitro.
Researchers developed dynamically stable self-healable wires by improving tensile strength and electrical stability through supramolecular chemistry. The wires showed negligible resistance fluctuation under various dynamic conditions, enabling reliable operation of interconnected wearable devices.
Nitrate helps maintain homeostasis by regulating nitric oxide levels and has been found to play a role in balancing microbiota, inflammatory immune response, and energy metabolism. Its clinical applications include treating oral diseases, digestive system disorders, cardiovascular diseases, and improving exercise ability.
Researchers have developed ATTECs, which harness the macroautophagy pathway for targeted protein and organelle degradation, potentially bypassing the limitations of conventional small-molecule drugs. This new strategy offers new directions in drug discovery, especially for diseases such as neurodegeneration and cancer.
Research findings reveal that cold epochs coincide with frequent major volcanic eruptions, leading to significant cooling globally and in China. The study also highlights inconsistencies in responses among different datasets and calls for further research on the impact of volcanoes on climate variability.
Scientists designed a series of sub-10 nm core-shell nanocatalysts with an Au core and Au <sub> x </sub> Ir <sub> 1-x </sub> alloy shell to enhance water-splitting performance. The optimal ratio of IrO <sub> x </sub> combined with a suitable <em>d</em>-band center yields the best OER activity.
Researchers have developed a nickel-modified In2O3 catalyst that exhibits high CO2 conversion rates and methanol selectivity. The catalyst's oxygen vacancies promote H2 activation, leading to higher productivity. DFT calculations suggest the optimal surface Ni content for balanced CO2 reactivity and methanol formation.
Researchers have developed a new sodium-ion battery cathode material that combines large grains, suppressed phase transitions, and improved Na+ transport kinetics. The material shows high energy density and good cycle performance, making it suitable for practical applications.
Researchers developed generative AI tools to predict protein structures and understand enzyme function. The study reveals the link between evolutionary patterns and catalytic activity, enabling the successful engineering of proteins like luciferase.
The DTEP model accurately predicts delayed treatment effects (DTE) in immuno-oncology trials, allowing for optimized trial designs. By tailoring trial lengths, the model enhances statistical power and accelerates immunotherapy development.
Researchers have developed a single molecular entity combining cisplatin and STING agonist, exhibiting potential as a versatile anticancer drug specifically targeting pancreatic cancer. The conjugate shows promise in elevating innate immunity and boosting the infiltration of natural killer cells into tumors.
Researchers developed MOTIF to predict immunotherapy response and guide combination therapy based on TMB-associated immune infiltration. High MOTIF scores correlate with patient responses to immunotherapy, while low scores indicate resistance.
Intermediate volatility compounds contribute up to 70% of secondary organic aerosols in biomass-burning emissions, surpassing volatile organic compounds. The study used a newly-developed reactor to analyze the composition, concentration, and yield of IVOCs-generated aerosols.
Studies reveal similar yet distinct structural/functional brain abnormalities between early-onset schizophrenia and autism spectrum disorder. Early-onset schizophrenia exhibits more severe anatomical abnormalities, while autism spectrum disorder shows a more subtle trend in connectomic properties.
The study designed and investigated Fe-Rh atom catalysts with varying atomic site distances for improved oxygen reduction reaction (ORR) efficiency. The researchers found that a specific Fe-Rh d2@NC catalyst exhibited optimal catalytic performance, outperforming commercial Pt/C catalysts.
This study investigates the effects of ocean chlorophyll interannual variability and tropical instability wave-scale perturbations on ENSO. Researchers found that large-scale chlorophyll variations dampen ENSO, while TIW-scale variations amplify it.
A large Chinese cohort study found that remnant cholesterol levels above 27.7 mg/dl are associated with elevated cardiovascular disease mortality and ischemic heart diseases, but lower cancer mortality rates for certain types of cancer like lung, liver, and gastric cancers
Researchers found that gut fungal variations, particularly Ascomycota and Candida genus abundance, correlate with liver disease progression. The study suggests potential fungal biomarkers and therapeutic targets for liver diseases, indicating gut mycobiota may play a role in prevention or treatment.
Researchers have developed flexible sensors with zero Poisson's ratio, enabling independent detection of biaxial stimuli. The sensors accurately detect force, strain, and motion status in robotic manipulation and locomotion with complex deformation.
Scientists have created a method for producing CAR-T cells within the body utilizing nanovesicles that mimic viruses. The fusion of nanovesicles with T-cells enables the efficient incorporation of CAR proteins, resulting in effective inhibition of B-cell lymphoma growth.
Researchers have discovered a universal propensity for forming stable hybrid compounds when molecules are inserted into ionic crystals under high pressure. This process can lead to the formation of novel materials with promising properties for green energy storage and potentially reveal insights into giant planets' structure and dynamics.
Researchers discovered that catalytic properties of buried transitional metals can be conducted to exposed inert main group metals through metallic bonding. The team built real metal systems containing buried transitional metal centers, showing expected catalytic performance in various reactions.
This study reviews 13 compound events, synthesizing ~350 peer-reviewed papers, to understand impacts, physical mechanisms, historical/future changes, and attribution evidences. The authors identified data and methodological challenges common to the field and proposed future directions.
Researchers uncover HUNK's role in regulating cellular transport by inhibiting CavME and promoting lysosomal maturation. This leads to improved delivery of nanoparticles and enhanced cancer treatment outcomes.
Researchers developed a novel MOF-based drug delivery system combining adavosertib with sonodynamic therapy to enhance synthetic lethal effect in p53-mutated gallbladder cancer. This approach provides a tumor-targeting ability and reduces drug resistance, offering a promising strategy for treating refractory cancers.
Researchers proposed PIANO, an operator learning framework that deciphers and incorporates physical invariants from PDE series via self-supervised learning and attention technique. This approach achieves superior performance in scenarios with different physical mechanisms.
Researchers analyzed one-year wind and wave observations from CFOSAT to understand the modulation characteristics of wave-induced stress on wind stress. The study found significant seasonal variations in wave-induced stress globally, with stronger effects in Southern Hemisphere westerly belt and high-latitude areas.
A new study suggests that targeting LTA4H improves the tumor immune microenvironment and increases sensitivity to cisplatin therapy in ovarian cancer. High expression of LTA4H indicates poor prognosis and is associated with decreased CD8+ cell infiltration.