Researchers have developed a single molecular entity combining cisplatin and STING agonist, exhibiting potential as a versatile anticancer drug specifically targeting pancreatic cancer. The conjugate shows promise in elevating innate immunity and boosting the infiltration of natural killer cells into tumors.
Researchers developed MOTIF to predict immunotherapy response and guide combination therapy based on TMB-associated immune infiltration. High MOTIF scores correlate with patient responses to immunotherapy, while low scores indicate resistance.
Intermediate volatility compounds contribute up to 70% of secondary organic aerosols in biomass-burning emissions, surpassing volatile organic compounds. The study used a newly-developed reactor to analyze the composition, concentration, and yield of IVOCs-generated aerosols.
Studies reveal similar yet distinct structural/functional brain abnormalities between early-onset schizophrenia and autism spectrum disorder. Early-onset schizophrenia exhibits more severe anatomical abnormalities, while autism spectrum disorder shows a more subtle trend in connectomic properties.
The study designed and investigated Fe-Rh atom catalysts with varying atomic site distances for improved oxygen reduction reaction (ORR) efficiency. The researchers found that a specific Fe-Rh d2@NC catalyst exhibited optimal catalytic performance, outperforming commercial Pt/C catalysts.
This study investigates the effects of ocean chlorophyll interannual variability and tropical instability wave-scale perturbations on ENSO. Researchers found that large-scale chlorophyll variations dampen ENSO, while TIW-scale variations amplify it.
A large Chinese cohort study found that remnant cholesterol levels above 27.7 mg/dl are associated with elevated cardiovascular disease mortality and ischemic heart diseases, but lower cancer mortality rates for certain types of cancer like lung, liver, and gastric cancers
Researchers found that gut fungal variations, particularly Ascomycota and Candida genus abundance, correlate with liver disease progression. The study suggests potential fungal biomarkers and therapeutic targets for liver diseases, indicating gut mycobiota may play a role in prevention or treatment.
Researchers have developed flexible sensors with zero Poisson's ratio, enabling independent detection of biaxial stimuli. The sensors accurately detect force, strain, and motion status in robotic manipulation and locomotion with complex deformation.
Scientists have created a method for producing CAR-T cells within the body utilizing nanovesicles that mimic viruses. The fusion of nanovesicles with T-cells enables the efficient incorporation of CAR proteins, resulting in effective inhibition of B-cell lymphoma growth.
Researchers have discovered a universal propensity for forming stable hybrid compounds when molecules are inserted into ionic crystals under high pressure. This process can lead to the formation of novel materials with promising properties for green energy storage and potentially reveal insights into giant planets' structure and dynamics.
Researchers discovered that catalytic properties of buried transitional metals can be conducted to exposed inert main group metals through metallic bonding. The team built real metal systems containing buried transitional metal centers, showing expected catalytic performance in various reactions.
This study reviews 13 compound events, synthesizing ~350 peer-reviewed papers, to understand impacts, physical mechanisms, historical/future changes, and attribution evidences. The authors identified data and methodological challenges common to the field and proposed future directions.
Researchers uncover HUNK's role in regulating cellular transport by inhibiting CavME and promoting lysosomal maturation. This leads to improved delivery of nanoparticles and enhanced cancer treatment outcomes.
Researchers developed a novel MOF-based drug delivery system combining adavosertib with sonodynamic therapy to enhance synthetic lethal effect in p53-mutated gallbladder cancer. This approach provides a tumor-targeting ability and reduces drug resistance, offering a promising strategy for treating refractory cancers.
Researchers proposed PIANO, an operator learning framework that deciphers and incorporates physical invariants from PDE series via self-supervised learning and attention technique. This approach achieves superior performance in scenarios with different physical mechanisms.
Researchers analyzed one-year wind and wave observations from CFOSAT to understand the modulation characteristics of wave-induced stress on wind stress. The study found significant seasonal variations in wave-induced stress globally, with stronger effects in Southern Hemisphere westerly belt and high-latitude areas.
A new study suggests that targeting LTA4H improves the tumor immune microenvironment and increases sensitivity to cisplatin therapy in ovarian cancer. High expression of LTA4H indicates poor prognosis and is associated with decreased CD8+ cell infiltration.
A chemical tool was developed to manipulate liquid-liquid phase separation (LLPS) reversibly and dynamically within living cells. The compound pairs BI-3802 and BI-3812 can readily modulate LLPS of fused proteins, enabling the study of their functions in vivo.
Researchers explore subduction initiation process with varying geological records, proposing two contrasting regimes: hot and cold. High-temperature ophiolites and metamorphic sole are characteristic of hot subduction initiation, while cold subduction zones lack these records.
Scientists used a new method to analyze zircon minerals, providing insight into the oxidation state of crustal magmatism and the supercontinent cycle. The study found that the redox state of magmas rose at 3.5 billion years ago, followed by a consistent average oxidation state over the last 3 billion years.
The Tibetan Plateau's pre-Cryogenian sedimentation records reveal the formation and evolution of early supercontinents. The study found three basement types: Tarim-, Yangtze-, and Lhasa-type, with distinct characteristics.
Researchers have developed a novel 'In−N−Out' strategy to mitigate safety issues in flammable electrolytes. The design allows for high-phosphate-content electrolytes without compromising Li+ insertion at the graphite anode. Excellent ion conductivity is achieved, making it suitable for extended battery application.
Researchers designed and synthesized raloxifene analogues, exhibiting dual-emission properties with blue fluorescence and orange phosphorescence. The crystals' RTP behavior is influenced by packing modes, allowing for multilevel stimuli-responsiveness to mechanical force, solvent vapor, and heat.
Researchers have discovered the most active Cu facet for ZnO-Cu interfacial catalysis, leading to improved efficiency in CO2 hydrogenation to methanol and reverse water-gas shift reactions. The study suggests that engineering Cu nanoparticles with minimized exposed bare Cu surfaces can lead to highly active and selective catalysts.
Scientists have identified a new oil-flower/oil-bee pollination mutualism in tropical Asia, where male bees collect oil from orchid flowers. This discovery highlights the challenge of maintaining natural orchid populations, which rely heavily on male oil-bees for reproduction.
A review article highlights the potential of AI in improving battery performance, safety, and lifespan through enhanced electrolyte design and interface mechanics. The technology combines machine learning models to gain deeper insights into battery formation processes and extract key descriptors from large data sets.
The study found that sintilimab was efficacious and well-tolerated in treating advanced NSCLC, with a confirmed ORR of 51.4% in the monotherapy arm. Treatment-related adverse events were consistent with previous phase III studies, but sintilimab had a higher incidence of rash compared to pembrolizumab.
Researchers have discovered that tailoring the morphology symmetry of bismuth vanadate (BiVO4) photocatalysts enables efficient charge separation and improved water oxidation activity. This is achieved by spatially separating photogenerated electrons and holes between different facets.
This study explores the emergence of a machine language using neural networks, allowing AI to generate variable-length, discrete representations. The research demonstrates potential advantages in interpretability, generalization, and robustness across diverse datasets.
Recent advances in solar-driven photo(electro)chemistry enable environmentally-friendly synthesis of epoxides, reducing reliance on hazardous oxidants and fossil fuels. Emerging systems promote efficient epoxide production with improved catalytic selectivity.
Researchers developed a novel method to quantify information loss caused by mutual coupling in digital metasurfaces. The study found that the probability distribution of current on the metasurface is a set of dependent normal distributions, indicating significant information loss when converting digital signals into electromagnetic waves.
The VPNVax platform utilizes a modular approach to create viromimetic polymer nanoparticle vaccines with enhanced surface valence, demonstrating improved immune stimulatory effects. The research offers new insights into designing the next generation of VLP vaccines with increased durability and versatility.
New research reveals that solar radiation, atmospheric humidity, and ecosystem processes significantly affect the oxygen concentration over the Qinghai-Tibetan Plateau. Vegetation is found to have a substantial contribution rate of 16.7-24.5%, contradicting existing estimates.
Between 1990 and 2022, China's urban FVC increased by 27.31% due to ecological construction policies and urban expansion, particularly in megacities.
The study assesses sustainable food system thresholds and proposes management strategies to reduce resource input and environmental impacts. Current indicators show that global cropland area has surpassed the upper boundary, while agricultural water use and fertilizer applications have also exceeded sustainability limits.
Researchers developed two complexes with five coplanar M–C σ bonds using a carbon chain ligand, exhibiting exceptional stability at high temperatures and in moist environments. The unique structures expand the record for coplanar M–C σ bonds to five.
This study elucidates the molecular mechanism governing TRIM71's RNA-binding property, revealing a specific nucleotide sequence and key residues essential for interaction with stem-loop structured RNAs. Mutations impairing these interactions are also identified, providing insights into TRIM71-related diseases.
Researchers have developed an efficient photothermal catalyst for CO2 methanation, achieving high conversion rates and selectivity without external heating. The NiFe alloy nanoparticles exhibit enhanced localized surface plasmon resonance effect, allowing for stable operation over 100 hours.
The article reviews the benefits of in-situ solidification in improving the safety and adaptability of high-energy-density lithium metal batteries. The technology enhances conformal contacts, reduces interfacial impedance, and improves electrochemical performance.
A team of scientists has identified two key proteins involved in a plant's ability to cope with nighttime heat stress, shedding light on the circadian clock's role in regulating this process. The discovery reveals that these proteins control mRNA alternative splicing and contribute to improved thermotolerance.
Researchers review recent progress in zirconium-based MOF development, highlighting reticular chemistry's role in designing targeted structures and properties. Future directions include exploring new design strategies, emerging synthesis techniques, and commercialization of multifunctional Zr-MOFs.
Researchers enhance electrochemical performance of Prussian blue analogues by applying ammonia etching, improving specific capacity and cycle stability. The method yields superior results, increasing discharge capacity from 76.8 mAh g-1 to 83.5 mAh g-1.
Prime editing is a genome editing technology that enables precise correction of pathogenic mutations in human diseases, showing great promise as a therapeutic strategy. The technology has rapidly progressed in the past four years, with advancements in architecture, targetability, and specificity.
Researchers have developed a novel approach to regulate perovskite film crystallization by introducing chiral molecules under magnetic-field control. This method significantly improves interaction energy between chiral molecules and perovskites, resulting in high-quality uniform films with enhanced crystal orientation.
Researchers explore opportunities for ionic liquid-based electrolytes to enhance the performance and safety of rechargeable lithium batteries. The study discusses various IL-based electrolyte types, including liquid, polymer, and composite polymer electrolytes.
Researchers developed a hydrogel fiber pattern that increases condensation rates by 85.9% and improves water collection efficiency in solar evaporative water purification. The pattern steers droplets using chemical wetting gradients and Laplace pressure difference.
Research found continuous vegetation greening and slight increase in land carbon sink during the maturation phase of the 2015/2016 El Niño event. The study attributed this to seasonal compensation effects that countered negative impacts on vegetation growth.
Experiments found that silica decreases olivine hydrothermal alteration rates and hydrogen production at lower temperatures. However, higher temperatures counteract this effect, suggesting a complex interaction between silica and the system.
Scientists reconstructed the history of great floods in the lower Pearl River area, finding seven flood deposits with an average return period of approximately 855 years. The floods were triggered by weakening Asian summer monsoons and enhanced ENSO frequency.