Researchers developed a bioinspired mechanical reinforcement strategy to improve polysaccharide-based membrane properties. The dual-scale network nanocomposite membrane exhibited excellent wet mechanical properties and good biological properties, indicating its large biomedical application potential.
This study proposes using SAR visual semantics to overcome challenges in TomoSAR, including incomplete building structures and large outliers. A three-level approach extracts low-, middle-, and high-level semantics, enabling efficient and realistic 3D modeling.
Researchers develop materiobiological approaches to rejuvenate aged bone by modulating biological functions through functionalized biomaterials. They establish a 'toolbox' of essential elements for material design and highlight the potential of artificial intelligence in accelerating aged bone regeneration.
The study introduces EPR-Net, a deep learning method that effectively characterizes Waddington landscapes in high-dimensional systems. It leverages the negative gradient of Waddington landscape to an extended Helmholtz decomposition, providing a breakthrough insight into non-equilibrium systems.
A new algorithm, developed by Prof. Linyuan Lü and Dr. Manuel S. Mariani, challenges the long-standing paradigm that network hubs are effective information spreaders. The research shows that users' behavioral traits provide more accurate early indicators of their spreading ability than their position in the social network.
This study reveals that LSD1 coordinates with FSH to promote antral follicle formation in mice by repressing Atg16l2, which inhibits autophagy. LSD1 also suppresses FSH responsiveness through Wt1 repression in granulosa cells.
China's karst inorganic carbon storage plays a significant role in mitigating climate change, with a calculated Concentration and Storage of Carbonate Sink Form (CCSF) of 22.76 t CO2 km-2 a-1. The CCSF varies by region, with higher values in the southern karst area due to high water and heat flux.
Researchers successfully synthesized a one-dimensional carbon chain on the Au(111) surface, characterized by bond-resolved atomic force microscopy. The polyynic nature of the carbon chain was unambiguously revealed, and its electronic properties were studied using scanning tunnelling spectroscopy, exhibiting a band gap of 5.8 eV.
Researchers developed a new method to measure bias distribution in two-electrode PEC cells, revealing that OER half-reaction is not always the rate-limiting factor. By tuning electrolyte pH and coupled half-reactions, they adjusted bias distribution and proposed a descriptor for designing efficient PEC cells.
Researchers analyzed over 5,000 metagenomic samples from 60 cities worldwide to understand the landscape of global urban environmental resistome. The study found significant regional specificity in antibiotic resistance and a positive correlation with antibiotic consumption.
A single-cell profile of cardiac immune cells reveals diverse types of infiltrating immune cells and their dynamic changes in response to myocardial ischemia-reperfusion injury (MIRI). A novel cardio-protective neutrophil subtype, Ym-1hi Neu, is identified with therapeutic potential.
Researchers have discovered two sex pheromone receptors in male American cockroaches that respond to female pheromones PA and PB. The study reveals a complex mechanism where these pheromones interact with specific olfactory receptors to regulate courtship and mating behavior.
Researchers investigated the effect of precise molecular structure on organic electrode performance, finding that a specific isomer had higher capacity and better rate capability due to reduced steric hinderance. This work demonstrates molecule-level precise structure regulation for improving organic energy storage.
Chinese scientists have discovered the spinning mechanism of silkworms, revealing that metal ions and pH gradients play a crucial role in forming highly ordered molecular alignments. This discovery could lead to the development of superfibers with higher strength and toughness.
A novel portable IOP tonometer utilizes a displacement-pressure biparametrically regulated softness sensory system to accurately assess eyeball pressure. The device, costing $200, surpasses commercial alternatives in accuracy and low cost, offering a high-comfort solution for IOP monitoring.
Researchers discovered a new method to boost thermopower in PEDOT:PSS films by manipulating polaron interfacial entropy using UV light. This increases the material's Seebeck coefficient and enhances its thermoelectric performance.
The study reveals that natural (-)-morphine binds to the μ-opioid receptor (MOR) in its activated state, resulting in pain relief. Conversely, (+)-morphine fails to sustain MOR's activation, with (-)-morphine demonstrating a longer residence time in MOR by a factor of 8,000.
Researchers successfully synthesized quantum dots in the nucleus of live cells by regulating glutathione levels, a breakthrough that could enable the production of inorganic nanomaterials. This achievement addresses the current limitations in synthetic biology and opens new possibilities for producing nanodrugs and nanorobots.
Researchers propose a novel methodology for efficient and robust wireless-powering of deep-tissue implantable electronic devices. The technology uses ultra-low frequency magnetic energy focusing to penetrate deeper biological tissues with minimal energy loss and thermal damage.
Scientists have developed a new universal nanosystem to enhance the efficacy of tirapazamine (TPZ) in cancer treatment. The system combines a tumor microenvironment remodeling agent with a TPZ derivative, resulting in increased hypoxic cytotoxicity and improved targeting ability.
Researchers have successfully controlled the charge type and concentration of lead halide perovskite thin films using molecular remote doping, preparing n-type low-dimensional structures on the surface to promote carrier collection. This method has improved solar cell efficiencies up to 27% and tandem cells over 19%.
The new material exhibits a safe working potential, maximum lithium storage of 393 mAh g−1 at 0.02 A g−1, superior rate capability and outstanding long-term cycling performance.
This study introduces intrinsic chaotic dynamics into brain-inspired SNNs, boosting learning and generalization performance on various datasets. Chaotic dynamics improve optimization efficiency without adding extra loss functions.
Researchers have identified ALDH6A1's tetrameric architecture and unique binding model with NAD+, revealing potential for developing targeted therapies in diseases like MMSDH deficiency and severe cancer.
A Tibetan ice core shows dramatic centennial-scale fluctuations in isotopic compositions, suggesting multiple meltwater events during the early to mid-Holocene. These findings imply rapid sea-level rise and unstable climate due to fast polar ice retreat under anthropogenic global warming.
Scientists have created a new class of therapies targeting the accumulation of pathological tau protein in brain diseases. The treatment, called DEPTAC, uses chimeras to specifically dephosphorylate tau, reducing neurodegeneration and improving memory deficits.
Ferumoxytol, a superparamagnetic iron oxide nanoparticle, has significantly reshaped CE-MRI practices due to its excellent safety profile and higher relaxivity rates. Its clinical applications span various fields, including cardiovascular systems, tumors, inflammation, and cell transplantation evaluation.
Researchers developed a simple, efficient chemical leaching strategy to extract active lithium from retired batteries. The method optimizes solvent and process parameters for high recovery rates and minimal environmental pollution.
Household consumption in China drives distinct urban-rural air pollution-related mortality, with rural areas facing higher health risks. Indirect and direct consumption activities contribute to pollution, with urban households bearing more risk from indirect pollution, and less from direct pollution.
A comprehensive analysis of Triassic biostratigraphy, lithostratigraphy, and paleogeography of the Qinghai-Tibetan Plateau reveals a complex tectonic history. The study proposes a 'two continents and one basin' model, suggesting that the Indus-Yarlungzangbo Suture Zone served as a rift axis during Triassic time.
Research finds that watersheds in arid zones are more sensitive to underlying characteristics and less sensitive to climate variation, leading to a decline in water yield stability. This study provides insights for sustainable water resources development under climate change.
Researchers reconstructed spatiotemporal variations of rainy season precipitation on the Tibetan Plateau, identifying four distinct patterns and linking them to Westerly winds and monsoons. The study provides natural background support for understanding the coupling between these factors.
Researchers identified Slc43a2+ T cell subsets that expanded in both spleen and brain after virus infection, suggesting a homologous origin. Single-cell transcriptomic analysis revealed these cells matured and migrated from the spleen to trigger an immune response in the brain.
Researchers have synthesized a previously unknown iron cluster with an icosahedral [Fe@Fe12]16+ core and multicenter iron-iron bonding. The cluster's low oxidation states and unique bonding modes offer insights into the evolution of physical/chemical properties in transition metal clusters.
Researchers developed a technique to enrich circulating cell-free RNA in blood using MOF materials, achieving higher efficiency than commercial kits and preventing RNA degradation. The method identified potential serum biomarkers for non-invasive liver cancer diagnosis with high diagnostic accuracy.
A study on rice inversion variation reveals its impact on gene expression and phenotypic traits, including stress resistance. The research found that inversion genotypes are common in indica rice and contribute to heat resistance differentiation between indica and japonica rice populations.
A recent study found that China's insect species diversity is highest in the Southeast and Southwest regions, as well as the Hengduan Mountains and Hainan Island. The researchers also discovered a positive correlation between human population density and insect biodiversity on a regional scale.
The Chinese Society of Cardiology has released the first diagnostic and treatment guidelines for adult fulminant myocarditis, focusing on early identification, diagnosis, and immunomodulatory therapy. The new regimen aims to reduce mortality rates from over 50% to below 5% with life support-based comprehensive treatment.
Researchers propose a new strategy for converting waste heat into chemical energy through thermoelectrocatalysis, offering improved energy utilization efficiency and emission reduction. The study identifies four major working modes and explores ways to optimize thermoelectric properties for enhanced performance.
Researchers review developments in Si-based MOSFETs, focusing on device structure innovations and key challenges in fabricating cutting-edge stacked nano-sheet/nano-wire gate-all-around FETs. The authors also explore the potential of CFETs for scaling toward 1nm node and their integration with new channel materials.
Researchers developed a biomaterial scaffold that mimics the structure and function of a lymph node to boost CAR-T cell therapy for solid tumors. The scaffold, made from poly(lactic-co-glycolic acid), can accommodate up to 38,000 CAR-T cells and induce a remarkable 50-fold expansion in vitro.
Researchers developed dynamically stable self-healable wires by improving tensile strength and electrical stability through supramolecular chemistry. The wires showed negligible resistance fluctuation under various dynamic conditions, enabling reliable operation of interconnected wearable devices.
Nitrate helps maintain homeostasis by regulating nitric oxide levels and has been found to play a role in balancing microbiota, inflammatory immune response, and energy metabolism. Its clinical applications include treating oral diseases, digestive system disorders, cardiovascular diseases, and improving exercise ability.
Researchers have developed ATTECs, which harness the macroautophagy pathway for targeted protein and organelle degradation, potentially bypassing the limitations of conventional small-molecule drugs. This new strategy offers new directions in drug discovery, especially for diseases such as neurodegeneration and cancer.
Research findings reveal that cold epochs coincide with frequent major volcanic eruptions, leading to significant cooling globally and in China. The study also highlights inconsistencies in responses among different datasets and calls for further research on the impact of volcanoes on climate variability.
Scientists designed a series of sub-10 nm core-shell nanocatalysts with an Au core and Au <sub> x </sub> Ir <sub> 1-x </sub> alloy shell to enhance water-splitting performance. The optimal ratio of IrO <sub> x </sub> combined with a suitable <em>d</em>-band center yields the best OER activity.
Researchers have developed a nickel-modified In2O3 catalyst that exhibits high CO2 conversion rates and methanol selectivity. The catalyst's oxygen vacancies promote H2 activation, leading to higher productivity. DFT calculations suggest the optimal surface Ni content for balanced CO2 reactivity and methanol formation.
Researchers have developed a new sodium-ion battery cathode material that combines large grains, suppressed phase transitions, and improved Na+ transport kinetics. The material shows high energy density and good cycle performance, making it suitable for practical applications.
Researchers developed generative AI tools to predict protein structures and understand enzyme function. The study reveals the link between evolutionary patterns and catalytic activity, enabling the successful engineering of proteins like luciferase.
The DTEP model accurately predicts delayed treatment effects (DTE) in immuno-oncology trials, allowing for optimized trial designs. By tailoring trial lengths, the model enhances statistical power and accelerates immunotherapy development.